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hemangiosarcoma

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https://read.qxmd.com/read/30767429/tumor-necrosis-factor-related-apoptosis-inducing-ligand-induces-apoptosis-in-canine-hemangiosarcoma-cells-in-vitro
#1
Minami Goto, Keishi Owaki, Akihiro Hirata, Tokuma Yanai, Hiroki Sakai
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is an apoptosis-inducing cytokine that shows potential therapeutic value for human neoplasms, and is effective in some canine tumors; however, its potential for killing canine hemangiosarcoma (HSA) cells is unknown. Thus, we evaluated the proapoptotic effect of TRAIL in nine canine HSA cell lines. Cells (JuA1, JuB2, JuB2-1, JuB4, Re11, Re12, Re21, Ud2, and Ud6) were cultured with three recombinant human TRAILs (rhTRAILs): TRAIL-TEC derived from Escherichia coli, TRAIL-TL derived from mammalian cells, and izTRAIL containing an isoleucine-zippered structure that facilitates trimerization...
February 15, 2019: Veterinary and Comparative Oncology
https://read.qxmd.com/read/30670791/dendritic-cell-vaccination-plus-low-dose-doxorubicin-for-the-treatment-of-spontaneous-canine-hemangiosarcoma
#2
V Konduri, M M Halpert, Y C Baig, R Coronado, J R Rodgers, J M Levitt, B Cerroni, S Piscoya, N Wilson, L DiBernardi, Z Omarbekov, L Seelhoff, V Ravi, L Douglass, W K Decker
Angiosarcoma is a deadly neoplasm of the vascular endothelium. Metastatic disease is often present at diagnosis, and 5-year survival is only 10-35%. Although there exist no immunocompetent mouse models of angiosarcoma with which to study immune-based approaches to therapy, angiosarcoma is a major killer of companion dogs, responsible for up to 2% of all canine deaths in some susceptible breeds or an estimated 120,000 per year in the US. The canine disease (HSA) often presents in the spleen as acute hemoabdomen secondary to splenic rupture...
January 23, 2019: Cancer Gene Therapy
https://read.qxmd.com/read/30666685/laparoscopic-access-to-the-liver-and-application-of-laparoscopic-microwave-ablation-in-2-dogs-with-liver-neoplasia
#3
Alberto Oramas, J Brad Case, Beau B Toskich, W Alexander Fox-Alvarez, Sarah E Boston, Robson F Giglio, Michael J Dark
OBJECTIVE: To determine laparoscopic accessibility of liver lobes and access to the hilus and describe laparoscopic microwave ablation (LMWA) in 2 dogs with hepatic neoplasia. STUDY DESIGN: Experimental/descriptive case series. SAMPLE POPULATION: Six canine cadavers and 2 clinical dogs. METHODS: Cadavers in dorsal recumbency underwent laparoscopic assessment of the liver. A 17 gauge MWA probe was inserted to create an ablation zone at the most proximal aspect of the hilus...
January 21, 2019: Veterinary Surgery: VS
https://read.qxmd.com/read/30601866/overexpression-of-prostate-specific-membrane-antigen-by-canine-hemangiosarcoma-cells-provides-opportunity-for-the-molecular-detection-of-disease-burdens-within-hemorrhagic-body-cavity-effusions
#4
Matthew Dowling, Jonathan Samuelson, Bahaa Fadl-Alla, Holly C Pondenis, Mark Byrum, Anne M Barger, Timothy M Fan
BACKGROUND: Canine hemangiosarcoma (cHSA) is a highly metastatic mesenchymal cancer that disseminates by hematogenous and direct implantation routes. Therapies for cHSA are generally ineffective, in part due to advanced clinical disease stage at the time of diagnosis. The validation of conventional molecular methods for detecting novel biomarkers preferentially expressed by cHSA could lead to more timely diagnosis, earlier therapeutic interventions, and improved outcomes. In humans, prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed by prostate carcinoma and tumor-associated endothelium of various solid cancer histologies...
