keyword
https://read.qxmd.com/read/38533252/the-prescription-trends-and-dosing-appropriateness-analysis-of-novel-oral-anticoagulants-in-ischemic-stroke-patients-a-retrospective-study-of-9-cities-in-china
#21
JOURNAL ARTICLE
Mingfen Wu, Hailun Jiang, Kefu Yu, Zhigang Zhao, Bin Zhu
Background: Novel oral anticoagulants (NOACs) have been recommended by guidelines as the first-line drugs for preventing cardiogenic stroke. We aimed to provide an overview of the prescription trends and dosing appropriateness of NOACs in China. Methods: We conducted a retrospective analysis of NOAC prescriptions using the Hospital Prescription Analysis Cooperation Project data from 2016 to 2022. Various patient features, such as gender, age, city, year, source, department visited, original diagnosis, dosing, cost, and insurance type, were collected and analyzed to examine the trends and dosing appropriateness of NOAC usage in ischemic stroke patients...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533144/successful-fluid-management-in-respiratory-failure-due-to-clazosentan-following-a-cerebral-aneurysm-clipping-a-case-report
#22
Hirotaka Kinoshita, Kodai Kato, Yuma Yamazaki, Eiji Hashiba, Kazuyoshi Hirota
Clazosentan, a potent selective endothelin receptor subtype A antagonist, has been demonstrated to be effective in preventing cerebral vasospasms after subarachnoid hemorrhage. We report the successful management of respiratory failure due to pulmonary edema associated with clazosentan, with a hemodynamic monitoring system. A 49-year-old Japanese man underwent emergency clipping for a right internal carotid-posterior communicating artery aneurysm. The surgery and general anesthesia for the rupture proceeded with no complications...
February 2024: Curēus
https://read.qxmd.com/read/38533051/therapeutic-potential-of-clinically-proven-natural-products-in-the-management-of-dementia
#23
REVIEW
Farzana Ansari, Md Sohel, Md Mahfujul Haque Haidary, Md Saqline Mostaq, Shamima Akter, Asrafun Nahar, Fatematuz Zohora Labony, Arman Ahmed, Mohammed Shamim Hasan, Mohammad Hasem Babu, Mohammad Nurul Amin
Dementia is a common neurodegenerative disorder connected to damage to nerve cells in the brain. Although some conventional drugs are available for dementia treatments and are still sanctified for dementia patients, their short- and long-term side effects and other limitations make treating patients more challenging. The authors aimed to explain novel options for treating dementia with natural products and unravel some clinically proven natural products. This article systematically reviewed recent studies that have investigated the role of natural products and their bioactive compounds for dementia...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532786/weak-base-drug-induced-endolysosome-iron-dyshomeostasis-controls-the-generation-of-reactive-oxygen-species-mitochondrial-depolarization-and-cytotoxicity
#24
JOURNAL ARTICLE
Peter W Halcrow, Darius N K Quansah, Nirmal Kumar, Rebecca L Solloway, Kayla M Teigen, Kasumi A Lee, Braelyn Liang, Jonathan D Geiger
OBJECTIVES: Approximately 75 % of marketed drugs have the physicochemical property of being weak bases. Weak-base drugs with relatively high pKa values enter acidic organelles including endosomes and lysosomes (endolysosomes), reside in and de-acidify endolysosomes, and induce cytotoxicity. Divalent cations within endolysosomes, including iron, are released upon endolysosome de-acidification. Endolysosomes are "master regulators of iron homeostasis", and neurodegeneration is linked to ferrous iron (Fe2+ )-induced reactive oxygen species (ROS) generation via Fenton chemistry...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532715/role-of-udp-n-acetylmuramic-acid-in-the-regulation-of-mura-activity-revealed-by-molecular-dynamics-simulations
#25
JOURNAL ARTICLE
Maycon Vinicius Damasceno de Oliveira, Kauê S da Costa, José Rogério A Silva, Jerônimo Lameira, Anderson H Lima
The peptidoglycan biosynthesis pathway plays a vital role in bacterial cells, and facilitates peptidoglycan layer formation, a fundamental structural component of the bacterial cell wall. The enzymes in this pathway are candidates for antibiotic development, as most do not have mammalian homologues. The UDP-N-acetylglucosamine (UNAG) enolpyruvyl transferase enzyme (MurA) in the peptidoglycan pathway cytoplasmic step is responsible for the phosphoenolpyruvate (PEP)-UNAG catalytic reaction, forming UNAG enolpyruvate and inorganic phosphate...
