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clinical micro review

Remi Remondi Re, Marin-Philippe Durafourg
The authors review the most significant recent stages in developments concerning physiotherapy in France by assessing its current state. The strength of this profession is that it was reformed in 2015 under the European Agreements of the Bologna Process.With its mutations and achievements in connection with biological, medical, and clinical research progress, physiotherapy is continuing to broaden its fields of practice in order to attract future students. Nevertheless, this remains insufficient to stimulate an exercise in hospitals...
November 2019: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
Osvaldo Daniel Messina, Maritza Vidal Wilman, Luis F Vidal Neira
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some relief but they do not affect the progression of the disease. The chronic intake of these drugs may result in severe adverse events. The aim of this review is to revise the effects of nutrition on cartilage metabolism and OA progression...
April 13, 2019: Aging Clinical and Experimental Research
Erkut Borazanci, Steven Sckolnik, Albert Amini
In 2018, pancreatic ductal adenocarcinoma (PDAC) was the 3rd highest cause cancer related death in the United States. Worldwide estimates in 2018 indicate 458,918 cases diagnosed with 432,242 deaths. Standard therapy for decades for localized PDAC has been to pursue surgical resection for localized disease. For the individuals who are diagnosed with localized PDAC and undergo surgical resection, historical survival has been reported to be around 24 months. While recent advancements in the use of multiagent systemic therapy has allowed for greater survival benefit, adjuvant therapy does have limitations...
April 12, 2019: Expert Review of Gastroenterology & Hepatology
Zhuo Chen, Jonathan J Chen, Rong Fan
Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level. Here, we review bioanalytical technologies and devices for detecting protein secretions from single cells. We begin by discussing conventional approaches followed by detailing the latest advances in microengineered systems for detecting single-cell protein secretions with an emphasis on multiplex measurement. These platforms include droplet microfluidics, micro-/nanowell-based assays, and microchamber-based assays, among which the advantages and limitations are compared...
April 12, 2019: Annual Review of Analytical Chemistry
Solène-Florence Kammerer-Jacquet, Amar Ahmad, Henrik Møller, Holly Sandu, Peter Scardino, Geraldine Soosay, Luis Beltran, Jack Cuzick, Daniel M Berney
Standard clinical parameters fail to accurately differentiate indolent from aggressive prostate cancer. Our previous studies showed that immunohistochemical testing for Ki-67 improved prediction of prostate cancer death in a previous cohort of conservatively treated clinically localized prostate cancer. However there is a need for validation of usage with whole biopsy sections rather than tissue micro-arrays for use in routine diagnostics. Prostate cancer biopsy cases were identified in the UK, between 1990 and 2003, treated conservatively...
April 11, 2019: Modern Pathology
Li Guowei, Lan Qing
OBJECTIVE: To investigate the clinical effect and surgical techniques of fourth ventricle astrocytoma resection through the median suboccipital keyhole approach. METHODS: Twelve patients received tumor resection through the median suboccipital keyhole approach in our department. A 4-cm median suboccipital excision starting 1 cm under the foramen magnum region and directed vertically upward was applied. The fourth ventricle was exposed through a cerebellomedullary fissure approach within a bone hole approximately 2...
April 8, 2019: World Neurosurgery
E D Williamson, G E Westlake
Globally, there are a number of emerging pathogens. For most, there are no licensed vaccines available for human use, although there is ongoing research and development. However, given the extensive and increasing list of emerging pathogens and the investment required to bring vaccines into clinical use, the task is huge. Overlaid on this task is the risk of anti-microbial resistance (AMR) acquisition by micro-organisms which can endow a relatively harmless organism with pathogenic potential. Furthermore, climate change also introduces a challenge by causing some of the insect vectors and environmental conditions prevalent in tropical regions to begin to spread out from these traditional areas, thus increasing the risk of migration of zoonotic disease...
April 11, 2019: Clinical and Experimental Immunology
Wolfgang Huber, Robert Zanner, Gerhard Schneider, Roland Schmid, Tobias Lahmer
Sufficient organ perfusion essentially depends on preserved macro- and micro-circulation. The last two decades brought substantial progress in the development of less and non-invasive monitoring of macro-hemodynamics. However, several recent studies suggest a frequent incoherence of macro- and micro-circulation. Therefore, this review reports on interactions of macro- and micro-circulation as well as on specific regional and micro-circulation. Regarding global micro-circulation the last two decades brought advances in a more systematic approach of clinical examination including capillary refill time, a graded assessment of mottling of the skin and accurate measurement of body surface temperatures...
