keyword
https://read.qxmd.com/read/38531261/developmental-programming-of-the-ovarian-reserve-in-livestock
#21
JOURNAL ARTICLE
Robert A Cushman, Vahid Akbarinejad, George A Perry, Clay A Lents
Mammalian females are born with a finite number of follicles in their ovaries that is referred to as the ovarian reserve. There is a large amount of variation between females in the number of antral follicles that they are born with, but this number is positively correlated to size of the ovarian reserve, has a strong repeatability within a female, and a moderate heritability. Although the heritability is moderate, numerous external factors including health, nutrition, ambient temperature, and litter size influence the size and function of the ovarian reserve throughout life...
March 19, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38530347/-chelatococcus-albus-sp-nov-a-bacterium-isolated-from-hot-spring-microbial-mat
#22
JOURNAL ARTICLE
Yi-Qing Lv, Chao-Jian Hu, Wen-Dong Xian, Meng-Meng Li, Lan Liu, Ze-Tao Liu, Sha Tan, Wei-Qiu Liu, Jian-Yu Jiao, Wen-Jun Li
A Gram-stain-negative, non-endospore-forming, motile, short rod-shaped strain, designated SYSU G07232T , was isolated from a hot spring microbial mat, sampled from Rehai National Park, Tengchong, Yunnan Province, south-western China. Strain SYSU G07232T grew at 25-50 °C (optimum, 37 °C), at pH 5.5-9.0 (optimum, pH 6.0) and tolerated NaCl concentrations up to 1.0 % (w/v). Phylogenetic analysis based on the 16S rRNA gene sequences revealed that strain SYSU G07232T showed closest genetic affinity with Chelatococcus daeguensis K106T ...
March 2024: International Journal of Systematic and Evolutionary Microbiology
https://read.qxmd.com/read/38530033/altered-pbp4-and-gdpp-functions-synergistically-mediate-mrsa-like-high-level-broad-spectrum-%C3%AE-lactam-resistance-in-staphylococcus-aureus
#23
JOURNAL ARTICLE
Li-Yin Lai, Nidhi Satishkumar, Sasha Cardozo, Vijay Hemmadi, Leonor B Marques, Liusheng Huang, Sergio R Filipe, Mariana G Pinho, Henry F Chambers, Som S Chatterjee
UNLABELLED: Infections caused by Staphylococcus aureus are a leading cause of mortality worldwide. S. aureus infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are particularly difficult to treat due to their resistance to next-generation β-lactams (NGBs) such as methicillin, nafcillin, and oxacillin. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance, is classically mediated by PBP2a, a penicillin-binding protein encoded by mecA (or mecC ) in MRSA...
March 26, 2024: MBio
https://read.qxmd.com/read/38530023/a-case-of-mild-partial-androgen-insensitivity-syndrome-in-a-juvenile-boy
#24
JOURNAL ARTICLE
Fen Wang, Shiying Shao, Wentao He, Shuhong Hu
Androgen insensitivity syndrome (AIS) is a rare disorder with X-linked recessive inheritance in 46 XY patients. The clinical manifestations vary between patients, especially regarding external genitalia development. Herein, the case of AIS in a 13-year-old male, who was born with hypospadias and presented to the hospital with gynaecomastia that had developed from 8 years of age, is reported. No micropenis, cryptorchidism or bifid scrotum were found. Testis volume was 12 ml on both sides. His testosterone and luteinizing hormone levels were normal compared with sex- and age-adjusted reference range...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38529929/auto-phylo-v2-and-auto-phylo-pipeliner-building-advanced-flexible-and-reusable-pipelines-for-phylogenetic-inferences-estimation-of-variability-levels-and-identification-of-positively-selected-amino-acid-sites
#25
JOURNAL ARTICLE
Hugo López-Fernández, Miguel Pinto, Cristina P Vieira, Pedro Duque, Miguel Reboiro-Jato, Jorge Vieira
The vast amount of genome sequence data that is available, and that is predicted to drastically increase in the near future, can only be efficiently dealt with by building automated pipelines. Indeed, the Earth Biogenome Project will produce high-quality reference genome sequences for all 1.8 million named living eukaryote species, providing unprecedented insight into the evolution of genes and gene families, and thus on biological issues. Here, new modules for gene annotation, further BLAST search algorithms, further multiple sequence alignment methods, the adding of reference sequences, further tree rooting methods, the estimation of rates of synonymous and nonsynonymous substitutions, and the identification of positively selected amino acid sites, have been added to auto-phylo (version 2), a recently developed software to address biological problems using phylogenetic inferences...
