keyword
https://read.qxmd.com/read/37080822/the-past-present-and-future-role-of-artificial-intelligence-in-ventilation-perfusion-scintigraphy-a-systematic-review
#21
REVIEW
Amir Jabbarpour, Siraj Ghassel, Jochen Lang, Eugene Leung, Grégoire Le Gal, Ran Klein, Eric Moulton
Ventilation-perfusion (V/Q) lung scans constitute one of the oldest nuclear medicine procedures, remain one of the few studies performed in the acute setting, and are amongst the few performed in the emergency setting. V/Q studies have witnessed a long fluctuation in adoption rates in parallel to continuous advances in image processing and computer vision techniques. This review provides an overview on the status of artificial intelligence (AI) in V/Q scintigraphy. To clearly assess the past, current, and future role of AI in V/Q scans, we conducted a systematic Ovid MEDLINE(R) literature search from 1946 to August 5, 2022 in addition to a manual search...
April 18, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37037750/donation-after-circulatory-death-heart-procurement-strategy-impacts-utilization-and-outcomes-of-concurrently-procured-abdominal-organs
#22
JOURNAL ARTICLE
Jason Thomas, Qiudong Chen, Amy Roach, Stanley Wolfe, Asishana A Osho, Vinay Sundaram, Steven A Wisel, Dominick Megna, Dominic Emerson, Lawrence Czer, Fardad Esmailian, Joanna Chikwe, Irene Kim, Pedro Catarino
INTRODUCTION: The impact of donation after circulatory death (DCD) heart procurement techniques on the utilization and outcomes of concurrently procured DCD livers and kidneys remains unclear. METHODS: Using the United Network for Organ Sharing database, we identified 246 DCD donors whose heart was procured using direct procurement and ex-situ machine perfusion and 128 DCD donors whose heart was procured using in-situ thoracoabdominal normothermic regional perfusion (12/2019-03/2022)...
July 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37032222/a-national-pilot-of-donation-after-circulatory-death-dcd-heart-transplantation-within-the-united-kingdom
#23
JOURNAL ARTICLE
Simon Messer, Sally Rushton, Lewis Simmonds, Debbie Macklam, Mubbasher Husain, Anand Jothidasan, Stephen Large, Steven Tsui, Pradeep Kaul, Jennifer Baxter, Mohamed Osman, Vipin Mehta, Derval Russell, Uli Stock, John Dunning, Diana Garcia Saez, Rajamiyer Venkateswaran, Philip Curry, Lynne Ayton, Majid Mukadam, Jorge Mascaro, Jacob Simmonds, Guy Macgowan, Stephen Clark, Jerome Jungschleger, Zdenka Reinhardt, Richard Quigley, Jane Speed, Jayan Parameshwar, David Jenkins, Sarah Watson, Fiona Marley, Ayesha Ali, Dale Gardiner, Antonio Rubino, Julie Whitney, Catherine Slater, Ian Currie, Liz Armstrong, Jeanette Foley, Marian Ryan, Sharon Gibson, Karen Quinn, Anna-Maria Macleod, Susan Spence, Christopher J E Watson, Pedro Catarino, Anthony Clarkson, John Forsythe, Derek Manas, Marius Berman
BACKGROUND: The United Kingdom (UK) was one of the first countries to pioneer heart transplantation from donation after circulatory death (DCD) donors. To facilitate equity of access to DCD hearts by all UK heart transplant centers and expand the retrieval zone nationwide, a Joint Innovation Fund (JIF) pilot was provided by NHS Blood and Transplant (NHSBT) and NHS England (NHSE). The activity and outcomes of this national DCD heart pilot program are reported. METHODS: This is a national multi-center, retrospective cohort study examining early outcomes of DCD heart transplants performed across 7 heart transplant centers, adult and pediatric, throughout the UK...
