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JOURNAL ARTICLE
Tefera B Agizew, Joseph Soka, Cynthia D Fast, Stephen Mwimanzi, Gilbert Mwesiga, Nashon Edward, Marygiven Stephen, Reheme Kondo, Robert Burny, Christophe Cox, Negussie Beyene
BACKGROUND: African giant pouched rats, trained by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO), have demonstrated their ability to detect tuberculosis (TB) from sputum. We assessed rat-based case detection and compared the mycobacterium bacillary load (MTB-load) in children versus adults. METHODS: From January-December 2022, samples were collected prospectively from 69 Directly Observed Therapy (DOT) facilities' presumed TB patients. Using an average of five rats, APOPO re-evaluated patients with bacteriologically negative (sputum-smear microscopy or Xpert MTB/RIF) results...
April 15, 2024: BMC Infectious Diseases
#22
JOURNAL ARTICLE
Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen
BACKGROUND: Genital infection with Chlamydia trachomatis (C. trachomatis) is a major public health issue worldwide. It can lead to cervicitis, urethritis, and infertility. This study was conducted to determine the characteristics of genital C. trachomatis infection among women attending to the infertility and gynecology clinics. METHODS: Endocervical swabs were collected from 8,221 women for C. trachomatis nucleotide screening and genotyping, while serum samples were collected for C...
April 15, 2024: BMC Infectious Diseases
#23
Thu Kim Nguyen, Yen Hai Nguyen, Hao Thi Nguyen, Quang Minh Khong, Ngoc Kim Tran
No abstract text is available yet for this article.
April 15, 2024: BMC Infectious Diseases
#24
JOURNAL ARTICLE
Alan Bulbin, Julia Shen, Carol Liotta-Bono, Tahir Ahmad
Severe malaria is not routinely considered when evaluating a febrile patient in the postoperative setting. Common bacterial infections, along with adverse drug reactions, are the usual differential concerns. We present a case of severe malaria emerging unexpectedly eight days after routine craniotomy.
April 15, 2024: BMC Infectious Diseases
#25
JOURNAL ARTICLE
Saugat Karki, Sarah Shaw, Michael Lieberman, Alejandro Pérez, Jonathan Pincus, Priya Jakhmola, Amrita Tailor, Oyinkansola Bukky Ogunrinde, Danielle Sill, Shane Morgan, Miguel Alvarez, Jonathan Todd, Dawn Smith, Ninad Mishra
BACKGROUND: The syndemic nature of gonococcal infections and HIV provides an opportunity to develop a synergistic intervention tool that could address the need for adequate treatment for gonorrhea, screen for HIV infections, and offer pre-exposure prophylaxis (PrEP) for persons who meet the criteria. By leveraging information available on electronic health records, a clinical decision support (CDS) system tool could fulfill this need and improve adherence to Centers for Disease Control and Prevention (CDC) treatment and screening guidelines for gonorrhea, HIV, and PrEP...
