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Mostafa Ahmadi, Ramin Khamene-Bagheri, Reza Jafarzadeh-Esfehani
BACKGROUND: Trans-radial coronary intervention is a popular technique due to patient comfort and lower complication rate. The main complications of this method are artery spasm, vessel perforation, and formation of pseudo-aneurysm. CASE REPORT: In this report, an unusual complication of radial access angiography was encountered. Shortly after the procedure, the patient's right arm began to swell and a pulsating mass grew over the medial aspect of the arm. Right brachial artery angiography was performed immediately for rolling out brachial artery perforation...
September 2018: ARYA Atherosclerosis
Y Zhou, D-D Peng, H Chong, S-Q Zheng, F Zhu, G Wang
OBJECTIVE: To investigate the effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 mitogen-activated protein kinase (MAPK) signaling pathway. MATERIALS AND METHODS: A total of 36 specific-pathogen-free (SPF) Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12) and isoflurane group (n=12). In model group and isoflurane group, the myocardial ischemia-reperfusion injury model was established via the ligation of left anterior descending coronary artery (ischemia for 30 min and reperfusion for 3 h)...
February 2019: European Review for Medical and Pharmacological Sciences
Meltem Kırlı, Doğukan Akçay, Mustafa Mahmut Barış, İlknur Bilkay Görken
PURPOSE: We developed a heart atlas for breast radiation therapy and evaluated the influence of education on intra and inter-observer similarity, and cardiac dose reporting. MATERIALS AND METHODS: The data of 16 left breast cancer patients were analyzed. Eight observers delineated heart and cardiac subunits [left (LCA) and right (RCA) coronary arteries, left anterior descending artery (LAD), bilateral atrium and ventricles] before the education. A radiologist and radiation oncologist developed the atlas and delineated the gold standard (GS) volumes...
February 18, 2019: Japanese Journal of Radiology
Daniel Teschner, Anna Cholaszczyńska, Frederic Ries, Hendrik Beckert, Matthias Theobald, Stephan Grabbe, Markus Radsak, Matthias Bros
ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. ß2 integrins are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Functional loss of CD18-termed leukocyte-adhesion deficiency type 1 (LAD1)-results in an immunocompromised state characterized by frequent occurrence of severe infections. In immunosuppressed individuals Aspergillus fumigatus is a frequent cause of invasive pulmonary fungal infection, and often occurs in patients suffering from LAD1...
2019: Frontiers in Immunology
Hakan Öztürk, Neslihan Ekşi Bozbulut, Sinan Sarı, Ödül Eğritaş Gürkan, Hakan Sözen, Ali Sapmaz, Aydın Dalgıç, Buket Dalgıç
OBJECTIVES: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children. MATERIALS AND METHODS: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. RESULTS: The mean age of children was 6.1 years, ranging from 3 months to 17 years (34 boys, 26 girls)...
January 2019: Experimental and Clinical Transplantation
Alejandro Hernández-Solís, Maribel González-Villa, Ernesto Ramírez-González, Heleodora González-González, Rocío de la Torriente-Mata, Arturo Reding-Bernal, Raúl Cícero-Sabido
Background: Tuberculosis is a global public health problem, especially in emerging countries. Mycobacterium tuberculosis is the main cause of cervical lymphadenopathy; nontuberculous mycobacteria are relatively common in children and rare in adults. Objective: To identify and establish the frequency of infectious etiology by nontuberculous mycobacteria in Mexican adult patients with cervical lymphadenopathy. Methods: The study included 85 patients over 18 years with cervical lymphadenopathy; 45 were HIV-positive, 40 were HIV-negative; they had no history of tuberculosis treatment and were selected from a third-level hospital...
January 28, 2019: Revista Médica del Instituto Mexicano del Seguro Social
John R Richards, Gagan D Singh, Aman K Parikh, Sandhya Venugopal
Excluding ethanol, cannabis is the most commonly used drug in the United States and worldwide. Several published case series and reports have demonstrated an association between cannabis use and acute coronary syndrome (ACS). We report the first ever published case of ACS precipitated by cannabis use that was confirmed with concomitant rising quantitative plasma levels of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol, a secondary metabolite of cannabis. A 63-year-old non-tobacco smoking male with no prior medical history presented to the emergency department with chest pain immediately after smoking cannabis, and anterior ST-segment elevation pattern was observed on his electrocardiogram...
