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Qian Yang, Kang Chen, Hanlin Zhang, Wanying Zhang, Changlin Gong, Qing Zhang, Pan Liu, Tianyi Sun, Yuanyuan Xu, Xiaojing Qian, Wenying Qiu, Chao Ma
In this study, the distribution of five Alzheimer's disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis. The associations among SNPs, clinical daily cognitive states, and postmortem neuropathological changes were analyzed in 110 human brains from the Chinese Academy of Medical Sciences/Peking Union Medical College (CAMS/PUMC) Human Brain Bank. APOE ε4 (OR = 4.482, P = 0...
February 19, 2019: Neuroscience Bulletin
Sinisa Maslovara, Silva Butkovic-Soldo, Mihaela Peric, Ivana Pajic Matic, Anamarija Sestak
BACKGROUND: The minimal number of studies have documented the impact of Vestibular rehabilitation (VR) on the recovery rate of patients with Chronic Unilateral Vestibular Hypofunction (CUVH) and Bilateral Vestibular Hypofunction (BVH). OBJECTIVES: The goal of the study was to show and compare the impact of vestibular rehabilitation (VR) in patients with CUVH and BVH. METHODS: We analysed the data of 30 patients with CUVH and 20 with BVH treated with VR...
February 7, 2019: NeuroRehabilitation
Maria Bach Laursen, Linn Reinholdt, Anna Amanda Schönherz, Hanne Due, Ditte Starberg Jespersen, Lykke Grubach, Marianne Schmidt Ettrup, Rasmus Røge, Steffen Falgreen, Suzette Sørensen, Julie Støve Bødker, Alexander Schmitz, Hans E Johnsen, Martin Bøgsted, Karen Dybkær
Survival of diffuse large B-cell lymphoma (DLBCL) patients has improved by inclusion of rituximab. Refractory/recurrent disease caused by treatment resistance is, however, a major problem. Determinants of rituximab sensitivity are not fully understood, but effect of rituximab are enhanced by antagonizing cell surface receptor CXCR4. In a two-step strategy, we tested the hypothesis that prognostic value of CXCR4 in DLBCL relates to rituximab treatment, due to a hampering effect of CXCR4 on the response of DLBCL cells to rituximab...
January 22, 2019: Oncotarget
Shirley Handelzalts, Michal Kenner-Furman, Ganit Gray, Nachum Soroker, Guy Shani, Itshak Melzer
BACKGROUND: Reactive balance responses are critical for fall prevention. Perturbation-based balance training (PBBT) has shown a positive effect in reducing the risk of falls among older adults and persons with Parkinson's disease. OBJECTIVE: To explore the effect of a short-term PBBT on reactive balance responses, performance-based measures of balance and gait and balance confidence. METHODS: Thirty-four moderate-high functioning, subacute persons with stroke (PwS) (lower extremity Fugl-Meyer score 29...
February 15, 2019: Neurorehabilitation and Neural Repair
Fady M Kaldas, Islam M Korayem, Tara A Russell, Vatche G Agopian, Antony Aziz, Joseph DiNorcia, Douglas G Farmer, Hasan Yersiz, Jonathan R Hiatt, Ronald W Busuttil
Importance: Anastomotic biliary complications (ABCs) constitute the most common technical complications in liver transplant (LT). Given the ever-increasing acuity of LT, identification of factors contributing to ABCs is essential to minimize morbidity and optimize outcomes. A detailed analysis in a patient population undergoing high-acuity LT is lacking. Objective: To evaluate the rate of, risk factors for, and outcomes of ABCs and acuity level in LT recipients...
February 13, 2019: JAMA Surgery
Bergthora Baldursdottir, Susan L Whitney, Alfons Ramel, Palmi V Jonsson, Brynjolfur Mogensen, Hannes Petersen, Ella K Kristinsdottir
BACKGROUND: Asymmetric vestibular function, decreased plantar sensation, postural control and functional ability have been associated with fall-related wrist fractures. OBJECTIVE: To investigate whether multi-sensory training (MST) improves postural control, vestibular function, foot sensation and functional ability among people with fall-related wrist fractures compared to wrist stabilization training (WT). METHODS: This was an assessor-blinded, randomized controlled trial...
February 11, 2019: Aging Clinical and Experimental Research
Lidia Wadolowska, Jadwiga Hamulka, Joanna Kowalkowska, Natalia Ulewicz, Monika Hoffmann, Magdalena Gornicka, Monika Bronkowska, Teresa Leszczynska, Pawel Glibowski, Renata Korzeniowska-Ginter
The sustainability of education focused on improving the dietary and lifestyle behaviours of teenagers has not been extensively studied. The aim of this study was to determine the sustainability of diet-related and lifestyle-related school-based education on sedentary and active lifestyle, diet quality and body composition of Polish pre-teenagers in a medium-term follow-up study. An education-based intervention study was carried out on 464 students aged 11⁻12 years (educated/control group: 319/145). Anthropometric measurements were taken and body mass index (BMI) and waist-to-height ratios (WHtR) were calculated, both at the baseline and after nine months...
