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Surbhi Sidana, Nidhi Tandon, Peter A Brady, Martha Grogan, Morie A Gertz, Angela Dispenzieri, Grace Lin, David Dingli, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Wilson I Gonsalves, Eli Muchtar, Rahma Warsame, Shaji K Kumar, Taxiarchis V Kourelis
OBJECTIVE: To evaluate the prognostic impact of Holter findings in patients with light chain amyloidosis. PATIENTS AND METHODS: We evaluated 239 patients in whom light chain amyloidosis was diagnosed from January 1, 2010, through December 31, 2015, who underwent 24-hour Holter monitoring. RESULTS: Holter testing was done before stem cell transplant evaluation in 183 of the 239 patients (76.6%) and at diagnosis in 50 (20.9%). Holter findings were nonsustained ventricular tachycardia (NSVT) in 60 patients (25...
February 1, 2019: Mayo Clinic Proceedings
Sílvia Aguiar Rosa, Pedro Silva Cunha, Ana Lousinha, Bruno Valente, Ana Sofia Delgado, Ricardo Pimenta, Manuel Brás, Madalena Coutinho Cruz, Guilherme Portugal, André Viveiros Monteiro, Mário Oliveira, Rui Cruz Ferreira
INTRODUCTION: Implantable cardioverter-defibrillator (ICD) monitoring zones (MZ) provide passive features that do not interfere with the functioning of active treatment zones. However, it is not known for certain whether programming an MZ affects arrhythmia detection by the ICD. The aim of the present study is to assess the clinical relevance of MZ in a population of patients with ICDs. METHODS: In this retrospective analysis of patients with ICDs, with or without cardiac resynchronization therapy, for primary prevention under remote monitoring, the MZ was analyzed and recorded arrhythmias were assessed in detail...
January 24, 2019: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Adaya Weissler-Snir, Waseem Hindieh, Danna A Spears, Arnon Adler, Harry Rakowski, Raymond H Chan
OBJECTIVES: To examine the relationship between late gadolinium enhancement (LGE) extent and Non-sustained ventricular tachycardia (NSVT) characteristics in patients with hypertrophic cardiomyopathy (HCM). BACKGROUND: NSVT has been shown to be independently associated with sudden death (SD) in HCM. Previous studies have found LGE on cardiac magnetic resonance (CMR) to be independently associated with NSVT. METHODS: Seventy-three patients who had 14-day Holter monitoring for either risk stratification for SD (n=62) or evaluation of atrial fibrillation (n=11) a CMR study were included...
January 24, 2019: Journal of Cardiovascular Electrophysiology
Stefano Poli, Domenico Facchin, Francesca Rizzetto, Luca Rebellato, Elisabetta Daleffe, Mauro Toniolo, Antonella Miconi, Alessandro Altinier, Corrado Lanera, Stefano Indrigo, Jennifer Comisso, Alessandro Proclemer
Background: Non-sustained ventricular tachycardia (NSVT) can occur asymptomatically and can be incidentally detected in the internal records of pacemakers (PM). The clinical value of NSVT in the population of PM patients is still uncertain.Our aim was to assess the prevalence of NSVT detected by remote PM control, to describe the clinical and demographic characteristics of patients with NSVT, and to assess the prognostic significance of NSVT in terms of both overall and cardiovascular mortality...
March 2019: IJC Heart & Vasculature
Tadaaki Abe, Etsuko Tsuda, Hisashi Sugiyama, Keisuke Kiso, Osamu Yamada
BACKGROUND: Sudden death can occur in some patients with non-sustained ventricular tachycardia (NSVT) after myocardial infarction (MI) in those with coronary artery lesions (CAL) caused by Kawasaki disease (KD). The aim of this study was to determine the risk factors for NSVT in the late period after KD by technetium-99m-tetrofosmin myocardial perfusion imaging (MPI). METHODS: We retrospectively analyzed the relation between the appearance of NSVT and the findings in MPI single-photon-emission computed tomography (SPECT) in 75 patients (55 males and 20 females) who had had CAL caused by KD...
December 31, 2018: Journal of Cardiology
Shengwei Wang, Hao Cui, Changpeng Song, Changsheng Zhu, Rong Wu, Liukun Meng, Qinjun Yu, Xiaohong Huang, Shuiyun Wang
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is associated with arrhythmias and cardiovascular death. Obstructive sleep apnea (OSA) is highly prevalent and independently associated with atrial fibrillation among patients with HCM. OBJECTIVE: To determine the relationship between non-sustained ventricular tachycardia (NSVT) and OSA in hypertrophic obstructive cardiomyopathy (HOCM). METHODS: One hundred thirty consecutive patients with a confirmed diagnosis of HOCM in Fuwai Hospital between September 2017 and May 2018 were included...
