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Uterus transplantation

L Dion, A Tardieu, P Collinet, O Garbin, J M Ayoubi, A Agostini, P Piver, Y Aubard, T Gauthier, V Lavoué
No abstract text is available yet for this article.
February 13, 2019: Journal of Gynecology Obstetrics and Human Reproduction
Siwen Zhang, Pingping Li, Zhengwei Yuan, Jichun Tan
BACKGROUND: Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregnancy and endometrium regeneration. We also initiated platelet-rich plasma (PRP) acted as a beneficial supplement in MenSC culturing and a potential endometrial receptivity regulator. Here, we investigated the therapeutic effect of combined transplantation of MenSCs with PRP in rat IUA models and the mechanisms of MenSCs in endometrium regeneration...
February 15, 2019: Stem Cell Research & Therapy
Iori Kisu, Yu Liu, Gaowen Chen, Min Jong Song, Cherry Yin-Yi Chang, Tan Hak Koon, Kouji Banno, Daisuke Aoki
Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. To date, three groups have performed UTx in humans in Asia, and many others are aiming for the clinical application of UTx with accumulation of basic experimental data...
February 14, 2019: Journal of Clinical Medicine
Philippe Tummers, Menekse Göker, Pernilla Dahm-Kahler, Mats Brännström, Stefan G Tullius, Xavier Rogiers, Steven Van Laecke, Steven Weyers
No abstract text is available yet for this article.
February 4, 2019: Transplantation
Bang Xiao, Wenjun Yang, Dong Lei, Jinfeng Huang, Yupeng Yin, Yiqing Zhu, Zhengwei You, Fang Wang, Shuhan Sun
Intrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive female mammals usually results from endometrium injury. Nevertheless, there is no efficient therapeutic method to avoid IUA. Bone marrow derived mesenchymal stem cells (BMSCs) are an important cell source for tissue regeneration. This study designs and explores the ability of BMSC-loaded elastic poly(glycerol sebacate) (PGS) scaffold to prevent IUA and compares the effect of PGS with poly(lactic-co-glycolic acid) (PLGA) and collagen scaffolds in resumption of damaged rat uteruses...
February 7, 2019: Advanced Healthcare Materials
S Zaami, A Di Luca, E Marinelli
Women suffering from Uterine Factor Infertility (UFI) arising from congenital conditions (e.g., Rokitansky-Kuster-Hauser syndrome) or hysterectomy can fulfill their wish to achieve motherhood only by resorting to surrogacy, which is, however, banned in most countries. Medical research has long been looking into uterus transplant (UTx), which may constitute a valuable alternative for such patients. Following decades of animal testing and clinical trials, several successful pregnancies have been carried to term...
January 2019: European Review for Medical and Pharmacological Sciences
Mats Brännström, Pernilla Dahm-Kähler
Absolute uterine factor infertility (AUFI), with uterine absence or presence of a non-functional uterus, was considered untreatable until 2014, when the first child was born after transplantation of a uterus from a postmenopausal woman to a woman of fertile age who was born with no uterus, as a part of the Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Concerning gynaecological cancer, AUFI may occur after hysterectomy for malignancy or after surgery/radiation that will preserve the uterus but causing non-functionality in terms of future implantation and pregnancy...
December 21, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han
Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells can be generated to mimic embryogenesis in vitro. However, the assembly system and developmental potential of such structures needs to be further studied. Here, we devise a nonadherent-suspension-shaking system to generate self-assembled embryo-like structures (ETX-embryoids) using mouse embryonic, trophoblast and extra-embryonic endoderm stem cells. When cultured together, the three cell types aggregate and sort into lineage-specific compartments...
January 30, 2019: Nature Communications
Yusuke Matoba, Iori Kisu, Asako Sera, Megumi Yanokura, Kouji Banno, Daisuke Aoki
Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myometrium in vivo . In the present report, those relevant articles are reviewed...
February 2019: Biomedical Reports
Marco Pappalardo, Luigi Montesano, Francesca Toia, Antonio Russo, Sara Di Lorenzo, Francesco Dieli, Francesco Moschella, Angelo A Leto Barone, Serena Meraviglia, Anna Barbara Di Stefano
Hand and face transplants are becoming increasingly common, recording progressively more penile, uterus, abdominal wall, and allotransplantation cases reported worldwide. Despite current protocols allow long-term survival of the allografts, the ultimate goal of donor-specific tolerance has not been achieved yet. In fact, the harmful adverse effects related to the lifelong administration of immunosuppressive agents are the main drawbacks for vascularized composite allotransplantations. Research is very active in investigating alternative methods to induce greater tolerance while minimizing toxicity...
February 2019: Annals of Plastic Surgery
Joey Berlin
In late 2017, Dallas obstetrician-gynecologist Robert Gundy, MD, delivered the first baby in the United States born from a transplanted uterus.
