keyword
https://read.qxmd.com/read/37822631/performance-enhancement-and-optimization-of-residential-air-conditioning-system-in-response-to-the-novel-fal-2-o-3-poe-nanolubricant-adoption
#21
JOURNAL ARTICLE
A Nugroho, R Mamat, J Xiaoxia, Z Bo, M F Jamlos, M F Ghazali
This paper aims to evaluate residential air conditioning systems' performance enhancement and optimization by adopting a novel functionalized Al2 O3 (FAl2 O3 )-Polyolester (POE) nanolubricant. Comprehensive discussions were conducted on key performance parameters, including heat absorption, compressor work, cooling capacity, coefficient of performance (COP), and power consumption. Novel FAl2 O3 nanoparticles were dispersed into the POE lubricant using a two-step method. The findings reveal that FAl2 O3 -POE nanolubricant exhibits superior heat absorption compared to pure POE...
October 2023: Heliyon
https://read.qxmd.com/read/37782142/-in-silico-analysis-of-sod1-aggregation-inhibition-modes-of-tertiary-amine-pyrazolone-and-pyrano-coumarin-ferulate-as-als-drug-candidates
#22
JOURNAL ARTICLE
Aziza Rahman, Bondeepa Saikia, Anupaul Baruah
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, the familial form (fALS) of which is often cognate to mutations in the antioxidant enzyme Cu/Zn superoxide dismutase 1 (SOD1) leading to misfolding and aggregation. Two small molecules, a tertiary amine pyrazolone (TAP) and a pyrano coumarin ferulate (PCF) were suggested to be ALS drug candidates following experimental observation of their ability to inhibit SOD1 protein misfolding and aggregation. The present work aims at computational investigation of these experimentally proposed drug candidates to gain insight into their mechanism of SOD1 misfolding and aggregation inhibition...
October 2, 2023: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/37751496/selective-and-robust-ru-catalyst-for-the-aqueous-phase-aerobic-oxidation-of-furfural-to-2-furoic-acid
#23
JOURNAL ARTICLE
Priya Lokhande, Paresh L Dhepe
Synthesis of 2-furoic acid (FURA) via oxidation of furfural (FAL) is vital in evolving the biorefinery concept as FURA has numerous important applications in the pharmaceuticals and optic areas. Though few works on this reaction are done, those are marred with shortcomings such as the nonrecyclability of catalyst, dilute solutions, lower yields, or use of H2 O2 as an oxidizing agent. Herein, we report catalytic aqueous phase oxidation of FAL to FURA using molecular oxygen as an oxidizing agent. For the synthesis of FURA, various catalysts with a combination of metal (Pt, Pd, Ru) and supports (carbon, Al2 O3 ) were prepared and characterized by multiple techniques (X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), X-ray photoelectron spectroscopy (XPS))...
September 26, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37693322/another-de-novo-mutation-in-the-sod1-gene-the-first-turkish-patient-with-sod1-his47arg-a-case-report
#24
Elif Bayraktar, Vildan Çiftçi, Hilmi Uysal, A Nazlı Başak
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease of motor neurons. Most ALS cases are considered sporadic due to the presence of a combination of environmental and complex genetic risk factors, while approximately 10% of cases have a family history. Pathogenic variants in the SOD1 gene are the second most frequent causative factor of genetics-based ALS worldwide, after C9ORF72 hexanucleotide repeat expansion. The De novo occurrence of pathogenic mutations in ALS-associated genes and its effect on disease progression have been studied previously, especially in the FUS gene...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37635231/il-25-induces-airway-remodeling-in-asthma-by-orchestrating-the-phenotypic-changes-of-epithelial-cell-and-fibrocyte
#25
JOURNAL ARTICLE
Xiujuan Yao, Qinglin Chen, Xiangdong Wang, Xiaofang Liu, Luo Zhang
BACKGROUND: Previous studies have shown that IL-25 levels are increased in patients with asthma with fixed airflow limitation (FAL). However, the mechanism by which IL-25 contributes to airway remodeling and FAL remains unclear. Here, we hypothesized that IL-25 facilitates pro-fibrotic phenotypic changes in bronchial epithelial cells (BECs) and circulating fibrocytes (CFs), orchestrates pathological crosstalk from BECs to CFs, and thereby contributes to airway remodeling and FAL. METHODS: Fibrocytes from asthmatic patients with FAL and chronic asthma murine models were detected using flow cytometry, multiplex staining and multispectral imaging analysis...
