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Cardiac markers

Carlos Galán-Arriola, Manuel Lobo, Jean Paul Vílchez-Tschischke, Gonzalo J López, Antonio de Molina-Iracheta, Claudia Pérez-Martínez, Jaume Agüero, Rodrigo Fernández-Jiménez, Ana Martín-García, Eduardo Oliver, Rocío Villena-Gutierrez, Gonzalo Pizarro, Pedro L Sánchez, Valentin Fuster, Javier Sánchez-González, Borja Ibanez
BACKGROUND: Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed. OBJECTIVES: The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multiparametric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model. METHODS: Twenty pigs were included. Of these, 5 received 5 biweekly intracoronary doxorubicin doses (0.45 mg/kg/injection) and were followed until sacrifice at 16 weeks...
February 26, 2019: Journal of the American College of Cardiology
Neale D Cohen, Sarah J Gutman, Esther M Briganti, Andrew J Taylor
BACKGROUND: The effects of empagliflozin on cardiac structure and function are not known AIMS: To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with Type 2 (T2D) diabetes using cardiac magnetic resonance (MR) imaging. METHODS: 20 patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patient with T2D on stable glucose lowering therapy were recruited for cardiac imaging...
February 19, 2019: Internal Medicine Journal
E K Shevchenko, K V Dergilev, Z I Tsokolaeva, I B Beloglazova, Yu D Molokotina, E V Parfenova, M Yu Men'shikov
We showed the possibility of generating combined tissue-engineered cell consisting of layers of rat cardiac stem cells and mesenchymal stromal cells from the adipose tissue. Cell-cell interaction within the cell sheet promoted proliferation of cardiac stem cells, expression of endothelial differentiation marker ETS1, and Notch signaling activation. The obtained results provide new insights into possible mechanisms of stimulation of endogenous regeneration processes after myocardial damage and demonstrate potential of cell-based cardiomyoplasty with the use of these combined cell sheets...
February 19, 2019: Bulletin of Experimental Biology and Medicine
Taofeek O Usman, Olufunto O Badmus, InKyeom Kim, Lawrence A Olatunji
Elevated testosterone during late pregnancy has been linked to cardiac dysfunction and poor pregnancy outcomes. The role of mineralocorticoid receptor (MR) in testosterone-induced cardiac dysfunction has not been fully elucidated. The study was therefore designed to investigate the role of MR on gestational excess androgen-induced cardiac disrupted glutathione-dependent antioxidant system and elevated endoglin (Eng) linking it with pregnancy outcomes. Thirty-two pregnant Wistar rats were randomly allotted into four groups (n = 8/group) receiving (sc) olive oil, testosterone propionate (0...
February 19, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
Lusha E, Hong Jiang, Zhibing Lu
Cardiovascular ischemic disease refers to a large class of conditions that are harmful to human health. A number of previous studies have demonstrated that microRNAs (miRs) have notable roles in regulating cardiac injury. miR-144 is influential in the differentiation, growth, and metastatic processes of cells; however, the impact of miR-144 in cardiac ischemia/reperfusion (I/R) injury has not been thoroughly elucidated to date. In the present study, reverse transcription quantitative polymerase chain reaction was used to evaluate RNA expression...
March 2019: Experimental and Therapeutic Medicine
Ali Eshraghi, Emadoddin Hoseinjani, Majid Jalalyazdi, Mohammad Vojdanparast, Reza Jafarzadeh-Esfehani
BACKGROUND: Slow coronary flow (SCF) phenomenon is an angiographic finding which is defined as slow contrast passage through coronary arteries which may predispose patients to serious cardiac complications such as fatal arrhythmias. P-wave and QT-interval dispersion are electrocardiographic findings which are related to atrial fibrillation and ventricular tachyarrhythmias. In the present study, the relation between SCF and presence of P-wave and QT-interval dispersion in electrocardiography has been evaluated...
September 2018: ARYA Atherosclerosis
Neha A John-Henderson, Cory J Counts, Courtney S Sanders, Annie T Ginty
Diminished cardiac reactions to acute psychological stress are associated with adverse behavioral and health-relevant outcomes. It has been proposed that diminished cardiac reactivity may be a marker for deficits in motivational functioning both at the biological and behavioral levels. Social participation reflects the frequency with which individuals participate in social events and has motivational components. As such, it is a distinct construct from other constructs such as social integration, which measures the number of social roles an individual has...
March 2019: Journal of Psychosomatic Research
Jeong Ho Park, Jung Hee Wee, Seung Pill Choi, Jae Hun Oh, Shin Cheol
Objective: Despite increased survival in patients with cardiac arrest, it remains difficult to determine patient prognosis at the early stage. This study evaluated the prognosis of cardiac arrest patients using brain injury, inflammation, cardiovascular ischemic events, and coagulation/fibrinolysis markers collected 24, 48, and 72 hours after return of spontaneous circulation (ROSC). Methods: From January 2011 to December 2016, we retrospectively observed patients who underwent therapeutic hypothermia...
