keyword
https://read.qxmd.com/read/38521506/quantification-of-ventricular-stress-in-univentricular-hearts-during-early-childhood-using-age-independent-zlog-nt-probnp
#21
JOURNAL ARTICLE
Jonas Palm, Masamichi Ono, Carolin Niedermaier, Jürgen Hörer, Georg Hoffmann, Stefan Holdenrieder, Frank Klawonn, Peter Ewert
BACKGROUND: Children with univentricular hearts (UVH) undergo up to three palliative surgical procedures to achieve complete circulatory separation (Fontan circulation). As a marker of cardiac wall stress, NT-proBNP is a promising tool to assess systemic ventricular load in these patients. However, different reference intervals (RI) apply to each stage, as NT-proBNP is highly age-dependent. METHODS: Children undergoing systemic-to-pulmonary (SP) shunt placement (stage 1), bidirectional cavopulmonary shunt (BCPS, stage 2) or total cavopulmonary connection (TCPC, stage 3) between 2011 and 2021 with NT-proBNP measurement within 7 days before surgery were included...
March 21, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38521371/cardioprotective-potential-of-compound-3k-a-selective-pkm2-inhibitor-in-isoproterenol-induced-acute-myocardial-infarction-a-mechanistic-study
#22
JOURNAL ARTICLE
Mohd Rihan, Shyam Sunder Sharma
Myocardial infarction (MI) or heart attack arises from acute or chronic prolonged ischemic conditions in the myocardium. Although several risk factors are associated with MI pathophysiology, one of the risk factors is an imbalance in the oxygen supply. The current available MI therapies are still inadequate due to the complexity of MI pathophysiology. Pyruvate kinase M2 (PKM2) has been implicated in numerous CVDs pathologies. However, the effect of specific pharmacological intervention targeting PKM2 has not been studied in MI...
March 21, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38520521/exploring-mitochondrial-biomarkers-for-friedreich-s-ataxia-a-multifaceted-approach
#23
JOURNAL ARTICLE
Lucie Stovickova, Hana Hansikova, Jitka Hanzalova, Zuzana Musova, Valerij Semjonov, Pavel Stovicek, Haris Hadzic, Ludmila Novotna, Martin Simcik, Pavel Strnad, Anastaziia Serbina, Simona Karamazovova, Jaroslava Schwabova Paulasova, Martin Vyhnalek, Pavel Krsek, Alena Zumrova
This study presents an in-depth analysis of mitochondrial enzyme activities in Friedreich's ataxia (FA) patients, focusing on the Electron Transport Chain complexes I, II, and IV, the Krebs Cycle enzyme Citrate Synthase, and Coenzyme Q10 levels. It examines a cohort of 34 FA patients, comparing their mitochondrial enzyme activities and clinical parameters, including disease duration and cardiac markers, with those of 17 healthy controls. The findings reveal marked reductions in complexes II and, specifically, IV, highlighting mitochondrial impairment in FA...
March 23, 2024: Journal of Neurology
https://read.qxmd.com/read/38520508/limited-relationship-between-echocardiographic-measures-and-electrocardiographic-markers-of-left-ventricular-size-in-healthy-children
#24
JOURNAL ARTICLE
Mark E Alexander, Russell Gongwer, Felicia L Trachtenberg, L LuAnn Minich, John K Triedman, Jonathan R Kaltman, Richard J Czosek, Martin Tristani-Firouzi, Martin J LaPage, Sabrina S Tsao, Andrew E Radbill, Michael P DiLorenzo, Joshua R Kovach, Elizabeth A Stephenson, Christopher Janson, Chad Mao, Jack C Salerno, Bradley C Clark, Joseph Mahgerefteh, Thomas Pilcher, Tiffanie R Johnson, Jeff J Kim, Santiago O Valdes, Nicole Cain, Lanier Jackson, Elizabeth V Saarel
Pediatric ECG standards have been defined without echocardiographic confirmation of normal anatomy. The Pediatric Heart Network Normal Echocardiogram Z-score Project provides a racially diverse group of healthy children with normal echocardiograms. We hypothesized that ECG and echocardiographic measures of left ventricular (LV) dimensions are sufficiently correlated in healthy children to imply a clinically meaningful relationship. This was a secondary analysis of a previously described cohort including 2170 digital ECGs...
