keyword
https://read.qxmd.com/read/38475454/analyzing-the-influence-of-conservation-tillage-and-manure-on-soil-parameter-modulations-in-croplands
#1
JOURNAL ARTICLE
Ivan Dugan, Paulo Pereira, Ivica Kisic, Manuel Matisic, Igor Bogunovic
Nowadays, when the human impact on the environment becomes prominent daily, specific steps are needed to mitigate or halt those changes. By far, agricultural land is most affected by the degradation process, leading to soil erosion and decreased soil quality. Sustainable measures are needed to find a solution to that problem. This study, located in an agricultural area in northwestern Croatia, gives an insight into how different tillage systems (conventional and conservation) with the addition of manure will affect soil physicochemical properties, hydrology response, and overall yield...
February 23, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38441014/plant-adaptation-and-tolerance-to-heat-stress-advance-approaches-and-future-aspects
#2
JOURNAL ARTICLE
Vineeta Pandey, Sonia Singh
Heat stress impacts plant growth at all phases of development, although the particular threshold for heat tolerance varies significantly across different developmental stages. During seed germination, elevated temperatures can either impede or completely halt the process, contingent upon the plant type and the severity of the stress. During advanced stages, high temperatures can have a negative impact on photosynthesis, respiration, water balance, and membrane integrity. Additionally, they can also influence the levels of hormones and primary and secondary metabolites...
March 4, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38314127/calcium-calcimimetic-via-calcium-sensing-receptor-ameliorates-cholera-toxin-induced-secretory-diarrhea-in-mice
#3
JOURNAL ARTICLE
Lie-Qi Tang, Johnathan Fraebel, Shi Jin, Steven P Winesett, Jane Harrell, Wen-Han Chang, Sam Xianjun Cheng
BACKGROUND: Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous system. Calcium-sensing receptor (CaSR) inhibits both actions. The latter has been well documented in vitro but not in vivo . The hypothesis to be tested was that activating CaSR inhibits diarrhea in vivo . AIM: To determine whether CaSR agonists ameliorate secretory diarrhea evoked by cholera toxin (CTX) in mice. METHODS: CTX was given orally to C57BL/6 mice to induce diarrhea...
January 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38154471/chronic-pulmonary-aspergillosis-clinical-presentation-and-management
#4
JOURNAL ARTICLE
Terry J Evans, AbdulAzeez Lawal, Chris Kosmidis, David W Denning
Chronic pulmonary aspergillosis (CPA) refers to a number of clinical syndromes resulting from the presence and local proliferation of Aspergillus organisms in the lungs of patients with chronic lung disease. CPA is more common than was realized two decades ago. Recognition remains poor, despite recent studies from many countries highlighting the high prevalence in at-risk populations. In low- and middle-income countries, CPA may be misdiagnosed and treated as tuberculosis (TB). In addition, CPA may develop following successful TB treatment...
February 2024: Seminars in Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38135499/cerebral-folate-deficiency-a-treatable-cause-of-late-deterioration-in-epilepsy-with-developmental-delay
#5
JOURNAL ARTICLE
Fahmida Amin Chowdhury, Elisaveta Sokolov, Jessica Anderson, Dragana J Josifova, Lina Nashef
A 25-year-old woman with childhood-onset refractory epilepsy and developmental delay experienced a gradually progressive marked deterioration in mobility and seizure control, with language regression. Investigation identified a homozygous deletion within the contactin-associated protein-like 2 gene ( CNTNAP2 ), underlying her early presentation, but also cerebral folate deficiency that most likely contributed to her later deterioration. Following antiseizure medication adjustment and treatment with folinic acid, she stabilised with improved seizure control and limited improvement in language and motor function; she has remained neurologically stable for more than a decade...
