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endometrial cancer

Fei Zheng, Huimin Yu, Jingjing Lu
Mucins (MUCs) have been reported to play a critical role in the tumorigenesis of different cancers. This study was performed to explore the effect of MUC20 in endometrial cancer (EC). A total of 541 patients with EC were examined from The Cancer Genome Atlas. The relationship between MUC20 expression and clinical characteristics was analyzed with the Wilcoxon signed-rank test and logistic regression. The Kaplan-Meier method and the Cox regression model was performed to evaluate the prognosis. Gene set enrichment analysis (GSEA) was conducted...
February 19, 2019: Journal of Cellular Biochemistry
Serina Dai, Samar Nahas, Joan K Murphy, Janet Lawrence, Taymaa May, Tomer Feigenberg
OBJECTIVE: To investigate the cost and impact of routine preoperative computed tomography (CT) in patients with high-grade endometrial cancer, and its role in identifying extrauterine disease. METHODS: We retrospectively identified patients with high-grade endometrial cancer who underwent routine CT scan prior to surgical procedure between September 1, 2005, and January 31, 2015. Cases in which CT findings led to alterations in the treatment plan were documented...
February 19, 2019: International Journal of Gynaecology and Obstetrics
Wan Ahmad Hazim Wan Ghazali, Siti Amira Jamil, Ili Abdullah Sharin
Objective: The objective of the study is to assess the efficacy of laparoscopy compared with laparotomy in extrafascial hysterectomy and lymphadenectomy for endometrial cancer. Design: This was a retrospective study of small cases over a 5-year period. Setting: This study was conducted in Putrajaya Hospital, a district hospital with consultant care level in obstetrics and gynecology. Sample: Forty women presented with confirmed cases of endometrial cancer based on histopathology result and underwent extrafascial hysterectomy with or without lymphadenectomy between January 2010 and December 2014...
January 2019: Gynecology and minimally invasive therapy
Salwa Abdullahi Idle, Haitham Hamoda
OBJECTIVE: This study correlates the transvaginal ultrasound findings with histopathology results in women who present with unscheduled bleeding on hormone replacement therapy. STUDY DESIGN: Retrospective analysis of 469 consecutive cases with unscheduled bleeding on hormone replacement therapy (203 patients on sequential hormone replacement therapy (seq-HRT) and 266 patients on continuous combined hormone replacement therapy (con-HRT)). MAIN OUTCOME MEASURES: Outcomes of endometrial assessment in women with unscheduled bleeding on hormone replacement therapy...
February 19, 2019: Post Reproductive Health
Ana-Maria Dull, Marius Alexandru Moga, Oana Gabriela Dimienescu, Gabriela Sechel, Victoria Burtea, Costin Vlad Anastasiu
Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiology and pathogenesis of this disease still remain not fully understood. Initially, endometriosis was related to retrograde menstruation, but new theories have been launched, suggesting that chronic inflammation can influence the development of endometriosis because inflammatory mediators have been identified elevated in patients with endometriosis, specifically in the peritoneal fluid...
February 13, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Peixin Dong, Ying Xiong, Junming Yue, Sharon J B Hanley, Noriko Kobayashi, Yukiharu Todo, Hidemichi Watari
Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways...
February 16, 2019: Cancers
Yu-Shen Wu, Huapeng Lin, Duke Chen, Ziying Yi, Beilei Zeng, Yicheng Jiang, Guosheng Ren
BACKGROUND: The microRNAs (miRNAs) have been validated as prognostic markers in many cancers. The aim of this study was to identify new miRNA prognostic biomarkers in endometrial cancer (EC) and to develop an expression-based miRNA signature to provide survival risk prediction for EC patients. METHODS: From TCGA database, the miRNA datasets of EC and clinical information were downloaded in April 2018. Using univariate and multivariate Cox regression analyses identify prognostic factors...
February 16, 2019: Gene
Antonio Raffone, Antonio Travaglino, Gabriele Saccone, Antonio Mollo, Giuseppe De Placido, Luigi Insabato, Fulvio Zullo
INTRODUCTION: Progestins are used as conservative treatment of endometrial hyperplasia (EH) and early endometrial cancer (EEC). We aimed to assess if immunohistochemical expression of estrogens and progesterone receptors (ER and PR) predicts the treatment response. MATERIAL AND METHODS: Electronic databases were searched for studies assessing ER and PR expression in EH and EEC treated with progestins. Relative risk for poor response, sensitivity, specificity, diagnostic odds ratio positive and negative likelihood ratios (LR+ and LR-) and area under the curve (AUC) on summary receiver operating characteristic curve were calculated...
February 19, 2019: Acta Obstetricia et Gynecologica Scandinavica
Xuanxuan Jing, Jin Peng, Yu Dou, Jintang Sun, Chao Ma, Qingjie Wang, Lin Zhang, Xia Luo, Beihua Kong, Yun Zhang, Lijie Wang, Xun Qu
Tumor associated macrophages (TAMs) exert tumor-promoting effects. There have been reports that Estrogen receptors (ERs) are expressed on the infiltrating macrophages of endometriosis, ovarian cancer and lung cancer. However, the role of ERs in macrophages is not well characterized. In this study, we first identified that ERα expression on the macrophages of human endometrial cancer was positively correlated with cancer progression. Conditioned medium from selective ERα agonist-treated M2 macrophages induced the epithelial to mesenchymal transition (EMT) in endometrial cancer cells...
February 18, 2019: Immunology and Cell Biology
M Herreros-Villanueva, Chih-Chieh Chen, Eing-Mei Tsai, Tze-Kiong Er
Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Recent molecular and pathological studies indicate that endometriosis may serve as a precursor of ovarian cancer (endometriosis-associated ovarian cancer, EAOC), particularly endometrioid and clear cell ovarian cancers...