March 23, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38519897/low-hdl-cholesterol-and-the-enos-glu298asp-polymorphism-are-associated-with-inducible-myocardial-ischemia-in-patients-with-suspected-stable-coronary-artery-disease
#25
JOURNAL ARTICLE
Cecilia Vecoli, Chiara Caselli, Martina Modena, Giancarlo Todiere, Rosa Poddighe, Serafina Valente, Fabrizio Bandini, Andrea Natali, Lorenzo Ghiadoni, Aldo Clerico, Concetta Prontera, Simona Vittorini, Nicoletta Botto, Michele Emdin, Danilo Neglia
BACKGROUND: The endothelial nitric oxide synthase (eNOS) gene deficiency is known to cause impaired coronary vasodilating capability in animal models. In the general clinical population, the eNOS gene polymorphisms, able to affect eNOS activity, were associated with cardiometabolic risk features and prevalence of coronary artery disease (CAD). AIM: To investigate the association of eNOS Glu298Asp gene polymorphism, cardiometabolic profile, obstructive CAD and inducible myocardial ischemia in patients with suspected stable CAD...
March 22, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38519622/impact-of-4d-flow-cmr-parameters-on-functional-evaluation-of-fontan-circulation
#26
JOURNAL ARTICLE
Lamia Ait Ali, Nicola Martini, Elisa Listo, Elisa Valenti, Julio Sotelo, Stefano Salvadori, Claudio Passino, Angelo Monteleone, Nicola Stagnaro, Gianluca Trocchio, Chiara Marrone, Francesca Raimondi, Giosuè Catapano, Pierluigi Festa
We sought to evaluate the potential clinical role of 4D-flow cardiac magnetic resonance (CMR)-derived energetics and flow parameters in a cohort of patients' post-Fontan palliation. In patients with Fontan circulation who underwent 4D-Flow CMR, streamlines distribution was evaluated, as well a 4D-flow CMR-derived energetics parameters as kinetic energy (KE) and energy loss (EL) normalized by volume. EL/KE index as a marker of flow efficiency was also calculated. Cardiopulmonary exercise test (CPET) was also performed in a subgroup of patients...
March 22, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38518637/exploring-the-role-and-mechanism-of-hyperoside-against-cardiomyocyte-injury-in-mice-with-myocardial-infarction-based-on-jak2-stat3-signaling-pathway
#27
JOURNAL ARTICLE
Tingcai Rao, Hua Tong, Jing Li, Jiahao Huang, Yanyan Yin, Junyan Zhang
BACKGROUND: Myocardial infarction (MI) is one of the most deadly diseases in the world. Hyperoside (Hyp) has been shown to have a protective effect on cardiovascular function through various signaling pathways, but whether it can protect myocardial infarction by regulating JAK2/STAT3 signaling pathway is unknown. AIM OF THE STUDY: To investigate whether Hyp could protect the heart against myocardial infarction injury in mice by modulating JAK2/STAT3 signaling pathway and its potential mechanism...
December 25, 2023: Phytomedicine
https://read.qxmd.com/read/38517275/remimazolam-improves-the-markers-of-post-resuscitation-cerebral-injury-in-a-swine-model-of-cardiac-arrest
#28
JOURNAL ARTICLE
Rongrong Shen, Zhilin Liu, Li Fei, Yixiang Zhang, Linwu Xu, Chaoqi Xuan
INTRODUCTION: Previous studies have manifested that those sedatives acting on γ-aminobutyric acid A (GABAa) receptor could produce effective brain protection against regional and global ischemic stimulation. The present study was designed to investigate the effect of a novel GABAa receptor agonist, remimazolam post-conditioning (RP) on cerebral outcome after global ischemic stimulation induced by cardiac arrest and resuscitation in swine. METHODS: A total of 24 swine were utilized in this study, in which the animals were randomly divided into the following three groups: Sham group (n = 6), CPR group (n = 9), and CPR + RP group (n = 9)...