August 27, 2023: Respiratory Research
https://read.qxmd.com/read/37621201/usefulness-of-fib-4-index-and-alt-at-1-year-of-nucleos-t-ide-analog-treatment-for-prediction-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-patients
#26
JOURNAL ARTICLE
Jun Inoue, Takehiro Akahane, Tomoo Kobayashi, Osamu Kimura, Kosuke Sato, Masashi Ninomiya, Tomoaki Iwata, Satoshi Takai, Norihiro Kisara, Toshihiro Sato, Futoshi Nagasaki, Masahito Miura, Takuya Nakamura, Teruyuki Umetsu, Akitoshi Sano, Mio Tsuruoka, Masazumi Onuki, Satoko Sawahashi, Hirofumi Niitsuma, Atsushi Masamune
AIM: Nucleos(t)ide analogs (NAs) do not completely prevent hepatocellular carcinoma (HCC) in chronic hepatitis B virus (HBV) infection. This study aimed to evaluate the dynamics of a non-invasive liver fibrosis marker, FIB-4 index, for predicting HCC development. METHODS: Among a total of 882 chronically HBV-infected patients who were treated with NAs, 472 patients without HCC history whose FIB-4 at baseline and 1 year of treatment was obtained were evaluated for the incidence of HCC...
August 25, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/37586503/new-easily-recycled-carrier-based-polyurethane-foam-by-loading-al-mof-and-biochar-for-selective-removal-of-fluoride-ion-from-aqueous-solutions
#27
JOURNAL ARTICLE
Zhe Wang, Xinyue Gu, Xinbo Zhang, Xiao Wang, Jianqing Zhang, Ying Liu, Xinai Tan, Ying Zhao, Dejun Kang, Wenshan Guo, Huu Hao Ngo
The production of Integrated circuits (ICs) generates wastewater with a high concentration of residual fluoride ions, necessitating highly efficient fluorine removal methods. In this study, a novel composite carrier was developed using a hydrothermal synthesis method to load Al-MOF and biochar (BC) onto polyurethane foam (PUF), resulting in the composite foam of Al-MOF-PUF@BC. The results showed that the composite carrier exhibited a stable fluoride removal effect, with a maximum adsorption capacity of 16.52 mg/g at room temperature...
August 14, 2023: Science of the Total Environment
https://read.qxmd.com/read/37566027/studies-of-genetic-and-proteomic-risk-factors-of-amyotrophic-lateral-sclerosis-inspire-biomarker-development-and-gene-therapy
#28
REVIEW
Eva Bagyinszky, John Hulme, Seong Soo A An
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease affecting the upper and lower motor neurons, leading to muscle weakness, motor impairments, disabilities and death. Approximately 5-10% of ALS cases are associated with positive family history (familial ALS or fALS), whilst the remainder are sporadic (sporadic ALS, sALS). At least 50 genes have been identified as causative or risk factors for ALS. Established pathogenic variants include superoxide dismutase type 1 ( SOD1 ), chromosome 9 open reading frame 72 ( c9orf72 ), TAR DNA Binding Protein ( TARDBP ), and Fused In Sarcoma ( FUS ); additional ALS-related genes including Charged Multivesicular Body Protein 2B ( CHMP2B ), Senataxin ( SETX ), Sequestosome 1 ( SQSTM1 ), TANK Binding Kinase 1 ( TBK1 ) and NIMA Related Kinase 1 ( NEK1 ), have been identified...
July 27, 2023: Cells
https://read.qxmd.com/read/37546673/cu-and-zn-bimetallic-co-modified-h-mor-catalyst-for-direct-oxidation-of-low-concentration-methane-to-methanol
#29
JOURNAL ARTICLE
Yan Fu, Cunshuo Li, Shengxin An, Wenzhi Li, Liang Yuan
The direct oxidation of low-concentration methane to value-added chemicals can not only reduce carbon emission but also provide an alternative production route for fossil fuels. Herein, we proposed a novel catalyst for the direct oxidation of low-concentration methane to methanol via the impregnation method, which selected copper and zinc as co-modifiers to modify the MOR catalyst. The highest methanol yield of 71.35 μmol·gcat -1 ·h-1 was obtained over a bimetallic Cu0.5 Zn0.35 -MOR catalyst...
August 1, 2023: ACS Omega
https://read.qxmd.com/read/37533911/arthroscopic-posterior-hagl-repair-using-a-direct-transaxillary-portal
#30
JOURNAL ARTICLE
Sebastian Albers, Milad Farkhondeh Fal, Jörn Kircher
Humeral avulsion of the glenohumeral ligament (HAGL lesion) is a challenging problem in surgery for shoulder instability. Open and arthroscopic approaches and techniques have been described to address this issue. Especially posterior HAGL lesions increase the surgical complexity, as open anterior approaches provide limited visibility and access for successful repair. This article describes an alternative technique using an arthroscopic transaxillary approach to deploy the suture anchor with a perpendicular angle to the humeral bone, thus, improving the ability to perfectly position the anchor at the anatomic insertion of the inferior humeral ligament...