2019: PloS One
https://read.qxmd.com/read/30565353/evaluation-of-hepatic-tumor-portal-perfusion-using-mesenteric-angiography-a-pilot-study-in-5-dogs
#5
Kelsey Goode, Chick Weisse, Allyson Berent, Ken Lamb
BACKGROUND: Mesenteric angiography is a sensitive method for visualizing portal perfusion in the dog. OBJECTIVES: To evaluate hepatic portal perfusion in dogs with incompletely resectable hepatic tumors using mesenteric angiography. ANIMALS: Five client-owned dogs with incompletely resectable hepatic tumors evaluated with mesenteric angiography. METHODS: Retrospective case series. Electronic medical records at the Animal Medical Center were analyzed to identify dogs that underwent mesenteric portography to determine blood flow to nonresectable hepatic tumors and subsequently determine ideal routes for transarterial embolization, vascular stent placement, or both...
December 18, 2018: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30536763/rhob-antibody-alters-retinal-vascularization-in-models-of-murine-retinopathy
#6
Rowena Almonte-Baldonado, Arturo Bravo-Nuevo, Damien Gerald, Laura E Benjamin, George C Prendergast, Lisa D Laury-Kleintop
Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells...
December 9, 2018: Journal of Cellular Biochemistry
https://read.qxmd.com/read/30532290/secondary-inappropriate-polycythemia-with-splenic-hemangiosarcoma-in-a-young-adult-cat
#7
Kyoung Won Seo, Hwaran Hong, Sung-Ah An, Jung Keun Lee, Robert Rebhun
A 20-month-old castrated male Korean shorthair cat was presented with a 3-week history of intermittent vomiting and anorexia, absolute erythrocytosis, and elevated erythropoietin levels. A diagnosis of splenic hemangiosarcoma was made by histopathology and immunohistochemical identification of factor VIII. Paraneoplastic erythrocytosis caused by a splenic hemangiosarcoma in a cat is described.
December 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/30506615/association-of-sphingosine-1-phosphate-s1p-s1p-receptor-1-pathway-with-cell-proliferation-and-survival-in-canine-hemangiosarcoma
#8
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/30450013/a-novel-cancer-syndrome-caused-by-kcnq1-deficiency-in-the-golden-syrian-hamster
#9
Rong Li, Jinxin Miao, Alexandru-Flaviu Tabaran, M Gerard O'Sullivan, Kyle J Anderson, Patricia M Scott, Zhongde Wang, Robert T Cormier
BACKGROUND: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is KCNQ1 which encodes for the KCNQ1 potassium channel and also has been implicated as a tumor suppressor gene. MATERIALS AND METHODS: We generated KCNQ1 knockout (KO) hamsters by CRISPR/Cas9-mediated gene targeting and investigated the effects of KCNQ1-deficiency on tumorigenesis...
2018: Journal of Carcinogenesis
https://read.qxmd.com/read/30410179/piecemeal-endoscopic-polypoidectomy-for-the-management-of-a-canine-pharyngeal-hemangiosarcoma
#10
Joseph Cyrus Parambeth, Jessica M Vallone, John F Griffin, Audrey K Cook
A 7-year-old castrated male Maltese dog was presented for increased respiratory sounds, inability to bark, dysphagia, and hyporexia. Radiographs revealed an ovoid, opaque mass in the caudal nasopharynx. An airway examination and computed tomography scan were followed by endoscopic polypoidectomy. The mass was a hemangiosarcoma, and the patient survived > 13 months.
November 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/30360911/retrospective-pathological-studies-of-splenic-lesions-in-domestic-hamsters-phodopus-spp
#11
Y C Tuan, R C Wan, J P Kao, H Y Chiou, K Takahashi, J W Liao
Fifteen splenic biopsy specimens from a total of 212 biopsy specimens and necropsy cases of domestic hamsters (Phodopus spp.) from the Division of Wild (Exotic) Animal Medicine, Veterinary Medical Teaching Hospital, National Chung Hsing University, Taiwan, collected between 2010 and 2017, were studied retrospectively. The incidence of lesions in the spleen was 7.1% (15/212). The mean age of affected hamsters was 16.6 months and females were affected more than males. The lesions consisted of 10 neoplasms and five non-neoplastic lesions...
