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Kidney,Chronic kidney disease,acute renal failure, dialysis

Khurram Jamil, Xingyue Huang, Belinda Lovelace, An T Pham, Kunal Lodaya, George Wan
OBJECTIVES: Hepatorenal Syndrome (HRS) is characterized by renal failure in patients with advanced chronic liver disease (CLD) and is the leading cause of hospitalizations in CLD. This study examines the clinical and economic burden, outcomes, and unmet need of HRS treatment in US hospitals. METHOD: A retrospective cohort study was conducted based on a large electronic health records database (Cerner HealthFacts) with records for hospitalized HRS patients from January 2009 - June 2015...
February 6, 2019: Journal of Medical Economics
Seung Don Baek, So Mi Kim, Jae-Young Kang, Minkyu Han, Eun Kyoung Lee, Jai Won Chang
Postcontrast acute kidney injury (AKI) occurs more frequently in patients with lower estimated glomerular filtration rate. We hypothesized that postcontrast AKI in chronic kidney disease (CKD) patients with distinct risk factors might be associated with accelerated renal progression.We undertook this retrospective cohort study to develop and validate a risk scoring model for predicting renal progression. In a development dataset, 18,278 contrast-enhanced CT scans were performed in 9097 patients with CKD (estimated glomerular filtration rate [eGFR] < 60 mL/min/1...
February 2019: Medicine (Baltimore)
I N Bobkova, S S Gussaova, E V Stavrovskaya, A V Struve
Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (СKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. The leading pathophysiological mechanisms of kidney damage in obesity are intrarenal hemodynamic disorders with the formation of hyperfiltration and damaging effects of adipokines produced by adipose tissue...
June 20, 2018: Terapevticheskiĭ Arkhiv
Guy J M Cameron, Simon H Jiang, Svenja Loering, Aniruddh V Deshpande, Philip M Hansbro, Malcolm R Starkey
Acute kidney injury remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an acute kidney injury are at increased risk of developing chronic kidney disease and end stage renal failure. Understanding the fundamental mechanisms underpinning the pathophysiology of acute kidney injury is critical for developing novel strategies for diagnosis and treatment. A growing body of evidence indicates that amplifying type 2 immunity may have therapeutic potential in kidney injury and disease...
January 25, 2019: Journal of Pathology
Filiz Markfeld-Erol, Juliane Farthmann, Johannes Donauer, Mirjam Kunze
HISTORY AND CLINICAL FINDINGS:  We report of three pregnancies, two with renal insufficiency and one with a history of renal transplantation. Pat.1 is a 32y at 20 weeks of gestation with acute renal failure, nephrotic syndrome and history of familial Mediterranean fever. Case 2 is a 23y with cirrhotic kidneys, stage 5 of chronic kidney disease and dialysis treatment 3 × a week. The pregnancy was an incidental finding. Pat. 3 is a 29y I/0 with history of renal transplantation years ago...
January 2019: Deutsche Medizinische Wochenschrift
Fernando Motta, Jason R Crowner, Corey A Kalbaugh, William A Marston, Luigi Pascarella, Katharine L McGinigle, Melina R Kibbe, Mark A Farber
OBJECTIVE: To report the outcomes of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aortic aneurysms with fenestrated and/or branched devices. METHODS: This study represents a retrospective analysis of a prospectively maintained database of patients enrolled in a physician-sponsored investigational device exemption trial for endovascular treatment of complex thoracoabdominal aneurysms between July 2012 and July 2017...
December 24, 2018: Journal of Vascular Surgery
Silvia Coelho, José Nuno Fonseca, Joana Gameiro, Sofia Jorge, José Velosa, José António Lopes
BACKGROUND: Acute Kidney Injury (AKI) is a very frequent complication in the Acute Liver Failure (ALF) population associated with negative outcomes. We aim to evaluate the impact of AKI duration on the outcomes of an ALF population. METHODS: A 20-year retrospective analysis of ALF patients admitted to an Intensive Care Unit (ICU) was performed. Chronic liver failure, chronic kidney disease on renal replacement therapy, dialysis requirement within the week prior or an ICU stay of less than 48 h after AKI diagnosis, were exclusion criteria...
December 19, 2018: Journal of Nephrology
Cédric Pinier, Philippe Gatault, Maud François, Christelle Barbet, Hélène Longuet, Nolwenn Rabot, Johann Noble, Elodie Bailly, Matthias Buchler, Bénédicte Sautenet, Jean-Michel Halimi
Background: Renal patients with diabetes mellitus are at very high risk of death before and after chronic dialysis initiation. Risk factors for death in this population are not clearly identified. Methods: We performed a retrospective survival analysis in 861 patients with diabetes mellitus consecutively followed up in the 2000-13 period in a nephrology setting. Results: The mean age was 70  ±  10 years [men 65.2%; diabetes duration 13...