March 13, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37031869/donor-heart-ischemic-time-can-be-extended-beyond-9-hours-using-hypothermic-machine-perfusion-in-sheep
#24
JOURNAL ARTICLE
Louise E See Hoe, Gianluigi Li Bassi, Karin Wildi, Margaret R Passmore, Mahe Bouquet, Kei Sato, Silver Heinsar, Carmen Ainola, Nicole Bartnikowski, Emily S Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G Obonyo, Tristan Shuker, Lucy Bradbury, Chiara Palmieri, Sanne Engkilde-Pedersen, Charles McDonald, Sebastiano M Colombo, Matthew A Wells, Janice D Reid, Hollier O'Neill, Samantha Livingstone, Gabriella Abbate, Andrew Haymet, Jae-Seung Jung, Noriko Sato, Lynnette James, Ting He, Nicole White, Meredith A Redd, Jonathan E Millar, Maximillian V Malfertheiner, Peter Molenaar, David Platts, Jonathan Chan, Jacky Y Suen, David C McGiffin, John F Fraser
BACKGROUND: The global shortage of donor hearts available for transplantation is a major problem for the treatment of end-stage heart failure. The ischemic time for donor hearts using traditional preservation by standard static cold storage (SCS) is limited to approximately 4 hours, beyond which the risk for primary graft dysfunction (PGD) significantly increases. Hypothermic machine perfusion (HMP) of donor hearts has been proposed to safely extend ischemic time without increasing the risk of PGD...
April 7, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37026713/normothermic-machine-perfusion-systems-where-do-we-go-from-here
#25
REVIEW
Sara López-Martínez, Carlos Simón, Xavier Santamaria
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating physiological conditions such as body temperature. Recent advancements in NMP system design have prompted the development of clinically effective devices for liver, heart, lung, and kidney transplantation that preserve organs for several hours/up to 1 d. In preclinical studies, adjustments to circuit structure, perfusate composition, and automatic supervision have extended perfusion times up to 1 wk of preservation. Emerging NMP platforms for ex vivo preservation of the pancreas, intestine, uterus, ovary, and vascularized composite allografts represent exciting prospects...
January 1, 2024: Transplantation
https://read.qxmd.com/read/37004663/single-fio-2-lung-modelling-with-machine-learning-a-computer-simulation-incorporating-volumetric-capnography
#26
JOURNAL ARTICLE
Thomas J Morgan, Peter H Scott, Adrian N Langley, Robin D C Barrett, Christopher M Anstey
We investigated whether machine learning (ML) analysis of ICU monitoring data incorporating volumetric capnography measurements of mean alveolar PCO2 can partition venous admixture (VenAd) into its shunt and low V/Q components without manipulating the inspired oxygen fraction (FiO2 ). From a 21-compartment ventilation / perfusion (V/Q) model of pulmonary blood flow we generated blood gas and mean alveolar PCO2 data in simulated scenarios with shunt values from 7.3% to 36.5% and a range of FiO2 settings, indirect calorimetry and cardiac output measurements and acid- base and hemoglobin oxygen affinity conditions...
April 1, 2023: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/36918339/ex-situ-oxygenated-hypothermic-machine-perfusion-in-donation-after-circulatory-death-heart-transplantation-following-either-direct-procurement-or-in-situ-normothermic-regional-perfusion
#27
JOURNAL ARTICLE
Niels Moeslund, Imran A Ertugrul, Michiel A Hu, Frederik Flyvholm Dalsgaard, Lars Bo Ilkjaer, Pia Ryhammer, Michael Pedersen, Michiel E Erasmus, Hans Eiskjaer
BACKGROUND: Heart transplantation in donation after circulatory death (DCD) relies on warm perfusion using either in situ normothermic regional perfusion (NRP) or ex situ normothermic machine perfusion. In this study, we explore an alternative: oxygenated hypothermic machine perfusion (HMP) using a novel clinically applicable perfusion system, which is compared to NRP with static cold storage (SCS). METHODS: In a porcine model, a DCD setting was simulated, followed by either (1) NRP and SCS (2) NRP and HMP with the XVIVO Heart preservation system or (3) direct procurement (DPP) and HMP...