March 27, 2024: Journal of Integrative Bioinformatics
https://read.qxmd.com/read/38529502/geny-a-genotyping-tool-for-allelic-decomposition-of-killer-cell-immunoglobulin-like-receptor-genes
#26
Qinghui Zhou, Mazyar Ghezelji, Ananth Hari, Michael K B Ford, Connor Holley, Lisa Mirabello, Stephen Chanock, S Cenk Sahinalp, Ibrahim Numanagić
Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the currently available genotyping methods are unable to accurately infer copy numbers, genotypes and haplotypes of individual KIR genes from next-generation sequencing data...
March 3, 2024: bioRxiv
https://read.qxmd.com/read/38529348/copd-systemic-proteomic-profiles-in-frequent-and-infrequent-exacerbators
#27
JOURNAL ARTICLE
Cesar Jessé Enríquez-Rodríguez, Carme Casadevall, Rosa Faner, Ady Castro-Costa, Sergi Pascual-Guàrdia, Luis Seijó, José Luis López-Campos, Germán Peces-Barba, Eduard Monsó, Esther Barreiro, Borja G Cosío, Alvar Agustí, Joaquim Gea
BACKGROUND: Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contrast the systemic proteomic profile in FE versus NFE. As a reference, we also determined the systemic proteomic profile of healthy controls (HC) and COPD patients during an actual episode of exacerbation (AE). METHODS: In the analysis we included 40 clinically stable COPD patients (20 FE and 20 NFE), and 20 HC and 10 AE patients...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38529304/association-of-single-nucleotide-polymorphisms-in-itln1-gene-with-ischemic-stroke-risk-in-xi-an-population-shaanxi-province
#28
JOURNAL ARTICLE
Wenzhen Shi, Qi Zhang, Ying Lu, Jie Liu, Xiaojuan Ma, Zhen Xie, Gejuan Zhang, Mingze Chang, Ye Tian
BACKGROUND: Ischemic stroke (IS) is the main cause of death and adult disability. However, the pathogenesis of this complicated disease is unknown. The present study aimed to assess the relationship between ITLN1 single nucleotide polymorphisms (SNPs) and the susceptibility to IS in Xi'an population, Shaanxi province. METHODS: In this study, we designed polymerase chain reaction (PCR) primers located at -3,308 bp upstream of the transcription initiation site within promoter region of the ITLN1 gene...
2024: PeerJ
https://read.qxmd.com/read/38529185/development-and-validation-of-a-pharmacogenomics-reporting-workflow-based-on-the-illumina-global-screening-array-chip
#29
JOURNAL ARTICLE
Pamela Gan, Muhammad Irfan Bin Hajis, Mazaya Yumna, Jessline Haruman, Husnul Khotimah Matoha, Dian Tri Wahyudi, Santha Silalahi, Dwi Rizky Oktariani, Fitria Dela, Tazkia Annisa, Tessalonika Damaris Ayu Pitaloka, Priscilla Klaresza Adhiwijaya, Rizqi Yanuar Pauzi, Robby Hertanto, Meutia Ayuputeri Kumaheri, Levana Sani, Astrid Irwanto, Ariel Pradipta, Kamonlawan Chomchopbun, Mar Gonzalez-Porta
Background: Microarrays are a well-established and widely adopted technology capable of interrogating hundreds of thousands of loci across the human genome. Combined with imputation to cover common variants not included in the chip design, they offer a cost-effective solution for large-scale genetic studies. Beyond research applications, this technology can be applied for testing pharmacogenomics, nutrigenetics, and complex disease risk prediction. However, establishing clinical reporting workflows requires a thorough evaluation of the assay's performance, which is achieved through validation studies...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38528365/methylation-of-microrna-genes-and-its-effect-on-secondary-xylem-development-of-stem-in-poplar
#30
JOURNAL ARTICLE
Ruiqi Wang, Meixuan Wu, Xiao Zhang, Tingbo Jiang, Zhigang Wei
MicroRNAs (miRNAs) and DNA methylation are both vital regulators of gene expression. DNA methylation can affect the transcription of miRNAs, just like coding genes, through methylating the CpG islands in the gene regions of miRNAs. Although previous studies have shown that DNA methylation and miRNAs can each be involved in the process of wood formation, the relationship between the two has been relatively little studied in plant wood formation. Studies have shown that the second internode (IN2) (from top to bottom) of 3-month-old poplar trees can represent the primary stage of poplar stem development and IN8 can represent the secondary stage...
