Shancy Jacob, Yasuhiro Kosaka, Seema Bhatlekar, Frederik Denorme, Haley Benzon, Alexandra Moody, Victoria Moody, Emilia Tugolukova, Grayson Hull, Nina Kishimoto, Bhanu K Manne, Li Guo, Rhonda Souvenir, Brayden J Seliger, Alicia S Eustes, Kelly Hoerger, Neal D Tolley, Amir N Fatahian, Sihem Boudina, David C Christiani, Yongyue Wei, Can Ju, Robert A Campbell, Matthew T Rondina, E Dale Abel, Paul F Bray, Andrew S Weyrich, Jesse W Rowley
BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele (MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are associated with reduced platelet MFN2 RNA expression and platelet counts. This study investigates the impact of MFN2 on megakaryocyte and platelet biology. METHODS: Mice with megakaryocyte/platelet deletion of Mfn2 ( Mfn2 -/- [Mfn2 conditional knockout]) were generated using Pf4-Cre crossed with floxed Mfn2 mice...
December 29, 2023: Circulation Research