December 2018: Clinical Kidney Journal
Anthony Bonavia, Kai Singbartl
The liver and kidney are key organs of metabolic homeostasis in the body and display complex interactions. Liver diseases often have direct and immediate effects on renal physiology and function. Conversely, acute kidney injury (AKI) is a common problem in patients with both acute and chronic liver diseases. AKI in patients with acute liver failure is usually multifactorial and involves insults similar to those seen in the general AKI population. Liver cirrhosis affects and is directly affected by aberrations in systemic and renal hemodynamics, inflammatory response, renal handling of sodium and free water excretion, and additional nonvasomotor mechanisms...
October 2018: Seminars in Respiratory and Critical Care Medicine
Asma Hasan, Sharon Maynard, Dominick Santoriello, Henry Schairer
Background: Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a mutation in the AGXT gene, resulting in deficiency of the alanineglyoxylate:aminotransferase enzyme. It is characterized by accumulation of oxalate in the kidneys and other organs. Case Presentation: A Syrian woman with a history of nephrolithiasis and heterozygosity for factor V Leiden and prothrombin gene mutations presented with postpartum renal failure. She required initiation of renal replacement therapy at 14 weeks postpartum...
September 2018: Case Reports in Nephrology and Dialysis
Cheng-Yi Chen, Vin-Cent Wu, Cheng-Jui Lin, Chih-Sheng Lin, Chi-Feng Pan, Han-Hsiang Chen, Yu-Feng Lin, Tao-Min Huang, Likwang Chen, Chih-Jen Wu
OBJECTIVE: To focus on the potential beneficial effects of the pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP4is) on attenuating progression of diabetic kidney disease in reducing the long-term effect of the acute kidney injury (AKI) to chronic kidney disease (CKD) transition. PATIENTS AND METHODS: Data from the National Health Insurance Research Database from January 1, 1999, to July 31, 2011, were analyzed, and patients with diabetes weaning from dialysis-requiring AKI were identified...
October 19, 2018: Mayo Clinic Proceedings
Zachary Bouck, Graham C Mecredy, Noah M Ivers, Moumita Barua, Danielle Martin, Peter C Austin, Joshua Tepper, R Sacha Bhatia
Importance: International nephrology societies advise against nonsteroidal anti-inflammatory drug (NSAID) use in patients with hypertension, heart failure, or chronic kidney disease (CKD); however, recent studies have not investigated the frequency or associations of use in these patients. Objectives: To estimate the frequency of and variation in prescription NSAID use among high-risk patients, to identify characteristics associated with prescription NSAID use, and to investigate whether use is associated with short-term, safety-related outcomes...
November 1, 2018: JAMA Internal Medicine
Tao-Min Huang, Vin-Cent Wu, Yu-Feng Lin, Jian-Jhong Wang, Chih-Chung Shiao, Likwang Chen, Shih-Chieh Jeff Chueh, Eric Chueh, Shao-Yu Yang, Tai-Shuan Lai, Shuei-Liong Lin, Tzong-Shinn Chu, Kwan-Dun Wu
Although statin treatment is recommended for patients with chronic kidney disease (CKD) stages I⁻IV, its potential benefits have not been reported in advanced CKD patients. Non-diabetic patients with advanced CKD (pre-dialysis patients, estimated glomerular filtration rate <15 mL/min/1.73 m²) were enrolled from a National Health Insurance Research Database with a population of 23 million. Statin users and non-users were matched using propensity scoring and analyzed using Cox proportional hazards models, taking mortality as a competing risk with subsequent end-stage renal disease (ESRD) and statin doses as time-dependent variables...
September 17, 2018: Journal of Clinical Medicine
Che-Hsiung Wu, Huang-Ming Chang, Cheng-Yi Wang, Likwang Chen, Liang-Wen Chen, Chien-Heng Lai, Shuenn-Wen Kuo, Hao-Chien Wang, Vin-Cent Wu
Both acute kidney injury (AKI) and chronic obstructive pulmonary disease (COPD) are associated with increased morbidity and mortality. However, the incidence of de novo COPD in patients with AKI, and the impact of concurrent COPD on the outcome during post-AKI care is unclear. Patients who recovered from dialysis-requiring AKI (AKI-D) during index hospitalizations between 1998 and 2010 were identified from nationwide administrative registries. A competing risk analysis was conducted to predict the incidence of adverse cardiovascular events and mortality...
