Róbert Tarszabó, Bálint Bányai, Éva Ruisanchez, Borbála Péterffy, Ágnes Korsós-Novák, Krisztina Lajtai, Réka Eszter Sziva, Dóra Gerszi, Ádám Hosszú, Rita Benkő, Zoltán Benyó, Eszter Mária Horváth, Gabriella Masszi, Szabolcs Várbíró
We examined the vasoactive effect of estradiol in a rat model of early PCOS and the influence of vitamin D deficiency (VDD). We created a model of chronic hyperandrogenism and VDD in adolescent female Wistar rats (N = 46) with four experimental groups: vitamin D supplemented (T-D+), VDD (T-D-), hyperandrogenic and vitamin D supplemented (T+D+), and hyperandrogenic and VDD (T+D-). T+ groups received an 8-week-long transdermal Androgel treatment, D-animals were on vitamin D-reduced diet and D+ rats were supplemented orally with vitamin D3...
August 30, 2021: International Journal of Molecular Sciences