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https://read.qxmd.com/read/30982220/nutrition-osteoarthritis-and-cartilage-metabolism
#1
REVIEW
Osvaldo Daniel Messina, Maritza Vidal Wilman, Luis F Vidal Neira
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some relief but they do not affect the progression of the disease. The chronic intake of these drugs may result in severe adverse events. The aim of this review is to revise the effects of nutrition on cartilage metabolism and OA progression...
April 13, 2019: Aging Clinical and Experimental Research
https://read.qxmd.com/read/30980770/implant-treatment-in-immunosuppressed-renal-transplant-patients-a-prospective-case-controlled-study
#2
Gonzalo Hernández, Víctor Paredes, Rosa María López-Pintor, Amado de Andrés, Juan Carlos de Vicente, Mariano Sanz
OBJECTIVES: The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group. MATERIAL AND METHODS: Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 2001 and 2011. Periodontal, clinical and radiographic parameters were prospectively measured with a mean follow-up of 116.8 months (range from 84 to 192 months)...
April 13, 2019: Clinical Oral Implants Research
https://read.qxmd.com/read/30975948/relationship-between-self-efficacy-and-pain-control-in-iranian-women-with-advanced-knee-osteoarthritis
#3
N Mirmaroofi, A Ghahramanian, M Behshid, F Jabbarzadeh, T C Onyeka, M Asghari-Jafarabadi, J Ganjpour-Sales
Objectives: This study aimed to determine the relationship between pain of osteoarthritis (OA) and body mass index (BMI), age, pain control strategy, self-efficacy for pain control, exercise, and functional activities in a cohort of Iranian women. Subjects and Methods: In total, 150 women with advanced knee OA, candidates for arthroplasty in Tabriz, in the Northwest of Iran were enrolled into the study. A convenience sampling method was used, and data was collected using demographic form, short-form McGill pain questionnaire, pain self-efficacy questionnaire, self-efficacy for exercise, and functional activities scales...
April 2019: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/30975594/chronic-pain-management-among-people-who-use-drugs-a-health-policy-challenge-in-the-context-of-the-opioid-crisis
#4
Lise Dassieu, Jean-Luc Kaboré, Manon Choinière, Nelson Arruda, Élise Roy
BACKGROUND: In Canada, the rise in prescription opioid (PO) overdoses and addiction is a major public health concern. Various health authorities have recently recommended that physicians use caution when prescribing opioids, especially to people with histories of substance use. As a result, fewer therapeutic options are available for people who use drugs (PWUD) and suffer from chronic non-cancer pain (CNCP). This paper examines how PWUD describe their experiences with CNCP management in the context of the opioid crisis...
April 8, 2019: International Journal on Drug Policy
https://read.qxmd.com/read/30973528/postoperative-pain-management-in-a-surgical-unit-in-a-basque-country-hospital-a-best-practice-implementation-project
#5
Verónica Tíscar-González, Ana Uriarte-Diaz, Noelia Morales-Boiza, Miren Bittore Linaza-Arriola, Nieves García-Guevara, María Jesús Izquierdo-García
OBJECTIVES: The objective of this project was to implement evidence-based recommendations for post-surgical pain management and improve quality of care for patients. INTRODUCTION: Inadequate approaches to postoperative pain can lead to the pain becoming chronic, which has an impact on the patient's quality of life. The focus of this project was to implement evidence-based recommendations to improve the effect or outcome of post-surgical pain management strategies and improve quality of care...
April 2019: JBI Database of Systematic Reviews and Implementation Reports
https://read.qxmd.com/read/30972009/music-enhanced-analgesia-and-antiseizure-activities-in-animal-models-of-pain-and-epilepsy-toward-preclinical-studies-supporting-development-of-digital-therapeutics-and-their-combinations-with-pharmaceutical-drugs
#6
Cameron S Metcalf, Merodean Huntsman, Gerry Garcia, Adam K Kochanski, Michael Chikinda, Eugene Watanabe, Tristan Underwood, Fabiola Vanegas, Misty D Smith, H Steve White, Grzegorz Bulaj
Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30972008/a-neuroscience-perspective-of-physical-treatment-of-headache-and-neck-pain
#7
René Castien, Willem De Hertogh
The most prevalent primary headaches tension-type headache and migraine are frequently associated with neck pain. A wide variety of treatment options is available for people with headache and neck pain. Some of these interventions are recommended in guidelines on headache: self-management strategies, pharmacological and non-pharmacological interventions. Physical treatment is a frequently applied treatment for headache. Although this treatment for headache is predominantly targeted on the cervical spine, the neurophysiological background of this intervention remains unclear...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30971478/ak106-001616-a-potent-and-selective-inhibitor-of-cytosolic-phospholipase-a2-in-vivo-efficacy-for-inflammation-neuropathic-pain-and-pulmonary-fibrosis
#8
Hirotomo Shimizu, Akitoshi Ito, Katsuhiko Sakurada, Junji Nakamura, Kosuke Tanaka, Masakazu Komatsu, Mineko Takeda, Kenichi Saito, Yukiko Endo, Tomohito Kozaki, Motoshi Shoda, Hiroshi Kuriyama
AK106-001616 is a novel, potent, and selective inhibitor of the cytosolic phospholipase A2 (cPLA2) enzyme. Unlike traditional non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors, AK106-001616 reduced prostaglandin (PG) E2 and leukotriene (LT) B4 production by stimulated cells. The suppression of PGE2 and LTB4 production was also confirmed using an air pouch model in rats administered a single oral dose of AK106-001616. AK106-001616 alleviated paw swelling in a rat adjuvant-induced arthritis (AIA) model...