August 24, 2018: Journal of Clinical Medicine
Chaan S Ng, Sanjeeva P Kalva, Candace Gunnarsson, Michael P Ryan, Erin R Baker, Ravindra L Mehta
BACKGROUND: There is little published evidence examining the use of contrast material (CM) and the risk of acute renal adverse events (AEs) in individuals with increasingly common risk factors including cancer and chronic kidney disease (CKD). The objective of this study was to use real world hospital data to test the hypothesis that inpatients with cancer having CT procedures with iodinated CM would have higher rates of acute renal AEs in comparison to inpatients without cancer. METHODS: Inpatient hospital visits in the Premier Hospital Database from January 1, 2010 through September 30, 2015 were eligible for inclusion...
August 24, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Gennaro Giustino, Roxana Mehran, Patrick W Serruys, Joseph F Sabik, Milan Milojevic, Charles A Simonton, John D Puskas, David E Kandzari, Marie-Claude Morice, David P Taggart, Anthony H Gershlick, Philippe Généreux, Zixuan Zhang, Thomas McAndrew, Björn Redfors, Michael Ragosta, Irving L Kron, Ovidiu Dressler, Martin B Leon, Stuart J Pocock, Ori Ben-Yehuda, Arie Pieter Kappetein, Gregg W Stone
BACKGROUND: The optimal revascularization strategy for patients with left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. OBJECTIVES: This study investigated the comparative effectiveness of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in patients with LMCAD and low or intermediate anatomical complexity according to baseline renal function from the multicenter randomized EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial...
August 14, 2018: Journal of the American College of Cardiology
Yu-Feng Lin, Likwang Chen, Shuei-Liong Lin, Yu-Chang Yeh, Tao-Min Huang, Yu-Hsiang Chou, Fan-Chi Chang, Yi-Ting Chen, Shao-Yu Yang, Tai-Shuan Lai, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu
OBJECTIVES: Acute kidney disease (AKD), the transition of acute kidney injury to chronic kidney disease, has major clinical significance. Whether mineralocorticoid receptor antagonist will afford target organ protection during this critical stage remains ill-defined. METHODS: Using a population-based cohort database from January 1999 to July 2011, we identified 7252 AKD patients with hypertension, of whom 2255 were treated with mineralocorticoid receptor antagonist (user) and 4997 were treated by other antihypertensive medication (nonuser)...
July 30, 2018: Journal of Hypertension
Magdalena Stârcea, Cristina Gavrilovici, Andra Elsayed, Mihaela Munteanu, Vasile Valeriu Lupu, Elena Cojocaru, Ingrith Miron, Lucian Miron
RATIONALE: Though to be rare, calcific uremic arteriolophathy (CUA) is an ectopic calcification entity causing pain and disabilities in patients with chronic renal insufficiency, thus increasing the morbidity and mortality. PATIENT CONCERN: We report a case of four years old boy admitted with acute respiratory failure. Physical examination revealed: irritability, purple subcutaneous hard nodules, tachypnea, dry spasmodic cough, respiratory rate 45/min, heart rate 110/min, blood pressure 100/60 mmHg, with normal heart sounds, no murmurs, hepatomegaly with hepato-jugular reflux...
July 2018: Medicine (Baltimore)
Maija Eskola, Suvi T Vaara, Anna-Maija Korhonen, Jukka Sauranen, Niina Koivuviita, Eero Honkanen, Ville Pettilä, Mikko Haapio
BACKGROUND: Studies reporting renal and overall survival after acute kidney injury (AKI) treated exclusively with intermittent modalities of renal replacement therapy (IRRT) are rare. This study focused on outcomes of AKI patients treated with IRRT both in intensive care units (ICUs) and non-ICU dialysis units. METHODS: This prospective observational study was carried on during a 5-month period in 17 ICUs and 17 non-ICUs. ICU and non-ICU patients (total n = 138; 65 ICU, 73 non-ICU) requiring RRT for AKI and chosen to receive IRRT were included...
November 2018: Acta Anaesthesiologica Scandinavica
Adrienne Lenhart, Salwa Hussain, Reena Salgia
BACKGROUND: Acute kidney injury in the setting of alcoholic liver disease portends a poor prognosis without liver transplant. AIMS: Using a tertiary care population, we aimed to evaluate the outcomes of renal replacement therapy in patients with alcoholic liver disease and acute kidney injury with < 6 months sobriety. METHODS: A retrospective review of hospitalized patients with alcoholic hepatitis/acute on chronic alcoholic cirrhosis and hepatorenal syndrome or acute tubular necrosis was performed...
October 2018: Digestive Diseases and Sciences
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