Agibothu Kupparam Hemanth Kumar, Abhijit Kadam, Ramesh Karunaianantham, Manoharan Tamizhselvan, Chandrasekaran Padmapriyadarsini, Anant Mohan, B Jeyadeepa, Ammayappan Radhakrishnan, Urvashi B Singh, Shraddha Bapat, Aarti Mane, Pradeep Kumar, Megha Mamulwar, Perumal Kannabiran Bhavani, Hemalatha Haribabu, Nibedita Rath, Randeep Guleria, Abdul Mabood Khan, Jaykumar Menon
BACKGROUND: To evaluate the effect of metformin on the plasma levels of rifampicin, isoniazid, and pyrazinamide in patients with drug-sensitive pulmonary tuberculosis being treated with first-line antituberculosis treatment (ATT) and to assess the influence of gene polymorphisms on the metabolic pathway of metformin and plasma levels of antitubercular drugs. METHODS: Nondiabetic adults aged 18-60 years with pulmonary tuberculosis were randomized to either the standard ATT (ATT group) or ATT plus metformin (METRIF group) groups in a phase IIB clinical trial...
November 28, 2023: Therapeutic Drug Monitoring