February 3, 2019: Nutrients
Lili Zhang, Yimei Liu, Ziyun Zhou, Yan Wei, Jie Wang, Jie Yang, Yanling Wu, Yan Sun
BACKGROUND: OBJECTIVE:This study aimed to investigate the effects of long-term rehabilitation and related factors affecting the recovery of autistic children. METHODS: A total of 137 autistic children were followed up for 3 years. They received two neuropsychological assessments at the first visit and 3 years after referral. Assessments included Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), and Developmental Diagnostic Scale of Children Aged 0-6 Years...
January 29, 2019: NeuroRehabilitation
Merrick S Fallah, Mateen R Shaikh, Binod Neupane, Daniel Rusiecki, Teresa A Bennett, Joseph Beyene
OBJECTIVE: Irritability is common in pediatric autism spectrum disorder (ASD) patients. This can have major implications in child development, receptivity to behavioral therapy, as well as child and caregiver well-being. A systematic review and network meta-analysis were conducted to assess the efficacy and safety of atypical antipsychotics in treating irritability in these patients. METHODS: Studies were identified from Medline, Embase, and PsycINFO from inception to March 2018...
February 1, 2019: Journal of Child and Adolescent Psychopharmacology
Kun-Chi Wu, Yu-Hsun Chang, Hwan-Wun Liu, Dah-Ching Ding
Objectives: Osteoarthritis (OA) is a chronic disease of degenerative joints. Mesenchymal stem cells (MSCs) have been used for cartilage regeneration in OA. We investigated the therapeutic potential of human umbilical cord-derived MSCs (HUCMSCs) with hyaluronic acid (HA) hydrogel transplanted into a porcine OA preclinical model. Materials and Methods: The HUCMSCs were characterized with respect to morphology, surface markers, and differentiation capabilities. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to examine gene expressions in a HUCMSC-HA coculture...
January 2019: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Patricia de Sequera Ortiz, Rafael Pérez García, Manuel Molina Nuñez, Rosa Inés Muñoz González, Gracia Álvarez Fernández, Eva Mérida Herrero, María Jesús Camba Caride, Luís Alberto Blázquez Collado, M Paz Alcaide Lara, Rocío Echarri Carrillo
INTRODUCTION: Dialysis fluid (DF), an essential element in hemodialysis (HD), is manufactured in situ by mixing three components: treated water, bicarbonate concentrate and acid concentrate. To avoid the precipitation of calcium and magnesium carbonate that is produced in DF by the addition of bicarbonate, it is necessary to add an acid. There are 2 acid concentrates that contain acetate (ADF) or citrate (CDF) as a stabilizer. OBJECTIVE: To compare the acute effect of HD with CDF vs...
January 24, 2019: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Cody L Sipe, Kevin D Ramey, Phil P Plisky, James David Taylor
Testing balance and fall risk with older adults of varying abilities is of increasing importance. The primary aim of this study was to evaluate the validity of the Y Balance Test Lower Quarter (YBT-LQ) in older adults. A secondary aim was to provide estimates of reliability with this population. Thirty male (n=15) and female (n=15) subjects (66.8+6.5 years) performed the YBT-LQ, 30-second Chair Stand Test (CST), 8' Up and Go (8UG), Timed Up and Go (TUG), Single Leg Stance (SLS) and Activities Specific Balance Confidence (ABCS) questionnaire...
January 24, 2019: Journal of Aging and Physical Activity
A Pels, O C Knaven, B J Wijnberg-Williams, M J C Eijsermans, S M Mulder-de Tollenaer, C S H Aarnoudse-Moens, C Koopman-Esseboom, J van Eyck, J B Derks, W Ganzevoort, A G van Wassenaer-Leemhuis
OBJECTIVE: The objective of this study is to explore developmental outcomes at five years after early-onset fetal growth restriction (FGR). STUDY DESIGN: Retrospective data analysis of prospective follow-up of patients of three Dutch centres, who participated in a twenty centre European randomized controlled trial on timing of delivery in early-onset FGR. Developmental outcome of very preterm infants born after extreme FGR is assessed at (corrected) age of five...
