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ulcerative colitis guidelines

Lindsay A Sceats, Arden M Morris, M Kate Bundorf, K T Park, Cindy Kin
BACKGROUND: Sex-based treatment disparities occur in many diseases. Women undergo fewer procedural interventions, and their care is less consistent with guideline-based therapy. There is limited research exploring sex-based differences in ulcerative colitis treatment. We hypothesized that women are less likely to be treated with strategies consistent with long-term disease remission, including surgery and maintenance medications. OBJECTIVE: The aim of this study was to determine if patient sex is associated with choice of treatment strategy for ulcerative colitis...
February 8, 2019: Diseases of the Colon and Rectum
Berkeley N Limketkai, Zipporah Iheozor-Ejiofor, Teuta Gjuladin-Hellon, Alyssa Parian, Laura E Matarese, Kelly Bracewell, John K MacDonald, Morris Gordon, Gerard E Mullin
BACKGROUND: Inflammatory bowel disease (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic mucosal inflammation, frequent hospitalizations, adverse health economics, and compromised quality of life. Diet has been hypothesised to influence IBD activity. OBJECTIVES: To evaluate the efficacy and safety of dietary interventions on IBD outcomes. SEARCH METHODS: We searched the Cochrane IBD Group Specialized Register, CENTRAL, MEDLINE, Embase, Web of Science, Clinicaltrials...
February 8, 2019: Cochrane Database of Systematic Reviews
Uday N Shivaji, Caroline L Sharratt, Tom Thomas, Samuel C L Smith, Marietta Iacucci, Gordon W Moran, Subrata Ghosh, Neeraj Bhala
BACKGROUND: Biological therapy is currently widely used to treat IBD. Infliximab, adalimumab and golimumab are currently licensed anti-TNF therapies. Biosimilar anti-TNF monoclonal antibodies are increasingly used. Anti-TNF therapies are widely used and their adverse effects are well characterised, and may cause significant morbidity and mortality in a small proportion of exposed patients. Gastroenterologists need to understand the mechanisms for these effects, recognise these swiftly and manage such events appropriately...
February 8, 2019: Alimentary Pharmacology & Therapeutics
Motohiro Okayasu, Haruhiko Ogata, Yuji Yoshiyama
Background : Corticosteroids may be temporarily effective for ulcerative colitis (UC), but long-term use increases the risk of adverse drug reactions. Objective : The goal of the study was to examine steroid use in remission induction therapy after diagnosis of UC. Study Design : A retrospective observational study using the Japan Medical Data Center (JMDC) Claims Database from January 2008 to December 2014. Setting : Clinics, university hospitals, and national/public hospitals. Intervention : Initiation of steroids after diagnosis of UC...
2019: Journal of Market Access & Health Policy
I V Maev, A N Kazulin, D N Andreev
AIM: Identification of subclinical and metamanifests state changes of cardiovascular system in patients with functional and inflammatory bow- el diseases (IBD) without a background of cardiac pathology. MATERIALS AND METHODS: Was examined 79 patients with colon diseases, 20 patients were diagnosed with irritable bowel syndrome (IBS) with diarrhea, a 37 - undifferentiated colitis (UdC) and 22 patients with ulcerative colitis (UC). As a control group were examined in 50 healthy subjects...
February 15, 2018: Terapevticheskiĭ Arkhiv
Raymond Cross, Cynthia W Ko, Siddharth Singh
No abstract text is available yet for this article.
January 23, 2019: Gastroenterology
Florian Kuehn, Richard A Hodin
Background: The primary treatment of ulcerative colitis (UC) is conservative, and substantial therapeutic progress has been made in the past few decades. Meanwhile, biologicals have become a mainstay in the treatment for steroid-refractory UC. Despite further development of drug therapy and an increased time span to operation, a significant proportion of patients with UC require surgical intervention. Surgical intervention needs to be carried out in medically refractory cases, imminent or malignant transformation, or complications...
December 2018: Visceral Medicine
Jiri Bronsky, Lissy de Ridder, Frank M Ruemmele, Anne Griffiths, Stephan Buderus, Ondrej Hradsky, Almuthe Christina Hauer
OBJECTIVES: Despite existence of international guidelines for diagnosis and management of inflammatory bowel diseases (IBD) in children, there might be differences in the clinical approach. METHODS: A survey on clinical practice in paediatric IBD was performed among members of the ESPGHAN Porto IBD working group and interest group, PIBD-NET, and IBD networks in Canada and German speaking countries (CIDsCANN, GPGE), using a web-based questionnaire. Responses to 63 questions from 106 paediatric IBD centres were collected...
