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JOURNAL ARTICLE
Ferdinamarie S Philomenadin, Mini P Singh, Jayanthi Shastri, Anil C Phukan, Muruganandam Nagarajan, Subashini Kaliaperumal, Radha Kanta Ratho, Jagat Ram, Madhav J Sathe, Avinash Ingole, Darshana B Rathod, Benjamin Nongrum, Rehnuma Parvez, Vineeta Malik, Rahul Dhodapkar
INTRODUCTION: Human mastadenovirus (HAdV) types 8, 37, 64 have been considered the major contributors in Epidemic keratoconjunctivitis (EKC) epidemics, but recent surveillance data have shown the involvement of emerging recombinants, including HAdV-53, HAdV-54, and HAdV-56. In our initial work, positive samples for adenovirus revealed that our strains were closer to HAdV-54 than HAdV-8. Hence, the current study aimed to use whole genome technology to identify the HAdV strain correctly...
March 31, 2024: Journal of Infection in Developing Countries
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JOURNAL ARTICLE
Ayaka Ishida, Yasuhiro Inokuchi, Makoto Hirata, Hiroto Narimatsu, Emi Yoshioka, Kota Washimi, Nozomu Machida, Shin Maeda
A 35-year-old woman of Asian descent with epigastralgia was referred to our hospital. Esophagogastroduodenoscopy revealed gastric cancer in the upper body and carpeting fundic gland polyposis in the fornix and body. Computed tomography revealed no metastases. Total colonoscopy and capsule endoscopy revealed no polyposis, except in the stomach. The patient was diagnosed with advanced gastric cancer and underwent open total gastrectomy. We speculated that her gastric cancer was a hereditary tumor due to its early onset and accompanying fundic gland polyposis...
April 18, 2024: Clinical Journal of Gastroenterology
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JOURNAL ARTICLE
J Sebastian Garcia-Medina, Karolina Sienkiewicz, S Anand Narayanan, Eliah G Overbey, Kirill Grigorev, Krista A Ryon, Marissa Burke, Jacqueline Proszynski, Braden Tierney, Caleb M Schmidt, Nuria Mencia-Trinchant, Remi Klotz, Veronica Ortiz, Jonathan Foox, Christopher Chin, Deena Najjar, Irina Matei, Irenaeus Chan, Carlos Cruchaga, Ashley Kleinman, JangKeun Kim, Alexander Lucaci, Conor Loy, Omary Mzava, Iwijn De Vlaminck, Anvita Singaraju, Lynn E Taylor, Julian C Schmidt, Michael A Schmidt, Kelly Blease, Juan Moreno, Andrew Boddicker, Junhua Zhao, Bryan Lajoie, Andrew Altomare, Semyon Kruglyak, Shawn Levy, Min Yu, Duane C Hassane, Susan M Bailey, Kelly Bolton, Jaime Mateus, Christopher E Mason
BACKGROUND: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. METHODS: To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction...
March 2024: Precision Clinical Medicine
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Kamil A Braima, Kim A Piera, Inke Nd Lubis, Rintis Noviyanti, Giri S Rajahram, Pinkan Kariodimedjo, Irbah Ra Nainggolan, Ranti Permatasari, Leily Trianty, Ristya Amalia, Sitti Saimah Binti Sakam, Angelica F Tan, Timothy William, Jacob Af Westaway, PingChin Lee, Sylvia Daim, Henry Surendra, Nathaniel Christy, Andrew G Letizia, Christopher L Peatey, Mohd Arshil Moideen, Bridget E Barber, Colin J Sutherland, Nicholas M Anstey, Matthew J Grigg
BACKGROUND: Zoonotic P. knowlesi and P. cynomolgi symptomatic and asymptomatic infections occur across endemic areas of Southeast Asia. Most infections are low-parasitemia, with an unknown proportion below routine microscopy detection thresholds. Molecular surveillance tools optimizing the limit of detection (LOD) would allow more accurate estimates of zoonotic malaria prevalence. METHODS: An established ultra-sensitive Plasmodium genus quantitative-PCR (qPCR) assay targeting the 18S rRNA gene underwent LOD evaluation with and without reverse transcription (RT) for P...
April 6, 2024: medRxiv
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JOURNAL ARTICLE
Erika Bastos Lima Freire, Catarina Brasil d'Alva, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, Leonardo Barreira Portella, Renan Galvão Ozório, Clarisse Mourão Melo Ponte, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro Junior
INTRODUCTION: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease caused by mutations in genes responsible for the formation and development of adipocytes. Bone abnormalities are described. However, there is a scarcity of data. OBJECTIVE: To describe bone characteristics in a large CGL1 and 2 case series. METHODS: Cross-sectional study that assessed bone radiological features of CGL patients of a reference hospital in Fortaleza (CE), Brazil...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
An Nguyen-Hoang, Felix L Sandell, Heinz Himmelbauer, Juliane C Dohm
Spinach ( Spinacia oleracea ) is an important leafy crop possessing notable economic value and health benefits. Current genomic resources include reference genomes and genome-wide association studies. However, the worldwide genetic relationships and the migration history of the crop remained uncertain, and genome-wide association studies have produced extensive gene lists related to agronomic traits. Here, we re-analysed the sequenced genomes of 305 cultivated and wild spinach accessions to unveil the phylogeny and history of cultivated spinach and to explore genetic variation in relation to phenotypes...
