keyword
https://read.qxmd.com/read/38419246/a-gluco-mindful-approach-to-diabetic-gastroparesis
#21
JOURNAL ARTICLE
Sanjay Kalra, Saptarshi Bhattacharya, Hitesh Punyani
Diabetes gastroparesis is a common manifestation of autonomic neuropathy in persons with long-standing, uncontrolled diabetes. Most discussion about its management revolves around the mitigation of symptoms. Here, we share tips on choosing the right glucose-lowering medication, based upon predominant symptomatology of gastroparesis. We highlight about insulin preparations, and their timing of administration, can be tailored according to need. We also emphasize the need to choose oral glucose lowering drugs with care...
February 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38418618/trends-in-diabetes-prevalence-awareness-treatment-and-control-in-french-speaking-switzerland
#22
JOURNAL ARTICLE
Ariane Pauli, Carlos de Mestral, Pedro Marques-Vidal
Diabetes is increasing in Switzerland, but whether its management has improved is unknown. We aimed to assess diabetes prevalence, diagnosis, treatment, and control in French-speaking Switzerland. Our study used cross-sectional data for years 2005-2019 from a population-based study in Geneva, Switzerland. Overall prevalence (self-reported diagnosis and/or fasting plasma glucose level ≥ 7 mmol/L), diagnosed, treated (among diagnosed participants) and controlled diabetes (defined as a fasting plasma glucose FPG < 6...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38417018/-kj-mhpc-enzyme-in-klebsiella-jilinsis-2n3-is-involved-in-the-degradation-of-chlorimuron-ethyl-via-de-esterification
#23
JOURNAL ARTICLE
Qianhang Zhai, Shuanglan Zheng, Cheng Zhang, Zhou Lu, Shuang Liang, Ranhong Li, Xianghui Zhang, Hongyu Pan, Hao Zhang
Microbial degradation is a highly efficient and reliable approach for mitigating the contamination of sulfonylurea herbicides, such as chlorimuron-ethyl, in soil and water. In this study, we aimed to assess whether Kj-mhpC plays a pivotal role in the degradation of chlorimuron-ethyl. Kj -mhpC enzyme purified via prokaryotic expression exhibited the highest catalytic activity for chlorimuron-ethyl at 35 °C and pH 7. Bioinformatic analysis and three-dimensional homologous modeling of Kj-mhpC were conducted...
February 28, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38416773/differential-effects-of-type-2-diabetes-treatment-regimens-on-diabetes-distress-and-depressive-symptoms-in-the-glycemia-reduction-approaches-in-diabetes-a-comparative-effectiveness-study-grade-a-randomized-clinical-trial
#24
JOURNAL ARTICLE
Jeffrey S Gonzalez, Ionut Bebu, Heidi Krause-Steinrauf, Claire J Hoogendoorn, Gladys Crespo-Ramos, Caroline Presley, Aanand D Naik, Shihchen Kuo, Mary L Johnson, Deborah Wexler, Jill P Crandall, Anne E Bantle, Valerie Arends, Andrea L Cherrington
OBJECTIVE: We evaluated whether adding basal insulin to metformin in adults with early type 2 diabetes mellitus (T2DM) would increase emotional distress relative to other treatments. RESEARCH DESIGN AND METHODS: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) of adults with T2DM of <10 years' duration, HbA1c 6.8-8.5%, and taking metformin monotherapy randomly assigned participants to add insulin glargine U-100, sulfonylurea glimepiride, the glucagon-like peptide-1 receptor agonist liraglutide, or the dipeptidyl peptidase 4 inhibitor sitagliptin...
