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https://read.qxmd.com/read/30740962/multidisciplinary-perspectives-on-newly-revised-2018-figo-staging-of-cancer-of-the-cervix-uteri
#1
REVIEW
Jonathan S Berek, Koji Matsuo, Brendan H Grubbs, David K Gaffney, Susanna I Lee, Aoife Kilcoyne, Gi Jeong Cheon, Chong Woo Yoo, Lu Li, Yifeng Shao, Tianhui Chen, Miseon Kim, Mikio Mikami
No abstract text is available yet for this article.
December 28, 2018: Journal of Gynecologic Oncology
https://read.qxmd.com/read/30739874/clinically-diagnosed-primary-transitional-cell-carcinoma-of-the-colon-a-case-report
#2
Ryuichi Taketomi, Naoto Ujiie, Yoshitaka Enomoto, Naruhito Takido, Yasushi Kawaharada, Masashi Zuguchi, Yosuke Kubota, Ken Saito
INTRODUCTION: Most transitional cell carcinomas (TCCs) occur in the urinary tract. There are no reports of TCC originating in the colon. This report presents a very rare case of TCC that primarily occurred in the colon. PRESENTATION OF CASE: A 78-year-old female presented with adenocarcinoma of the rectum and TCC of the ascending colon. She was screened for urologic and gynecologic carcinomas because the TCC was considered a metastatic lesion; however, cytodiagnosis of urine, the cervix and corpus uteri revealed no abnormal findings...
January 31, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30698052/clinical-evaluation-and-treatment-of-chronic-bowel-symptoms-following-cancer-in-the-colon-and-pelvic-organs
#3
Helene Mathilde Larsen, Mette Borre, Peter Christensen, Asbjørn Mohr Drewes, Søren Laurberg, Klaus Krogh, Janne Fassov
BACKGROUND: Chronic gastrointestinal symptoms are common among patients surviving surgery and/or radio-/chemotherapy for cancer in the pelvic organs. However, little is known about the pathophysiology behind symptoms or the effect of treatment. The aim of the present study was to present the results of clinical evaluation and treatment of patients with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs. MATERIAL AND METHODS: All patients referred to our department of gastroenterology between May 2016 and June 2018 with chronic bowel symptoms after treatment for cancer in the colon or pelvic organs were prospectively evaluated...
January 30, 2019: Acta Oncologica
https://read.qxmd.com/read/30679392/prevalence-of-human-papillomavirus-related-diseases-in-the-republic-of-korea-a-cross-sectional-study
#4
Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Jae-Kwan Lee, Kyung-Jin Min, Moran Ki
OBJECTIVE: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea. METHODS: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63...
January 24, 2019: Sexually Transmitted Infections
https://read.qxmd.com/read/30659331/-squamous-cell-precancerous-lesions-of-the-cervix-uteri
#5
REVIEW
D Schmidt
BACKGROUND: The histological and immunohistochemical evaluation of tissue samples obtained in the course of the investigation and treatment of precancerous squamous lesions of the cervix uteri is an essential task of the pathologist. Given the surprising variety of morphological findings, including the many possible differential diagnoses of dysplastic changes, this is not an easy task. DIFFERENTIATION: Biologically, only two prognostically different groups can be distinguished, which according to the WHO classification are referred to as low-grade or high-grade squamous intraepithelial lesions (LSILs or HSILs)...