February 20, 2019: Clinical and Experimental Emergency Medicine
Gabriela Corina Zaharie, Monica Hasmasanu, Ligia Blaga, Melinda Matyas, Daniel Muresan, Sorana Daniela Bolboaca
AIM: To asses the cardiac morphology and functional changes specific for newborns from intrauterine growth restriction (IUGR) pregnancies. MATERIAL AND METHOD: A cohort of IUGR infants were evaluated by serial echocardiographies at delivery and at the first and six months follow-ups. IUGR newborn delivery status was compared to that of newborns in the control group according to gestational age (AGA). RESULTS: Left heart measurements were significantly lower in IUGR newborns compared to AGA babies...
February 17, 2019: Medical Ultrasonography
M Anette E Haukilahti, Lauri Holmström, Juha Vähätalo, Tuomas Kenttä, Jani Tikkanen, Lasse Pakanen, Marja-Leena Kortelainen, Juha Perkiömäki, Heikki Huikuri, Robert J Myerburg, M Juhani Junttila
BACKGROUND: Despite recent progress in profiling of risk for sudden cardiac death (SCD) and prevention and intervention of cardiac diseases, SCD remains a major cause of death. Among women, the incidence of SCD is significant, but lower than in men, particularly in the premenopausal and early postmenopausal years. Possibly, as a consequence of the difference in population burden, the mechanisms and risk markers of SCD are not as well defined for women. The aim of this study was to determine the autopsy findings and causes of death among women in a large SCD population...
February 19, 2019: Circulation
Tuomas Kerola, Jenni Kauppi, Laura Sares-Jäske, Olli Anttonen, M Juhani Junttila, Heikki V Huikuri, Tuomo Nieminen, Harri Rissanen, Markku Heliövaara, Markku J Kauppi, Paul Knekt, Antti Eranti
The debate whether an elevated level of serum uric acid (SUA) is an independent marker of cardiovascular risk is still going on. We examined morbidity and mortality related to SUA and hyperuricemia in a well-characterized population with very long follow-up. Study included 4696 participants (aged 30-59 years at baseline) of the coronary heart disease (CHD) Study of the Finnish Mobile Clinic Health Examination Survey. Adjusted hazard ratios (HRs) of hyperuricemia (defined as ≥360 µmol/l and ≥420 µmol/l) and SUA quintiles for mortality and adverse cardiovascular outcomes are reported...
February 19, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Hatice Ayan, Rabia Akilli, Bulent Kaya, Saime Paydas, Ertan Kara, Asligul Cureoglu
OBJECTIVES: In patients with advanced-stage chronic kidney disease, renal insufficiency, arterial stiffness, and vascular calcification are strong predictors of cardiovascular risk. Signal peptide-CUB-EGF-like protein-1 (SCUBE1) levels increase during platelet activation and acute ischemic events. Here, we evaluated associations between SCUBE1 levels and electrocardiographic/echocardiographic findings, epicardial adipose tissue thickness, and carotid intimamedia thickness in patients with chronic kidney disease...
January 2019: Experimental and Clinical Transplantation
Marlone Cunha-Silva, Daniel Ferraz de Campos Mazo, Igor Logetto Caetité Gomes, Marcello Rabello Imbrizi, Tiago Sevá-Pereira, Nayana Fonseca Vaz, Mariana Sandoval Lourenço, Larissa Bastos Eloy da Costa, Cecilia Amelia Fazzio Escanhoela, Jazon Romilson de Souza Almeida
The differential diagnosis of hepatic focal lesions is challenging because the etiology can be inflammatory, infectious, and even neoplastic. A rare cause of metastatic liver nodules is cardiac angiosarcoma. We report a case of this tumor, which was diagnosed only after autopsy. A 26-year-old Caucasian man was admitted for progressive dyspnea and cough over the past 3 weeks. Physical examination showed only hypophonetic heart sounds. Laboratory analysis demonstrated anemia and elevated inflammatory markers, despite normal biochemical parameters and liver function...
October 2018: Autopsy & Case Reports
Yang Liu, Eleni Dakou, Ying Meng, Luc Leyns
Isolated mouse embryonic stem cells (mESCs) retain the capacities to self-renew limitlessly and to give rise to all tissues of an adult mouse. A precise understanding of the relationships, mechanisms of action and functions of novel genes involved in mESCs differentiation is crucial to expand our knowledge of vertebrate development. The epithelial membrane protein 2 (EMP2) is a membrane-spanning protein found in epithelial and endothelial cell-cell junctions that has been implicated in the regulation of cell proliferation and migration in normal and tumor tissues...
