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Heloïse De Kermadec, Emilie Bequignon, Francoise Zerah-Lancner, Antoine Garin, Marie Devars du Mayne, André Coste, Bruno Louis, Jean-François Papon
PURPOSE: Stress has been suspected to play a role in rhinitis. The role of stress on nasal patency has been not yet elucidated. The aim was to evaluate the potential effects of stress on nasal patency in healthy subjects. METHODS: We conducted a prospective pilot study including 12 healthy subjects. Experimental protocol was divided in three periods (pre-task, task and recovery). In the task period, subjects were exposed to the "Trier Social Stress Test" (TSST), a standardized laboratory stressor...
February 15, 2019: European Archives of Oto-rhino-laryngology
Katrin Gekeler, Andreas Schatz, Manuel Dominik Fischer, Kai Schommer, Katrin Boden, Karl Ulrich Bartz-Schmidt, Florian Gekeler, Gabriel Willmann
BACKGROUND/AIMS: The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure in healthy subjects due to the effects of hypobaric hypoxia. This study is related to the Tübingen High Altitude Ophthalmology study. METHODS: Visual acuity and Weber CS were tested monocularly using the Freiburger Visual Acuity and Contrast Test under standardised conditions in 14 healthy subjects at high altitude at the Capanna Margherita (4559 m, Italy) and compared with baseline measurements in Tübingen (341 m, Germany)...
February 15, 2019: British Journal of Ophthalmology
Masatake Kobayashi, Masataka Watanabe, Stefano Coiro, Matthieu Bercker, Yuki Paku, Yoichi Iwasaki, Taishiro Chikamori, Akira Yamashina, Kevin Duarte, João Pedro Ferreira, Patrick Rossignol, Faiez Zannad, Nicolas Girerd
AIMS: Pulmonary congestion is associated with poor prognosis following hospitalization for worsening heart failure (HF), although its quantification and optimal timing during HF hospitalization remains challenging. The aim of this study was to assess the prognostic value of radiographic pulmonary congestion at admission and discharge in patients with worsening HF. METHODS AND RESULTS: Clinical, echocardiographic, laboratory and chest X-ray data of 292 acute decompensated HF patients were retrospectively studied (follow-up 1 year)...
February 8, 2019: International Journal of Cardiology
Owen Thomas, John Cain, Mehran Nasralla, Alan Jackson
INTRODUCTION: To test the hypotheses that changes in the aortic pulse-wave produced by arterial stiffening are (1) propagated into cerebral small vessels, (2) associated with reduced compliance of small cerebral arterial vessels, and (3) associated with the presence of dilated perivascular spaces (PVS). METHODS: Fifteen volunteers and 19 patients with late-onset depression (LOD) were prospectively recruited, of which 6 fulfilled the criteria for treatment-resistant depression (TRD)...
February 12, 2019: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Olusola A Orimoloye, Mohammadhassan Mirbolouk, S M Iftekhar Uddin, Zeina A Dardari, Michael D Miedema, Mouaz H Al-Mallah, Joseph Yeboah, Ron Blankstein, Khurram Nasir, Michael J Blaha
Importance: The interplay of self-rated health (SRH), coronary artery calcium (CAC) scores, and cardiovascular risk is poorly described. Objectives: To assess the degree of correlation between SRH and CAC, to determine whether these measures are complementary for risk prediction, and to assess the incremental value of the addition of SRH to established risk tools. Design, Setting, and Participants: The Multi-Ethnic Study of Atherosclerosis (MESA) is a large population-based prospective cohort study of adults aged 45 to 84 years who were recruited from 6 US communities...
February 1, 2019: JAMA network open
Joo Heung Yoon, Lidan Mu, Lujie Chen, Artur Dubrawski, Marilyn Hravnak, Michael R Pinsky, Gilles Clermont
Tachycardia is a strong though non-specific marker of cardiovascular stress that proceeds hemodynamic instability. We designed a predictive model of tachycardia using multi-granular intensive care unit (ICU) data by creating a risk score and dynamic trajectory. A subset of clinical and numerical signals were extracted from the Multiparameter Intelligent Monitoring in Intensive Care II database. A tachycardia episode was defined as heart rate ≥ 130/min lasting for ≥ 5 min, with ≥ 10% density. Regularized logistic regression (LR) and random forest (RF) classifiers were trained to create a risk score for upcoming tachycardia...
February 14, 2019: Journal of Clinical Monitoring and Computing
M Gonzalez-Saenz de Tejada, A Bilbao, L Ansola, R Quirós, L García-Perez, G Navarro, A Escobar
BACKGROUND: The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is one of the most widely used health-related quality of life questionnaires for patients with heart failure (HF). The objective of the present study was to explore the responsiveness of the MLHFQ by estimating the minimal detectable change (MDC) and the minimal clinically important difference (MCID) in Spain. METHODS: Patients hospitalized for HF in the participating hospitals completed the MLHFQ at baseline and 6 months, plus anchor questions at 6 months...