January 11, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Atanu Banerjee, Poonam Vishwakarma, Antresh Kumar, Andrew M Lynn, Rajendra Prasad
ABC transporters are membrane-bound pumps composed of two major domains: the transmembrane domain(s) (TMDs) and the nucleotide-binding domain(s) (NBDs). Sequence analyses of the NBDs of key ABC exporters revealed a residue position within the H-loop to be differentially conserved in the ABCG family, wherein there lies glutamine instead of positively charged arginine/lysine as in non-ABCG members. Consequently, contrasting NBD sequences of fungal Pleiotropic Drug Resistance transporters (PDR/ABCG) with that of Cholesterol/Phospholipid and Retinal (CPR/ABCA) Flippase family revealed a high Cumulative Relative Entropy (CRE) score of this residue position implying its family-specific functional significance...
January 14, 2019: Archives of Biochemistry and Biophysics
Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu, Quchang Ouyang
BACKGROUND: Among breast cancer (BC) patients, near 40% are post-menopause, and 70%-80% are hormone receptor (HR)-positive. About 30%-40% BC patients who are diagnosed as invasive carcinoma HR-positive BC would eventually develop metastatic breast cancers. In 2016, FALCON trial proves Fulvestrant as an effective first-line endocrine therapy for post-menopause HR-positive advanced BC (ABC) patients. But even after FALCON published, Fulvestrant is rarely used as first-line in real world ABC patients in China...
January 15, 2019: Journal of Translational Medicine
Chie Aita, Yoshito Mizoguchi, Miwako Yamamoto, Yasuhisa SeguchI, Chiho Yatsuga, Taisuke Nishimura, Yoshiki Sugimoto, Daiki Takahashi, Reiko Nishihara, Takefumi Ueno, Masahiro Nakayama, Toshihide Kuroki, Hiromi Nabeta, Yoshiomi Imamura, Akira Monji
There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16-60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R)...
December 27, 2018: Psychiatry Research
Birgitte Sandfeld-Paulsen, Peter Meldgaard, Boe S Sorensen, Akmal Safwat, Ninna Aggerholm-Pedersen
OBJECTIVE: Inflammation has been validated as a host-related prognostic marker in cancer. The Glasgow Prognostic score (GPS) and neutrophil-to-lymphocyte ratio (NLR) are suggested measures of inflammation. However, the allocation of patients has been questioned. Hence, optimized inflammation-scores has been developed, such as the combined NLR and GPS (CNG) system, and the Aarhus composite biomarker score (ACBS). So far, these optimized inflammation-scores have not been validated in lung cancer patients...
January 11, 2019: Acta Oncologica
Magdalena Klanova, Laurie H Sehn, Isabelle Bence-Bruckler, Federica Cavallo, Jie Jin, Maurizio Martelli, Douglas Stewart, Umberto Vitolo, Francesco Zaja, Qingyuan Zhang, Federico Mattiello, Gila Sellam, Elizabeth A Punnoose, Edith Szafer-Glusman, Christopher R Bolen, Mikkel Z Oestergaard, Guenter R Fingerle-Rowson, Tina Nielsen, Marek Trneny
Central nervous system (CNS) relapse carries a poor prognosis in diffuse large B-cell lymphoma (DLBCL). Integrating biomarkers into the CNS International Prognostic Index (CNS-IPI) risk model may improve identification of patients at high risk of developing secondary CNS disease. CNS relapse was analyzed in 1,418 DLBCL patients treated with obinutuzumab or rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy in the phase III GOYA study. Cell-of-origin (COO) was assessed using gene expression profiling...
January 7, 2019: Blood
Anna Stelmaszczyk-Emmel, Anna Sosnowska, Justyna Kurkowiak, Magdalena Sagała, Lidia Zawadzka-Głos, Beata PyrŻak, Urszula Demkow
Introduction: Accurate diagnosis of bacterial and viral infection is very difficult. Unfortunately, there is still no quick and discriminative diagnostic test that would help clinicians in establishing the diagnosis and taking a decision on treatment. The aim of the study was to compare the expression of antigens on phagocytes, which are involved in the first defence line during bacterial and viral infections in children, as a potential tool to distinguish the etiology of the infection...
2018: Central-European Journal of Immunology
David Douglas Berg, Christian T Ruff, Petr Jarolim, Robert P Giugliano, Francesco Nordio, Hans J Lanz, Michele F Mercuri, Elliott M Antman, Eugene Braunwald, David A Morrow
BACKGROUND: The ABC-stroke and ABC-bleeding risk scores incorporate clinical variables and cardiovascular biomarkers to estimate risk of stroke or systemic embolic events (S/SEE) and bleeding, respectively, in patients with atrial fibrillation (AF). These scores have been proposed for routine clinical use but their performance in external cohorts remains uncertain. METHODS: ENGAGE AF-TIMI 48 was a multinational, randomized trial of the oral factor Xa inhibitor edoxaban in patients with AF and CHADS2 score ≥2...
November 11, 2018: Circulation
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