June 2024: NAR genomics and bioinformatics
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JOURNAL ARTICLE
Weilong Gao, Jiangbo Nie, Jia Yao, Jianxin Wang, Shengshu Wang, Xueli Zhang, Yonghong Liu, Yulin Liu
UNLABELLED: The Cellulose Synthase gene ( CS ) superfamily and COBRA-like ( COBL ) gene family are essential for synthesizing cellulose and hemicellulose, which play a crucial role in cell wall biosynthesis and the hardening of plant tissues. Our study identified 126 ZbCS and 31 ZbCOBL genes from the Zanthoxylum bungeanum ( Zb ) genome. Phylogenetic analysis and conservative domain analysis unfolded that ZbCS and ZbCOBL genes were divided into seven and two subfamilies, respectively. Gene duplication data suggested that more than 75% of these genes had tandem and fragment duplications...
March 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
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JOURNAL ARTICLE
Ahmed A H Ali, Fatma Abdallah, Omayma A Shemies, Gamilat Kotb, Maged R Nafea
BACKGROUND: Equine herpesvirus type 1 (EHV-1) is a major cause of abortion and respiratory disease. Equine herpesvirus type 4 (EHV-4), on the other hand, is exclusively associated with respiratory disease in horse populations worldwide, particularly in Egypt and Arabian countries. AIM: This study aims to investigate the circulation of EHV-1 and EHV-4 in the Arabian horse population through molecular detection and genetic characterization of EHV-1 and/or EHV-4 that may threaten the stability of horse industry...
January 2024: Open Veterinary Journal
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JOURNAL ARTICLE
Ahmed S Atwa, Lamis Gomaa, Wael Elmenofy, Haitham M Amer, Basem M Ahmed
BACKGROUND: Equine influenza (EI) is a transmissible viral respiratory sickness of the Equidae family. Two viruses, H7N7 and H3N8 caused EI; however, H7N7 has not been detected for decades. H3N8 has circulated and bifurcated into Eurasian and American lineages. The latter subsequently diversified into Kentucky, South America, and Florida sub-lineages. Florida clade 1 (FC1) and Florida clade 2 (FC2) strains are the only circulating EI viruses (EIVs) in the meantime. Immunization is considered the major means for the prevention and control of EI infection...
January 2024: Open Veterinary Journal
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JOURNAL ARTICLE
Rowyda Mohamed Yousry Elshazely, Ibrahim H Amer, Salah F A Abd-El Aal, Salah F A Abd-El Aal, Asmaa B M B Tahoun
BACKGROUND: Pseudomonas aeruginosa ( P. aeruginosa ) and Staphylococcus aureus ( S. aureus ) are well defined as food poisoning pathogens that are highly resistant and need continuous studies. AIM: The purpose of the work was to examine phenotypic and genotypic characteristics of both P. aeruginosa and S. aureus , and treatment trials with medicinal plants. METHODS: Samples were examined for isolation of P. aeruginosa and S. aureus on selective media followed by biochemical confirmation, biofilm formation, genes detection , and expression of P...
January 2024: Open Veterinary Journal
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JOURNAL ARTICLE
Susan L McEvoy, Patrick G S Grady, Nicole Pauloski, Rachel J O'Neill, Jill L Wegrzyn
DNA methylation is critical to the regulation of transposable elements and gene expression and can play an important role in the adaptation of stress response mechanisms in plants. Traditional methods of methylation quantification rely on bisulfite conversion that can compromise accuracy. Recent advances in long-read sequencing technologies allow for methylation detection in real time. The associated algorithms that interpret these modifications have evolved from strictly statistical approaches to Hidden Markov Models and, recently, deep learning approaches...
April 2024: Evolutionary Applications
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JOURNAL ARTICLE
Yilin Mao, Liang Wang, Zhengyi Xu, Wenjia Xie, Yuting Wang, Wei Qiao, Zhou Zhu, Jian Wang
In recent years, nanomaterials have gained widespread use in the biomedical field, with ZIF-8 and ZnO emerging as promising candidates due to their remarkable performance in osteogenesis, angiogenesis, and antimicrobial therapy. However, before advancing these nanomaterials for clinical applications, it is imperative to evaluate their biocompatibility. In particular, comparing nanomaterials with similar biomedical functions is crucial for identifying the most suitable nanomaterials for further development and market entry...
April 17, 2024: ACS Biomaterials Science & Engineering
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JOURNAL ARTICLE
Sasibha Jantrakajorn, Watcharapol Suyapoh, Janenuj Wongtavatchai
OBJECTIVE: Acute mortality with clinical symptoms of streptococcal-like infections was observed in red tilapia Oreochromis sp. cultured in floating cages in Prachin Buri Province, Thailand, during May 2023. Herein, we identified an emerging pathogen, Lactococcus garvieae, as the etiological agent. METHODS: After bacterial isolation from the brain and kidney of diseased fish, identification was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and the VITEK 2 system...