February 28, 2024: Diabetes Care
https://read.qxmd.com/read/38414281/analyzing-gene-expression-after-administration-of-low-intensity-therapeutic-ultrasound-in-human-islet-cells
#25
JOURNAL ARTICLE
John Hill, James Messina, Aleksandar Jeremic, Vesna Zderic
OBJECTIVES: Diabetes mellitus is a complex heterogenous metabolic disease that significantly affects the world population. Although many treatments exist, including medications such as metformin, sulfonylureas, and glucagon-like peptide-1 (GLP) receptor agonist, there is growing interest in finding alternative methods to noninvasively treat this disease. It has been previously shown that low-intensity ultrasound stimulation of pancreatic β-cells in mice can elicit insulin secretion as a potential treatment for this disease...
February 27, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38412282/continuous-glucose-monitoring-profiles-and-health-outcomes-after-dapagliflozin-plus-saxagliptin-vs-insulin-glargine
#26
JOURNAL ARTICLE
Donald C Simonson, Marcia A Testa, Ella Ekholm, Maxwell Su, Tina Vilsbøll, Serge A Jabbour, Marcus Lind
CONTEXT: Glycemic variability and hypoglycemia during diabetes treatment may impact therapeutic effectiveness and safety, even when glycated hemoglobin (HbA1c) reduction is comparable between therapies. OBJECTIVE: We employed masked continuous glucose monitoring (CGM) during a randomized trial of dapagliflozin plus saxagliptin (DAPA+SAXA) vs insulin glargine (INS) to compare glucose variability and patient-reported outcomes (PROs). DESIGN: 24-week sub-study of a randomized, open-label, two-arm, parallel-group, phase 3b study...
February 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38412261/standardizing-to-specific-target-populations-in-distributed-networks-and-multi-site-pharmacoepidemiologic-studies
#27
JOURNAL ARTICLE
Michael Webster-Clark, Kristian B Filion, Robert W Platt
Distributed networks and other multi-site studies assess drug safety and effectiveness in diverse populations by pooling information. Targeting groups of clinical or policy interest (including specific sites or site combinations) and applying weights based on effect measure modifiers (EMMs) prior to pooling estimates within multi-site studies may increase interpretability and improve precision. We simulated a four-site study, standardized each site using inverse odds weights (IOW) to resemble the three smallest sites or the smallest site, estimated IOW-weighted RDs, and combined estimates with inverse variance weights (IVW)...
February 27, 2024: American Journal of Epidemiology
https://read.qxmd.com/read/38407631/more-rapid-bone-mineral-density-loss-in-older-men-with-diabetes-the-osteoporotic-fractures-in-men-mros-study
#28
JOURNAL ARTICLE
Flavia Tramontana, Nicola Napoli, Stephanie Litwack-Harrison, Douglas C Bauer, Eric S Orwoll, Jane A Cauley, Elsa S Strotmeyer, Ann V Schwartz
CONTEXT: Type 2 diabetes mellitus (T2D) is associated with more rapid bone loss in women, but less evidence is available for men or those with prediabetes. OBJECTIVE: To determine whether bone loss rate is affected by diabetes status in older men, we analyzed data from the Osteoporotic Fractures in Men (MrOS) study. METHODS: The multisite MrOS study enrolled 5,994 men aged ≥65 years. Diabetes status was defined by self-report, diabetes medication use, or elevated fasting serum glucose at baseline...
February 26, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38406628/qualitative-and-quantitative-evaluation-of-an-innovative-primary-and-secondary-diabetes-clinic-in-western-sydney
#29
Sumathy Ravi, Gideon Meyerowitz-Katz, Anandhi Murugesan, Julie Ayre, Rajini Jayaballa, Duncan Rintoul, Marina Sarkis, Kirsten McCaffery, Glen Maberly, Carissa Bonner
INTRODUCTION: Western Sydney Diabetes (WSD) established an innovative diabetes service in May 2020, using virtual and in-person care, linking primary care with the diabetes specialist team. This study evaluated the service's feasibility using qualitative and quantitative methods. METHOD: Evaluation included: 1) thematic analysis of interviews and workshops with patients and health professionals (n = 28); 2) quantitative analysis of records of patients admitted July 2020-June 2021 (n = 110)...