July 2023: Arthroscopy Techniques
https://read.qxmd.com/read/37508270/potential-saving-of-antibiotics-for-respiratory-infections-in-several-european-countries-insights-from-market-research-data
#31
JOURNAL ARTICLE
André Gessner, Ludger Klimek, Ernest Kuchar, Ingrid Stelzmueller, Andrzej M Fal, Peter Kardos
Antibiotics represent an essential pillar in the treatment of respiratory infections (RI). Overuse of antibiotics in avoidable cases and inappropriate application in bacterial infections facilitate treatment resistance, threatening their effectiveness and causing a significant healthcare challenge. We therefore assessed the savings potential for antibiotics in ambulant care of selected RI (bronchitis and cough, pharyngitis, rhinosinusitis) in several European countries based on market research data for the year 2019...
July 11, 2023: Antibiotics
https://read.qxmd.com/read/37506106/republication-of-cross-sectional-assessment-of-orthopedic-foot-and-ankle-patient-knowledge
#32
JOURNAL ARTICLE
Andrew J Rosenbaum, Anca Gabriela Marinescu, David Levine, Scott J Ellis
BACKGROUND: Individuals with limited health literacy often struggle in effectively communicating with their physicians and may lack the skills needed to make informed health decisions. It is therefore important that providers have insight into patients' baseline medical knowledge, as this can help physicians customize their approach to, and conversations with, each patient. As such, this study evaluated the foot and ankle-specific knowledge of patients seeking care for various foot and ankle ailments...
July 2023: Foot & ankle orthopaedics
https://read.qxmd.com/read/37491426/impaired-atf3-signaling-involves-snap25-in-sod1-mutant-als-patients
#33
JOURNAL ARTICLE
Volkan Yazar, Julia K Kühlwein, Antje Knehr, Veselin Grozdanov, Arif B Ekici, Albert C Ludolph, Karin M Danzer
Epigenetic remodeling is emerging as a critical process for several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Genetics alone fails to explain the etiology of ALS, the investigation of the epigenome might therefore provide novel insights into the molecular mechanisms of the disease. In this study, we interrogated the epigenetic landscape in peripheral blood mononuclear cells (PBMCs) of familial ALS (fALS) patients with either chromosome 9 open reading frame 72 (C9orf72) or superoxide dismutase 1 (SOD1) mutation and aimed to identify key epigenetic footprints of the disease...
July 25, 2023: Scientific Reports
https://read.qxmd.com/read/37488208/integrative-proteomics-highlight-presynaptic-alterations-and-c-jun-misactivation-as-convergent-pathomechanisms-in-als
#34
JOURNAL ARTICLE
Amr Aly, Zsofia I Laszlo, Sandeep Rajkumar, Tugba Demir, Nicole Hindley, Douglas J Lamont, Johannes Lehmann, Mira Seidel, Daniel Sommer, Mirita Franz-Wachtel, Francesca Barletta, Simon Heumos, Stefan Czemmel, Edor Kabashi, Albert Ludolph, Tobias M Boeckers, Christopher M Henstridge, Alberto Catanese
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting an extremely complex pathogenic landscape. This heterogeneity has limited the identification of an effective therapy, and this bleak prognosis will only improve with a greater understanding of convergent disease mechanisms. Recent evidence from human post-mortem material and diverse model systems has highlighted the synapse as a crucial structure actively involved in disease progression, suggesting that synaptic aberrations might represent a shared pathological feature across the ALS spectrum...
July 24, 2023: Acta Neuropathologica
https://read.qxmd.com/read/37482248/mid-term-outcomes-of-autologus-bridging-of-rotator-cuff-tears-with-an-autologous-tendon-patch-tear-patch
#35
JOURNAL ARTICLE
Sebastian Albers, Yohei Ono, Florian Kirchner, Milad Farkhondeh Fal, Jörn Kircher
BACKGROUND: Large and massive rotator cuff tears and tears after failed surgical repair are a challenging clinical problem with different treatment options. The purpose of the study was to evaluate the mid-term outcomes following rotator cuff repair (RCR) with autologous hamstring tendon graft bridging (TEAR patch) with the hypothesis, that outcomes would be reasonable and complication rates low. METHODS: This is a retrospective case series study of patients who underwent open RCR using a TEAR patch from June, 2015 to March, 2019...