April 17, 2024: Journal of Aquatic Animal Health
#14
JOURNAL ARTICLE
Xiao Song, Jiajing Li, Yaoguang Chang, Xuanwei Mei, Jiayi Luan, Xiaoxiao Jiang, Changhu Xue
In recent years, the wide application of mannan has driven the demand for the exploration of mannanase. As one of the main components of hemicellulose, mannan is an important polysaccharide that ruminants need to degrade and utilize, making rumen a rich source of mannanases. In this study, gene mining of mannanases was performed using bioinformatics, and potential dual-catalytic domain mannanases were heterologously expressed to analyze their properties. The hydrolysis pattern and enzymatic products were identified by liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS)...
April 17, 2024: Journal of Agricultural and Food Chemistry
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JOURNAL ARTICLE
Bacha Mekonen, Sisay Dugassa, Sindew Mekasha Feleke, Boja Dufera, Bedasa Gidisa, Aderaw Adamu, Aynalem Mandefro, Geremew Tasew, Lemu Golassa
BACKGROUND: Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasmodium falciparum infection. However, the evolution and spread of P. falciparum parasite strains with deleted hrp2/3 genes, causing false-negative results, have been reported. This study assessed the diagnostic performance of HRP2-detecting RDTs for P. falciparum cases and the prevalence of pfhrp2/3 deletions among symptomatic patients seeking malaria diagnosis at selected health facilities in southern Ethiopia...
April 17, 2024: Malaria Journal
#16
JOURNAL ARTICLE
Dustin Baldridge, Levi Kaster, Catherine Sancimino, Siddharth Srivastava, Sophie Molholm, Aditi Gupta, Inez Oh, Virginia Lanzotti, Daleep Grewal, Erin Rooney Riggs, Juliann M Savatt, Rachel Hauck, Abigail Sveden, John N Constantino, Joseph Piven, Christina A Gurnett, Maya Chopra, Heather Hazlett, Philip R O Payne
Monogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes...
April 17, 2024: Journal of Neurodevelopmental Disorders
#17
JOURNAL ARTICLE
Nasim Bashour, Arash Aminpour, Shabnam Vazifehkhah, Rasool Jafari
Toxoplasmosis is a frequent infection among the human population. The infection can cause devastating complications for the fetus during pregnancy. The present study aimed to determine the serological and molecular prevalence of the infection and molecular characterization of Toxoplasma gondii isolates among pregnant women referred to Kowsar Hospital, Urmia, Iran. In a cross-sectional study, 340 blood samples were collected from pregnant women referred to Kowsar Hospital, Urmia, Iran from May to July 2022. Anti-T...
April 17, 2024: BMC Infectious Diseases
#18
JOURNAL ARTICLE
Dan Zuo, Shaolin Lei, Fang Qian, Lei Gu, Hongcheng Wang, Xuye Du, Tuo Zeng, Bin Zhu
BACKGROUND: Calcium-dependent protein kinases (CPKs) are crucial for recognizing and transmitting Ca2+ signals in plant cells, playing a vital role in growth, development, and stress response. This study aimed to identify and detect the potential roles of the CPK gene family in the amphidiploid Brassica carinata (BBCC, 2n = 34) using bioinformatics methods. RESULTS: Based on the published genomic information of B. carinata, a total of 123 CPK genes were identified, comprising 70 CPK genes on the B subgenome and 53 on the C subgenome...
April 17, 2024: BMC Plant Biology
#19
JOURNAL ARTICLE
Jiaolei Shangguan, Jinjin Qiao, He Liu, Lei Zhu, Xiaofei Han, Liang Shi, Jing Zhu, Rui Liu, Ang Ren, Mingwen Zhao
Cellulose is an important abundant renewable resource on Earth, and the microbial cellulose utilization mechanism has attracted extensive attention. Recently, some signalling molecules have been found to regulate cellulose utilization and the discovery of underlying signals has recently attracted extensive attention. In this paper, we found that the hydrogen sulfide (H2 S) concentration under cellulose culture condition increased to approximately 2.3-fold compared with that under glucose culture condition in Ganoderma lucidum...
April 17, 2024: Communications Biology
#20
JOURNAL ARTICLE
Yuka Ishida, Mami Matsushita, Takeshi Yoneshiro, Masayuki Saito, Sayuri Fuse, Takafumi Hamaoka, Miyuki Kuroiwa, Riki Tanaka, Yuko Kurosawa, Takayuki Nishimura, Midori Motoi, Takafumi Maeda, Kazuhiro Nakayama
BACKGROUND: Sympathetic activation of brown adipose tissue (BAT) thermogenesis can ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β-adrenergic receptor (AR), as well as effects of its genetic variants on functions of BAT, remains unclear in humans. We conducted association analyses of genes encoding β-ARs and BAT activity in human adults. METHODS: Single nucleotide polymorphisms (SNPs) in β1-, β2-, and β3-AR genes (ADRB1, ADRB2, and ADRB3) were tested for the association with BAT activity under mild cold exposure (19 °C, 2 h) in 399 healthy Japanese adults...
April 17, 2024: International Journal of Obesity
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