June 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/36915006/continuous-versus-pulsatile-flow-in-24-hour-vascularized-composite-allograft-machine-perfusion-in-swine-a-pilot-study
#28
JOURNAL ARTICLE
Pierre Tawa, Marion Goutard, Alec R Andrews, Reinier J de Vries, Ivy A Rosales, Heidi Yeh, Basak Uygun, Mark A Randolph, Alexandre G Lellouch, Korkut Uygun, Curtis L Cetrulo
INTRODUCTION: Multiple perfusion systems have been investigated on vascularized composite allografts, with various temperatures and different preservation solutions, most using continuous flow (CF). However, physiological flow is pulsatile and provides better outcomes in kidney and lung ex vivo perfusions. The objective of this pilot study is to compare pulsatile flow (PF) with CF in our 24-h subnormothermic machine perfusion protocol for swine hindlimbs. METHODS: Partial hindlimbs were harvested from Yorkshire pigs and perfused with a modified Steen solution at 21°C for 24 h either with CF (n = 3) or with pulsatile flow (PF) at 60 beats/min (n = 3)...
March 2023: Journal of Surgical Research
https://read.qxmd.com/read/36797458/review-of-cardiovascular-imaging-in-the-journal-of-nuclear-cardiology-2022-single-photon-emission-computed-tomography
#29
REVIEW
Wael A AlJaroudi, Fadi G Hage
In this review, we will summarize a selection of articles on single-photon emission computed tomography published in the Journal of Nuclear Cardiology in 2022. The aim of this review is to concisely recap major advancements in the field to provide the reader a glimpse of the research published in the journal over the last year. This review will place emphasis on myocardial perfusion imaging using single-photon emission computed tomography summarizing advances in the field including in prognosis, non-perfusion variables, attenuation compensation, machine learning and camera design...
April 2023: Journal of Nuclear Cardiology
https://read.qxmd.com/read/36747380/update-on-state-of-the-art-for-arterial-spin-labeling-asl-human-perfusion-imaging-outside-of-the-brain
#30
REVIEW
Manuel Taso, Veronica Aramendía-Vidaurreta, Erin K Englund, Susan Francis, Suzanne Franklin, Ananth J Madhuranthakam, Petros Martirosian, Krishna S Nayak, Qin Qin, Xingfeng Shao, David L Thomas, Zungho Zun, Maria A Fernández-Seara
This review article provides an overview of developments for arterial spin labeling (ASL) perfusion imaging in the body (i.e., outside of the brain). It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group. In this review, we focus on specific challenges and developments tailored for ASL in a variety of body locations. After presenting common challenges, organ-specific reviews of challenges and developments are presented, including kidneys, lungs, heart (myocardium), placenta, eye (retina), liver, pancreas, and muscle, which are regions that have seen the most developments outside of the brain...
February 6, 2023: Magnetic Resonance in Medicine
https://read.qxmd.com/read/36742211/the-design-and-implementation-of-a-convertible-extracorporeal-circuit-for-lung-transplantation
#31
Rachel Gambino, Desiree Bonadonna, William Dauch
Intraoperative management for patients during orthotopic lung transplantation may be performed without mechanical circulatory support, with veno-arterial extracorporeal membrane oxygenation (VA-ECMO), or cardiopulmonary bypass (CPB). For certain patients, an intraoperative conversion from VA-ECMO to CPB may be indicated. If a VA-ECMO patient requires CPB conversion, the previous model at our institution used two separate machines and was overall inefficient. The primary aim of this project was to develop a CPB pack modification to create a circuit that easily converts from VA-ECMO to CPB if indicated...
