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JOURNAL ARTICLE
Fathia Meirina, Dina Keumala Sari, Inke Nadia Diniyanti Lubis, Rini Savitri Daulay, Finny Fitry Yani, Bugis Mardina Lubis, Rosita Juwita Sembiring, Pandiaman Pandia, Muhammad Rusda, Mustafa Mahmud Amin
BACKGROUND: Pregnant women with latent tuberculosis infection (LTBI) may develop active tuberculosis infection and could infect their neonates, which could impair the child's immune system due to infection-mediated immunological responses. In order to develop a preventative TB program in this study, we desired to understand the impact of calcitriol in LTBI pregnant women and immunological responses in neonates. PATIENTS AND METHODS: In three hospitals in Medan, North Sumatra, we implemented a case-control design with 84 pregnant women in their third trimester and their newborns...
2024: ImmunoTargets and Therapy
#22
JOURNAL ARTICLE
Maoying Li, Bin Deng, Yuhong Huang, Qiong Li, Jing Han, Shenjie Tang, Lei Chen
To investigate the status of the drug-resistant tuberculosis (DR-TB) among children in Sichuan, and to find out the risk factors and high-risk population related to drug resistance among children. The clinical data of tuberculosis patients ≤14 years old with culture-confirmed tuberculosis hospitalized in Chengdu Public Health Clinical Center from January 2013 through December 2022 were collected. Clinical data such as gender, age, ethnicity, history of anti-TB treatment, history of exposure to tuberculosis, nutritional status, and specific drug resistance of the children were collected and recorded...
April 12, 2024: Medicine (Baltimore)
#23
JOURNAL ARTICLE
Samson Omongot, Winters Muttamba, Irene Najjingo, Joseph Baruch Baluku, Sabrina Kitaka, Stavia Turyahabwe, Bruce Kirenga
In 2021, an estimated 10.6 million people fell ill with tuberculosis (TB) globally and 11.3% were children. About 40% of children aged five to fourteen years with TB are missed annually. In Uganda, 44% of adolescents with chronic cough of more than two weeks do not seek care from health facilities. Therefore, strategies to promote health care-seeking behaviour among adolescents were urgently needed to resolve the gap. In regard to this, the research project utilized a before and after design, in which the number of adolescents (10-19years) enrolled in the project health facilities were compared before and after the intervention...
2024: PloS One
#24
JOURNAL ARTICLE
Ritu Kumari, Rakesh Kumar, Anita, Sweta Muni, Shailesh Kumar, Namrata Kumari
Background Tuberculosis (TB) remains a global health concern, with India bearing a substantial burden. Paediatric TB, especially extrapulmonary TB (EPTB), presents unique diagnostic challenges due to its paucibacillary nature and the difficulty in obtaining suitable samples in children. Accurate and timely diagnosis is crucial to initiate appropriate treatment and mitigate disease spread. The MPT64 antigen test has shown promise in diagnosing TB, but its performance in paediatric EPTB remains underexplored...
March 2024: Curēus
#25
JOURNAL ARTICLE
Chishala Chabala, Eric Wobudeya, Marieke M van der Zalm, Monica Kapasa, Priyanka Raichur, Robert Mboizi, Megan Palmer, Aarti Kinikar, Syed Hissar, Veronica Mulenga, Vidya Mave, Philippa Musoke, Anneke C Hesseling, Helen McIlleron, Diana Gibb, Angela Crook, Anna Turkova
BACKGROUND: Children living with HIV(CLWH) are at high risk of tuberculosis(TB) and face poor outcomes, despite antiretroviral treatment(ART). We evaluated outcomes in CLWH and HIV-uninfected children treated for non-severe TB in the SHINE trial. METHODS: SHINE was a randomized trial that enrolled children aged <16 years with smear-negative, non-severe TB who were randomized to receive 4 vs 6 months of TB treatment and followed for 72 weeks. We assessed TB relapse/recurrence, mortality, hospitalizations, grade ≥3 adverse events by HIV status, and HIV virological suppression in CLWH...