October 2018: Journal of Comparative Pathology
https://read.qxmd.com/read/30285832/notch2-signal-is-required-for-the-maintenance-of-canine-hemangiosarcoma-cancer-stem-cell-like-cells
#12
Keisuke Aoshima, Yuki Fukui, Kevin Christian Montecillo Gulay, Ochbayar Erdemsurakh, Atsuya Morita, Atsushi Kobayashi, Takashi Kimura
BACKGROUND: Hemangiosarcoma (HSA) is a malignant tumor derived from endothelial cells which usually shows poor prognosis due to its high invasiveness, metastatic rate and severe hemorrhage from tumor ruptures. Since the pathogenesis of HSA is not yet complete, further understanding of its molecular basis is required. RESULTS: Here, we identified Notch2 signal as a key factor in maintaining canine HSA cancer stem cell (CSC)-like cells. We first cultured HSA cell lines in adherent serum-free condition and confirmed their CSC-like characteristics...
October 3, 2018: BMC Veterinary Research
https://read.qxmd.com/read/30267450/in-vitro-effects-of-the-chemotherapy-agent-water-soluble-micellar-paclitaxel-paccal-vet-on-canine-hemangiosarcoma-cell-lines
#13
Caroline R Reckelhoff, Amandine Lejeune, Patrick M Thompson, Keijiro Shiomitsu
Paccal Vet (Osamia Pharmaceuticals) is a water-soluble nanoparticle micellar formulation of the drug paclitaxel that is well tolerated in dogs. This study evaluated the in vitro effect of Paccal Vet on two canine hemangiosarcoma (HSA) cell lines and their expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Paccal Vet caused HSA cell death in a dose- and time-dependent manner. The 50% inhibitory concentration (IC50 ) for the two HSA cell lines were 7 to 610 ng/mL, which are clinically achievable...
September 28, 2018: Veterinary and Comparative Oncology
https://read.qxmd.com/read/30246401/anatomic-site-and-etiology-of-hemorrhage-in-small-versus-large-dogs-with-spontaneous-hemoperitoneum
#14
Jeremy Fleming, Michelle A Giuffrida, Jeffrey J Runge, Ingrid M Balsa, William T N Culp, Philipp D Mayhew, Michele Steffey, Steven E Epstein
OBJECTIVE: To compare anatomic sources and underlying etiology of hemorrhage in small vs large dogs with spontaneous hemoperitoneum (SH). STUDY DESIGN: Retrospective cross-sectional study. ANIMALS: Client-owned dogs with SH at 2 academic institutions. METHODS: Medical records were reviewed for age, breed, sex, weight, and results of imaging, surgery, necropsy, cytology, and histopathology. Dogs were divided according to body weight (≤ 20 kg = small, > 20 kg = large)...
November 2018: Veterinary Surgery: VS
https://read.qxmd.com/read/30242852/long-term-postoperative-effects-of-administration-of-allogeneic-blood-products-in-104-dogs-with-hemangiosarcoma
#15
MULTICENTER STUDY
Brittany J Ciepluch, Heather M Wilson-Robles, Medora B Pashmakova, Christine M Budke, Gary W Ellison, Kelley M Thieman Mankin
OBJECTIVE: To determine the influence of administering allogeneic blood products (ABP) on the progression of hemangiosarcoma in dogs. STUDY DESIGN: Multi-institutional, retrospective study. SAMPLE POPULATION: One hundred four dogs with hemangiosarcoma that survived until postoperative discharge from the hospital. METHODS: Medical records of dogs that had been operated on for hemoangiosarcoma were reviewed for signalment, presence of a hemoabdomen, presence of metastatic disease, and whether the dog had received chemotherapy or Yunnan Baiyao...