February 14, 2019: Health and Quality of Life Outcomes
Miki Tsujiuchi, Takenori Yamauchi, Mio Ebato, Hideyuki Maezawa, Ayaka Nogi, Naoko Ikeda, Takuya Mizukami, Sakura Nagumo, Yoshitaka Iso, Toshio Nakadate, Akatsuki Kokaze, Hiroshi Suzuki
BACKGROUND: The prognostic value of indices for left atrial volumes (LAV) and reservoir function measured by 3D speckle-tracking analysis (3DSTA) has not been determined. Methods and Results: LA maximal and minimal volume indices (LAVImax, LAVImin), and LA emptying fraction (LAEmpF) were measured via 2D echocardiography (2DE) and 3DSTA in 514 patients (62% male, mean age: 66±15 years) with various cardiovascular diseases. Two cutoff values using normal±2SD (cutoff criterion 1) and receiver-operating characteristic analysis (cutoff criterion 2) were evaluated...
February 13, 2019: Circulation Journal: Official Journal of the Japanese Circulation Society
Andreu Porta-Sánchez, Andrew C T Ha, Xuesong Wang, Fahad Almehmadi, Peter C Austin, Hadas D Fischer, Atif Al-Qubbany, Diego Chemello, Vijay Chauhan, Eugene Downar, Douglas S Lee, Kumaraswamy Nanthakumar
BACKGROUND: Catheter ablation of ventricular tachycardia (VT) can reduce the burden of ventricular arrhythmia (VA) but its effect on health care utilization and costs after such therapy is poorly known. We sought to compare the rates of cardiovascular (CV)-related hospitalizations, survival, and health care costs in patients with recurrent VT treated either with VT ablation or with medical therapy. METHODS: One-hundred implantable cardioverter-defibrillator patients with structural heart disease who underwent VT ablation were included...
February 2019: Canadian Journal of Cardiology
Jussi P Posti, Riikka Sk Takala, Linnéa Lagerstedt, Alex Mountfort Dickens, Iftakher Hossain, Mehrbod Mohammadian, Henna Maria Ala-Seppälä, Janek Frantzén, Mark Van Gils, Peter John Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David Menon, Virginia Newcombe, Jussi Tallus, Kevin Hrusovsky, David Wilson, Jessica Gill, Jean-Charles Sanchez, Olli Tenovuo, Henrik Zetterberg, Kaj Blennow
The aim of the study was to examine the ability of eight protein biomarkers and their combinations in discriminating CT-negative and CT-positive patients with TBI, utilizing highly sensitive immunoassays in a well-characterized cohort. Blood samples were obtained from 160 patients with acute TBI within 24h from admission. Levels of β-amyloid isoforms 1-40 (Aβ40) and 1-42 (Aβ42), glial fibrillary acidic protein (GFAP), heart fatty-acid binding protein (H-FABP), interleukin 10 (IL-10), neurofilament light (NF-L), S100 calcium-binding protein B (S100B) and tau were measured...
February 14, 2019: Journal of Neurotrauma
Sandra Korol, Michel White, Eileen O'Meara, Jean-Lucien Rouleau, Brian White-Guay, Marc Dorais, Ali Ahmed, Simon de Denus, Sylvie Perreault
PURPOSE: Some evidence suggests that spironolactone may have a deleterious effect on glucose homeostasis. The objective of this study was to assess whether spironolactone use is associated with a higher risk of developing diabetes in a large cohort of patients with heart failure (HF). METHODS: Two Quebec government administrative databases were used to identify a cohort of hospitalized patients discharged between January 1995 and December 2009 with a primary discharge diagnosis of HF and without secondary discharge diagnosis of diabetes...
February 13, 2019: European Journal of Clinical Pharmacology
Tatiana Albuquerque Gonçalves de Lima, Evandro Cabral de Brito, Robson Martins, Sandro Gonçalves de Lima, Rodrigo Pinto Pedrosa
OBJECTIVE: To evaluate quality of life in elderly patients with obstructive sleep apnea (OSA) who have a pacemaker. METHODS: This was a cross-sectional study involving elderly patients (≥ 60 years of age) with a pacemaker. The dependent variable was quality of life, as evaluated with the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36). Sociodemographic and clinical parameters, including anxiety and depression (Hospital Anxiety and Depression Scale score), as well as the presence of OSA (defined as an apnea-hypopnea index ≥ 15 events/h), were analyzed as independent variables...
February 11, 2019: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Lukasz Sokolowski, Maria Respondek-Liberska, Marek Pietryga, Maciej Slodki
OBJECTIVES: This prospective study aimed to assess the effectiveness of foramen ovale examination in classifying prenatal hypoplastic left heart syndrome (HLHS) in accordance with the new classification groupings for congenital heart defects. MATERIAL AND METHODS: The analysis included 145 fetuses with HLHS, diagnosed and monitored between 2008 and 2015 in Prenatal Cardiology Department at Polish Mother's Memorial Hospital Research Institute in Lodz. The main criteria for classifying our study population into three sub-groups was was the presence of a foramen ovale restriction, which we diagnosed by evaluating the diameter and blood flow through the foramen ovale...