March 1, 2018: Texas Medicine
Florin-Andrei Taran, Dorit Schöller, Katharina Rall, Silvio Nadalin, Alfred Königsrainer, Melanie Henes, Hans Bösmüller, Falko Fend, Konstantin Nikolaou, Mike Notohamiprodjo, Christian Grasshoff, Eckhard Heim, Stephan Zipfel, Norbert Schäffeler, Tamam Bakchoul, Nils Heyne, Martina Guthoff, Bernhard Krämer, Christl Reisenauer, Markus Hoopmann, Karl-Oliver Kagan, Mats Brännström, Diethelm Wallwiener, Sara Y Brucker
OBJECTIVE: To report our experience with the screening and selection of potential recipients and living donors of our uterus transplantation (UTx) program. DESIGN: Part of an observational program. SETTING: University hospital. PATIENT(S): Patients with absolute uterine factor infertility (AUFI). INTERVENTION(S): Screening by e-mail and telephone, selection during surgical consultation, and preoperative investigations according to a multistep procedure for living donation...
January 2019: Fertility and Sterility
Reshef Tal, Dirong Dong, Shafiq Shaikh, Ramanaiah Mamillapalli, Hugh S Taylor
Angiogenesis is essential for cyclic endometrial growth, implantation and pregnancy maintenance. Vasculogenesis, the formation of new blood vessels by bone marrow (BM)-derived endothelial progenitor cells (EPCs), has been shown to contribute to endometrial vasculature. However, it is unknown whether vasculogenesis occurs in neovascularization of the decidua during pregnancy. To investigate the contribution of BM-derived EPCs to vascularization of the pregnant uterus, we induced non-gonadotoxic submyeloablation by 5-fluorouracil administration to wild-type FVB/N female mice recipients followed by BM transplantation from transgenic mice expressing GFP under regulation of Tie2 endothelial-specific promoter...
January 2, 2019: Biology of Reproduction
Cesar Diaz-Garcia, Antonio Pellicer
No abstract text is available yet for this article.
December 4, 2018: Lancet
Dani Ejzenberg, Wellington Andraus, Luana Regina Baratelli Carelli Mendes, Liliana Ducatti, Alice Song, Ryan Tanigawa, Vinicius Rocha-Santos, Rubens Macedo Arantes, José Maria Soares, Paulo Cesar Serafini, Luciana Bertocco de Paiva Haddad, Rossana Pulcinelli Francisco, Luiz Augusto Carneiro D'Albuquerque, Edmund Chada Baracat
BACKGROUND: Uterus transplantation from live donors became a reality to treat infertility following a successful Swedish 2014 series, inspiring uterus transplantation centres and programmes worldwide. However, no case of livebirth via deceased donor uterus has, to our knowledge, been successfully achieved, raising doubts about its feasibility and viability, including whether the womb remains viable after prolonged ischaemia. METHODS: In September, 2016, a 32-year-old woman with congenital uterine absence (Mayer-Rokitansky-Küster-Hauser [MRKH] syndrome) underwent uterine transplantation in Hospital das Clínicas, University of São Paulo, Brazil, from a donor who died of subarachnoid haemorrhage...
December 4, 2018: Lancet
Jacqui Wise
No abstract text is available yet for this article.
December 4, 2018: BMJ: British Medical Journal
Jacques Balayla, Togas Tulandi
OBJECTIVE: This study sought to evaluate perceptions and insights regarding uterine transplantation among members of a women's health care national specialty organization in Canada. METHODS: The investigators obtained permission and used an electronic survey developed by Bortoletto et al. to conduct a cross-sectional study of members of the SOGC between April and May 2018. Participants were requested to answer a total of 29 questions grouped into four different categories: personal opinions and attitudes, medical opinions, ethical opinions, and demographics...
December 1, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Antoine Tardieu, Ludivine Dion, Pierre Collinet, Jean Marc Ayoubi, Olivier Garbin, Aubert Agostini, Yves Aubard, Pascal Piver, Vincent Lavoué, Tristan Gauthier
No abstract text is available yet for this article.
December 1, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Antoine Tardieu, Camille Sallée, Ludivine Dion, Pascal Piver, Vincent Lavoué, Tristan Gauthier
No abstract text is available yet for this article.
January 2019: Journal of Gynecology Obstetrics and Human Reproduction
Angeline Favre-Inhofer, Marie Carbonnel, Aurélie Revaux, Olivier Sandra, Valérie Mougenot, Romain Bosc, Valérie Gelin, Arash Rafii, Barbara Hersant, François Vialard, Pascale Chavatte-Palmer, Christophe Richard, Jean-Marc Ayoubi
BACKGROUND: Recent reports have demonstrated uterus transplantation as a relevant solution to treat absolute uterine infertility. Training on animal models is a prerequisite to set up a uterine transplantation program in humans. Sheep have been used as an optimal model for training and research as they display similar vessels size to human. While the ovine model might seem easy there are many difficulties in performing this complex surgery. In this study we describe through our experience the critical initial steps toward building a learning curve toward an optimal ovine uterine transplantation model...
November 24, 2018: International Journal of Surgery
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