September 2022: Journal of Extra-corporeal Technology
https://read.qxmd.com/read/36626269/strategies-for-organ-preservation-current-prospective-and-challenges
#32
REVIEW
Seema Tripathy, Saroj Kumar Das
In current therapeutic approaches, transplantation of organs provides the best available treatment for a myriad of end-stage organ failures. However, shortage of organ donors, lacunae in preservation methods, and lack of a suitable match are the major constraints in advocating this life-sustaining therapy. There has been continuous progress in the strategies for organ preservation since its inception. Current strategies for organ preservation are based on the University of Wisconsin (UW) solution using the machine perfusion technique, which allows successful preservation of intra-abdominal organs (kidney and liver) but not intra-thoracic organs (lungs and heart)...
March 2023: Cell Biology International
https://read.qxmd.com/read/36569522/optimisation-of-volume-flow-rates-when-using-endovascular-shunting-techniques-an-experimental-study-in-different-bench-flow-circuits
#33
JOURNAL ARTICLE
Johan Millinger, Daniel Bengtsson, Marcus Langenskiöld, Andreas Nygren, Klas Österberg, Joakim Nordanstig
OBJECTIVE: Acute tissue ischaemia may arise due to arterial emergencies or during more complex vascular procedures and may be mitigated by temporary shunting techniques.
Endovascular shunting (ES) techniques enable percutaneous access and shunting from the donor artery without the need to completely interrupt the arterial flow in the donor artery. An endoshunt system may also cover longer distances than most conventional shunts. The aim was to investigate and optimise the flow rates in different endovascular shunt systems...
2023: EJVES vascular forum
https://read.qxmd.com/read/36509177/emerging-applications-of-extracardiac-ultrasound-in-critically-ill-cardiac-patients
#34
REVIEW
Martin Girard, Jean Deschamps, Saad Razzaq, Nicolas Lavoie, André Denault, William Beaubien-Souligny
Point-of-care ultrasound has evolved as an invaluable diagnostic modality and procedural guidance tool in the care of critically ill cardiac patients. Beyond focused cardiac ultrasound, additional extracardiac ultrasound modalities may provide important information at the bedside. In addition to new uses of existing modalities, such as pulsed-wave Doppler ultrasound, the development of new applications is fostered by the implementation of additional features in mid-range ultrasound machines commonly acquired for intensive care units, such as tissue elastography, speckle tracking, and contrast-enhanced ultrasound quantification software...
April 2023: Canadian Journal of Cardiology
https://read.qxmd.com/read/36299442/application-of-ex-vivo-normothermic-machine-perfusion-in-deceased-donors-with-acute-kidney-injury-with-successful-renal-transplantation-a-preliminary-experience
#35
JOURNAL ARTICLE
Devprakash Choudhary, Ashish Sharma, Sarbpreet Singh, Deepesh B Kenwar, Ranjana Walker Minz, Harbir Singh Kohli, Ritambhra Nada, Sujata Wangkheimayum, Kajal Jain, Shivakumar S Patil
UNLABELLED: Ex vivo normothermic machine perfusion (NMP) has improved organ preservation and viability assessment among heart, liver, and lung transplantation. However, literature regarding the application of NMP in human clinical kidney transplantation remains limited. Numerous kidneys, especially from donors with stage 3 acute kidney injury (AKI), are not utilized concerning the high rate of delayed graft function (DGF) and primary nonfunction. The present study investigated the impact of NMP (135-150 min) on short-term outcomes after kidney transplantation from deceased donors with AKI...
November 2022: Transplantation Direct
https://read.qxmd.com/read/36162409/quantification-of-pulmonary-functional-mri-state-of-the-art-and-emerging-image-processing-methods-and-measurements
#36
JOURNAL ARTICLE
Maksym Sharma, Paulina Victoria Wyszkiewicz, Vedanth Desaigoudar, Fumin Guo, Dante Capaldi, Grace Parraga
Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively map and measure the spatial distribution of pulmonary ventilation, perfusion and gas-exchange abnormalities with unprecedented detail of functional processes at the level of airways, alveoli and the alveolar-capillary membrane. Current PfMRI approaches are dominated by hyperpolarized helium-3 (3 He) and xenon-129 (129 Xe) gases, which both provide rapid (8-15s) and well-tolerated imaging examinations in patients with severe pulmonary diseases and pediatric populations, whilst employing no ionizing radiation...