April 10, 2019: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/30971304/randomized-controlled-trial-of-transcutaneous-electrical-nerve-stimulation-for-pain-relief-during-transvaginal-oocyte-retrieval-using-conscious-sedation-study-protocol-for-a-randomized-controlled-trial
#9
Queenie Ho Yan Wong, Man Wa Lui, Sofie Shuk Fei Yung, Jennifer Ka Yee Ko, Raymond Hang Wun Li, Ernest Hung Yu Ng
BACKGROUND: Transvaginal oocytes retrieval is an essential step in in-vitro fertilization treatment. There are different pain relief methods, but none has been shown to be superior than the others. Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological and non-invasive pain relief method. This study aims to compare the pain levels experienced by the women using the conscious sedation and those who had TENS in addition to conscious sedation. METHODS AND ANALYSIS: This is a double-blinded randomized trial that will be carried out in a university-assisted conception unit...
April 11, 2019: Trials
https://read.qxmd.com/read/30967354/managing-neonatal-pain-in-the-era-of-non-invasive-respiratory-support
#10
REVIEW
Manon Tauzin, Xavier Durrmeyer
Non-invasive ventilation is currently the preferred respiratory support for premature infants with respiratory distress. The lung-protective effects of non-invasive ventilation should however not prompt disregard for the possible pain and discomfort it can generate. Non-pharmacological interventions should be used in all premature infants, regardless of their respiratory support, and are not detailed in this review. This review includes currently available evidence and gaps in knowledge regarding three aspects of pain management in premature infants receiving non-invasive ventilation: optimisation of non-invasive ventilation especially through the choice of positive pressure source, appropriate interface and synchronisation; sedative or analgesic drug use for strategies aiming at administering surfactant with reduction or avoidance of tracheal ventilation; risks and benefits of some analgesic and/or sedative drugs used to treat or prevent prolonged pain and discomfort during non-invasive ventilation...
April 4, 2019: Seminars in Fetal & Neonatal Medicine
https://read.qxmd.com/read/30965058/pharmacology-of-jnj-28583113-a-novel-trpm2-antagonist
#11
Lawrence Fourgeaud, Curt Dvorak, Malika Faouzi, John Starkus, Sunil Sahdeo, Qi Wang, Brian Lord, Heather Coate, Natalie Taylor, Yingbo He, Ning Qin, Alan Wickenden, Nicholas Carruthers, Timothy W Lovenberg, Reinhold Penner, Anindya Bhattacharya
Transient receptor potential melastatin type 2 (TRPM2) is a cation channel activated by free intracellular ADP-ribose and reactive oxygen species. TRPM2 signaling has been linked to the pathophysiology of CNS disorders such as neuropathic pain, bipolar disorder and Alzheimer's disease. In this manuscript, we describe the discovery of JNJ-28583113, a potent brain penetrant TRPM2 antagonist. Ca2+ flux assays in cells overexpressing TRPM2 and electrophysiological recordings were used to test the pharmacology of JNJ-28583113...
April 6, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30964363/cannabis-use-and-acute-coronary-syndrome
#12
John R Richards, Mary L Bing, Aimee K Moulin, Joshua W Elder, Robert T Rominski, Phillip J Summers, Erik G Laurin
INTRODUCTION: Cannabis smoking can result in elevation of heart rate and blood pressure immediately after use, possibly from sympathetic nervous system stimulation and parasympathetic nervous system inhibition. Vascular inflammation, platelet activation, and carboxyhemoglobin generation have also been proposed as potential side effects of cannabis smoking. As such, an association between cannabis use and acute coronary syndrome has been postulated. OBJECTIVE: The objective of our study was to analyze systematically the medical literature pertaining to this putative association...
April 9, 2019: Clinical Toxicology
https://read.qxmd.com/read/30961654/optimizing-the-treatment-of-pain-and-anxiety-in-pediatric-emergencies-the-role-of-accreditation
#13
Aaron Brody, Usha Sethuraman
Pervasive disparities exist in the treatment of pain and anxiety in pediatric patients presenting to hospitals with emergency conditions. This finding has been demonstrated worldwide, and is especially exacerbated in general emergency departments, which treat both adults and children. Policies to promote appropriate analgesia in the context of pediatric emergency care have been developed by several professional societies and governmental agencies in the United States; however, progress has been uneven, and data regarding these questions is lacking...