April 2024: Protein Science
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#26
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38532395/providing-medication-for-opioid-use-disorder-and-hiv-pre-exposure-prophylaxis-at-syringe-services-programs-via-telemedicine-a-pilot-study
#27
JOURNAL ARTICLE
Mehri S McKellar, Andrea C Des Marais, Hillary Chen, Yujung Choi, Rebecca Lilly, Denae Ayers, Jesse Bennett, Lauren Kestner, Brian Perry, Stephanie Poley, Amy Corneli, Christina S Meade, Nidhi Sachdeva
BACKGROUND: People who inject drugs (PWID) are at high risk for opioid overdose and infectious diseases including HIV. We piloted PARTNER UP, a telemedicine-based program to provide PWID with medication for opioid use disorder (MOUD) with buprenorphine/naloxone (bup/nx) and oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine through two syringe services programs (SSP) in North Carolina. We present overall results from this project, including participant retention rates and self-reported medication adherence...
March 26, 2024: Harm Reduction Journal
https://read.qxmd.com/read/38532262/binding-affinity-selectivity-and-pharmacokinetics-of-the-oxytocin-receptor-antagonist-l-368-899-in-the-coyote-canis-latrans
#28
JOURNAL ARTICLE
Sara M Freeman, J Leon Catrow, James Eric Cox, Alexandra Turano, McKenna A Rich, Hillary P Ihrig, Naveena Poudyal, Cheng-Wei Tom Chang, Eric M Gese, Julie K Young, Aaron L Olsen
L-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and monkeys, but very little work has been done in other mammals, and only a single paper in macaques has provided any evidence that L-368,899 can be detected in the CNS after peripheral delivery...
February 1, 2024: Comparative Medicine
https://read.qxmd.com/read/38532223/fixed-dose-combination-therapy-for-the-prevention-of-atherosclerotic-cardiovascular-disease
#29
JOURNAL ARTICLE
Anubha Agarwal, Priya M Mehta, Tyler Jacobson, Nilay S Shah, Jiancheng Ye, JingJing Zhu, Q Eileen Wafford, Ehete Bahiru, Angharad N de Cates, Shah Ebrahim, Dorairaj Prabhakaran, Anthony Rodgers, Mark D Huffman
Fixed-dose combination (FDC) therapy, also known as polypill therapy, targets risk factors for atherosclerotic cardiovascular disease (ASCVD) and has been proposed as a strategy to reduce global ASCVD burden. Here we conducted a systematic search for relevant studies from 2016-2022 to assess the effects of FDC therapy for prevention of ASCVD. The studies selected include randomized trials evaluating FDC therapy with at least one blood pressure-lowering drug and one lipid-lowering drug. The study data were independently extracted, the quality of evidence was appraised by multiple reviewers and effect estimates were pooled using a fixed-effect meta-analysis when statistical heterogeneity was low to moderate...
March 26, 2024: Nature Medicine
https://read.qxmd.com/read/38531754/detection-and-reduction-of-errors-in-parenteral-nutrition-compounding-through-gravimetric-and-product-control
#30
JOURNAL ARTICLE
Daniel Gómez-Costas, Rosa María Romero-Jiménez, Maria Elena Lobato-Matilla, Raquel Culebras, Judy Alejandra González, Sergio Herrero-Bermejo, Ana María Herranz-Alonso, María Sanjurjo
OBJECTIVE: To analyze the errors in the preparation of parenteral nutrition in a Pharmacy Service, detected through an already consolidated gravimetric and product quality control, and compare them with those detected during the initial years of implementing this quality control. METHODS: All errors detected through quality control in the compounding of pediatric and adult parenteral nutrition between 2019 and 2021 were prospectively analyzed. This quality control consisted of 3 sequential processes: a visual check, a gravimetric control, and a product control...