January 23, 2024: Practical Neurology
https://read.qxmd.com/read/37807597/h-58-medical-competency-and-translational-fallouts-a-need-for-advocacy-for-ethnic-minorities
#6
JOURNAL ARTICLE
Jazmin Gomez, Michelle Miranda, Franchesca Arias
OBJECTIVE: Despite a growing ethnically and linguistically diverse population, the medical system in the U.S. continues to lack the cultural sensitivity needed to provide patients from underrepresented groups with culturally relevant care. This case study of a 32-year-old Mexican woman, by the pseudo name of Ella, will be reviewed to describe her family's journey through the medical system. Ella was referred for neuropsychological testing to determine medical capacity for kidney transplant...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37695623/efficacy-and-safety-of-ravulizumab-a-complement-c5-inhibitor-in-adults-with-amyotrophic-lateral-sclerosis-a-randomized-clinical-trial
#7
JOURNAL ARTICLE
Angela Genge, Leonard H van den Berg, Glen Frick, Steve Han, Cori Abikoff, Adam Simmons, Qun Lin, Kaushik Patra, Erik Kupperman, James D Berry
IMPORTANCE: Additional therapies for amyotrophic lateral sclerosis (ALS) are urgently needed. Immune-mediated complement activation may be involved in ALS pathogenesis as evidenced by the upregulation of terminal components; thus, complement inhibition could potentially slow progression. OBJECTIVE: To evaluate the safety and efficacy of the terminal complement C5 inhibitor ravulizumab in adults with ALS. DESIGN, SETTING, AND PARTICIPANTS: This double-blind, placebo-controlled, parallel-group, multinational, randomized, phase 3 clinical trial was conducted from March 30, 2020, to October 17, 2021, in 81 ALS specialty centers across 17 countries...
September 11, 2023: JAMA Neurology
https://read.qxmd.com/read/37598709/a-positive-consequence-of-the-covid-19-pandemic-how-the-counterfactual-experience-of-school-closures-is-accelerating-a-multisectoral-response-to-the-treatment-of-neglected-tropical-diseases
#8
REVIEW
Donald A P Bundy, Linda Schultz, Manos Antoninis, Fatoumata B M Barry, Carmen Burbano, Kevin Croke, Lesley Drake, John Gyapong, Carol Karutu, Jimmy Kihara, Mouhamadou Moustapha Lo, Prerna Makkar, Charles Mwandawiro, Suzy J Ossipow, Ana Ramos Bento, David Rollinson, Hemang Shah, Hugo C Turner
Global access to deworming treatment is one of the public health success stories of low-income countries in the twenty-first century. Parasitic worm infections are among the most ubiquitous chronic infections of humans, and early success with mass treatment programmes for these infections was the key catalyst for the neglected tropical disease (NTD) agenda. Since the launch of the 'London Declaration' in 2012, school-based deworming programmes have become the world's largest public health interventions. WHO estimates that by 2020, some 3...
October 9, 2023: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/37579631/vaginal-bleeding-as-a-rare-presentation-of-metastatic-renal-cell-carcinoma-case-report-and-literature-review
#9
Abdelhamid Benlghazi, Moad Belouad, Mohammed Hallak, Saad Benali, Rachid Aitbouhou, Jaouad Kouach
INTRODUCTION AND IMPORTANCE: Renal cell carcinoma (RCC) is a relatively uncommon malignancy, comprising only 3 % of adult cancers, but it is responsible for 85 % of primary renal tumors. When RCC metastasizes, the most common sites are the lungs, liver, bones, and brain. Although it is rare, RCC can also metastasize to the vagina. About 18-33 % of RCC cases are diagnosed with metastasis at the time of initial diagnosis. CASE PRESENTATION: A 48-year-old woman presented with postcoital bleeding and dyspareunia...
September 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37513824/evaluation-of-cisplatin-induced-acute-renal-failure-amelioration-using-fondaparinux-and-alteplase
#10
JOURNAL ARTICLE
Mohamed S Abdel-Bakky, Anas S A Aldakhili, Hussein M Ali, Ali Y Babiker, Ahmad H Alhowail, Salman A A Mohammed
Acute renal failure (ARF) is a deleterious condition with increased mortality or healthcare costs or dialysis-dependent end-stage renal disease. The study aims to compare prophylaxis with fondaparinux (Fund) vs. treatment with alteplase (Alt) in ameliorating cisplatin (Cis)-induced ARF. Sixty male mice were equally divided randomly into six groups of control, Cis, Alt, and Cis + Alt groups receiving normal saline for 10 days. All four groups except for the control received Cis (30 mg/kg, i.p.) on day 7, and 6 h later, both the Alt groups received Alt (0...
June 21, 2023: Pharmaceuticals
https://read.qxmd.com/read/37360763/a-disruption-not-an-interruption-the-impact-of-covid-19-on-child-care-in-iowa
#11
JOURNAL ARTICLE
Laura E Wallace, Christine Lippard, Faith M Molthen, Ji-Young Choi, Heather Rouse
BACKGROUND: In March 2020, when public health stay home orders began in order to halt the spread of COVID-19, child care as an industry was drastically and abruptly impacted. This public health emergency highlighted the weaknesses in the child care system in the United States. OBJECTIVE: This study investigated the changes in operations cost, child enrollment and attendance, and state and federal support that occurred during the first year of the COVID-19 pandemic among both center-based and home-based child care programs...
