keyword
https://read.qxmd.com/read/38520800/multiscale-neuro-inspired-models-for-interpretation-of-eeg-signals-in-patients-with-epilepsy
#1
JOURNAL ARTICLE
Fabrice Wendling, Elif Koksal-Ersoz, Mariam Al-Harrach, Maxime Yochum, Isabelle Merlet, Giulio Ruffini, Fabrice Bartolomei, Pascal Benquet
OBJECTIVE: The aim is to gain insight into the pathophysiological mechanisms underlying interictal epileptiform discharges observed in electroencephalographic (EEG) and stereo-EEG (SEEG, depth electrodes) recordings performed during pre-surgical evaluation of patients with drug-resistant epilepsy. METHODS: We developed novel neuro-inspired computational models of the human cerebral cortex at three different levels of description: i) microscale (detailed neuron models), ii) mesoscale (neuronal mass models) and iii) macroscale (whole brain models)...
March 16, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38508712/coupling-of-sharp-wave-events-between-zebrafish-hippocampal-and-amygdala-homologues
#2
JOURNAL ARTICLE
Ismary Blanco, Adam Caccavano, Jian-Young Wu, Stefano Vicini, Eric Glasgow, Katherine Conant
The mammalian hippocampus exhibits spontaneous sharp wave events (1-30 Hz) with an often-present superimposed fast ripple oscillation (120-220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas exhibit SWR events that are coupled to hippocampal SWRs, and studies in mammals suggest that coupling may be critical for the consolidation and recall of specific memories...
March 20, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38454016/sustainable-power-management-in-light-electric-vehicles-with-hybrid-energy-storage-and-machine-learning-control
#3
JOURNAL ARTICLE
R Punyavathi, A Pandian, Arvind R Singh, Mohit Bajaj, Milkias Berhanu Tuka, Vojtech Blazek
This paper presents a cutting-edge Sustainable Power Management System for Light Electric Vehicles (LEVs) using a Hybrid Energy Storage Solution (HESS) integrated with Machine Learning (ML)-enhanced control. The system's central feature is its ability to harness renewable energy sources, such as Photovoltaic (PV) panels and supercapacitors, which overcome traditional battery-dependent constraints. The proposed control algorithm orchestrates power sharing among the battery, supercapacitor, and PV sources, optimizing the utilization of available renewable energy and ensuring stringent voltage regulation of the DC bus...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38405778/functional-architecture-of-intracellular-oscillations-in-hippocampal-dendrites
#4
Zhenrui Liao, Kevin C Gonzalez, Deborah M Li, Catalina M Yang, Donald Holder, Natalie E McClain, Guofeng Zhang, Stephen W Evans, Mariya Chavarha, Jane Yi, Christopher D Makinson, Michael Z Lin, Attila Losonczy, Adrian Negrean
Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present across the complex three-dimensional dendritic arbor in vivo . Here, we perform fast two-photon imaging of dendritic and somatic membrane potential dynamics in single pyramidal cells in the CA1 region of the mouse hippocampus during awake behavior. We study the dynamics of subthreshold membrane potential and suprathreshold dendritic events throughout the dendritic arbor in vivo by combining voltage imaging with simultaneous local field potential recording, post hoc morphological reconstruction, and a spatial navigation task...
February 12, 2024: bioRxiv
https://read.qxmd.com/read/38401712/immature-status-epilepticus-alters-the-temporal-relationship-between-hippocampal-interictal-epileptiform-discharges-and-high-frequency-oscillations
#5
JOURNAL ARTICLE
Konstantinos Kalogeropoulos, Caterina Psarropoulou
The aim was to investigate the long-term effects of a single episode of immature Status Epilepticus (SE) on the excitability of the septal and temporal hippocampus in vitro, by studying the relationship between interictal-like epileptiform discharges (IEDs) and high-frequency oscillations (HFOs; Ripples, Rs and Fast Ripples, FRs). A pentylenetetrazol-induced Status Epilepticus-(SE)-like generalized seizure was induced at postnatal day 20 in 22 male and female juvenile rats, sacrificed >40 days later to prepare hippocampal slices...