April 8, 2019: Israel Journal of Health Policy Research
https://read.qxmd.com/read/30961418/non-pharmacologic-therapies-for-systemic-lupus-erythematosus
#14
M Fangtham, S Kasturi, R R Bannuru, J L Nash, C Wang
BACKGROUND: Non-pharmacologic therapies have been deemed as potentially beneficial for patients with systemic lupus erythematosus. We conducted an updated review to determine the effects of these therapies to inform practice. METHODS: A literature search was performed using PubMed (MEDLINE), EMBASE, Cochrane, PsychINFO, the Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Google Scholar from inception until August 2018. We included randomized controlled trials of non-pharmacologic therapies in systemic lupus erythematosus patients with sample size ≥10...
April 8, 2019: Lupus
https://read.qxmd.com/read/30959106/frailty-identification-and-care-pathway-an-interdisciplinary-approach-to-care-for-older-trauma-patients
#15
Elizabeth A Bryant, Samir Tulebaev, Manuel Castillo-Angeles, Esther Moberg, Steven S Senglaub, Lynne O'Mara, Meghan McDonald, Ali Salim, Zara Cooper
BACKGROUND: Frailty is a well-established marker of poor outcomes in geriatric trauma patients. There are few interventions to improve outcomes in this growing population. Our goal was to determine if an interdisciplinary care pathway for frail trauma patients improved in-hospital mortality, complications, and 30-day readmissions. STUDY DESIGN: This was a retrospective cohort study of frail patients ≥65 years admitted to the trauma service at an academic, urban level I trauma center between 2015-2017...
March 21, 2019: Journal of the American College of Surgeons
https://read.qxmd.com/read/30952826/infographic-international-olympic-committee-consensus-statement-on-pain-management-in-athletes-non-pharmacological-strategies
#16
Brian Hainline, Wayne Derman, Alan Vernec, Richard Budgett, Masataka Deie, Jiri Dvorak, Christopher A Harle, Stanley Herring, Michael McNamee, Willem Meeuwisse, G Lorimer Moseley, Bade Omololu, John Orchard, Andrew Pipe, Babette M Pluim, Johan Raeder, David Siebert, Mike Stewart, Mark Campbell Stuart, Judith Turner, Mark Ware, David Zideman, Lars Engebretsen
No abstract text is available yet for this article.
April 5, 2019: British Journal of Sports Medicine
https://read.qxmd.com/read/30948580/from-pain-treatment-to-opioid-dependence-a-qualitative-study-of-the-environmental-influence-on-codeine-use-in-uk-adults
#17
Emma Kinnaird, Andreas Kimergård, Stacey Jennings, Colin Drummond, Paolo Deluca
OBJECTIVES: To investigate the views and experiences of people who use codeine in order to describe the 'risk environment' capable of producing and reducing harm. DESIGN: This was a qualitative interview study. Psychological dependence on codeine was measured using the Severity of Dependence Scale. A cut-off score of 5 or higher indicates probable codeine dependence. SETTING: Participants were recruited from an online survey and one residential rehabilitation service...
April 3, 2019: BMJ Open
https://read.qxmd.com/read/30944985/relaxation-guided-imagery-reduces-perioperative-anxiety-and-pain-in-children-a-randomized-study
#18
Laura Vagnoli, Alessandra Bettini, Elena Amore, Salvatore De Masi, Andrea Messeri
Several studies have shown the efficacy of psychological interventions in reducing preoperative anxiety in children undergoing surgery. This study aims to investigate the effectiveness of a specific non-pharmacological technique, the relaxation-guided imagery, in reducing both preoperative anxiety and postoperative pain in a sample of 60 children (6-12 years old) undergoing minor surgery who were randomly assigned to the experimental group (N = 30) or the control group (N = 30). The first group received the relaxation-guided imagery, before the induction of general anesthesia; the second group received standard care...
April 3, 2019: European Journal of Pediatrics
https://read.qxmd.com/read/30938843/herbal-medicinal-products-or-preparations-for-neuropathic-pain
#19
REVIEW
Adele Boyd, Chris Bleakley, Deirdre A Hurley, Chris Gill, Mary Hannon-Fletcher, Pamela Bell, Suzanne McDonough
BACKGROUND: Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), or surgery. Evidence suggests that people suffering from neuropathic pain are likely to seek alternative modes of pain relief such as herbal medicinal products due to adverse events brought about by current pharmacological agents used to treat neuropathic pain...
April 2, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/30935724/-we-do-it-together-an-ethnographic-study-of-the-alliance-between-child-and-hospital-clown-during-venipunctures
#20
Helle Nygaard Kristensen, Erik Elgaard Sørensen, Jennifer Stinson, Helle Haslund Thomsen
PURPOSE: Hospital clowns are widely used as a means of non-pharmacological intervention in the treatment of hospitalized children. However, little research has examined the impact of clowns on common painful needle-related procedures. This study explored children's pain experience and their ability to cope during a venipuncture while interacting with a clown in the acute admission unit. DESIGN AND METHODS: An ethnographic fieldwork study was conducted. Data were collected over a 10-month period through participant observation and informal interviews, supplemented by video recordings...
March 29, 2019: Journal of Pediatric Nursing
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