April 15, 2024: JMIR Formative Research
#26
JOURNAL ARTICLE
Qianwen Li, Zhi Yang, Kaili Chen, Ming Zhao, Hai Long, Yueming Deng, Haoran Hu, Chen Jia, Meiyu Wu, Zhidan Zhao, Huan Zhu, Suqing Zhou, Mingming Zhao, Pengpeng Cao, Shengnan Zhou, Yang Song, Guishao Tang, Juan Liu, Jiao Jiang, Wei Liao, Wenhui Zhou, Bingyi Yang, Feng Xiong, Suhan Zhang, Xiaofei Gao, Yiqun Jiang, Wei Zhang, Bo Zhang, Yan-Ling He, Liwei Ran, Chunlei Zhang, Wenting Wu, Quzong Suolang, Hanhuan Luo, Xiaojing Kang, Caoying Wu, Hongzhong Jin, Lei Chen, Qing Guo, Guangji Gui, Shanshan Li, Henan Si, Shuping Guo, Hong-Ye Liu, Xiguang Liu, Guo-Zhang Ma, Danqi Deng, Limei Yuan, Jianyun Lu, Jinrong Zeng, Xian Jiang, Xiaoyan Lyu, Liuqing Chen, Bin Hu, Juan Tao, Yuhao Liu, Gang Wang, Guannan Zhu, Zhirong Yao, Qianyue Xu, Bin Yang, Yu Wang, Yan Ding, Xianxu Yang, Hu Kai, Haijing Wu, Qianjin Lu
BACKGROUND: Lupus erythematosus (LE) is a spectrum of autoimmune diseases. Due to the complexity of cutaneous LE (CLE), clinical skin image-based artificial intelligence is still experiencing difficulties in distinguishing subtypes of LE. OBJECTIVES: We aim to develop a multimodal deep learning system (MMDLS) for human-AI collaboration in diagnosis of LE subtypes. METHODS: This is a multi-centre study based on 25 institutions across China to assist in diagnosis of LE subtypes, other eight similar skin diseases and healthy subjects...
April 15, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#27
REVIEW
D Potvin, P D'Angelo, S Bennett, J Jankicevic, R Bissonnette
Current drug development strategies present many challenges that can impede drug approval by regulatory agencies. Alternative study models, such as adaptive trial designs, have recently sparked interest, as they provide a flexible and more efficient approach in conducting clinical trials. Adaptive trial designs offer several potential benefits over traditional randomized controlled trials, which include decrease in costs, reduced clinical development time and limiting exposure of patients to potentially ineffective treatments allowing completion of studies with fewer patients...
April 15, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#28
JOURNAL ARTICLE
Salome-Joelle Gass, Valerie Yelverton, Jan Ostermann, Sharon Weissman, Helmut Albrecht
Telehealth was rapidly implemented in HIV care during COVID-19 yet remains understudied. To assess the importance of telehealth features, we conducted a mixed-methods study with HIV care providers and people living with HIV. Qualitative interviews and ranking exercises revealed heterogeneity in preference-relevant features of telehealth in HIV care.
May 1, 2024: Sexually Transmitted Diseases
#29
JOURNAL ARTICLE
Li Chen, Wen Yuan, Mengjie Geng, Rongbin Xu, Yi Xing, Bo Wen, Yao Wu, Xiang Ren, Yue Shi, Yi Zhang, Xinli Song, Yang Qin, RuoLin Wang, Jianuo Jiang, Ziqi Dong, Jieyu Liu, Tongjun Guo, Zhiying Song, Liping Wang, Yinghua Ma, Yanhui Dong, Yi Song, Jun Ma
This study assesses the association of short-term exposure to PM2.5 (particles ≤2.5 μm) on infectious diseases among Chinese children and adolescents. Analyzing data from 507 cities (2008-2021) on 42 diseases, it focuses on PM2.5 components (black carbon (BC), ammonium (NH4 + ), inorganic nitrate (NO3 - ), organic matter (OM), and sulfate (SO4 2- )). PM2.5 constituents significantly associated with incidence. Sulfate showed the most substantial effect, increasing all-cause infectious disease risk by 2...
April 11, 2024: Science of the Total Environment
#30
JOURNAL ARTICLE
Jaheersha Pakran, Amal Mohammed Alsaberi, Amani AlFalasi, Tarek Mohamed Karam Husein Ibrahim, Amel Abdalla Eisa Fadl Alnuaimi, Srikumar Goturu, Muneer Mohamed, Reena Mary Abraham, Vidya Lakshmi Sundaramurthi, Aneesh Kunnath Parambath, Beena Jose, Divya Kamat, Thencheri Cheriath Satish, Juwariya Tasneem Syeda, Lubna Gul, Rohini Mathias, Sajeela Rasheed Vattiyamveetil, Shaheela Backar, C Vijay Krishna, Laila Al Dhabal
BACKGROUND: MPOX (Monkeypox) viral infection, a zoonotic disease previously confined to the African sub-continent, has caught attention worldwide recently due to its resurgence in a new 'avatar' among urban communities. Dermatologists in the U. A. E. started to see patients with fever and a self-limiting pustular necrotic rash that was negative for all other infectious investigations. METHODS: We performed a prospective observational multicenter clinical study of the demographics, skin manifestations, and outcomes of patients presenting with necrotic pustular lesions and/or fever...