February 22, 2024: Neuroscience
https://read.qxmd.com/read/38389239/-diagnostic-value-of-high-frequency-oscillation-in-localization-of-type-%C3%A2-focal-cortical-dysplasia-epilepsy
#6
JOURNAL ARTICLE
Z Mei, Y X Lin, P S Yao, F Wang, X F Huang, H Lin, X Q Hu, Y Q Lin, L Gao, D Z Kang
Retrospective analysis was conducted on 9 patients with type Ⅱ focal cortical dysplasia (FCD) who underwent stereo-electroencephalography (SEEG) implantation in the Department of Neurosurgery of the First Affiliated Hospital of Fujian Medical University from November 2020 to February 2023. The onset area, onset time, and frequency of high-frequency oscillations (HFO) were analyzed and the correlation of HFOs with interictal, preictal, and ictal periods. SEEG recordings of 80-500 Hz HFOs were observed in both interictal and ictal periods in 9 patients, with 6 patients exhibiting fast ripples (FR) in the range of 250-500 Hz...
February 27, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38366848/effects-of-midazolam-on-high-frequency-oscillations-in-amygdala-and-hippocampus-of-epilepsy-patients
#7
JOURNAL ARTICLE
Jonas M Hebel, Michael Lanz, Thomas Malina, Stefan R G Stodieck, Michel Le Van Quyen
High-frequency oscillations (HFOs) are associated with normal brain function, but are also increasingly recognized as potential biomarkers of epileptogenic tissue. Considering the important role of interneuron activity in physiological HFO generation, we studied their modulation by midazolam (MDZ), an agonist of γ-aminobutyric acid type A (GABAA )-benzodiazepine receptors. Here, we analyzed 80 intracranial electrode contacts in amygdala and hippocampus of 13 patients with drug-refractory focal epilepsy who had received MDZ for seizure termination during presurgical monitoring...
February 17, 2024: Epilepsia
https://read.qxmd.com/read/38351166/energy-management-of-electric-vehicle-using-a-new-strategy-based-on-slap-swarm-optimization-and-differential-flatness-control
#8
JOURNAL ARTICLE
Houssam Eddine Ghadbane, Said Barkat, Ali Djerioui, Azeddine Houari, Mihai Oproescu, Nicu Bizon
Optimal energy management of electric vehicles using slap swarm optimization and differential flatness control has been proposed. A battery-supercapacitor power system is adopted. Each source is connected in parallel to the DC-bus using DC-DC bidirectional converters and supplies a synchronous reluctance motor (SynRM) based drive. The proposed EMS fundamental forces lie in using a combination of complementary proprieties of two approaches, a Slap Swarm optimization Algorithm and Differential Flatness (DF). With a fast optimization mechanism, the Slap Swarm optimization algorithm allows adapting in real-time conditions the DF gains to optimize the system performances...
February 13, 2024: Scientific Reports
https://read.qxmd.com/read/38338895/age-dependent-activation-of-pannexin1-function-contributes-to-the-development-of-epileptogenesis-in-autosomal-dominant-sleep-related-hypermotor-epilepsy-model-rats
#9
JOURNAL ARTICLE
Kouji Fukuyama, Eishi Motomura, Motohiro Okada
To explore the processes of epileptogenesis/ictogenesis, this study determined the age-dependent development of the functional abnormalities in astroglial transmission associated with pannexin1-hemichannel using a genetic rat model of autosomal dominant sleep-related hypermotor epilepsy (ADSHE) named 'S286L-TG'. Pannexin1 expression in the plasma membrane of primary cultured cortical astrocytes and the orbitofrontal cortex (OFC), which is an ADSHE focus region, were determined using capillary immunoblotting...
January 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336945/implementation-of-high-step-up-power-converter-for-fuel-cell-application-with-hybrid-mppt-controller
#10
JOURNAL ARTICLE
V Prashanth, Shaik Rafikiran, C H Hussaian Basha, Jinka Anil Kumar, C Dhanamjayulu, Hossam Kotb, Ali ELrashidi
As of now, there are multiple types of renewable energy sources available in nature which are hydro, wind, tidal, and solar. Among all of that the solar energy source is used in many applications because of its features are low maitainence cost, less human power for handling, a clean source, more availability in nature, and reduced carbon emissions. However, the disadvantages of solar networks are continuously depending on the weather conditions, high complexity of the solar energy storage, and lots of installation place is required...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38325327/spike-ripples-localize-the-epileptogenic-zone-best-an-international-intracranial-study
#11
JOURNAL ARTICLE
Wen Shi, Dana Shaw, Katherine G Walsh, Xue Han, Uri T Eden, Robert M Richardson, Stephen V Gliske, Julia Jacobs, Benjamin H Brinkmann, Gregory A Worrell, William C Stacey, Birgit Frauscher, John Thomas, Mark A Kramer, Catherine J Chu
We evaluated whether spike ripples, the combination of epileptiform spikes and ripples, provide a reliable and improved biomarker for the epileptogenic zone (EZ) compared to other leading interictal biomarkers in a multicenter, international study. We first validated an automated spike ripple detector on intracranial EEG recordings. We then applied this detector to subjects from four centers who subsequently underwent surgical resection with known 1-year outcomes. We evaluated the spike ripple rate in subjects cured after resection (ILAE 1 outcome) and those with persistent seizures (ILAE 2-6) across sites and recording types...