2024: International Journal of Integrated Care
https://read.qxmd.com/read/38405103/doege-potter-syndrome-a-solitary-fibrous-tumor-causing-non-islet-cell-tumor-hypoglycemia
#30
Khalid Sheikh, Avni Mody, Alex B Haynes, Pratima Kumar
Doege-Potter syndrome occurs when incompletely processed insulin-like growth factor 2 (IGF-2), also known as big IGF-2 , is produced by a solitary fibrous tumor (SFT) and results in non-islet cell tumor hypoglycemia (NICTH). We discuss here the case of a 66-year-old male who presented with a 2-week history of increasing confusion and a serum glucose of 34 mg/dL. The patient's symptoms immediately improved with dextrose. The patient did not use insulin, serum sulfonylurea screen was negative, and testing for adrenal insufficiency was unremarkable...
February 2024: JCEM Case Rep
https://read.qxmd.com/read/38401183/preparation-and-sustained-release-mechanism-of-hydroxybutyl-chitosan-graphene-oxide-temperature-sensitive-hypoglycaemic-subcutaneous-implants
#31
JOURNAL ARTICLE
Li Li, Fengting Xiang, Fan Wang, Anqi Chen, Yu Liu
The current situation of diabetes prevention and control is extremely severe. For instance, glimepiride (GLM), a third-generation sulfonylurea, demonstrates suboptimal clinical efficacy in oral dosage forms, which underscores the pressing need for the development of a new dosage form. Recently, in situ gel subcutaneous implants have garnered considerable attention. Hydroxybutyl chitosan (HBC) can spontaneously crosslink to form a thermosensitive hydrogel and has good biocompatibility. However, its application is hindered by its limited mechanical properties...
February 14, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38389876/glucosamine-substituted-sulfonylureas-irs-pi3k-pkc-akt-glut4-insulin-signalling-pathway-intriguing-agent
#32
JOURNAL ARTICLE
Ghadeer A R Y Suaifan, Bayan Alkhawaja, Mayadah B Shehadeh, Mridula Sharmaa, Chan Hor Kuan, Patrick Nwabueze Okechukwu
Normally, skeletal muscle accounts for 70-80% of insulin-stimulated glucose uptake in the postprandial hyperglycemia state. Consequently, abnormalities in glucose uptake by skeletal muscle or insulin resistance (IR) are deemed as initial metabolic defects in the pathogenesis of type 2 diabetes mellitus (T2DM). Globally, T2DM is growing in exponential proportion. The majority of T2DM patients are treated with sulfonylureas in combination with other drugs to improve insulin sensitivity. Glycosylated sulfonylureas (sulfonylurea-glucosamine analogues) are modified analogues of sulfonylurea that have been previously reported to possess antidiabetic activity...
February 21, 2024: RSC medicinal chemistry
https://read.qxmd.com/read/38370787/comparative-effectiveness-of-second-line-antihyperglycemic-agents-for-cardiovascular-outcomes-a-large-scale-multinational-federated-analysis-of-the-legend-t2dm-study
#33
Rohan Khera, Arya Aminorroaya, Lovedeep Singh Dhingra, Phyllis M Thangaraj, Aline Pedroso Camargos, Fan Bu, Xiyu Ding, Akihiko Nishimura, Tara V Anand, Faaizah Arshad, Clair Blacketer, Yi Chai, Shounak Chattopadhyay, Michael Cook, David A Dorr, Talita Duarte-Salles, Scott L DuVall, Thomas Falconer, Tina E French, Elizabeth E Hanchrow, Guneet Kaur, Wallis Cy Lau, Jing Li, Kelly Li, Yuntian Liu, Yuan Lu, Kenneth Kc Man, Michael E Matheny, Nestoras Mathioudakis, Jody-Ann McLeggon, Michael F McLemore, Evan Minty, Daniel R Morales, Paul Nagy, Anna Ostropolets, Andrea Pistillo, Thanh-Phuc Phan, Nicole Pratt, Carlen Reyes, Lauren Richter, Joseph Ross, Elise Ruan, Sarah L Seager, Katherine R Simon, Benjamin Viernes, Jianxiao Yang, Can Yin, Seng Chan You, Jin J Zhou, Patrick B Ryan, Martijn J Schuemie, Harlan M Krumholz, George Hripcsak, Marc A Suchard
BACKGROUND: SGLT2 inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1-RAs) reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus (T2DM). However, their effectiveness relative to each other and other second-line antihyperglycemic agents is unknown, without any major ongoing head-to-head trials. METHODS: Across the LEGEND-T2DM network, we included ten federated international data sources, spanning 1992-2021. We identified 1,492,855 patients with T2DM and established cardiovascular disease (CVD) on metformin monotherapy who initiated one of four second-line agents (SGLT2is, GLP1-RAs, dipeptidyl peptidase 4 inhibitor [DPP4is], sulfonylureas [SUs])...