March 13, 2023: Child & Youth Care Forum
https://read.qxmd.com/read/37295470/systemic-lupus-erythematosus-flare-up-manifestation-as-intramedullary-and-posterior-pharynx-hemorrhage
#12
JOURNAL ARTICLE
Minjie Cai, Nanjin Chen, Yongpo Jiang
Systemic lupus erythematosus (SLE) is a common clinical condition, and one of its more common complications is bleeding. Intramedullary and posterior pharynx hemorrhage in systemic lupus erythematosus is rare and disastrous. We describe a patient with a predominantly neurological clinical presentation, which upon examination was thought to be the result of active SLE complicated by intramedullary and pharynx hemorrhage. Intravenous glucocorticoids were administered for the acute SLE flare-up. The patient's neurological deficits improved gradually...
June 7, 2023: World Neurosurgery
https://read.qxmd.com/read/37292414/rapid-expansion-of-post-traumatic-syringomyelia-following-parathyroidectomy-a-case-report-and-review-of-the-literature
#13
Hunter A O'Connor, Paul F Thanel, Shouri K Dirks, Abdul R Alchaki
BACKGROUND: Post-traumatic syringomyelia (PTS) is an uncommon complication of spinal cord injury (SCI) characterized by development of a fluid filled cavity in the spinal cord parenchyma. Presentation involves pain, weakness, and abnormal reflexes. There are few known triggers for disease progression. We present a case of symptomatic PTS that appears to have been triggered by parathyroidectomy. CASE DESCRIPTION: A 42-year-old female with a distant history of SCI developed clinical and imaging findings consistent with acute expansion of PTS immediately following parathyroidectomy...
2023: Surgical Neurology International
https://read.qxmd.com/read/37239101/successful-treatment-of-a-rare-cholesterol-homeostasis-disorder-due-to-cyp27a1-gene-mutation-with-chenodeoxycholic-acid-therapy
#14
Petar Brlek, Luka Bulić, David Glavaš Weinberger, Jelena Bošnjak, Tomislav Pavlović, Svetlana Tomić, Zdravka Krivdić Dupan, Igor Borić, Dragan Primorac
Cerebrotendinous xanthomatosis (CTX) is a genetic disorder of the cholesterol metabolic pathway, most often associated with variants in the CYP27A1 gene. The dysregulation of cholesterol metabolism results in the accumulation of metabolites such as cholestanol, which has a predilection for neuronal tissue and tendons. The condition is treatable with chenodeoxycholic acid (CDCA), which halts the production of these metabolites. We present two adult brothers, without diagnosis, suffering from ataxia, general muscle weakness and cognitive deficits...
May 12, 2023: Biomedicines
https://read.qxmd.com/read/37182034/anesthetic-management-of-a-patient-with-massive-pulmonary-secretion-during-cardiopulmonary-bypass-probably-due-to-transfusion-related-acute-lung-injury-type-%C3%A2
#15
Yasuhiro Watanabe, Mitsumasa Miyagi, Toru Kaneda
Transfusion-related acute lung injury (TRALI) is potentially life-threatening adverse reaction associated with blood transfusion and can induce perioperative pulmonary secretion. TRALI that develops during cardiopulmonary bypass (CPB) may be difficult to detect; however, the pathophysiology might manifest as derangements in CPB operations. A 79-year-old man was scheduled to undergo partial replacement of the aortic arch with CPB. Two units of red blood cells were loaded into the priming solution. Although the vital signs, including oxygenation, remained stable in the prebypass period, perfusionists noticed a decreasing trend in the venous reservoir level early in the CPB operations...