July 21, 2023: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/37477388/analysis-of-lncrnas-profiles-associated-with-ferroptosis-can-predict-prognosis-and-immune-landscape-and-drug-sensitivity-in-patients-with-clear-cell-renal-cell-carcinoma
#36
JOURNAL ARTICLE
Huantao Zong, Anning Li, Yongjin Huang, Xuanyan Che, Yong Zhang, Guikai Ma, Zhongbao Zhou
Ferroptosis is a novel kind of iron- and reactive oxygen-induced cell death, investigation into ferroptosis-associated long noncoding RNAs (FALs) in clear cell renal cell carcinoma (ccRCC) is scarce. The goal of the research was to look at FALs' possible predictive significance, as well as their interaction with the immune microenvironment and therapeutic responsiveness of ccRCC. The Cancer Genome Atlas database was employed to retrieve RNA sequencing data from 530 individuals with ccRCC. Patients with ccRCC were randomly assigned to one of two groups: training or testing...
July 21, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/37464396/metabolic-engineering-of-corynebacterium-glutamicum-for-fatty-alcohol-production-from-glucose-and-wheat-straw-hydrolysate
#37
JOURNAL ARTICLE
Felix Werner, Lynn S Schwardmann, Daniel Siebert, Christian Rückert-Reed, Jörn Kalinowski, Marie-Theres Wirth, Katharina Hofer, Ralf Takors, Volker F Wendisch, Bastian Blombach
BACKGROUND: Fatty acid-derived products such as fatty alcohols (FAL) find growing application in cosmetic products, lubricants, or biofuels. So far, FAL are primarily produced petrochemically or through chemical conversion of bio-based feedstock. Besides the well-known negative environmental impact of using fossil resources, utilization of bio-based first-generation feedstock such as palm oil is known to contribute to the loss of habitat and biodiversity. Thus, the microbial production of industrially relevant chemicals such as FAL from second-generation feedstock is desirable...
July 18, 2023: Biotechnol Biofuels Bioprod
https://read.qxmd.com/read/37440173/telehealth-use-in-a-national-pediatric-weight-management-sample-during-the-covid-19-pandemic
#38
JOURNAL ARTICLE
Kristin M W Stackpole, Roohi Y Kharofa, Jared M Tucker, Marsha B Novick, Angela M Fals, Angelina V Bernier, Erin M Tammi, Philip R Khoury, Robert Siegel, Suzanne Paul, Sara K Naramore, Jaime M Moore
Background: This study aimed to assess the implementation and access to telehealth-delivered pediatric weight management (PWM) during the initial phase of the COVID-19 pandemic at six US PWM programs (PWMP) using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework. Methods: The COVID-19 period (COVID) was defined in this retrospective, multisite study as the time when each site closed in-person care during 2020. The Pre-COVID period (Pre-COVID) was an equivalent time frame in 2019...
July 13, 2023: Childhood Obesity
https://read.qxmd.com/read/37384409/reduction-of-nemo-like-kinase-increases-lysosome-biogenesis-and-ameliorates-tdp-43-related-neurodegeneration
#39
JOURNAL ARTICLE
Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Changwoo Lee, Benjamin Sanders, Paul J Lee, Yangfei Xiang, Kimberly Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah H Ro, Hyoungseok Ju, Clara Liao, Sofia Massaro Tieze, Frank Rigo, Paymaan Jafar-Nejad, Janghoo Lim
Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in TARDBP, encoding TDP-43, account for less than 1% of all ALS cases, TDP-43-positive aggregates are present in nearly all ALS patients, including patients with sporadic ALS (sALS) or carrying other familial ALS (fALS)-causing mutations. Interestingly, TDP-43 inclusions are also present in subsets of patients with frontotemporal dementia, Alzheimer's disease, and Parkinson's disease; therefore, methods of activating intracellular protein quality control machinery capable of clearing toxic cytoplasmic TDP-43 species may alleviate disease-related phenotypes...
June 29, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37354094/synthesis-characterization-and-trapping-of-a-cyclic-diborylcarbene-an-electrophilic-carbene
#40
JOURNAL ARTICLE
Yuki Shibutani, Shuhei Kusumoto, Kyoko Nozaki
A carbene bearing two geminal boryl substituents, called diborylcarbene (DBC), has been predicted to be highly Lewis acidic in sharp contrast to the well-studied persistent carbenes stabilized by π-donating substituents. Studies on DBC have been limited to either the base-trapping or theoretical calculations. Herein, we developed chemical equivalents for DBC, namely, K/X-diborylcarbenoids 2X (X = F or Cl). Treatment of 2F with Al(C6 F5 )3 yielded [AlF(C6 F5 )3 ]- -stabilized DBC 1-FAl , which showed a significant low-field shift of the carbenoid carbon from 169 ppm (doublet, coupling with 19 F) to 242 ppm (singlet)...
June 24, 2023: Journal of the American Chemical Society
keyword
keyword
109491
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.