April 9, 2024: Clinical Infectious Diseases
#26
JOURNAL ARTICLE
Sidhartha Giri, Priyanka Sahu, Srikanta Kanungo, Himadri Bhusan Bal, Sujeet Kumar, Sarita Kar, Triyambakesh Mohanty, Jyotirmayee Turuk, Dasarathi Das, Prasanta Kumar Hota, Sanghamitra Pati
BACKGROUND: Modelling studies have indicated that approximately 20% of all tuberculosis (TB) cases may suffer from diabetes mellitus (DM). DM increases the risk of developing active TB disease by 2-3 times. People living with HIV (PLHIV) are more likely to develop TB disease, and TB is a leading cause of hospitalization and death among PLHIV. Despite the substantial burden of DM and HIV in India, few studies have evaluated the prevalence of DM and HIV among active cases of TB, and its impact on the treatment outcome for TB...
April 2024: Indian Journal of Tuberculosis
#27
JOURNAL ARTICLE
Zinia T Nujum, Sindhu S, P S Rakesh, Remya G, Anuja U
BACKGROUND: India accounts for one fourth of the TB burden globally. One of the objectives of the National Strategic Plan is to achieve 90% notification rate of all TB cases. Screening of high risk groups is one of the important components towards achieving this objective. Inmates of homes for the aged and orphanages are at higher risk of having TB infection and disease. Hence this study was conducted with the objective of identifying the prevalence of TB among inmates of homes for the aged and orphanages...
April 2024: Indian Journal of Tuberculosis
#28
JOURNAL ARTICLE
Mortality variability and differentials by age and causes of death in rural South Africa, 1994-2018.
Brian Houle, Chodziwadziwa Kabudula, Sanyu A Mojola, Nicole Angotti, Francesc Xavier Gómez-Olivé, Dickman Gareta, Kobus Herbst, Samuel J Clark, Jane Menken, Vladimir Canudas-Romo
INTRODUCTION: Understanding mortality variability by age and cause is critical to identifying intervention and prevention actions to support disadvantaged populations. We assessed mortality changes in two rural South African populations over 25 years covering pre-AIDS and peak AIDS epidemic and subsequent antiretroviral therapy (ART) availability. METHODS: Using population surveillance data from the Agincourt Health and Socio-Demographic Surveillance System (AHDSS; 1994-2018) and Africa Health Research Institute (AHRI; 2000-2018) for 5-year periods, we calculated life expectancy from birth to age 85, mortality age distributions and variation, and life-years lost (LYL) decomposed into four cause-of-death groups...
April 8, 2024: BMJ Global Health
#29
JOURNAL ARTICLE
Qiannan Wang, Mathieu Nacher, Alice Tosi, Loreinzia Clarke, Joseph Rwagitinywa, Kinan Drak Alsibai, Marie-Josiane Castor
INTRODUCTION: The overall incidence of tuberculosis (TB) in France is low; thus, BCG vaccination is no longer mandatory. In French Guiana - a French overseas territory - BCG vaccination is strongly recommended because the incidence of TB is high in the context of mass immigration from endemic countries with low BCG vaccination rates. Thus, it is important to assess Bacillus Calmette-Guérin (BCG) vaccination coverage and its predictors. METHODS: We used data from the 2014 French Guiana Yellow Fever survey, which was conducted by the Observatoire Régional de la Santé de Guyane...
April 4, 2024: J Epidemiol Popul Health
#30
JOURNAL ARTICLE
Paula Rodríguez-Molino, Araceli González Sánchez, Antoni Noguera-Julián, Aleix Soler-García, Patricia Martínez Paz, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Miguel González Muñoz, María Jesús Ruíz-Serrano, Manuel Monsonís, Rocío Sánchez León, Jesús Saavedra-Lozano, Begoña Santiago-García, Talía Sainz
We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs . -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs . -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern...