November 2018: Veterinary Surgery: VS
https://read.qxmd.com/read/30197439/canine-visceral-hemangiosarcoma-treated-with-surgery-alone-or-surgery-and-doxorubicin-37-cases-2005-2014
#16
Karen Batschinski, Alessandra Nobre, Ernesto Vargas-Mendez, Marcello V Tedardi, Juliana Cirillo, Greice Cestari, Rodrigo Ubukata, Maria Lucia Z Dagli
The purpose of this retrospective study was to determine survival times and prognostic factors of dogs with visceral hemangiosarcoma (HSA) treated with surgery alone or surgery and doxorubicin. Medical records from 2 hospitals from 2005 to 2014 were searched for dogs with histopathologically confirmed visceral HSA. Data relevant to patient demographics, tumor characteristics, and outcomes were abstracted. The most common primary organ affected was the spleen; however, primary tumor location had no influence on prognosis...
September 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://read.qxmd.com/read/30136913/cutaneous-epithelioid-hemangiosarcoma-with-granular-cell-differentiation-in-a-dog-a-case-report-and-review-of-the-literature
#17
Pompei Bolfa, Lusan DellaGrotte, Teri Weronko, Anibal G Armien
We report a case of cutaneous epithelioid hemangiosarcoma in a dog in which the majority of the neoplastic cells displayed histologic and ultrastructural features similar to those seen in granular cell tumors (GCTs). This intersection of hemangiosarcoma and granular cell change adds to the argument that GCTs are heterogeneous in histologic origin and underlines the fact that pathologists should not consider all GCTs as a single entity. The combination of histology in typical areas of the tumor with ultrastructural changes and the correct immunohistochemical markers can facilitate the accurate diagnosis of tumors with granular cell differentiation...
August 23, 2018: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/30066297/vimentin-osteocalcin-and-osteonectin-expression-in-canine-primary-bone-tumors-diagnostic-and-prognostic-implications
#18
Camila Barbosa Amaral, Juliana da Silva Leite, Ana Beatriz Monteiro Fonseca, Ana Maria Reis Ferreira
Canine primary bone tumors have a plastic radiographic image, demanding histopathological confirmation. Bone tumors are characterized by the type and amount of extracellular matrix produced what cannot be easily recognized, especially in biopsy samples. Identifying cellular markers that could aid diagnosis has supported various studies in oncological pathology. This study aimed to evaluate 22 canine primary bone neoplasms, establishing their histopathological diagnosis and evaluated vimentin, osteonectin and osteocalcin expression and their implication in diagnosis and prognosis...
October 2018: Molecular Biology Reports
https://read.qxmd.com/read/30051473/primary-appendicular-hemangiosarcoma-and-telangiectatic-osteosarcoma-in-70-dogs-a-veterinary-society-of-surgical-oncology-retrospective-study
#19
Michelle A Giuffrida, Debra A Kamstock, Laura E Selmic, William Pass, Anna Szivek, Michael B Mison, Sarah E Boston, Leslie E Fox, Cecilia Robat, Janet A Grimes, Karl C Maritato, Nicholas J Bacon
OBJECTIVE: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis. STUDY DESIGN: Multi-institutional retrospective study. ANIMALS: Seventy dogs with primary appendicular HSA or tOSA. METHODS: Patient data were obtained from institutions' medical records. Immunohistochemistry was applied to archived tissues to establish tumor type...
August 2018: Veterinary Surgery: VS
https://read.qxmd.com/read/30039997/pericardial-hemangiosarcoma-in-a-10-year-old-papillon
#20
Dana M DeSandre-Robinson, Mariana T Quina, David M Lurie
A 10 yr old papillon was evaluated for lethargy, inappetence, tachypnea, and labored breathing. Physical examination findings included dehydration, tachypnea, tachycardia, and muffled heart sounds. Thoracic radiographs revealed an enlarged cardiac silhouette. Echocardiography revealed a mild volume of pericardial effusion and no evidence of right atrial tamponade or a cardiac-associated mass. Cytological analysis of the pericardial effusion was consistent with blood. There was no evidence of neoplasia. Coagulation parameters were within normal limits...
September 2018: Journal of the American Animal Hospital Association
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