February 5, 2024: Shock
https://read.qxmd.com/read/38517003/plasma-neutrophil-gelatinase-associated-lipocalin-2-0-index-a-precise-and-sensitive-predictor-of-acute-kidney-injury-in-children-undergoing-cardiopulmonary-bypass
#29
JOURNAL ARTICLE
Hanan El-Halaby, Mohammed A El-Bayoumi, Mohamed El-Assmy, Angi A Al-Wakeel, Ahmed ElHusseiny, Hala Elmarsafawy, Mohamed A Elgamal, Ahmed Noaman
OBJECTIVES: Children undergoing cardiopulmonary bypass (CPB) are at risk of acute kidney injury (AKI). Rise in serum creatinine occurs slowly and late, hence other markers are crucially needed to recognize AKI early. The aim of the study is to detect the efficacy of Neutrophil gelatinase-associated lipocalin (NGAL) in the early prediction of AKI. METHODS: A prospective observational study with enrollment of 174 patients, aged 6 months to 60 months, with congenital heart disease, undergoing CPB...
March 22, 2024: Indian Pediatrics
https://read.qxmd.com/read/38516440/japanese-traditional-herbal-medicine-rikkunshito-partially-suppresses-inflammatory-responses-in-myocardial-ischemia-reperfusion-injury
#30
JOURNAL ARTICLE
Tomoe Sato, Yasuaki Sawashita, Yusuke Yoshikawa, Michiaki Yamakage
INTRODUCTION: Myocardial ischemia/reperfusion (I/R) injury can cause additional damage to an ischemic myocardium, even after successful reperfusion therapy. Inflammation is a mechanism that exacerbates myocardial damage after I/R injury. Rikkunshito   (RKT) is a traditional Japanese herbal medicine widely used to treat gastrointestinal symptoms. It attenuates inflammation and fibrosis in some diseases of the heart; however, it remains unclear whether RKT exerts cardioprotective effects against myocardial I/R injury...
February 2024: Curēus
https://read.qxmd.com/read/38515646/mesenchymal-stem-cells-derived-from-chir99021-and-tgf%C3%A2-%C3%AE-induction-remained-on-the-colicomentum-and-improved-cardiac-function-of-a-rat-model-of-acute-myocardium-infarction
#31
JOURNAL ARTICLE
Yusen Zhang, Yanmin Zhang, Azhen Hu, Fanhua Meng, Peng Cui, Tianshi Li, Guanghui Cui
Human induced pluripotent stem cells (hiPSCs) have been regarded as a potential stem cell source for cell therapy. However, the production of cells with mesenchymal potential from hiPSCs through spontaneous differentiation is time consuming and laborious. In the present study, the combined use of the GSK-3 inhibitor CHIR99021 and TGF-β was used to obtain mesenchymal stem cell (MSC)-like cells from hiPSCs. During the induction process, the transcription of epithelial-mesenchymal transition (EMT)-related genes N-cadherin and Vimentin in the transformed cells was upregulated, whereas the transcription of E-cadherin and pluripotency-related transcription factors SOX2, OCT4 and NANOG did not change significantly...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38515030/association-of-red-cell-distribution-width-albumin-ratio-and-in-hospital-mortality-in-patients-with-atrial-fibrillation-base-on-medical-information-mart-for-intensive-care-iv-database
#32
JOURNAL ARTICLE
Li-Ya Pan, Jing Song
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence regarding the association between RDW to albumin ratio (RAR) and in hospital mortality in patients with AF admitted to the Intensive Care Unit (ICU) currently was unclear. The purpose of this study was to explore the association between RAR and in hospital mortality in patients with AF in the ICU...
March 21, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38514519/longitudinal-aortic-strain-ventriculo-arterial-coupling-and-fatty-acid-oxidation-novel-insights-into-human-cardiovascular-aging
#33
JOURNAL ARTICLE
Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Ru-San Tan, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Xiaodan Zhao, John Allen, Qinghua Wu, Tim Leiner, Liang Zhong, Angela S Koh
Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus...
March 22, 2024: GeroScience
https://read.qxmd.com/read/38514212/myocardial-fibrosis-in-right-heart-dysfunction
#34
JOURNAL ARTICLE
Lucia Agoston-Coldea, Andra Negru
Cardiac fibrosis, associated with right heart dysfunction, results in significant morbidity and mortality. Stimulated by various cellular and humoral stimuli, cardiac fibroblasts, macrophages, CD4+ and CD8+ T cells, mast and endothelial cells promote fibrogenesis directly and indirectly by synthesizing numerous profibrotic factors. Several systems, including the transforming growth factor-beta and the renin-angiotensin system, produce type I and III collagen, fibronectin and α-smooth muscle actin, thus modifying the extracellular matrix...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38513575/esculin-targets-tlr4-to-protect-against-lps-induced-septic-cardiomyopathy
#35
JOURNAL ARTICLE
Zhenyang Su, Min Gao, Liqing Weng, Tianhua Xu
BACKGROUND: Esculin, a main active ingredient from Cortex fraxini, possesses biological activities such as anti-thrombosis, anti-inflammatory, and anti-oxidation effects. However, the effects of Esculin on septic cardiomyopathy remains unclear. This study aimed to explore the protective properties and mechanisms of Esculin in countering sepsis-induced cardiac trauma and dysfunction. METHODS AND RESULTS: In lipopolysaccharide (LPS)-induced mice model, Esculin could obviously improve heart injury and function...