March 25, 2024: Plant Genome
https://read.qxmd.com/read/38528337/utilizing-pharmacogenomics-results-to-guide-antidepressant-selection-a-case-report
#31
JOURNAL ARTICLE
Nicholas Vernacchia, Nicole Del Toro-Pagán, Chandni Bardolia, Nishita Shah Amin
The case discussion demonstrates the benefit of using Pharmacogenomic (PGx) results to aid in the selection of antidepressant therapy and improve response to treatment. Nearly half of patients diagnosed with major depressive disorder fail initial therapy and may require multiple trials of antidepressants. Genetic variation in several metabolic enzymes contribute to the variable response to antidepressant therapy. PGx testing provides an opportunity to inform antidepressant selection and optimize therapeutic outcomes, while minimizing risk of adverse events...
April 1, 2024: Senior Care Pharmacist
https://read.qxmd.com/read/38528286/exploring-epigenetic-and-genetic-modulation-in-animal-responses-to-thermal-stress
#32
REVIEW
Wang Jianfang, Sayed Haidar Abbas Raza, Sameer D Pant, Zhao Juan, Ajit Prakash, Sameh A Abdelnour, Bandar Hamad Aloufi, Zeinab M H Mahasneh, Ahmed A Amin, Borhan Shokrollahi, Linsen Zan
There is increasing evidence indicating that global temperatures are rising significantly, a phenomenon commonly referred to as 'global warming', which in turn is believed to be causing drastic changes to the global climate. Global warming (GW) directly impacts animal health, reproduction, production, and welfare, presenting several challenges to livestock enterprises. Thermal stress (TS) is one of the key consequences of GW, and all animal species, including livestock, have diverse physiological, epigenetic and genetic mechanisms to respond to TS...
March 25, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38528062/extend-the-benchmarking-indel-set-by-manual-review-using-the-individual-cell-line-sequencing-data-from-the-sequencing-quality-control-2-seqc2-project
#33
JOURNAL ARTICLE
Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi, Zehui Cao, Mingyang Chen, Ning Chen, Qiaochu Chen, Qingwang Chen, Jiacheng Dai, Qiang Gan, Yuechen Gao, Mingkun Guo, Gunjan Hariani, Yujie He, Wanwan Hou, He Jiang, Garima Kushwaha, Jian-Liang Li, Jianying Li, Yulan Li, Liang-Chun Liu, Ruimei Liu, Shiming Liu, Edwin Meriaux, Mengqing Mo, Mathew Moore, Tyler J Moss, Quanne Niu, Ananddeep Patel, Luyao Ren, Nedda F Saremi, Erfei Shang, Jun Shang, Ping Song, Siqi Sun, Brent J Urban, Danke Wang, Shangzi Wang, Zhining Wen, Xiangyi Xiong, Jingcheng Yang, Lihui Yin, Chao Zhang, Ruolan Zhang, Ambica Bhandari, Wanshi Cai, Agda Karina Eterovic, Dalila B Megherbi, Tieliu Shi, Chen Suo, Ying Yu, Yuanting Zheng, Natalia Novoradovskaya, Renee L Sears, Leming Shi, Wendell Jones, Weida Tong, Joshua Xu
Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527945/a-comparative-assessment-of-reference-genes-in-mouse-brown-adipocyte-differentiation-and-thermogenesis-in-vitro
#34
JOURNAL ARTICLE
Trang Huyen Lai, Jin Seok Hwang, Quang Nhat Ngo, Dong-Kun Lee, Hyun Joon Kim, Deok Ryong Kim
Adipogenic differentiation and thermogenesis in brown adipose tissue (BAT) undergo dynamic processes, altering phenotypes and gene expressions. Proper reference genes in gene expression analysis are crucial to mitigate experimental variances and ensure PCR efficacy. Unreliable reference genes can lead to erroneous gene expression quantification, resulting in data misinterpretation. This study focused on identifying suitable reference genes for mouse brown adipocyte research, utilizing brown adipocytes from the Ucp1-luciferase ThermoMouse model...
December 2024: Adipocyte
https://read.qxmd.com/read/38527506/-clinical-and-genetic-characteristics-of-21-children-with-rubinstein-taybi-syndrome
#35
JOURNAL ARTICLE
S H Yang, H R Liu, J Y Li, Y Zhang, Z Q Liu, L Wang, X L Chen, S F Shangguan
Objective: To investigate the phenotypes of Rubinstein-Taybi syndrome (RSTS) caused by variants in the CREBBP or EP300 gene, and the correlation between genotype and phenotype. Methods: This case series study was performed on pediatric patients who were referred to the Children's Hospital of Capital Institute of Pediatrics between January 2013 and July 2022. Both point variant and copy number deletion in CREBBP or EP300 gene were detected by whole exome sequencing, chromosomal microarray analysis, or copy number variation sequencing (CNV-seq)...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38527422/pax1-and-sox1-gene-methylation-as-a-detection-and-triage-method-for-cervical-intraepithelial-neoplasia-diagnosis
#36
JOURNAL ARTICLE
Yan Gao, Dan Zi, Wentong Liang, Fang Qiu, Jie Zheng, Xuelian Xiao, Engli Jiang, Yuwei Xu
INTRODUCTION: Methylation assays have demonstrated potential as dependable and high-precision approaches for identifying or triaging individuals with cervical cancer (CA) or cervical intraepithelial neoplasia (CIN). Our investigation aimed to assess the efficacy of diagnosis and triage of the PAX1/SOX1 methylation panel in detecting CIN or CA. METHODS: A total of 461 patients with abnormal high-risk human papillomavirus (hrHPV) or cytology test results were recruited for this study...