February 7, 2024: Brain
https://read.qxmd.com/read/38316828/waveform-based-classification-of-dentate-spikes
#12
JOURNAL ARTICLE
Rodrigo M M Santiago, Vítor Lopes-Dos-Santos, Emily A Aery Jones, Yadong Huang, David Dupret, Adriano B L Tort
Synchronous excitatory discharges from the entorhinal cortex (EC) to the dentate gyrus (DG) generate fast and prominent patterns in the hilar local field potential (LFP), called dentate spikes (DSs). As sharp-wave ripples in CA1, DSs are more likely to occur in quiet behavioral states, when memory consolidation is thought to take place. However, their functions in mnemonic processes are yet to be elucidated. The classification of DSs into types 1 or 2 is determined by their origin in the lateral or medial EC, as revealed by current source density (CSD) analysis, which requires recordings from linear probes with multiple electrodes spanning the DG layers...
February 5, 2024: Scientific Reports
https://read.qxmd.com/read/38308906/epileptic-tissue-localization-using-graph-based-networks-in-the-high-frequency-oscillation-range-of-intracranial-electroencephalography
#13
JOURNAL ARTICLE
Christos Stergiadis, Dimitrios Kazis, Manousos A Klados
PURPOSE: High frequency oscillations (HFOs) are an emerging biomarker of epilepsy. However, very few studies have investigated the functional connectivity of interictal iEEG signals in the frequency range of HFOs. Here, we study the corresponding functional networks using graph theory, and we assess their predictive value for automatic electrode classification in a cohort of 20 drug resistant patients. METHODS: Coherence-based connectivity analysis was performed on the iEEG recordings, and six different local graph measures were computed in both sub-bands of the HFO frequency range (80-250 Hz and 250-500 Hz)...
January 29, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38295042/enhancing-interfacial-capacitance-by-boron-doping-in-vertically-porous-carbon-toward-high-performance-ac-filtering-electrochemical-capacitors
#14
JOURNAL ARTICLE
Bin Chen, Nan Huang, Zhaofeng Zhai, Chuyan Zhang, Lusheng Liu, Bing Yang, Xin Jiang
Electrochemical capacitors (ECs) show great perspective in alternate current (AC) filtering once they simultaneously reach ultra-fast response and high capacitance density. Nevertheless, the structure-design criteria of the two key properties are often mutually incompatible in electrode construction. Herein, it is proposed that combining vertically oriented porous carbon with enhanced interfacial capacitance (Ci ) can efficiently solve this issue. Theoretically, the density function theory calculation shows that the Ci of a carbon electrode can be enhanced by boron doping due to the corresponding compact induced charge layer...
January 31, 2024: Small
https://read.qxmd.com/read/38275582/tuning-microelectrodes-impedance-to-improve-fast-ripples-recording
#15
JOURNAL ARTICLE
Hajar Mousavi, Gautier Dauly, Gabriel Dieuset, Amira El Merhie, Esma Ismailova, Fabrice Wendling, Mariam Al Harrach
Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal hyperexcitability. In the case of pharmacoresistant epilepsy requiring resection surgery, the identification of the Epileptogenic Zone (EZ) is critical. Fast Ripples (FRs; 200-600 Hz) are one of the promising biomarkers that can aid in EZ delineation. However, recording FRs requires physically small electrodes. These microelectrodes suffer from high impedance, which significantly impacts FRs' observability and detection...