2024: Frontiers in Immunology
#31
JOURNAL ARTICLE
Ole Magnus Bjørgaas Helle, Mala Kanthali, Sheeba Ishtiaq, Atiqa Ambreen, Manju Raj Purohit, Tehmina Mustafa
Diagnosing extrapulmonary tuberculosis (EPTB) is challenging. Immunohistochemistry or immunocytochemistry has been used to diagnose tuberculosis (TB) by detection of MPT64 antigen from various extrapulmonary specimens and has shown good diagnostic performance in our previous studies. The test can distinguish between disease caused by Mycobacterium tuberculosis (Mtb) complex and nontuberculous mycobacteria and can be applied on formalin-fixed paraffin-embedded tissue. As the antibodies previously used were in limited supply, a new batch of polyclonal antibodies was developed for scale-up and evaluated for the first time in this study...
May 2024: Journal of Pathology. Clinical Research
#32
JOURNAL ARTICLE
Jasmine Singh, Pallavi Sharma, Shivani Randev, Narinder Kaur, Pankaj Kumar, Vishal Guglani
Tuberculosis is a leading cause of mortality in children worldwide. One of the greatest challenges in its management is the difficulty of diagnosis as the manifestations are non-specific and often mimic other illnesses. Neurological infection occurs in approximately 1% of patients diagnosed with tuberculosis, and usually takes the form of tuberculous meningitis or tuberculoma. An 11-year-old girl who was diagnosed with acute disseminated encephalomyelitis, a rare immunological manifestation of tuberculosis, is presented...
April 3, 2024: Paediatrics and International Child Health
#33
JOURNAL ARTICLE
Paula Rodríguez-Molino, Marc Tebruegge, Antoni Noguera-Julian, Olaf Neth, Katy Fidler, Folke Brinkmann, Talia Sainz, Inga Ivaskeviciene, Nicole Ritz, Maria Joao Brito, Tiago Milheiro Silva, Vira Chechenieva, Maryna Serdiuk, Laura Lancella, Cristina Russo, Aleix Soler-García, Maria Luisa Navarro, Renate Krueger, Cornelia Feiterna-Sperling, Anna Starshinova, Antonina Hiteva, Anna Hoffmann, Paulius Kalibatas, Andrea Lo Vecchio, Sara Maria Scarano, Matilde Bustillo, Daniel Blázquez Gamero, María Espiau, Danilo Buonsenso, Lola Falcón, Louise Turnbull, Elena Colino, Santiago Rueda, Charlotte Buxbaum, Begoña Carazo, Cristina Alvarez, Marta Dapena, Anabel Piqueras, Svetlana Velizarova, Iveta Ozere, Florian Götzinger, Marta Pareja, Maria Isabel Garrote Llanos, Beatriz Soto, Sonia Rodríguez Martín, Jose Javier Korta, Beatriz Pérez-Gorricho, Mercedes Herranz, Ángel Hernández-Bartolomé, Mariana Díaz-Almirón, Malte Kohns Vasconcelos, Laura Ferreras-Antolín, Begoña Santiago-García
BACKGROUND: In high-resource settings the survival of immunocompromised (IC) children has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools and outcome of IC children with TB in Europe. METHODS: Multicentre, matched case-control study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), capturing TB cases <18 years diagnosed 2000-2020...
April 3, 2024: Clinical Infectious Diseases
#34
JOURNAL ARTICLE
A Shaikh, K Sriraman, S Vaswani, I Shah, V Poojari, V Oswal, S Mane, S Rajagara, N Mistry
<sec id="st1"><title>BACKGROUND</title>Key challenges in paediatric TB diagnosis are invasive sampling and poor sensitivity of standard methods. This study demonstrates the diagnostic potential of non-invasive sampling of bioaerosols from children using SMaRT-PCR, comprising mask sampling combined with reverse transcriptase-polymerase chain reaction (RT-PCR) for TB.</sec><sec id="st2"><title>METHODS</title>Exhaled bioaerosols were captured on modified N-95 masks in a 10-min talk-cough-breathe process from 51 children (30 with TB confirmed using standard sampling methods and 21 without TB) aged 2-15 years...