January 18, 2019: Der Pathologe
https://read.qxmd.com/read/30656645/revised-figo-staging-for-carcinoma-of-the-cervix-uteri
#6
Neerja Bhatla, Jonathan S Berek, Mauricio Cuello Fredes, Lynette A Denny, Seija Grenman, Kanishka Karunaratne, Sean T Kehoe, Ikuo Konishi, Alexander B Olawaiye, Jaime Prat, Rengaswamy Sankaranarayanan, James Brierley, David Mutch, Denis Querleu, David Cibula, Michael Quinn, Hennie Botha, Lax Sigurd, Laurel Rice, Hee-Sug Ryu, Hextan Ngan, Johanna Mäenpää, Andri Andrijono, Gatot Purwoto, Amita Maheshwari, Uttam D Bafna, Marie Plante, Jayashree Natarajan
OBJECTIVE: To revise FIGO staging of carcinoma of the cervix uteri, allowing incorporation of imaging and/or pathological findings, and clinical assessment of tumor size and disease extent. METHODS: Review of literature and consensus view of the FIGO Gynecologic Oncology Committee and related societies and organizations. RESULTS: In stage I, revision of the definition of microinvasion and lesion size as follows. Stage IA: lateral extension measurement is removed; stage IB has three subgroups-stage IB1: invasive carcinomas ≥5 mm and <2 cm in greatest diameter; stage IB2: tumors 2-4 cm; stage IB3: tumors ≥4 cm...
January 17, 2019: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/30585589/-gelatinases-a-and-b-and-their-endogenous-regulators-in-the-corpus-uteri-in-squamous-cell-cervical-carcinoma
#7
O S Timoshenko, T A Gureeva, E V Kugaevskaya, L E Zavalishina, Yu Yu Andreeva, N I Solovyeva
OBJECTIVE: To investigate the expression of gelatinases A and B (matrix metalloproteinases (MMP 2 and MMP 9) and endogenous regulators of their activity, such as a tissue inhibitor of MMP - TIMP-2 and a Pro-MMP-9 activator - urokinase-type plasminogen activator (uPA) as factors of corpus uteri invasion in squamous cell cervical carcinoma (SCCC). MATERIAL AND METHODS: The surgical material obtained after hysterectomy in patients diagnosed with SCCC was examined. RT-PCR, immunohistochemistry (IHC), and enzyme-linked immunosorbent assay were used...
2018: Arkhiv Patologii
https://read.qxmd.com/read/30565668/overweight-in-midlife-and-risk-of-cancer-in-late-life-a-nationwide-swedish-twin-study
#8
Cuiping Bao, Rongrong Yang, Nancy L Pedersen, Weige Xu, Hui Xu, Ruixue Song, Xiuying Qi, Weili Xu
This study examined whether midlife overweight (body mass index [BMI] ≥25) is associated with late-life cancer risk and explored the role of genetic and early-life environmental factors in this association. The study included 14,766 individuals from the Swedish Twin Registry, whose midlife (30-50 years) height and weight were recorded. Information on cancer diagnoses in late life (>65 years) was derived from the National Patient Registry and Cancer Registry. Generalized estimating equation (GEE) models were used to analyze unmatched case-control data (controlled for the clustering of twins within a pair)...
November 22, 2018: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30540870/-influence-of-hpv-infection-on-cell-cycle-regulation-in-epithelial-cell-alterations-of-cervix-uteri-immunohistochemical-and-in-situ-hybridization-observations
#9
Zoltán Szentirmay
The HPV16 E6 DNA incorporation into the cervical epithelial cell genome was determined. In addition, using p16, p21 and p27 protein immunohistochemistry, we intended to present how the normal cell cycle machinery was disturbed in cervical epithelial cells. In CIN1 the epithelial cells are transformed into koilocytes, p16 is not expressed. p21 is only visible over the parabasal cell layers, while p27 manifests in koilocytes and lymphocytes. In CIN2/3, one copy of HPV16 DNA is integrated in the epithelial cell genome...
December 12, 2018: Magyar Onkologia
https://read.qxmd.com/read/30537646/transition-of-cancer-in-populations-in-india
#10
Aleyamma Mathew, Preethi Sara George, Jagathnath Krishna K M, Durga Vasudevan, Francis V James
BACKGROUND & OBJECTIVES: An assessment of transition of cancer in India during the past 30 years, according to changes in demographic and epidemiologic risk factors was undertaken. MATERIALS & METHODS: Cancer registry data (http://www.ncdirindia.org), (population coverage <10%), was compared with transition in life-expectancy and prevalence on smoking, alcohol and obesity. We fitted linear regression to the natural logarithm of the estimated incidence rates of various cancer registries in India...