April 12, 2024: International Journal of STD & AIDS
#31
JOURNAL ARTICLE
Juanjuan Cui, Wen Cai, Jing Lin, Li Zhang, Youhan Miao, Ying Xu, Weifeng Zhao
BACKGROUND: Immunosuppression is a leading cause of septic death. Therefore, it is necessary to search for biomarkers that can evaluate the immune status of patients with sepsis. We assessed the diagnostic and prognostic value of low-density neutrophils (LDNs) and myeloid-derived suppressor cells (MDSCs) subsets in the peripheral blood mononuclear cells (PBMCs) of patients with sepsis. METHODS: LDNs and MDSC subsets were compared among 52 inpatients with sepsis, 33 inpatients with infection, and 32 healthy controls to investigate their potential as immune indicators of sepsis...
April 13, 2024: BMC Infectious Diseases
#32
JOURNAL ARTICLE
Yang-Ming Lee, Yuag-Meng Liu, Tsung-Chia Chen
BACKGROUND: Cryptococcal osteomyelitis is a rare and potentially serious condition, typically encountered in individuals with compromised immune systems. This case underscores the unusual occurrence of disseminated Cryptococcosis in an immunocompetent person, involving multiple bones and lungs, with Cryptococcus neoformans identified as the causative agent. CASE PRESENTATION: An Indonesian man, previously in good health, presented with a chief complaint of successive multiple bone pain lasting for more one month, without any prior history of trauma...
April 12, 2024: BMC Infectious Diseases
#33
JOURNAL ARTICLE
Tomohide Okinaka, Kenjiro Fujimura, Yuka Hamasaki, Yuichi Hasegawa, Takashi Matono
BACKGROUND: Non-tuberculous mycobacteria (NTM) are environmental organisms that are increasingly contributing to human infections. Mycobacterium immunogenum, a variant of NTM discovered in 2001, is a rapidly growing mycobacterium that exhibits multidrug resistance. Reports of infections caused by this organism, particularly tenosynovitis in the musculoskeletal system, are limited. CASE PRESENTATION: A 71-year-old female with vesicular pemphigus, undergoing immunosuppressive therapy, presented with a progressively enlarging tumour on the dorsum of her right hand, along with erythematous papules that extended across her right forearm...
April 12, 2024: BMC Infectious Diseases
#34
JOURNAL ARTICLE
Masoumeh Tavakoli-Yaraki, Aida Abbasi, Fatemeh Nejat Pishkenari, Saeed Baranipour, Alireza Jahangirifard, Seyed Bashir Mirtajani, Zahra Noorani Mejareh, Mohammad Amin Vaezi, Jila Yavarian, Bahare Abdollahi, Talat Mokhtari-Azad, Vahid Salimi
BACKGROUND: This study aims to explore the potential of utilizing the expression levels of cannabinoid receptor 2 (CB2), μ-opioid receptor (MOR), MCP-1, IL-17, IFN-γ, and osteopontin as predictors for the severity of SARS-CoV-2 infection. The overarching goal is to delineate the pathogenic mechanisms associated with SARS-CoV-2. METHODS: Using quantitative Real-time PCR, we analyzed the gene expression levels of CB2 and MOR in nasopharynx specimens obtained from patients diagnosed with SARS-CoV-2 infection, with 46 individuals classified as having severe symptoms and 46 as non-severe...