January 22, 2024: Bioengineering
https://read.qxmd.com/read/38253581/self-filtering-based-on-the-fault-ride-through-technique-using-a-robust-model-predictive-control-for-wind-turbine-rotor-current
#16
JOURNAL ARTICLE
Abdelkader Achar, Youcef Djeriri, Habib Benbouhenni, Ilhami Colak, Mihai Oproescu, Nicu Bizon
This paper studies the possibility of connecting Wind Farms (WF) to the electric grid with the use of finite space model predictive command (FS-MPC) to manage wind farms to improve the quality of the current output from the doubly-fed induction generator (DFIG) with considering fault ride-through technique. This proposed system can generate active power and enhance the power factor. Furthermore, the reduction of harmonics resulting from the connection of non-linear loads to the electrical grid is achieved through the self-active filtering mechanism in DFIGs-WF, facilitated by the now algorithm proposed...
January 22, 2024: Scientific Reports
https://read.qxmd.com/read/38221670/temporal-association-between-sleep-spindles-and-ripples-in-the-human-anterior-and-mediodorsal-thalamus
#17
JOURNAL ARTICLE
Orsolya Szalárdy, Péter Simor, Péter Przemyslaw Ujma, Zsófia Jordán, László Halász, Loránd Erőss, Dániel Fabó, Róbert Bódizs
Sleep spindles are major oscillatory components of Non-Rapid Eye Movement (NREM) sleep, reflecting hyperpolarization-rebound sequences of thalamocortical neurons. Reports suggest a link between sleep spindles and several forms of high-frequency oscillations which are considered as expressions of pathological off-line neural plasticity in the central nervous system. Here we investigated the relationship between thalamic sleep spindles and ripples in the anterior and mediodorsal nuclei (ANT and MD) of epilepsy patients...
February 2024: European Journal of Neuroscience
https://read.qxmd.com/read/38182733/application-of-fractional-order-synergetic-proportional-integral-controller-based-on-pso-algorithm-to-improve-the-output-power-of-the-wind-turbine-power-system
#18
JOURNAL ARTICLE
Habib Benbouhenni, Gasmi Hamza, Mihai Oproescu, Nicu Bizon, Phatiphat Thounthong, Ilhami Colak
It is noted that the traditional direct filed-oriented control (DFOC) is widely used in the field of electric power generation from wind due to its fast response dynamic, ease of implementation and simplicity, but this strategy is characterized by the presence of large ripples at the level of both active and reactive powers. This work presents a new algorithm for DFOC strategy of an asynchronous generator (AG) in a wind power (WP) system, which is based on the use of a new nonlinear controller called fractional-order synergetic control-fractional-order proportional-integral (FOSC-FOPI) controller, where the proposed technique parameters are calculated using the particle swarm optimization (PSO) strategy...
January 5, 2024: Scientific Reports
https://read.qxmd.com/read/38114051/mouse-model-of-focal-cortical-dysplasia-type-ii-generates-a-wide-spectrum-of-high-frequency-activities
#19
JOURNAL ARTICLE
Jan Chvojka, Natalie Prochazkova, Monika Rehorova, Jan Kudlacek, Salome Kylarova, Michaela Kralikova, Peter Buran, Romana Weissova, Martin Balastik, John G R Jefferys, Ondrej Novak, Premysl Jiruska
High-frequency oscillations (HFOs) represent an electrographic biomarker of endogenous epileptogenicity and seizure-generating tissue that proved clinically useful in presurgical planning and delineating the resection area. In the neocortex, the clinical observations on HFOs are not sufficiently supported by experimental studies stemming from a lack of realistic neocortical epilepsy models that could provide an explanation of the pathophysiological substrates of neocortical HFOs. In this study, we explored pathological epileptiform network phenomena, particularly HFOs, in a highly realistic murine model of neocortical epilepsy due to focal cortical dysplasia (FCD) type II...
January 2024: Neurobiology of Disease
https://read.qxmd.com/read/38114050/reproducible-network-changes-occur-in-a-mouse-model-of-temporal-lobe-epilepsy-but-do-not-correlate-with-disease-severity
#20
JOURNAL ARTICLE
Isotta Rigoni, Guru Prasad Padmasola, Laurent Sheybani, Karl Schaller, Charles Quairiaux, Serge Vulliemoz
Studying the development of brain network disruptions in epilepsy is challenged by the paucity of data before epilepsy onset. Here, we used the unilateral, kainate mouse model of hippocampal epilepsy to investigate brain network changes before and after epilepsy onset and their stability across time. Using 32 epicranial electrodes distributed over the mouse hemispheres, we analyzed EEG epochs free from epileptic activity in 15 animals before and 28 days after hippocampal injection (group 1) and in 20 animals on two consecutive days (d28 and d29, group 2)...
January 2024: Neurobiology of Disease
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