January 17, 2019: Journal of Pediatric Gastroenterology and Nutrition
(no author information available yet)
This guideline provides evidence-based key recommendations for diagnosis and treatment of ulcerative colitis and upgrades the 2011 version. The guideline was developed by an interdisciplinary team of gastroenterologists, surgeons, pathologists, nutrition experts, and patient support groups under the auspice of the German Society for Gastroenterology and Metabolic Diseases. The guideline used structural S3 consensus-based methodology and includes statements on clinical practice, prevention, infectiological problems, surgery and nutrition...
January 17, 2019: Zeitschrift Für Gastroenterologie
Farid Poursadegh, Mitra Ahadi, Hassan Vosoughinia, Maryam Salehi, Ali Beheshti Namdar, Mohammad Reza Farzanehfar, Bahram Memar, Reza Ziaolhagh
Nutritional deficiencies and malnutrition are considered to be related to ulcerative colitis (UC); however, the association between serum levels of micronutrients and UC is not well known. This study aimed to evaluate the serum levels of micronutrients in UC patients and investigate their association with disease activity.This cross-sectional study was conducted on UC patients visiting the Department of Gastroenterology at 3 different teaching hospitals between January 2016 and January 2017. UC activity was measured based on Truelove and Witts' severity index and guidelines for colonoscopy...
December 2018: Medicine (Baltimore)
Mark A Samaan, Katrina Forsyth, Jonathan P Segal, Djuna de Jong, Jasper LA Vleugels, Soad Elkady, Misha Kabir, Samantha Campbell, Klaartje Kok, David G Armstrong, Lawrence Penez, Aitor P Arenaza, Edward Seward, Roser Vega, Shameer Mehta, Farooq Rahman, Sara McCartney, Stuart Bloom, Kamal Patel, Richard Pollok, Edward Westcott, Amir Darakhshan, Andrew Williams, Ioannis Koumoutsos, Shuvra Ray, Joel Mawdsley, Simon Anderson, Jeremy D Sanderson, Evelien Dekker, Geert R D'Haens, Ailsa Hart, Peter M Irving
Background & Aims: There are no universally accepted guidelines regarding surveillance of UC patients after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). There also exists a lack of validated quality assurance standards for performing pouchoscopy. To better understand IPAA surveillance practices in the face of this clinical equipoise, we carried out a retrospective cohort study at five IBD referral centres. Methods: Records of patients who underwent IPAA for UC or IBD-U were reviewed and patients with <1-year follow-up after restoration of intestinal continuity were excluded...
December 24, 2018: Journal of Crohn's & Colitis
Cynthia W Ko, Siddharth Singh, Joseph D Feuerstein, Corinna Falck-Ytter, Yngve Falck-Ytter, Raymond K Cross
No abstract text is available yet for this article.
December 18, 2018: Gastroenterology
Siddharth Singh, Joseph D Feuerstein, David G Binion, William J Tremaine
Most patients with ulcerative colitis (UC) have mild to moderate disease activity, with low risk of colectomy, and are managed by primary care physicians or gastroenterologists. Optimal management of these patients decreases the risk of relapse and proximal disease extension, and may prevent disease progression, complications and need for immunosuppressive therapy. With several medications (sulfasalazine, diazo-bonded 5-aminosalicylates [ASA], mesalamines, corticosteroids including budesonide, etc.) and complex dosing formulations, regimens and routes, to treat a disease with variable anatomic extent, there is considerable practice variability in the management of patients with mild-moderate UC...
December 18, 2018: Gastroenterology
Satoshi Kinoshita, Toshihiro Nishizawa, Naohisa Yahagi, Toshio Uraoka
Patients with ulcerative colitis have an increased risk of developing colorectal cancer. This risk has been estimated to reach about 7% at 20 years of disease, 7-14% at 25 years, and as high as 30% after 35 years. The guidelines for the management of inflammatory bowel disease recommend endoscopic resection of circumscribed dysplasia and ongoing colonoscopic surveillance as a reasonable strategy in patients with ulcerative colitis. Submucosal fibrosis due to background inflammation could hamper adequate lifting and endoscopic treatment...