April 1, 2024: International Journal of Tuberculosis and Lung Disease
#35
JOURNAL ARTICLE
Dong-Mei Wang, Chuan Wang, Qi An, Qing Yang, Yi Liao
BACKGROUND: The data report of a large sample, dynamic epidemiology, and characteristic analysis of pediatric tuberculosis (TB) in Southwest China is not clear. Herein, we conducted descriptive dynamic epidemiology, characteristic analysis and geographical distribution study of pediatric TB inpatients in Southwest China for more than 20 years. METHODS: Patients with pediatric TB were recruited from October 2002 to September 2022 in Southwest of China based on etiology or clinical confirmation...
2024: Frontiers in Pediatrics
#36
JOURNAL ARTICLE
Mahsa Kamali, Mohammad Reza Navaeifar, Ali Abbaskhanian, Azin Hajialibeig, Farnaz Godazandeh, Mahsa Salehpour, Mohammad Sadegh Rezai
BACKGROUND: Miliary tuberculosis (TB) is a lethal hematogenous spread form of mycobacterium tuberculosis with approximately 15-20% mortality rate in children. The present report highlights the clinical manifestations of an unusual presentation of miliary tuberculosis in a 12-year-old girl. CASE PRESENTATION: In this case, extensive lung involvement was presented despite the absence of respiratory symptoms. Also, some central hypo-intense with hyper-intense rim nodules were detected in the brain's pons, right cerebral peduncles and lentiform nucleus...
April 1, 2024: BMC Pediatrics
#37
JOURNAL ARTICLE
P Octaviani, Z Ikawati, N M Yasin, S A Kristina, I Y Kusuma
INTRODUCTION: Inappropriate treatment and non-adherence use of anti-tuberculosis (TB) drugs trigger the spread of multidrug-resistant tuberculosis (MDR-TB) strains and causes an emerging public health threat worldwide. Therefore, non-adherence to MDR-TB treatment leading to prolonged medication period, increase incidence of adverse event and financial burden, thus it requires interventions to achieve a therapeutic outcome. OBJECTIVE: This scoping review aims to provide an overview of interventions to improve the adherence level to medication of MDR-TB patients...
March 2024: Medical Journal of Malaysia
#38
JOURNAL ARTICLE
Yecai Liu, Drew L Posey, Michelle S Weinberg, Christina R Phares
Persons may seek asylum in the United States or at a U.S. port of entry. Principal asylees are those who are granted asylum status. Their spouse and unmarried children under 21 years of age may be granted asylum if accompanying, or following to join, the principal asylees. U.S.-bound follow-to-join asylees must undergo an overseas medical examination that includes tuberculosis (TB) screening. Culture-based overseas TB screening in U.S.-bound follow-to-join asylees has not been evaluated. We evaluated data from overseas TB screening in 19,088 arrivals of follow-to-join asylees during 2014-2019 and assessed data from their postarrival evaluation, which is recommended for those at risk for TB...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
#39
JOURNAL ARTICLE
Esin Nkereuwem, Marieke M van der Zalm, Beate Kampmann, Toyin Togun
No abstract text is available yet for this article.
March 22, 2024: Lancet Respiratory Medicine
#40
JOURNAL ARTICLE
Abay Burusie, Fikre Enquesilassie, Nicole Salazar-Austin, Adamu Addissie
BACKGROUND: One of the global key indicators for monitoring the implementation of the World Health Organization's End Tuberculosis (TB) Strategy is the treatment outcome rate. OBJECTIVE: This study aims to assess the magnitude of unfavorable treatment outcomes and estimate their relationship with baseline undernutrition and sustained undernutrition among children receiving TB treatment in central Ethiopia. METHODS: This retrospective cohort study included children treated for drug-susceptible TB between June 2014 and February 2022...
March 30, 2024: Heliyon
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