September 26, 2022: Physics in Medicine and Biology
https://read.qxmd.com/read/36125270/cavoatrial-hypernephroma-resection-on-cardiopulmonary-bypass-mild-normo-versus-moderate-hypothermia
#37
JOURNAL ARTICLE
Andreas Möbius, Philippe Grieshaber, Jan Turra, David Riesterer, Marcin Zaradzki, Petar Soso, Gencay Hatiboglu, Markus Hohenfellner, Gregor Warnecke, Ursula Tochtermann
INTRODUCION: Renal cell carcinoma (RCC) is one of the most prevalent malignant tumors. It extends up into the systemic veins and right atrium. Surgical extraction of such extensions is usually carried out using cardiopulmonary bypass (CPB) with moderate hypothermic (MH) being frequently applied in order to obtain a clear surgical field. However, due to obvious disadvantages of hypothermia, approaches with mild/normothermia (NT) during CPB have also been established. The current study aims to compare the outcomes of patients undergoing RCC tumor and extensions resection using MH versus NT...
September 20, 2022: Perfusion
https://read.qxmd.com/read/36048266/radiation-and-immune-checkpoint-inhibitor-mediated-pneumonitis-risk-stratification-in-patients-with-locally-advanced-non-small-cell-lung-cancer-role-of-functional-lung-radiomics
#38
JOURNAL ARTICLE
Hannah M T Thomas, Daniel S Hippe, Parisa Forouzannezhad, Balu Krishna Sasidharan, Paul E Kinahan, Robert S Miyaoka, Hubert J Vesselle, Ramesh Rengan, Jing Zeng, Stephen R Bowen
BACKGROUND: Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI) therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary toxicity at higher rates than historical reports. Identifying biomarkers beyond conventional clinical factors and radiation dosimetry is especially relevant in the modern cancer immunotherapy era. We investigated the role of novel functional lung radiomics, relative to functional lung dosimetry and clinical characteristics, for pneumonitis risk stratification in locally advanced NSCLC...
September 1, 2022: Discover. Oncology
https://read.qxmd.com/read/35950888/the-role-of-ex-situ-perfusion-for-thoracic-organs
#39
JOURNAL ARTICLE
Maximilian J Roesel, Bettina Wiegmann, Fabio Ius, Christoph Knosalla, Jasper Iske
PURPOSE OF REVIEW: Ex-situ machine perfusion for both heart (HTx) and lung transplantation (LuTx) reduces ischemia-reperfusion injury (IRI), allows for greater flexibility in geographical donor management, continuous monitoring, organ assessment for extended evaluation, and potential reconditioning of marginal organs. In this review, we will delineate the impact of machine perfusion, characterize novel opportunities, and outline potential challenges lying ahead to improve further implementation...
August 4, 2022: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/35844566/gene-therapy-will-the-promise-of-optimizing-lung-allografts-become-reality
#40
REVIEW
Qimeng Gao, Isabel F DeLaura, Imran J Anwar, Samuel J Kesseli, Riley Kahan, Nader Abraham, Aravind Asokan, Andrew S Barbas, Matthew G Hartwig
Lung transplantation is the definitive therapy for patients living with end-stage lung disease. Despite significant progress made in the field, graft survival remains the lowest of all solid organ transplants. Additionally, the lung has among the lowest of organ utilization rates-among eligible donors, only 22% of lungs from multi-organ donors were transplanted in 2019. Novel strategies are needed to rehabilitate marginal organs and improve graft survival. Gene therapy is one promising strategy in optimizing donor allografts...
2022: Frontiers in Immunology
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