2019: Digestion
Lea I Kredel, Oliver Schneidereit, Jörg C Hoffmann, Britta Siegmund, Jan C Preiß
PURPOSE: There is a growing evidence for over-, under-, or misuse of health care in patients with inflammatory bowel disease. Most studies looked at treatment variability or used quality measures, which mostly capture supportive interventions rather than treatment of IBD in itself. We aimed to evaluate if current recommendations in clinical practice guidelines regarding the medical treatment of patients with inflammatory bowel diseases are being followed in Germany. METHODS: A questionnaire was sent to 1901 patients insured with two large German statutory sickness funds and an ICD 10 diagnosis of Crohn's disease (CD) or ulcerative colitis (UC)...
December 7, 2018: International Journal of Colorectal Disease
Laura E Targownik, Eric I Benchimol, Charles N Bernstein, Harminder Singh, MSc Lisa Lix, Aruni Tennakoon, Stella Leung, Antonio Aviña, Stephanie Coward, Jennifer Jones, Gil Kaplan, Sanjay K Murthy, Geoffrey C Nguyen, Juan Nicolás Peña-Sánchez
BACKGROUND & AIMS: Although guidelines recommend inclusion of immune modulators in anti-tumor necrosis factor (TNF) initiation therapy for Crohn's disease (CD) or ulcerative colitis (UC), there are limited data on the incremental effectiveness of this treatment strategy from the real world. METHODS: We collected data from the Manitoba Inflammatory Bowel Disease (IBD) Epidemiology database on persons with CD (n=852) or UC (n=303), from 2001 through 2016, who began treatment with a TNF antagonist...
November 15, 2018: Clinical Gastroenterology and Hepatology
Jarek Kobiela, Małgorzata Dobrzycka, Roman Danielewicz, Justyna Jończyk, Andrzej J Łachiński, Zbigniew Śledziński, Alicja Dębska-Ślizień
BACKGROUND Screening colonoscopy is not obligatory in kidney pre-transplant work-up guidelines. According to recommendations, only transplant recipients over age 50 years should be screened. The aim of this study was to characterize endoscopic findings revealed as part of pre-transplant work-up. MATERIAL AND METHODS We retrospectively reviewed pre-transplant work-up charts of 434 adult patients who received a cadaveric donor kidney transplantation (KT) from 2012 to 2015. Endoscopic findings analysis with age subgroup (<50 and ³50) analysis were performed...
November 9, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Michail Galanopoulos, Emmanouela Tsoukali, Filippos Gkeros, Marina Vraka, Georgios Karampekos, Gerassimos J Matzaris
Patients with long-standing ulcerative colitis (UC) and extensive Crohn's colitis (CC) are at increased risk for dysplasia and colorectal cancer (CRC). Several studies have shown that UC extending proximal to the rectum, CC involving at least 1/3 of the colon, co-existence of primary sclerosing cholangitis, undetermined or unclassified colitis, family history of CRC and young age at diagnosis appear to be independent risk factors for inflammatory bowel disease (IBD) - related CRC. Therefore, screening and surveillance for CRC in IBD patients is highly recommended by international and national guidelines, whilst colonoscopy remains the unequivocal tool in order to detect potentially resectable dysplastic lesions or CRC at an early stage...
October 16, 2018: World Journal of Gastrointestinal Endoscopy
Silvio Danese, Rupa Banerjee, Jr Fraser Cummings, Iris Dotan, Paulo G Kotze, Rupert Wing Loong Leong, Kristine Paridaens, Laurent Peyrin-Biroulet, Glyn Scott, Gert Van Assche, Jan Wehkamp, Jesús K Yamamoto-Furusho
Symptomatic ulcerative colitis (UC) can be a chronic, disabling condition. Flares in disease activity are associated with many of the negative impacts of mild-to-moderate UC. Rapid resolution of flares can provide benefits to patients and healthcare systems. i Support Therapy-Access to Rapid Treatment (iSTART) introduces patient-centered care for mild-to-moderate UC. iSTART provides patients with the ability to self-assess symptomology and self-start a short course of second-line treatment when necessary. An international panel of experts produced consensus statements and recommendations...
October 2018: Intestinal Research
Iago Rodríguez-Lago, Rocío Ferreiro-Iglesias, Pilar Nos, Javier P Gisbert
INTRODUCTION: Ulcerative colitis (UC) is a chronic disease of the digestive tract and up to 20-30% of UC patients may suffer a severe flare-up during the course of the disease. Although there are national and international recommendations about its clinical management, there is not enough information about the treatment of acute severe UC in clinical practice. METHODS: An electronic and anonymous survey with 51 multiple-choice questions was performed among all the members of the Spanish Crohn's Disease and Ulcerative Colitis Working Group (GETECCU)...
February 2019: Gastroenterología y Hepatología
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