March 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38513382/vagus-nerve-stimulation-alleviates-cardiac-dysfunction-and-inflammatory-markers-during-heart-failure-in-rats
#36
JOURNAL ARTICLE
Misty M Owens, Suman Dalal, Aleksandra Radovic, Luciano Fernandes, Hassan Syed, Mary-Katherine Herndon, Coty Cooper, Krishna Singh, Eric Beaumont
Vagus nerve stimulation (VNS) is under clinical investigation as a therapy for heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF...
March 4, 2024: Autonomic Neuroscience: Basic & Clinical
https://read.qxmd.com/read/38513212/ternary-bioi-bi-2-s-3-au-nanosheet-arrays-as-a-photoelectrochemical-signal-converter-for-the-detection-of-cardiac-troponin-i
#37
JOURNAL ARTICLE
Weixuan Xu, Xuelin Zhang, Shanghua Liu, Feng Jiang, Yueyuan Li, Zhen Xu, Yueyun Li
Nanosheet arrays with stable signal output have become promising photoactive materials for photoelectrochemical (PEC) immunosensors. However, an essential concern is the facile recombination of carriers in one-component nanoarrays, which cannot be readily prevented, ultimately resulting in weak photocurrent signals. In this study, an immunosensor using gold nanoparticle-anchored BiOI/Bi2 S3 nanosheet arrays (BiOI/Bi2 S3 /Au) as a signal converter was fabricated for sensitive detection of cardiac troponin I (cTnI)...
March 21, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38512651/bmscs-derived-exosome-cish-alleviates-myocardial-infarction-by-inactivating-the-nf-%C3%AE%C2%BAb-pathway-to-stimulate-macrophage-m2-polarization
#38
JOURNAL ARTICLE
Minzhi Ouyang, Yang Yang, Guolong Yu, Jiling Zhao, Yi Peng
Current myocardial infarction (MI) treatments are suboptimal, necessitating deeper pathogenesis understanding of MI. This research explored how exosomes (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) contribute to MI mitigation and their therapeutic potential. Isolated BMSCs was identified by microscope, flow cytometry, alizarin red and oil red O staining. Exo were identified by TEM, NTA and western blot. HE staining, masson staining, and cardiac function parameters were used to assess the cardiac function in MI mice...
March 21, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38512003/association-of-myocardial-injury-with-adverse-long-term-survival-among-cancer-patients
#39
JOURNAL ARTICLE
Hussein Bashar, Ofer Kobo, Nick Curzen, Mamas A Mamas
AIMS: Over time, cardiovascular disease (CVD) deaths increasingly exceed those from malignancy among cancer survivors. However, the association of myocardial injury with long-term survival (beyond three years) in cancer patients has not been previously described. METHODS: The National Health and Nutrition Examination Survey high-sensitivity cardiac troponin (hs-cTn) and morbidities databases (1999-2004) were linked with the latest mortality dataset isolating records were respondents reported cancer diagnosis by a healthcare professional...
March 21, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38511041/long-term-complete-response-with-single-agent-capecitabine-in-her-2-neu-positive-metastatic-breast-cancer-a-rare-case-report
#40
Mukesh Rulaniya, Manish Sahni, Sandeep Jasuja, Suresh Singh
The standard treatment approach for metastatic breast cancer with HR- and Her-2-neu + disease is trastuzumab with systemic therapy. But in patients having severe cardiac dysfunction, trastuzumab is avoided. Various combination regimens are available in that setting, but no study has shown better efficacy of capecitabine monotherapy in this setting. We hereby present a case report of using capecitabine monotherapy in first-line setting, and the patient had complete resolution of lung metastasis from the last 2 years...
March 2024: Indian Journal of Surgical Oncology
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