February 8, 2024: medRxiv
https://read.qxmd.com/read/38367257/time-dependent-risk-of-fracture-in-adults-with-type-2-diabetes-receiving-anti-diabetic-drug-a-one-stage-network-meta-analysis
#34
JOURNAL ARTICLE
Yanjiao Shen, Qingyang Shi, Xinyu Zou, Wentong Meng, Haoming Tian, Liang Du, Sheyu Li
AIMS: To assess the time-dependent risk of fracture in adults with type 2 diabetes receiving anti-diabetic drugs. MATERIALS AND METHODS: We searched MEDLINE, EMBASE, and Cochrane Library up to 18 November 2021, for randomized controlled trials (RCTs) and propensity-score-matched non-randomized studies (NRSs) comparing all anti-diabetic drugs with standard treatment or with each other on fracture in adults with type 2 diabetes. The study performed a one-stage network meta-analysis using discrete-time hazard regression with reconstructed individual time-to-event data...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38366195/a-loss-of-function-mutation-in-kcnj11-causing-sulfonylurea-sensitive-diabetes-in-early-adult-life
#35
JOURNAL ARTICLE
Natascia Vedovato, Maria V Salguero, Siri Atma W Greeley, Christine H Yu, Louis H Philipson, Frances M Ashcroft
AIMS/HYPOTHESIS: The ATP-sensitive potassium (KATP ) channel couples beta cell electrical activity to glucose-stimulated insulin secretion. Loss-of-function mutations in either the pore-forming (inwardly rectifying potassium channel 6.2 [Kir6.2], encoded by KCNJ11) or regulatory (sulfonylurea receptor 1, encoded by ABCC8) subunits result in congenital hyperinsulinism, whereas gain-of-function mutations cause neonatal diabetes. Here, we report a novel loss-of-function mutation (Ser118Leu) in the pore helix of Kir6...
February 17, 2024: Diabetologia
https://read.qxmd.com/read/38355814/real-world-study-on-effectiveness-of-insulin-glargine-u300-after-oral-antidiabetic-drug-failure-in-patients-with-type-2-diabetes-in-the-gulf-region
#36
JOURNAL ARTICLE
Niaz E Khan, AbdulRahman A M Al Shaikh, Ahmed A K Hassoun, Amr M Hassan, Mona M Salah, Nabeela A Al Abdella, Saher S M Safarini, Waleed A Al Dahi, Yasser A Akil
INTRODUCTION: The effectiveness and safety of long-acting insulin glargine U300 (Gla-300), in patients with type 2 diabetes mellitus (T2DM) requiring insulin, has not been reported in the Gulf region. METHODS: Insulin-naïve patients with T2DM, uncontrolled on OADs, and prescribed Gla-300 were followed up in a 12-month prospective observational study. Gla-300 was titrated to glycemic targets. The primary endpoint (achieving glycemic targets) was evaluated at month 6 of treatment...