2019: Frontiers in Medicine
Sarah J Schep, Marianne L Boes, Roger E G Schutgens, Lize F D van Vulpen
Nowadays, one of the most serious treatment complications in haemophilia A is the formation of neutralizing antibodies against coagulation factor VIII (FVIII). These so-called inhibitors develop in about 30% of all patients with severe haemophilia A. Once formed, inhibitors reduce FVIII efficacy in blood coagulation, which has a negative impact on patients' health and quality of life and significantly increases haemophilia A treatment costs. The pathophysiology of inhibitor development is a complex and multi-causal process, in which both genetic factors as well as environmental factors participate...
April 5, 2019: Expert Review of Hematology
Yanshan Wang, Saeed Mehrabi, Sunghwan Sohn, Elizabeth J Atkinson, Shreyasee Amin, Hongfang Liu
BACKGROUND: Osteoporosis has become an important public health issue. Most of the population, particularly elderly people, are at some degree of risk of osteoporosis-related fractures. Accurate identification and surveillance of patient populations with fractures has a significant impact on reduction of cost of care by preventing future fractures and its corresponding complications. METHODS: In this study, we developed a rule-based natural language processing (NLP) algorithm for identification of twenty skeletal site-specific fractures from radiology reports...
April 4, 2019: BMC Medical Informatics and Decision Making
Md Shahid Alam, Nisar Sonam Poonam, Bipasha Mukherjee
Purpose: To evaluate outcomes of canaliculotomy in cases of recalcitrant canaliculitis. Methods: All cases diagnosed with canaliculitis who subsequently underwent canaliculotomy over a 15 year period were included in the study. We reviewed and analyzed demographic data, clinical presentation, microbiological profile and management outcomes. Results: Out of 40 patients, 21 (52.5%) were males. Age range was 17-89 years. Lower canaliculus was affected most commonly (53...
January 2019: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Sang Yub Lee, Young Soo Do, Chang Won Kim, Kwang Bo Park, Young Hwan Kim, Young Jun Cho
PURPOSE: To evaluate the efficacy and safety of transvenous coil embolization of the venous sac for type II renal arteriovenous malformation (AVM). MATERIALS AND METHODS: A retrospective review was conducted of 8 patients (5 women and 3 men; mean age, 57 years; age range, 41-69 years) who underwent transvenous coil embolization for type II congenital renal AVM at 5 different hospitals between 2012 and 2018. Additional intra-arterial ethanol injection was performed if shunt flow persisted after venous sac coiling...
March 28, 2019: Journal of Vascular and Interventional Radiology: JVIR
Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A B Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S Cooper, Susanna Dunachie, Catrin E Moore, Christiane Dolecek, H Rogier van Doorn, Philippe J Guerin, Nicholas P J Day, Elizabeth A Ashley
BACKGROUND: There is a pressing need to understand better the extent and distribution of antimicrobial resistance on a global scale, to inform development of effective interventions. Collation of datasets for meta-analysis, mathematical modelling and temporo-spatial analysis is hampered by the considerable variability in clinical sampling, variable quality in laboratory practice and inconsistencies in antimicrobial susceptibility testing and reporting. METHODS: The Microbiology Investigation Criteria for Reporting Objectively (MICRO) checklist was developed by an international working group of clinical and laboratory microbiologists, infectious disease physicians, epidemiologists and mathematical modellers...
March 29, 2019: BMC Medicine
Gareth L Ackland, Charles S Brudney, Maurizio Cecconi, Can Ince, Michael G Irwin, Jonathan Lacey, Michael R Pinsky, Michael Pw Grocott, Monty G Mythen, Mark R Edwards, Timothy E Miller
BACKGROUND: Perioperative arterial blood pressure management is a physiologically complex challenge influenced by multiple factors. METHODS: A multidisciplinary, international working subgroup of the Third Perioperative Quality Initiative (POQI) consensus meeting reviewed the (patho)physiology and measurement of arterial pressure as applied to perioperative medicine. We addressed predefined questions by undertaking a modified Delphi analysis, in which primary clinical research and review articles were identified using MEDLINE...