2019: Ginekologia Polska
Dionne E Swor, Leena F Thomas, Matthew B Maas, Daniela Grimaldi, Edward M Manno, Farzaneh A Sorond, Ayush Batra, Minjee Kim, Shyam Prabhakaran, Andrew M Naidech, Eric M Liotta
BACKGROUND: Fever is associated with worse outcome after intracerebral hemorrhage (ICH). Autonomic dysfunction, commonly seen after brain injury, results in reduced heart rate variability (HRV). We sought to investigate whether HRV was associated with the development of fever in patients with ICH. METHODS: We prospectively enrolled consecutive patients with spontaneous ICH in a single-center observational study. We included patients who presented directly to our emergency department after symptom onset, had a 10-second electrocardiogram (EKG) performed within 24 h of admission, and were in sinus rhythm...
February 12, 2019: Neurocritical Care
Chris Kite, Ian M Lahart, Islam Afzal, David R Broom, Harpal Randeva, Ioannis Kyrou, James E Brown
BACKGROUND: Typically, management of PCOS focuses on lifestyle changes (exercise and diet), aiming to alleviate symptoms, and lower the associated risk of type 2 diabetes and cardiovascular disease. Our objective was to analyse evidence on the effectiveness of exercise in the management of PCOS, when compared to (i) usual care, (ii) diet alone, and (iii) exercise combined with diet, and also exercise combined with diet, compared to (i) control or usual care and (ii) diet alone. METHODS: Relevant databases were searched (June 2017) with no time limit for trial inclusion...
February 12, 2019: Systematic Reviews
Takashi Hisamatsu, Kiang Liu, Cheeling Chan, Amy E Krefman, Akira Fujiyoshi, Matthew J Budoff, Katsuyuki Miura, Donald M Lloyd-Jones, Hirotsugu Ueshima
Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3...
February 2019: Circulation. Cardiovascular Imaging
Sika M Kumordzie, Seth Adu-Afarwuah, Rebecca R Young, Brietta M Oaks, Solace M Tamakloe, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Kathryn G Dewey
Background: In the International Lipid-Based Nutrient Supplements (iLiNS)-DYAD-Ghana trial, prenatal small-quantity lipid-based nutrient supplements (LNSs) had a positive effect on birth weight. Birth weight may be inversely related to blood pressure (BP) later in life. Objectives: We examined the effect of the intervention on BP at 4-6 y of age, and maternal and child factors related to BP. Methods: The iLiNS-DYAD-Ghana study was a partially double-blind, randomized controlled trial which assigned women (n = 1320) ≤20 weeks of gestation to daily supplementation with: 1) iron and folic acid during pregnancy and 200 mg Ca for 6 mo postpartum , 2) multiple micronutrients during pregnancy and postpartum, or 3) LNSs during pregnancy and postpartum plus LNSs for infants from 6 to 18 mo of age...
February 11, 2019: Journal of Nutrition
Supreet P Marathe, Douglas Bell, Kim Betts, Sajid Sayed, Benjamin Dunne, Cameron Ward, Chris Whight, Homayoun Jalali, Prem Venugopal, David Andrews, Nelson Alphonso
OBJECTIVES: The aim of this study was to compare the performance of pulmonary homografts with stentless bioprosthetic valves [Medtronic Freestyle™ (Medtronic, Minneapolis, MN, USA)] in the pulmonary position in patients with congenital heart disease (CHD) younger than 20 years. METHODS: Between January 2000 and December 2017, 215 patients were retrospectively identified from hospital databases in 3 congenital heart centres in Australia. Valve performance was evaluated using standard criteria...
February 7, 2019: European Journal of Cardio-thoracic Surgery
Peter Novak, Donna Felsenstein, Charlotte Mao, Nadlyne R Octavien, Nevena Zubcevik
OBJECTIVES: To examine whether post-treatment Lyme disease syndrome (PTLDS) defined by fatigue, cognitive complaints and widespread pain following the treatment of Lyme disease is associated with small fiber neuropathy (SFN) manifesting as autonomic and sensory dysfunction. METHODS: This single center, retrospective study evaluated subjects with PTLDS. Skin biopsies for assessment of epidermal nerve fiber density (ENFD), sweat gland nerve fiber density (SGNFD) and functional autonomic testing (deep breathing, Valsalva maneuver and tilt test) were performed to assess SFN, severity of dysautonomia and cerebral blood flow abnormalities...
2019: PloS One
Thuong Nguyen Van, Tan Nguyen Manh, Phuong Pham Thi Minh, Trang Trinh Minh, Nghi Dinh Huu, Kiem Pham Cao, Quang Nguyen Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Up to now, surgical excision of apocrine glands still has been a method that yields high treatment results and low rate of odour recurrent for patients, but many people worry about some serious complications that have been observed postoperatively, such as hematoma and skin necrosis. These prolong wound healing, leading to unsightly scars in the axillary fossae. AIM: We conducted this research to investigate the effects and complications of our surgical technique for axillary bromhidrosis...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
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