April 12, 2024: BMC Infectious Diseases
#35
JOURNAL ARTICLE
Jacob Nignan Nabei, Harriet Affran Bonful, Edwin Andrews Afari, Abdul Gafaru Mohammed, Adote Anum
BACKGROUND: Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-morbidity continues to be a serious worldwide health issue, particularly in Sub-Saharan Africa. Studies on the quality of life (QOL) of TB/HIV co-infected patients guide stakeholders on the delivery of patient-centred healthcare. This study evaluated QOL of TB/HIV co-infected individuals and its contributing factors. METHODS: We conducted a cross-sectional study among TB/HIV co-infected patients, receiving treatment at clinics in the Northern Region of Ghana...
April 12, 2024: BMC Infectious Diseases
#36
REVIEW
Abram L Wagner, Ashley Lacombe-Duncan, Matthew L Boulton
Widespread uptake of a future gonorrhea vaccine could decrease the burden of disease and limit the spread of antibiotic resistance. However, gonorrhea vaccination will occur in the backdrop of the roll-out of the coronavirus disease 2019 (COVID-19) vaccine, which could have influenced parental perceptions about other, non-COVID-19 vaccines. In an internet-based cross-sectional survey, 74% of parents would get a gonorrhea vaccine for their child, and this was higher among those whose trust in pharmaceutical companies increased since the start of the COVID-19 pandemic...
November 2023: Medical Clinics of North America
#37
JOURNAL ARTICLE
Danielle Solomon, Jo Gibbs, Fiona Burns, Hamish Mohammed, Stephanie J Migchelsen, Caroline A Sabin
BACKGROUND: Women aged 16-24 in England have a high burden of sexual and reproductive morbidity, with particularly poor outcomes among people living in more deprived areas (including racially minoritised populations). This analysis used national data to examine the disparities within sexual and reproductive outcomes among this population and to assess whether the patterns of inequality were consistent across all outcomes. METHODS: Within this ecological study, univariable and multivariable Poisson regression analyses of neighbourhood-level data from national data sets were carried out to investigate the relationships of deprivation and ethnicity with each of six dependent variables: gonorrhoea and chlamydia testing rates, gonorrhoea and chlamydia test positivity rates, and abortion and repeat abortion rates...
April 12, 2024: Journal of Epidemiology and Community Health
#38
JOURNAL ARTICLE
Richard W Kim, Ning C McKenzie, Kieron S Leslie
No abstract text is available yet for this article.
April 10, 2024: Journal of the American Academy of Dermatology
#39
JOURNAL ARTICLE
Li Chen, Yi Xing, Yi Zhang, Junqing Xie, Binbin Su, Jianuo Jiang, Mengjie Geng, Xiang Ren, Tongjun Guo, Wen Yuan, Qi Ma, Manman Chen, Mengjie Cui, Jieyu Liu, Yi Song, Liping Wang, Yanhui Dong, Jun Ma
BACKGROUND: An accelerated epidemiological transition, spurred by economic development and urbanization, has led to a rapid transformation of the disease spectrum. However, this transition has resulted in a divergent change in the burden of infectious diseases between urban and rural areas. The objective of our study was to evaluate the long-term urban-rural disparities in infectious diseases among children, adolescents, and youths in China, while also examining the specific diseases driving these disparities...
April 2024: PLoS Medicine
#40
JOURNAL ARTICLE
Thibaut Vanbaelen, Irith De Baetselier, Sheeba Santhini Manoharan-Basil, Chris Kenyon
OBJECTIVE: Tetracycline and macrolide resistance are frequently linked in streptococci and other species. We aimed to assess the association between doxycycline use and azithromycin MICs in oral streptococci. METHODS: Linear regression was used to assess the association between doxycycline use in the prior year and the median MIC per participant of oral streptococcal colonies isolated at the baseline visit of the ResistAZM study. The analysis controlled for receipt of other antimicrobials as well as time since antimicrobial consumption...
April 12, 2024: International Journal of STD & AIDS
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