February 13, 2019: American Journal of Emergency Medicine
Yoonsun Chung, Jeong Il Yu, Won Park, Doo Ho Choi
Purpose: This first Korean prospective study is to evaluate the feasibility of prone breast radiotherapy after breast conserving surgery for left breast cancer patients who have relatively small breast size and we present dosimetric comparison between prone and supine positions. Materials and Methods: Fifty patients underwent two computed tomography (CT) simulations in supine and prone positions. Whole breast, ipsilateral lung, heart, and left-anterior-descending coronary artery were contoured on each simulation CT images...
February 18, 2019: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Asmâa Biaz, Jean Uwingabiye, Elmostafa Benaissa, Emmanuel Millbank Owusu, Samira El Machtani Idrissi, Abdellah Dami, Zohra Ouzzif, Sanae Bouhsain
BACKGROUND: The authors report a clinical case where biological interference rendered the electrophoretic trace of serum proteins obtained by capillary electrophoresis as uninterpretable. METHODS: Electrophoresis of serum proteins and immunotyping immunoassay were performed on Capillary 2 Flex Piercing® Sebia. RESULTS: A 72-year-old male patient was hospitalized in the clinical hematology department for deep lymphadenopathies with hepatocellular failure...
January 1, 2019: Clinical Laboratory
Katherine Ann Devitt, Juli-Anne Gardner
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma with an estimated incidence of less than one per million. Unlike other hematopoietic malignancies, lymphadenopathy and hepatosplenomegaly are uncommon, and patients typically present with nonspecific symptoms. IVLBCL presents a diagnostic challenge and patients are usually diagnosed late in the disease course, if at all, and the prognosis is poor. The differential diagnosis is broad, and physicians often pursue multiple diagnostic possibilities during patient workup...
October 2018: Autopsy & Case Reports
Zeki Islamoğlu, Ali Erkan Duman, Göktuğ Sirin, Hasan Yılmaz, Meral Uluköylü Mengüç, Yiğit Erçetin, Süheyla Bozkurt, Sadettin Hülagü, Altay Çelebi
TAFRO syndrome is a rare subtype of the Castleman's disease which has been described over the last years. The name of TAFRO syndrome comes from thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. We report a young Turkish male patient presented with fever, night sweats, fatigue, nausea, bilateral pretibial pitting edema, abdominal pain and watery diarrhea. PET/CT revealed multiple lymphadenopathies in cervical, axillary, mediastinal, paraaortic, mesenteric and inguinal lymph nodes...
October 1, 2018: International Journal of Hematology-oncology and Stem Cell Research
Fikri Selcuk Simsek, Saadet Akarsu, Yavuz Narin
One of the most important benign tumors in neurofibromatosis type 1 (NF1) is plexiform neurofibroma, and there is a risk of developing malignant peripheral nerve sheath tumor (MPNST) throughout life approximately 10%. However lesion characterization by anatomical imaging methods are not possible. Because of that most of cases goes to biopsy. Using of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) for lesion characterization can be helpful in NF1 patients. We aimed to present an example of the efficacy of FDG-PET/CT in distinguishing benign neurofibroma from MPNST...
January 2019: World Journal of Nuclear Medicine
Y Zhang, J X Zhang, J Shi, Y Yu, Z F Yuan, G Z Lu, Y Gao, Y M Gao, X H Guo
OBJECTIVE: To discuss the clinical characteristics and diagnostic and therapeutic considerations of primary thyroid lymphoma (PTL) by reviewing PTL cases. METHODS: In the study, 12 cases of PTL diagnosed and treated in Peking University First Hospital between January 1995 and September 2015 were identified. The clinical characteristics, management experiences and prognosis of these cases were reviewed retrospectively. RESULTS: A total of 12 PTL patients (four males and eight females) were collected, with an average age of 63 years (42 to 81 years) at the time of diagnosis...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
G Y Yu, X Hong, W Li, Y Y Zhang, Y Gao, Y Chen, Z Y Zhang, X Y Xie, Z G Li, Y Y Liu, J Z Su, W X Zhu, Z P Sun
Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. The comorbid diseases of head and neck region including rhinosinusitis, allergic rhinitis, and lymphadenopathy were commonly seen, which could occur more early than enlargement of major salivary glands...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Takamasa Ishii, Yosuke Sasaki, Tadashi Maeda, Fumiya Komatsu, Takeshi Suzuki, Yoshihisa Urita
INTRODUCTION: Infectious mononucleosis (IM) is a common viral infection that typically causes fever, pharyngitis, and lymphadenopathy in young patients. The Epstein-Barr virus (EBV) is the most common cause of IM, followed by cytomegalovirus (CMV). Given that serological testing is associated with limitations regarding its accuracy, availability, and time to receive results, clinical differentiation based on symptoms, signs, and basic tests would be useful. We evaluated whether clinical findings could be used to differentiate EBV-IM from CMV-IM...