March 25, 2024: Farmacia Hospitalaria
https://read.qxmd.com/read/38531707/relationships-between-medications-used-in-a-mental-health-hospital-and-types-of-medication-errors-a-cross-sectional-study-over-an-8-year-period
#31
JOURNAL ARTICLE
Robin Lebas, Benjamin Calvet, Laurence Schadler, Pierre-Marie Preux, Marie-Laure Laroche
BACKGROUND: Particularities in psychiatry care can increase the risk of medication errors (MEs). OBJECTIVE: To analyze the MEs that occurred in a psychiatric hospital and to quantify relationships between the use of certain types of medication and the type of MEs. METHODS: We conducted a retrospective register based cross-sectional study in a French psychiatric hospital (2014-2021). All MEs were analyzed using ALARM method to identify type, stage of occurring and interception (defenses), consequences, drug involved and root causes...
March 20, 2024: Research in Social & Administrative Pharmacy: RSAP
https://read.qxmd.com/read/38531334/drug-target-mendelian-randomization-study-of-pcsk9-and-hmg-coa-reductase-inhibition-and-atrial-fibrillation
#32
JOURNAL ARTICLE
Fuyuan Li, Yibin Mei, Qiongbi Wu, Xianjun Wu
INTRODUCTION: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant clinical implications. The potential influence of lipid-lowering therapies, specifically PCSK9 inhibitors (PCSK9i) and HMG-CoA reductase inhibitors (statins), on AF risk remains a topic of interest. This Mendelian Randomization (MR) study aimed to elucidate the causal relationship between genetically predicted inhibition of PCSK9 and HMG-CoA reductase and the risk of AF. METHODS: Utilizing publicly available, summary-level genome-wide association study (GWAS) data, we employed single-nucleotide polymorphisms (SNPs) associated with lower LDL-C levels as instruments for gene-simulated inhibition of PCSK9 and HMG-CoA reductase...
March 26, 2024: Cardiology
https://read.qxmd.com/read/38530775/prevalence-and-concentration-of-pesticides-in-european-waters-a-protocol-for-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Manuel Serrano Valera, Nuria Vela, Grasiela Piuvezam, Francisco Mateo-Ramírez, Isac Davidson Santiago Fernandes Pimenta, Isabel Martínez-Alcalá
There is currently a growing interest in the so-called emerging pollutants, such as pesticides, pharmaceuticals, personal hygiene care products, drugs, etc., whose presence in natural ecosystems is not necessarily recent, but the development in latest years of new and more sensitive methods of analysis has allowed their detection. They can be present in the natural environment, food, and many products of everyday origin, which suggests that human exposure to them is massive and universal. Therefore, the study of this type of substances is becoming one of the priority lines of research of the main agencies dedicated to the protection of public and environmental health, such as the World Health Organization (WHO), United States Environmental Protection Agency (USEPA) or European Union (EU)...
2024: PloS One
https://read.qxmd.com/read/38530632/level-of-aflatoxins-in-dairy-feeds-poultry-feeds-and-feed-ingredients-produced-by-feed-factories-in-addis-ababa-ethiopia
#34
JOURNAL ARTICLE
Genet Mengesha, Tilahun Bekele, Henok Ashagrie, Ashagrie Zewdu Woldegiorgis
Aflatoxins are one of the major factors that affect the quality and safety of feeds. They can be transferred into livestock through contaminated feed and then onto humans via animal sources of food such as milk, meat, and eggs. The objective of this study was to detect and quantify the level of aflatoxins (B1, B2, G1, G2, and total aflatoxin) in dairy feeds, poultry (layer and broiler) feeds, and feed ingredients produced in Addis Ababa. A total of 42 feeds and feed ingredients consisting of dairy feeds (n = 5), poultry broiler feeds (n = 6), layer feeds (n = 6), and feed ingredients (n = 25) were collected from feed factories in the city and analyzed in fresh weigh basis...
March 26, 2024: Mycotoxin Research
https://read.qxmd.com/read/38530596/developing-a-program-costs-checklist-of-digital-health-interventions-a-scoping-review-and-empirical-case-study
#35
JOURNAL ARTICLE
Zareen Abbas Khan, Kristian Kidholm, Sindre Andre Pedersen, Silje Marie Haga, Filip Drozd, Thea Sundrehagen, Ellen Olavesen, Vidar Halsteinli
INTRODUCTION: The rate of development and complexity of digital health interventions (DHIs) in recent years has to some extent outpaced the methodological development in economic evaluation and costing. Particularly, the choice of cost components included in intervention or program costs of DHIs have received scant attention. The aim of this study was to build a literature-informed checklist of program cost components of DHIs. The checklist was next tested by applying it to an empirical case, Mamma Mia, a DHI developed to prevent perinatal depression...