December 8, 2018: Cancer Epidemiology
https://read.qxmd.com/read/30480570/cancer-burden-in-adolescents-and-young-adults-a-review-of-epidemiological-evidence
#11
Annalisa Trama, Laura Botta, Eva Steliarova-Foucher
Cancer burden in adolescents and young adults (AYAs) is expressed through a large proportion of the quality of life lost on individual level and also causes losses to the society in terms of a decreased productivity and social structure. A specific cancer spectrum and distinctive needs of AYA patients require targeted studies and cancer control measures. Incidence is intermediate between that for children and for older adults, and two-thirds of the AYA cancers affect women. Cancers of the breast and cervix uteri, representing a large portion of the burden, are amenable to prevention...
November 2018: Cancer Journal
https://read.qxmd.com/read/30446779/ectopias-of-the-kidney-urinary-tract-organs-and-male-genitalia
#12
REVIEW
G Mikuz
The most frequent anomaly of the urogenital tract is a simple renal ectopia with one organ lying in the pelvis. Crossed renal ectopia is a less common condition in which the ectopic kidney is located on the opposite side of the midline from the ureteral insertion in the urinary bladder. The cause of both types of renal ectopia is the arrest or failure of the kidney ascent from the pelvic to the lumbar position. Whereas an accelerated ascent leads to a subdiaphragmal or intrathoracic ectopic position, an ectopic ureter can be defined as one that does not drain into the trigonum vesicae...
November 16, 2018: Der Pathologe
https://read.qxmd.com/read/30324544/mesothelin-as-a-target-for-cervical-cancer-therapy
#13
Korinna Jöhrens, Lea Lazzerini, Jana Barinoff, Jalid Sehouli, Guenter Cichon
PURPOSE: The cell surface glycoprotein Mesothelin is overexpressed in several tumor entities and novel immune-based therapies are currently under the early clinical evaluation for the treatment of malignant pleura mesothelioma, ovarian cancer, and pancreatic cancer. Cervical cancer has not been recognized as a suitable target for Mesothelin-directed immune therapies so far. METHODS: To exploit a possible role of Mesothelin in cervical cancer treatment, we analysed Mesothelin expression in 79 cervical carcinomas and aligned expressions patterns with tumor growth parameters...
October 15, 2018: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/30306584/cancer-of-the-cervix-uteri
#14
Neerja Bhatla, Daisuke Aoki, Daya Nand Sharma, Rengaswamy Sankaranarayanan
Since the publication of the last FIGO Cancer Report there have been giant strides in the global effort to reduce the burden of cervical cancer, with WHO announcing a call for elimination. In over 80 countries, including LMICs, HPV vaccination is now included in the national program. Screening has also seen major advances with implementation of HPV testing on a larger scale. However, these interventions will take a few years to show their impact. Meanwhile, over half a million new cases are added each year...
October 2018: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/30257658/greater-family-size-is-associated-with-less-cancer-risk-an-ecological-analysis-of-178-countries
#15
Wenpeng You, Frank J Rühli, Renata J Henneberg, Maciej Henneberg
BACKGROUND: Greater family size measured with total fertility rate (TFR) and with household size, may offer more life satisfaction to the family members. Positive psychological well-being has been postulated to decrease cancer initiation risk. This ecological study aims to examine the worldwide correlation between family size, used as the measure of positive psychological well-being, and total cancer incidence rates. METHODS: Country specific estimates obtained from United Nations agencies on total cancer incidence rates (total, female and male rates in age range 0-49 years and all ages respectively), all ages site cancer incidence (bladder, breast, cervix uteri, colorectum, corpus uteri, lung, ovary and stomach), TFR, household size, life expectancy, urbanization, per capita GDP PPP and self-calculated Biological State Index (Ibs ) were matched for data analysis...