December 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Haqeel A Jamil, Sajeel A Mohammed, John Gierula, Maria F Paton, Judith E Lowry, Richard M Cubbon, Mark T Kearney, Klaus K A Witte
Symptomatic sustained ventricular tachycardia is a life threatening arrhythmia requiring prompt treatment. However, the risk associated with asymptomatic nonsustained ventricular tachycardia (NSVT) detected on routine permanent pacemaker (PPM) interrogation in patients with known cardiac conduction disease is unknown. Our aim is to determine if asymptomatic NSVT detected on PPM interrogation is associated with increased mortality. As part of a prospective observational cohort study, 582 patients with long-term pacemakers were recruited at a tertiary cardiac centre, and followed for 4 ± 1...
November 7, 2018: American Journal of Cardiology
Juyi Wan, Mu Chen, Zhuo Wang, Thomas H Everett, Michael Rubart-von der Lohe, Changyu Shen, Zhilin Qu, James N Weiss, Penelope A Boyden, Peng-Sheng Chen
BACKGROUND: The apamin-sensitive small-conductance calcium-activated K (SK) current (IKAS ) modulates automaticity of the sinus node; IKAS blockade by apamin causes sinus bradycardia. OBJECTIVE: To test the hypothesis that IKAS modulates ventricular automaticity. METHODS: We tested the effects of apamin (100 nM) on ventricular escape rhythms in Langendorff perfused rabbit ventricles with atrioventricular (AV) block (Protocol 1) and on recorded transmembrane action potential (TMP) of pseudotendons of superfused right ventricular (RV) endocardial preparations (Protocol 2)...
November 1, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Balbir Singh, Shu Zhang, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A Rodriguez, Azlan Hussin, Young-Hoon Kim, Alexandr Robertovich Chasnoits, Jeffrey Cerkvenik, Katy A Muckala, Alan Cheng
BACKGROUND: Despite available evidence that implantable cardioverter defibrillators (ICDs) reduce all-cause mortality among patients at risk for sudden cardiac death, utilization of ICDs is low especially in developing countries. OBJECTIVE: To summarize reasons for ICD or cardiac resynchronization therapy defibrillator implant refusal by patients at risk for sudden cardiac arrest (Improve SCA) in developing countries. METHODS: Primary prevention (PP) and secondary prevention (SP) patients from countries where ICD use is low were enrolled...
October 15, 2018: Pacing and Clinical Electrophysiology: PACE
Giovanni Donato Aquaro, Alessandro Pingitore, Gianluca Di Bella, Paolo Piaggi, Raffaella Gaeta, Crysanthos Grigoratos, Alessandro Altinier, Adriana Pantano, Elisabetta Strata, Raffaele De Caterina, Gianfranco Sinagra, Michele Emdin
We sought to evaluate the prognostic role of cardiac magnetic resonance (CMR) in patients with definite, borderline and possible diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) as defined by the International Task Force (TF) in 2010. CMR was performed in 175 patients: 52 with definite, 50 with borderline and 73 possible ARVC. Abnormal-CMR was defined as the presence of ≥1 CMR abnormalities (including abnormalities of right ventricular and left ventricular wall motion, fat infiltration, late gadolinium enhancement, dilation and dysfunction of either ventricles)...
August 21, 2018: American Journal of Cardiology
Rajin Choudhury, Hugo-Enrique Coutino, Radu Darciuc, Erwin Ströker, Valentina De Regibus, Giacomo Mugnai, Gaetano Paparella, Muryio Terasawa, Varnavas Varnavas, Francesca Salghetti, Saverio Iacopino, Ken Takarada, Juan-Pablo Abugattas, Juan Sieira, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
BACKGROUND: The second-generation cryoballoon (CB) is effective in achieving pulmonary vein isolation. Continuous monitoring would eliminate any over- or underestimated freedom from atrial fibrillation (AF) postablation. OBJECTIVE: The purpose of this study was to differentiate between arrhythmias occurring after cryoballoon ablation (CBA), detecting true AF in symptomatic patients and detecting silent subclinical AF. METHODS: Between June 2012 and January 2015, 54 patients with a preexisting cardiac implantable electronic device (CIED) who had undergone CBA for paroxysmal atrial fibrillation (PAF) were included in our retrospective study...
August 18, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Mariusz Klopotowski, Aleksandra Kwapiszewska, Krzysztof Kukula, Jacek Jamiolkowski, Maciej Dabrowski, Pawel Derejko, Artur Oreziak, Rafal Baranowski, Mateusz Spiewak, Magdalena Marczak, Anna Klisiewicz, Barbara Szepietowska, Zbigniew Chmielak, Adam Witkowski
BACKGROUND: Atrial fibrillation (AF) is a common complication in patients with hypertrophic cardiomyopathy (HCM) and may contribute to high cardiovascular morbidity and mortality. Therefore, it is important to assess parameters associated with AF in HCM patients. HYPOTHESIS: The aim of the study was to evaluate AF prevalence in patients with HCM and to investigate risk factors for AF. METHODS: Five hundred and forty-six HCM patients aged below 65 were included into analysis...
October 2018: Clinical Cardiology
Takahiro Kamihara, Fumihiko Yasuma, Toyoaki Murohara
Background: Nonsustained ventricular tachycardia (NSVT) is sometimes observed in patients with neuromuscular diseases (NMDs). The aim of this study was to assess the role of NSVT in the survival prognosis of NMD patients. Methods: We retrospectively analyzed the patients with NMDs who had undergone Holter ECG recordings at a single center between February and August 2012. Sixty-eight patients were enrolled in this study. The 5 year follow-up was assessed according to the cumulative event-free rate...
