Zahra Saadatian, Ziba Nariman-Saleh-Fam, Milad Bastami, Yasser Mansoori, Isa Khaheshi, Saeed Alipour Parsa, Abdolreza Daraei, Sepideh Zununi Vahed, Bahman Yousefi, Hossein Samadi Kafil, Shirin Eyvazi, Sayyed Mohammad Hossein Ghaderian, Mir Davood Omrani
Coronary artery disease (CAD) is a multicellular disease characterized by chronic inflammation. Peripheral blood-mononuclear cells (PBMCs), as a critical component of immune system, actively cross-talk with pathophysiological conditions induced by endothelial cell injury, reflecting in perturbed PBMC expression. STAT1 is believed to be relevant to CAD pathogenesis through regulating key inflammatory processes and modulating STAT1 expression play key roles in fine-tuning CAD-related inflammatory processes. This study evaluated PBMC expressions of STAT1, and its regulators (miR-150 and miR-223) in a cohort including 72 patients with CAD with significant ( ≥ 50%) stenosis, 30 patients with insignificant ( < 50%) coronary stenosis (ICAD), and 74 healthy controls, and assessed potential of PBMC expressions to discriminate between patients and controls...
December 2019: Journal of Cellular Biochemistry