February 15, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38345802/outcomes-of-various-classes-of-oral-antidiabetic-drugs-on-nonalcoholic-fatty-liver-disease
#37
JOURNAL ARTICLE
Heejoon Jang, Yeonjin Kim, Dong Hyeon Lee, Sae Kyung Joo, Bo Kyung Koo, Soo Lim, Woojoo Lee, Won Kim
IMPORTANCE: Several oral antidiabetic drug (OAD) classes can potentially improve patient outcomes in nonalcoholic fatty liver disease (NAFLD) to varying degrees, but clinical data on which class is favored are lacking. OBJECTIVE: To investigate which OAD is associated with the best patient outcomes in NAFLD and type 2 diabetes (T2D). DESIGN, SETTING, AND PARTICIPANTS: This retrospective nonrandomized interventional cohort study used the National Health Information Database, which provided population-level data for Korea...
February 12, 2024: JAMA Internal Medicine
https://read.qxmd.com/read/38341541/reduction-of-prevalence-of-patients-meeting-the-criteria-for-metabolic-syndrome-with-tirzepatide-a-post-hoc-analysis-from-the-surpass-clinical-trial-program
#38
JOURNAL ARTICLE
Stephen J Nicholls, Santiago Tofé, Carel W le Roux, David A D'Alessio, Russell J Wiese, Imre Pavo, Katelyn Brown, Govinda J Weerakkody, Meltem Zeytinoglu, Irene C Romera
BACKGROUND: Metabolic syndrome is characterized as the co-occurrence of interrelated cardiovascular risk factors, including insulin resistance, hyperinsulinemia, abdominal obesity, dyslipidemia and hypertension. Once weekly tirzepatide is approved in the US and EU for the treatment of type 2 diabetes (T2D) and obesity. In the SURPASS clinical trial program for T2D, tirzepatide demonstrated greater improvements in glycemic control, body weight reduction and other cardiometabolic risk factors versus placebo, subcutaneous semaglutide 1 mg, insulin degludec, and insulin glargine...
February 10, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38341041/the-effect-of-frailty-on-post-discharge-management-and-outcomes-of-acute-glycaemic-crises-analysis-of-admissions-for-hypoglycaemia-and-hyperglycaemia-in-australia
#39
JOURNAL ARTICLE
Jedidiah I Morton, Jenni Ilomäki, Stephen J Wood, Shin J Liau, Michelle Steeper, Hannah Doody, J Simon Bell
OBJECTIVE: To describe changes in glucose-lowering drug (GLD) dispensing by frailty status for people with diabetes following admission for hypoglycaemia or hyperglycaemia. METHODS: This study included all people with probable type 2 diabetes in the state of Victoria, Australia, admitted to hospital for hypoglycaemia (n = 2,506 admissions) or hyperglycaemia (n = 1,693) between 1 July 2013 and 29 June 2017. Frailty was defined via the Hospital Frailty Risk Score (HFRS)...
February 8, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38338467/biospeciation-of-oxidovanadium-iv-imidazolyl-carboxylate-complexes-and-their-action-on-glucose-stimulated-insulin-secretion-in-pancreatic-cells
#40
JOURNAL ARTICLE
Vital Ugirinema, Frank Odei-Addo, Carminita L Frost, Zenixole R Tshentu
The reaction of the vanadyl ion (VO2+ ) with imidazole-4-carboxylic acid (Im4COOH), imidazole-2-carboxylic acid (Im2COOH) and methylimidazole-2-carboxylic acid (MeIm2COOH), respectively, in the presence of small bioligands (bL) [oxalate (Ox), lactate (Lact), citrate (Cit) and phosphate (Phos)] and high-molecular-weight (HMW) human serum proteins [albumin (HSA) and transferrin (hTf)] were studied in aqueous solution using potentiometric acid-base titrations. The species distribution diagrams for the high-molecular-mass (HMM) proteins with oxidovanadium(IV) under physiological pH were dominated by VO(HMM)2 , VOL(HMM) for unsubstituted ligands (L- = Im4COO- and Im2COO- )...
February 4, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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