April 2023: Curēus
https://read.qxmd.com/read/37155680/modeling-the-impact-of-xenointoxication-in-dogs-to-halt-trypanosoma-cruzi-transmission
#16
JOURNAL ARTICLE
Jennifer L Rokhsar, Brinkley Raynor, Justin Sheen, Neal D Goldstein, Michael Z Levy, Ricardo Castillo-Neyra
BACKGROUND: Chagas disease, a vector-borne parasitic disease caused by Trypanosoma cruzi, affects millions in the Americas. Dogs are important reservoirs of the parasite. Under laboratory conditions, canine treatment with the systemic insecticide fluralaner demonstrated efficacy in killing Triatoma infestans and T. brasiliensis, T. cruzi vectors, when they feed on dogs. This form of pest control is called xenointoxication. However, T. cruzi can also be transmitted orally when mammals ingest infected bugs, so there is potential for dogs to become infected upon consuming infected bugs killed by the treatment...
May 8, 2023: PLoS Computational Biology
https://read.qxmd.com/read/36977364/who-benefits-from-allowing-the-physis-to-grow-in-slipped-capital-femoral-epiphysis
#17
JOURNAL ARTICLE
Breanna J Winger, Ashlee M Dobbe, Tegan L Cheng, David G Little, Paul J Gibbons
BACKGROUND: The globally acknowledged treatment for mild to moderate slipped capital femoral epiphysis (SCFE) is single screw in situ fixation, also used for prophylactic contralateral fixation. The Free-Gliding Screw (FG; Pega Medical) is a 2-part free-extending screw system designed to allow the growth of the proximal femur. We aimed to analyze the relationship between skeletal maturity and potential growth of the proximal physis and remodeling of the femoral neck using this implant...
July 1, 2023: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/36747723/modeling-the-impact-of-xenointoxication-in-dogs-to-halt-trypanosoma-cruzi-transmission
#18
Jennifer L Rokhsar, Brinkley Raynor, Justin Sheen, Neal D Goldstein, Michael Z Levy, Ricardo Castillo-Neyra
BACKGROUND: Chagas disease, a vector-borne parasitic disease caused by Trypanosoma cruzi , affects millions in the Americas. Dogs are important reservoirs of the parasite. Under laboratory conditions, canine treatment with the systemic insecticide fluralaner demonstrated efficacy in killing Triatoma infestans and T. brasiliensis, T. cruzi vectors, when they feed on dogs. This form of pest control is called xenointoxication. However, T. cruzi can also be transmitted orally when mammals ingest infected bugs, so there is potential for dogs to become infected upon consuming infected bugs killed by the treatment...
January 25, 2023: medRxiv
https://read.qxmd.com/read/36648215/neoadjuvant-treatment-for-stage-iii-and-iv-cutaneous-melanoma
#19
REVIEW
Claire Gorry, Laura McCullagh, Helen O'Donnell, Sarah Barrett, Susanne Schmitz, Michael Barry, Kay Curtin, Eamon Beausang, Rupert Barry, Imelda Coyne
BACKGROUND: Cutaneous melanoma is amongst the most aggressive of all skin cancers. Neoadjuvant treatment is a form of induction therapy, given to shrink a cancerous tumour prior to the main treatment (usually surgery). The purpose is to improve survival and surgical outcomes. This review systematically appraises the literature investigating the use of neoadjuvant treatment for stage III and IV cutaneous melanoma. OBJECTIVES: To assess the effects of neoadjuvant treatment in adults with stage III or stage IV melanoma according to the seventh edition American Joint Committee on Cancer (AJCC) staging system...
January 17, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/36405719/interleukin-6-and-indoleamine-2-3-dioxygenase-as-potential-adjuvant-targets-for-papillomavirus-related-tumors-immunotherapy
#20
JOURNAL ARTICLE
Roberta Liberato Pagni, Patrícia da Cruz Souza, Rafael Pegoraro, Bruna Felício Milazzotto Maldonado Porchia, Jamile Ramos da Silva, Luana Raposo de Melo Moraes Aps, Mariângela de Oliveira Silva, Karine Bitencourt Rodrigues, Natiely Silva Sales, Luís Carlos de Souza Ferreira, Ana Carolina Ramos Moreno
High-risk Human papillomavirus (HPV) infections represent an important public health issue. Nearly all cervical malignancies are associated with HPV, and a range of other female and male cancers, such as anogenital and oropharyngeal. Aiming to treat HPV-related tumors, our group developed vaccines based on the genetic fusion of the HSV-1 glycoprotein D (gD) with the HPV-16 E7 oncoprotein (gDE7 vaccines). Despite the promising antitumor results reached by gDE7 vaccines in mice, combined therapies may increase the therapeutic effects by improving antitumor responses and halting immune suppressive mechanisms elicited by tumor cells...
2022: Frontiers in Immunology
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