February 14, 2019: Biochemical and Biophysical Research Communications
Amardeep Ghosh Dastidar, Anna Baritussio, Estefania De Garate, Zsofia Drobni, Giovanni Biglino, Priyanka Singhal, Elena G Milano, Gianni D Angelini, Stephen Dorman, Julian Strange, Thomas Johnson, Chiara Bucciarelli-Ducci
OBJECTIVES: This study sought to assess the prognostic impact of cardiovascular magnetic resonance (CMR) and conventional risk factors in patients with myocardial infarction with nonobstructed coronaries (MINOCA). BACKGROUND: Myocardial infarction with nonobstructed coronary arteries (MINOCA) represents a diagnostic dilemma, and the prognostic markers have not been clarified. METHODS: A total of 388 consecutive patients with MINOCA undergoing cardiac magnetic resonance (CMR) assessment were identified retrospectively from a registry database and prospectively followed for a primary clinical endpoint of all-cause mortality...
February 11, 2019: JACC. Cardiovascular Imaging
Cheng-Yang Hsieh, Cheng-Han Lee, Sheng-Feng Sung
BACKGROUND AND AIMS: Stroke occurrence while on antiplatelet therapy, i.e., a breakthrough stroke, is often conveniently attributed to antiplatelet resistance. However, undetected paroxysmal atrial fibrillation (AF) may underlie breakthrough strokes. We hypothesized that a breakthrough stroke may be a clinical marker for patients at risk of having AF detected after stroke (AFDAS). METHODS: Consecutive patients without known AF hospitalized for ischemic stroke between 2000 and 2013 were identified from nationwide claims data...
January 24, 2019: Atherosclerosis
Cecilia Carubbi, Elena Masselli, Giulia Pozzi, Maria Mattioli, Silvia Martini, Matteo Goldoni, Rosalia Aloe, Gianfranco Cervellin, Marco Vitale, Giuliana Gobbi
A rapid differential diagnosis of the clinical conditions underlying chest pain is a relevant clinical issue. Specifically, a fast rule-in or -out of acute myocardial infarction (AMI) is mandatory to improve diagnostic outcome and cost-effectiveness of patient management. We demonstrated that Protein Kinase C (PKC) epsilon is selectively expressed by platelets from AMI patients, accounting for increased platelet activation. Thus, we hypothesized that PKCepsilon-expressing platelets may represent a pathophysiological marker of AMI that could be utilized in combination with troponin-I, the conventional marker of cardiac injury, to add diagnostic information in chest pain workup...
February 14, 2019: Scientific Reports
Samadrita Bhattacharyya, Jialei Duan, Lin Wang, Boxun Li, Minoti Bhakta, Antonio Fernandez-Perez, Gary C Hon, Nikhil V Munshi
The atrioventricular node (AVN) coordinates the timing of atrial and ventricular contraction to optimize cardiac performance. To study this critical function using mouse genetics, however, new reagents are needed that allow AVN-specific manipulation. Here we describe a novel Gjd3-CreEGFP mouse line that successfully recombines floxed alleles within the AVN beginning at E12.5. These mice have been engineered to express CreEGFP under the control of endogenous Gjd3 regulatory elements without perturbing native protein expression...
February 14, 2019: Scientific Reports
Matthew Jankowich, Gaurav Choudhary
Circulating plasma levels of endothelin-1 and related peptides generated during the synthesis of endothelin-1 from its precursor molecule pre-proendothelin-1 have been widely studied as potential risk markers for cardiovascular events. The associations of endothelin-1 with aging, blood pressure, lung function, and chronic kidney disease have been described, as have relations between endothelin-1 levels and evidence of cardiac remodeling, including increased left atrial diameter and increased left ventricular mass...
February 1, 2019: Trends in Cardiovascular Medicine
Jie Li, Brandon A Kemp, Nancy L Howell, James Massey, Krzysztof Mińczuk, Qiao Huang, Mahendra D Chordia, R Jack Roy, James T Patrie, Giovanni E Davogustto, Christopher M Kramer, Frederick H Epstein, Robert M Carey, Heinrich Taegtmeyer, Susanna R Keller, Bijoy K Kundu
Background Sustained pressure overload leads to changes in cardiac metabolism, function, and structure. Both time course and causal relationships between these changes are not fully understood. Therefore, we studied spontaneously hypertensive rats (SHR) during early hypertension development and compared them to control Wistar Kyoto rats. Methods and Results We serially evaluated myocardial glucose uptake rates (Ki) with dynamic 2-[18 F] fluoro-2-deoxy-D-glucose positron emission tomography, and ejection fraction and left ventricular mass to body weight ratios with cardiac magnetic resonance imaging in vivo, determined glucose uptake and oxidation rates in isolated perfused hearts, and analyzed metabolites, mammalian target of rapamycin activity and endoplasmic reticulum stress in dissected hearts...
February 19, 2019: Journal of the American Heart Association
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