February 15, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Amita Maheshwari, Sudeep Gupta, Jaime Prat
Since the last update of the International Federation of Gynecology and Obstetrics (FIGO) staging for corpus uteri cancer in 2009, a number of new insights into pathology, molecular genetics, and prognostic factors that justify a revision have been made. We recommend incorporation of histotype and grade along with depth of myometrial invasion to define stage I endometrial cancer, a change from 3-tier grading to binary grading, and inclusion of lymph node status (negative versus not removed) in the definition of stage I disease...
February 18, 2019: International Journal of Gynaecology and Obstetrics
Yashoda Ghanekar, Subhashini Sadasivam
Background: Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the CASP8 gene . Uterine Corpus Endometrial Carcinoma (UCEC) is another cancer where ∼10% cases harbor CASP8 mutations. Caspase-8, the protease encoded by CASP8 gene, plays a dual role in programmed cell death, which in turn has an important role in tumor cell death and drug resistance...
2019: PeerJ
Hanna E Teasley, Munseok Paul Jeong, Tae Hoon Kim
The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. MIG-6 mediates P4 signaling and acts as a tumor suppressor during endometrial tumorigenesis in both humans and mice. In previous studies, we developed the conditional knockout of Mig-6 in all uterine compartments (Pgrcre/+ Mig-6f/f ; Mig-6KO ) and endometrial epithelial cell-specific Mig-6 knockout (Sprr2fcre/+ Mig-6f/f ; Mig-6Ep-KO ) mice...
February 14, 2019: Biochemical and Biophysical Research Communications
Zeinab Latifi, Hamid Reza Nejabati, Sina Abroon, Aynaz Mihanfar, Laya Farzadi, Parvin Hakimi, Hamed Hajipour, Mohammad Nouri, Amir Fattahi
TGF-β signaling in the endometrium is active during the implantation period and has a pivotal role in regulating endometrial receptivity and embryo implantation. During embryo implantation, both apoptosis and proliferation of endometrial cells happen at the same time and it seems TGF-β is the factor that controls both of these processes. As shown in cancer cells, in special conditions this cytokine can have a dual effect and switch the action from apoptosis to proliferation. Owing to the similarity between embryo implantation and cancer development and also unusual pattern of proliferation and remodeling in the uterus, in this review we suggest the existence of such a switching in endometrium during the early pregnancy...
February 17, 2019: Biology of Reproduction
Giorgio Bogani, Maria Teresa Ricci, Marco Vitellaro, Antonino Ditto, Valentina Chiappa, Francesco Raspagliesi
OBJECTIVE: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer. METHODS: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Patients were classified on the basis of classes of risk according to the ESGO-ESGO-ESTRO (European Society of Medical Oncology/European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology) guidelines...
February 16, 2019: International Journal of Gynecological Cancer
S Gandini, M Lazzeroni, F A Peccatori, B Bendinelli, C Saieva, D Palli, G Masala, S Caini
We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. We included 32 studies published between 1989 and 2018. We found an increased risk of endometrial (SRR 1.38, 95%CI 1.10-1.74) and thyroid cancer (SRR 1.38, 95%CI 1.17-1.63), and inverse association with cervical cancer (SRR 0...
February 2019: Critical Reviews in Oncology/hematology
Aniket V Mali, Subhash B Padhye, Shrikant Anant, Mahabaleshwar V Hegde, Shivajirao S Kadam
Currently cancer is the second leading cause of death globally and worldwide incidence and mortality rates of all cancers of males and females are rising tremendously. In spite of advances in chemotherapy and radiation, metastasis and recurrence are considered as the major causes of cancer related deaths. Hence there is a mounting need to develop new therapeutic modalities to treat metastasis and recurrence in cancers. A significant amount of substantiation from epidemiological, clinical and laboratory research highlights the importance of diet and nutrition in cancer chemoprevention...
February 13, 2019: European Journal of Pharmacology
Anna Jo Bodurtha Smith, Sanskriti Varma, Anne F Rositch, Kimberly L Levinson
OBJECTIVE: While there is a significant body of literature on cervical cancer in HIV-positive women, little is known about other gynecologic cancers in this population. The objective of this systematic review and meta-analysis is to describe the incidence, presentation, treatment, and outcomes for HIV-positive women with non-AIDS-defining gynecologic cancers. DATA SOURCE: We searched Medline, Embase,, and the Cochrane Central Registry of Controlled trials for English-language studies published from 2000 to May 1, 2017...
February 13, 2019: American Journal of Obstetrics and Gynecology
Tian Yao, Runyu Cao, Wen Xiao, Feng Pan, Xiaoping Li
Platinum chemo-sensitivity detection plays a vital role during endometrial cancer treatment because chemotherapy responses have profound influences on patient's prognosis. Although several methods can be used to detect drug resistance characteristics, studies on detecting drug sensitivity based on dynamic and quantitative phase imaging of cancer cells are rare. In this study, digital holographic microscopy was applied to distinguish drug-resistant and non-drug-resistant endometrial cancer cells. Based on the reconstructed phase images, temporal evolutions of cell height, cell projected area and cell volume were quantitatively measured...
February 15, 2019: Journal of Biophotonics
Kumar U Nithin, M G Sridhar, K Srilatha, S Habebullah
Background: Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB. Objectives: To estimate and compare serum prolactin, Cancer Antigen 125 (CA-125), Cancer Antigen 15-3 (CA15-3), and Carcino embryonic antigen (CEA) levels in patients with endometrial cancer and abnormal uterine bleeding; To evaluate the role of these markers in diagnosing endometrial cancer...
December 2018: African Health Sciences
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