March 25, 2024: Acta Cytologica
https://read.qxmd.com/read/38526778/donkey-like-kirkovirus-is-associated-with-diarrhea-in-piglets
#37
JOURNAL ARTICLE
Panpan Tong, Zunbao Wang, Yueyi Dang, Lei Zhang, Guangwei Song, Xiaozhen Song, Juanjuan Pan, Ling Kuang, Junhui Li, Gang Lu, Jinxin Xie
Kirkovirus (kirV), a seemingly novel virus family, has been found in horses and donkeys. The study's objectives are to investigate the presence of the virus in swine. In this study, donkey-like kirV was detected in rectal swabs of piglets with diarrhea, and the positive rate was found to be 100% (149/149). However, this virus was detected in only one of 261 clinically healthy piglets, which suggested a strong relationship between the kirV and the diarrheic disease. We obtained the whole-genome sequences of three kirVs (Cj-D5, Cj-D32, and Cj-D43), with a length of 3750 nucleotides (nt) and sharing 99...
March 25, 2024: Virus Genes
https://read.qxmd.com/read/38526344/a-genome-sequence-for-the-threatened-whitebark-pine
#38
JOURNAL ARTICLE
David B Neale, Aleksey V Zimin, Amy Meltzer, Akriti Bhattarai, Maurice Amee, Laura Figueroa Corona, Brian J Allen, Daniela Puiu, Jessica Wright, Amanda R De La Torre, Patrick E McGuire, Winston Timp, Steven L Salzberg, Jill L Wegrzyn
Whitebark pine (WBP, Pinus albicaulis) is a white pine of subalpine regions in western contiguous US and Canada. WBP has become critically threatened throughout a significant part of its natural range due to mortality from the introduced fungal pathogen white pine blister rust (WPBR, Cronartium ribicola) and additional threats from mountain pine beetle (Dendroctonus ponderosae), wildfire, and maladaptation due to changing climate. Vast acreages of WBP have suffered nearly complete mortality. Genomic technologies can contribute to a faster, more cost-effective approach to the traditional practices of identifying disease-resistant, climate-adapted seed sources for restoration...
March 25, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38525388/ctns-mutations-causing-autosomal-recessive-cystinosis-in-a-subset-of-iranian-population-report-of-two-new-variants
#39
JOURNAL ARTICLE
Zahra Mohammadi Chermahini, Mansoor Salehi, Alaleh Gheissari, Faeze Ahmadi Beni, Farinaz Khosravian, Mohammad Kazemi
BACKGROUND: Nephropathic cystinosis (NC) is an uncommon autosomal recessive disease with abnormality in lysosomal storage that appearances in patients with mutations in the CTNS gene encoding a lysosomal transporter cystinosin. Disrupted function of this transporter is followed by accumulation of cysteine crystals in cells of many various organs. This study aimed to investigate the mutations of the CTNS gene in 20 Iranian patients suffering from NC. MATERIALS AND METHODS: Twenty Iranian cystinosis patients referring to Imam Hossein Hospital of Isfahan were employed in this case-series study...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38525148/a-chromosome-level-genome-assembly-of-solanum-chilense-a-tomato-wild-relative-associated-with-resistance-to-salinity-and-drought
#40
JOURNAL ARTICLE
Corentin Molitor, Tomasz J Kurowski, Pedro M Fidalgo de Almeida, Zoltan Kevei, Daniel J Spindlow, Steffimol R Chacko Kaitholil, Justice U Iheanyichi, H C Prasanna, Andrew J Thompson, Fady R Mohareb
INTRODUCTION: Solanum chilense is a wild relative of tomato reported to exhibit resistance to biotic and abiotic stresses. There is potential to improve tomato cultivars via breeding with wild relatives, a process greatly accelerated by suitable genomic and genetic resources. METHODS: In this study we generated a high-quality, chromosome-level, de novo assembly for the S. chilense accession LA1972 using a hybrid assembly strategy with ~180 Gbp of Illumina short reads and ~50 Gbp long PacBio reads...
2024: Frontiers in Plant Science
keyword
keyword
109419
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.