February 15, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Deepesh Lad, Qing Huang, Romy Hoeppli, Rosa Garcia, Lixin Xu, Megan Levings, Kevin Song, Raewyn Broady
The role of regulatory T-cells (Treg) and Th17 cells in the progression of multiple myeloma has been unclear. There are conflicting reports of the Treg and Th17 frequency being increased, decreased, and unchanged as compared with controls. In this study, we sought to characterize the T-cell subsets including Treg function in both blood and marrow compartments of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). The Treg/Th17 ratio is skewed toward the suppressive phenotype in MGUS and MM...
February 18, 2019: Leukemia & Lymphoma
Suheil Albert Atallah-Yunes, Jackson Clark, Shazia Samanani, Myat Soe
BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Although pituitary gland metastasis is rare, it is underestimated, as it is commonly misdiagnosed with pituitary gland adenoma due to the lack of clear radiological criteria differentiating between both...
February 17, 2019: American Journal of Case Reports
Hiroshi Okamoto, Yasuyuki Fujimoto
Left sinus of Valsalva aneurysm(SVAn)is a very rare clinical entity. We present a 68-year-old female with left SVAn, 5 cm in diameter, compressing the left main coronary artery and causing antero-septal asynergy. She also had massive pericardial effusion, moderate to severe(grade Ⅲ)aortic regurgitation, and mitral regurgitation. One month after pericardial drainage, the patient successfully underwent composite graft replacement of the aortic root, reimplantation of the right coronary artery and suture closure of thin friable left main trunk(LMT)orifice, as well as double coronary artery bypass grafting with bilateral internal mammary arteries to the left anterior descending artery and the diagonal branch...
February 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
John M Aalen, Espen W Remme, Camilla K Larsen, Oyvind S Andersen, Magnus Krogh, Jürgen Duchenne, Einar Hopp, Stian Ross, Ahmed S Beela, Erik Kongsgaard, Jacob Bergsland, Hans H Odland, Helge Skulstad, Anders Opdahl, Jens-Uwe Voigt, Otto A Smiseth
OBJECTIVES: This study sought to investigate how regional left ventricular (LV) function modifies septal motion in left bundle branch block (LBBB). BACKGROUND: In LBBB, the interventricular septum often has marked pre-ejection shortening, followed by immediate relengthening (rebound stretch). This motion, often referred to as septal flash, is associated with positive response to cardiac resynchronization therapy (CRT). METHODS: In 10 anesthetized dogs, we induced LBBB by radiofrequency ablation and occluded the circumflex (CX) (n = 10) and left anterior descending (LAD) (n = 6) coronary arteries, respectively...
February 11, 2019: JACC. Cardiovascular Imaging
Dan He, Zhenhua Wu, Jiayong He, Yang Wang, Zulei Li, Shugeng Gao
OBJECTIVE: This study aimed to investigate the biological role of C5orf34 in Lung adenocarcinoma (LAD) and the mechanism of such role. METHODS: The mRNA expression of C5orf34 was analyzed using student's t-test based on the data obtained from TCGA database. Kaplan-Meier analysis was performed to evaluate the prognosis value of C5orf34. Chi-square (χ2 ) test was performed to analyze the correlation between C5orf34 expression and clinical features. The effect of C5orf34 siRNA on A549 and SPCA1 cells proliferation and migration were explored using CCK8 assay, wound healing assay and transwell assays, respectively...
February 13, 2019: Gene
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