May 2019: British Journal of Anaesthesia
Rebecca Gormley, Brian Vickers, Wendy V Norman
BACKGROUND: For women seeking permanent contraception, there are a variety of options available including surgical techniques such as tubal ligation or bilateral salpingectomy, in-clinic procedures such as hysteroscopic techniques using micro-inserts, or the levonorgestrel-releasing intrauterine contraceptive. Despite the various methods available for women who are seeking permanent contraception, there is not a review or decision-making tool that systematically brings together outcomes related to effectiveness, tolerability, adverse effects, non-contraceptive benefits, recovery, or accessibility: all of which are important for shared decision-making between patients and health care providers...
March 26, 2019: Systematic Reviews
Huai-Wu He, Yun Long, Da-Wei Liu, Can Ince
OBJECTIVE: Poor tissue perfusion/cellular hypoxia may persist despite restoration of the Macrocirculation (Macro). This paper reviewed the literatures of coherence between hemodynamics and tissue perfusion in circulatory shock. DATA SOURCES: We retrieved information from the PubMed database up to Jan 2018 using various search terms or/and their combinations, including resuscitation, circulatory shock, septic shock, tissue perfusion, hemodynamic coherence, microcirculation (Micro)...
March 19, 2019: Chinese Medical Journal
Leonardo Cavinatto, Betina B Hinkel, Ryan E Tomlinson, Sunny Gupta, Jack Farr, Arthur R Bartolozzi
PURPOSE: To summarize currently available data regarding the use of bone marrow aspirate concentrate (BMAC) for the treatment of focal chondral lesions of the knee in experimental animal models and human clinical studies. METHODS: A systematic review searching for the terms "(bone marrow)" AND "(aspirate OR concentrate)" AND "(cartilage OR chondral OR osteochondral)" was performed in the databases PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar regarding the use of BMAC for the treatment of focal chondral lesions of the knee...
March 11, 2019: Arthroscopy
Lan Yu, Zhi-Kai Xing, Shuang-Li Mi, Xia Wu
As a large micro-ecosystem in the human body,the intestinal microbiota is closely associated with the occurrence of many diseases.The clinical investigations and animal experiments have showed that traditional Chinese medicine(TCM) could maintain the balance of the intestinal micro-ecological system.This review summarized the research methods and literatures on the regulation effects of TCM,including different effective ingredients,extracts and Chinese herbal formulae,on intestinal microflora in recent five years,in order to provide a reference for the further research and development of TCM...
January 2019: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Fuhao Qiao, Peng Pan, Jiaping Yan, Jing Sun, Yan Zong, Zhiyong Wu, Xiaoqin Lu, Na Chen, Rui Mi, Yongbin Ma, Yuan Ji
Extracellular vesicles (EVs), including micro‑vesicles and exosomes, are heterogeneous small membranous vesicles shed from the surface of myriad cells and are crucial in mediating intercellular communication. The vertical trafficking of cargo to the plasma membrane and subsequent redistribution of surface lipids may contribute to EV formation. Tumor‑derived extracellular vesicles (TD‑EVs) can carry complex, bioactive cargo, such as nucleic acids and proteins, during tumor metastasis. Paracrine information gets relayed by TD‑EVs to adjacent tumor cells and this allows a crosstalk between malignant cells...
March 12, 2019: International Journal of Oncology
Sónia P Miguel, Rosa S Sequeira, André F Moreira, Cátia C Cabral, António G Mendonça, Paula Ferreira, Ilídio J Correia
Nowadays, despite the intensive research performed in the area of skin tissue engineering, the treatment of skin lesions remains a big challenge for healthcare professionals. In fact, none of the wound dressings currently used in the clinic is capable of re-establishing all the native features of skin. An ideal wound dressing must confer protection to the wound from external microorganisms, chemical, and physical aggressions, as well as promote the healing process by stimulating the cell adhesion, differentiation, and proliferation...
March 7, 2019: European Journal of Pharmaceutics and Biopharmaceutics
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