September 26, 2018: BMC Cancer
https://read.qxmd.com/read/30144282/alk-rearrangement-in-lung-adenocarcinoma-with-concurrent-cervix-and-breast-metastases-a-case-report
#16
Xin Chuang, Ying Chen, Ping Yu, Xueshan Qiu, Jian Wang, Xiujuan Qu, Yuee Teng, Yunpeng Liu, Bo Jin
Distant metastases of pulmonary adenocarcinoma are regularly observed in the bones, brain, adrenal gland, and liver, but rarely in the breast or cervix. In this report, we describe a novel case of concurrent cervix and breast metastases from lung adenocarcinoma, with ALK rearrangements that were strongly consistent between the primary and metastatic cancers. A 44-year-old Chinese woman with a chief complaint of abdominal discomfort was referred to our hospital. Based on diagnostic imaging, pathology, immunohistochemistry, and next-generation sequencing, the patient was diagnosed with lung adenocarcinoma with breast and cervical metastases, and ALK rearrangements were found in all three lesions...
November 2018: Thoracic Cancer
https://read.qxmd.com/read/30141405/cervical-cancer-in-iran-integrative-insights-of-epidemiological-analysis
#17
Zohre Momenimovahed, Hamid Salehiniya
BACKGROUND: Cervical cancer is a common cancer among women around the world. Due to the geographical differences in incidence, mortality and risk factors of cervical cancer, it is necessary to conduct different studies in different countries. This review study is aimed to investigate the most important aspects of cervical cancer in Iran. METHODS: Reviewing papers without time limitation was conducted with the keywords cervical cancer, Cervix uteri cancer and Iran in their title or abstract...
September 2018: BioMedicine
https://read.qxmd.com/read/30138963/-value-of-mri-in-the-pre-operative-diagnosis-and-classification-of-oblique-vaginal-septum-syndrome
#18
Y Wang, Q Lin, Z J Sun, B Jiang, B Hou, J J Lu, L Zhu, F Feng, Z Y Jin, J H Lang
Objective: To explore the role of MRI in the pre-operative diagnosis and classification of oblique vaginal septum syndrome (OVSS) . Methods: A retrospective analysis of the clinical records and pre-operative MRI images of 19 patients with surgery proved OVSS was carried out. Two experienced radiologists reviewed the pre-operative pelvic MRI of the 19 patients in consensus blind to the surgery results. Characteristics including malformations of the uterus, cervix and vagina, the diagnosis of the disorder and classification were evaluated...
August 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/30135974/-ectopias-of-the-kidney-urinary-tract-organs-and-male-genitalia-german-version
#19
REVIEW
G Mikuz
The most frequent anomaly of the urogenital tract is a simple renal ectopia with one organ lying in the pelvis. Crossed renal ectopia is a less common condition in which the ectopic kidney is located on the opposite side of the midline from the ureteral insertion in the urinary bladder. The cause of both types of renal ectopia is the arrest or failure of the kidney ascent from the pelvic to the lumbar position. Whereas an accelerated ascent leads to a subdiaphragmal or intrathoracic ectopic position, an ectopic ureter can be defined as one that does not drain into the trigonum vesicae...
September 2018: Der Pathologe
https://read.qxmd.com/read/30125346/hpv-mrna-and-hpv-dna-detection-in-samples-taken-up-to-seven-years-before-severe-dysplasia-of-cervix-uteri
#20
Ola Forslund, K Miriam Elfström, Helena Lamin, Joakim Dillner
Randomized clinical trials using human papillomavirus (HPV) DNA testing have found increased protection against cervical cancer and HPV-based screening is globally recommended for women ≥30 years of age. HPV-mRNA is a promising alternative target for cervical screening tests, but assessing equivalence requires longitudinal evaluation over at least the length of a screening interval. Our aim is to analyze the longitudinal sensitivity of HPV-mRNA and HPV-DNA in cervical samples taken up to 7 years before severe cervical intraepithelial neoplasia or worse (CIN3+)...
August 19, 2018: International Journal of Cancer. Journal International du Cancer
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