June 2018: Journal of Arrhythmia
Anne-Floor B E Quast, Tom F Brouwer, Fleur V Y Tjong, Arthur A M Wilde, Reinoud E Knops
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) lacks the antitachycardia pacing (ATP) capability of tranvenous ICDs (TV-ICD). S-ICD patient selection can be challenging as some patients may benefit from ATP. We aim to identify clinical predictors of ATP benefit, in order to improve patient selection for S-ICD or TV-ICD therapy. METHODS: De novo single- and dual-chamber TV-ICD patients implanted between March 2011 and December 2015 were included...
June 13, 2018: Pacing and Clinical Electrophysiology: PACE
Daniel A Jones, Krishnaraj S Rathod, Anna Williamson, Deirdre Harrington, Mervyn Andiapen, Sven van Eijl, Mark Westwood, Sotiris Antoniou, Richard J Schilling, Amrita Ahluwalia, Anthony Mathur
OBJECTIVE: Pre-clinical evidence suggests delivery of nitric oxide (NO) through administration of inorganic nitrite suppresses arrhythmias resulting from acute ischaemia and reperfusion (I/R). To date no assessment of whether inorganic nitrite might limit reperfusion arrhythmia has occurred in man, therefore we explored the effects on I/R-induced ventricular arrhythmias in the NITRITE-AMI cohort. METHODS: In the NITRITE-AMI cohort, Holter analysis was performed prior to and for 24 h after primary PCI in 80 patients who received either intra-coronary sodium nitrite (N = 40) or placebo (N = 40) during primary PCI for AMI...
September 1, 2018: International Journal of Cardiology
Pietro Francia, Carmen Adduci, Beatrice Musumeci, Lorenzo Semprini, Francesca Palano, Luigi Zezza, Massimo Volpe, Camillo Autore
In women with hypertrophic cardiomyopathy (HCM), pregnancy prompts major changes in hemodynamic and cardiac autonomic function that may precipitate heart failure (HF) or increase the risk of cardiac arrhythmia. We report the clinical follow-up of two patients with non-obstructive HCM implanted with a cardioverter defibrillator (ICD) allowing for continuous analysis of heart rate (HR), heart rate variability (HRV) and cardiac arrhythmia throughout the entire course of pregnancy. Both patients experienced increased HR and decreased HRV from the early stages of pregnancy, which persisted until delivery...
April 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Hisashi Yokoshiki, Akihiko Shimizu, Takeshi Mitsuhashi, Hiroshi Furushima, Yukio Sekiguchi, Tetsuyuki Manaka, Nobuhiro Nishii, Takeshi Ueyama, Norishige Morita, Hideo Okamura, Takashi Nitta, Kenzo Hirao, Ken Okumura
Background: Whether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT-D) for primary prevention. Methods: Among the follow-up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT-D implantation for primary prevention had been registered in 269 patients...
April 2018: Journal of Arrhythmia
Peter Magnusson, Stellan Mörner
INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease associated with sudden cardiac death (SCD) mainly due to ventricular tachycardia (VT) or fibrillation even though life-threatening bradycardia occurs. Risk stratification takes several variables into consideration including non-sustained VT (NSVT). An implantable cardioverter defibrillator effectively prevents SCD.Atrial fibrillation (AF) is common among patients with HCM and warrants anticoagulation even without conventional risk factors according to European guidelines...
December 12, 2017: BMJ Open
Sorcha M Allen, Victor A Abrich, Paul S Bibby, Daniel Fishman, Win-Kuang Shen, Dan Sorajja
The risk of life-threatening ventricular arrhythmias in patients with mild-to-moderately reduced left ventricular ejection fraction (LVEF) is unknown. This retrospective case-control study aims to identify the prevalence, risk factors, and outcomes associated with the development of nonsustained ventricular tachycardia (NSVT) as documented on permanent pacemakers or implantable loop recorders in tertiary care center patients with an LVEF of 35% to 50%. Data pertaining to patient demographics, previous medical history, heart failure functional class, echocardiographic parameters, and survival were compared between the groups...
February 1, 2018: American Journal of Cardiology
Carlos de Diego, Luis González-Torres, José María Núñez, Raúl Centurión Inda, David A Martin-Langerwerf, Antonio D Sangio, Piotr Chochowski, Pilar Casasnovas, Julio C Blazquéz, Jesús Almendral
BACKGROUND: Angiotensin-neprilysin inhibition compared to angiotensin inhibition decreased sudden cardiac death in patients with reduced ejection fraction heart failure (rEFHF). The precise mechanism remains unclear. OBJECTIVE: The purpose of this study was to explore the effect of angiotensin-neprilysin inhibition on ventricular arrhythmias compared to angiotensin inhibition in rEFHF patients with an implantable cardioverter-defibrillator (ICD) and remote monitoring...
March 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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