March 26, 2024: PharmacoEconomics
https://read.qxmd.com/read/38530510/poverty-work-intensity-and-disability-evidence-from-european-countries
#36
JOURNAL ARTICLE
Chiara Mussida, Dario Sciulli
We use 2015-2018 European Union Statistics on Income and Living Conditions longitudinal data for four European countries (the UK, Germany, France, and Italy) and a dynamic trivariate panel data model to analyze the complex relationship between poverty, work intensity, and disability. We find evidence of genuine state dependence in the three processes and feedback effects from past poverty to work intensity in all countries and from past poverty to disability in the UK, Germany, and Italy. Disability is detrimental to poverty, despite the mitigating role played by disability cash benefits...
March 26, 2024: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://read.qxmd.com/read/38530454/effectiveness-of-remimazolam-in-preventing-postoperative-delirium-in-elderly-patients-with-proximal-femoral-fractures
#37
JOURNAL ARTICLE
Daichi Fujimoto, Norihiko Obata, Satoshi Mizobuchi
PURPOSE: Elderly patients with proximal femoral fractures are known to be a high-risk group for postoperative delirium (POD). The aim of this study was to determine the association of the benzodiazepine drug remimazolam with POD in elderly patients with proximal femoral fractures. METHODS: In this single-center retrospective observational study, we included patients aged 65 years or older who underwent general anesthesia for proximal femoral fractures. We collected data for the incidence of POD within 3 days after surgery...
March 26, 2024: Journal of Anesthesia
https://read.qxmd.com/read/38530152/artificial-intelligence-and-the-national-violent-death-reporting-system-a-rapid-review
#38
JOURNAL ARTICLE
Lisa C Lindley, Christina N Policastro, Brianne Dosch, Joshua G Ortiz Baco, Charles Q Cao
As the awareness on violent deaths from guns, drugs, and suicides emerges as a public health crisis in the United States, attempts to prevent injury and mortality through nursing research are critical. The National Violent Death Reporting System provides public health surveillance of US violent deaths; however, understanding the National Violent Death Reporting System's research utility is limited. The purpose of our rapid review of the 2019-2023 literature was to understand to what extent artificial intelligence methods are being used with the National Violent Death Reporting System...
March 26, 2024: Computers, Informatics, Nursing: CIN
https://read.qxmd.com/read/38530134/anthraquinones-against-cryptococcus-neoformans-sensu-stricto-antifungal-interaction-biofilm-inhibition-and-pathogenicity-in-the-caenorhabditis-elegans-model
#39
JOURNAL ARTICLE
Géssica Dos Santos Araújo, Raimunda Sâmia Nogueira Brilhante, Maria Gleiciane da Rocha, Lara de Aguiar, Débora de Souza Collares Maia Castelo-Branco, Glaucia Morgana de Melo Guedes, José Júlio Costa Sidrim, Waldemiro Aquino Pereira Neto, Marcos Fábio Gadelha Rocha
Introduction. Cryptococcal biofilms have been associated with persistent infections and antifungal resistance. Therefore, strategies, such as the association of natural compounds and antifungal drugs, have been applied for the prevention of biofilm growth. Moreover, the Caenorhabditis elegans pathogenicity model has been used to investigate the capacity to inhibit the pathogenicity of Cryptococcus neoformans sensu stricto . Hypothesis. Anthraquinones and antifungals are associated with preventing C. neoformans sensu stricto biofilm formation and disrupting these communities...
March 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38529927/primary-and-secondary-prevention-of-stroke-and-cardiovascular-events-using-evolocumab-and-alirocumab-meta-analysis-of-randomized-controlled-trials
#40
JOURNAL ARTICLE
Kwang-Hee Shin, Hye Duck Choi
OBJECTIVES: Although the clinical role of protein convertase subtilisin kexin type 9 (PCSK9) inhibitors for cholesterol management is increasing, the post-marketing period of use is short compared to other lipid-lowering drugs, so there is still insufficient evidence for their efficacy and safety. In this meta-analysis, we evaluated preventive effects of stroke and cardiovascular (CV) events using evolocumab and alirocumab. MATERIALS AND METHODS: We assessed the relative risk of stroke and CV events after alirocumab or evolocumab treatment in individuals with or without clinical CV diseases compared with that in controls...
March 26, 2024: International Journal of Clinical Pharmacology and Therapeutics
keyword
keyword
109535
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.