Christine Hill-Kayser, Ellen Yorke, Andrew Jackson, Clarisa Gracia, Jill Ginsberg, Kimberly Keene, Cecile Ronckers, Monika L Metzger, Zhenghong Li, Louis Constine, Chia-Ho Hua
PURPOSE: The PENTEC (Pediatric Normal Tissue Effects in the Clinic) task force aimed to quantify effects of radiation therapy (RT) dose to the female reproductive organs after treatment for childhood cancer. METHODS AND MATERIALS: Relevant studies published 1970 to 2017 were identified systematically through PubMed, Medline, and Cochrane databases with additional articles before 2021 identified by the group. Two large studies reported sufficient data to allow modeling of acute ovarian failure (AOF; loss of function ≤5 year from diagnosis) and premature ovarian insufficiency (POI; loss of function at attained age <40 years) based on maximum dose to least affected ovary...
October 5, 2023: International Journal of Radiation Oncology, Biology, Physics