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María Elena Sánchez-Mendoza, Yaraset López-Lorenzo, Leticia Cruz-Antonio, Audifás-Salvador Matus-Meza, Yolanda Sánchez-Mendoza, Jesús Arrieta
Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia ), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group...
February 11, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Laura Pavel, Gheorghe Gh Bălan, Alexandra Nicorescu, Georgiana Emmanuela Gîlcă-Blanariu, Cătălin Sfarti, Ștefan Chiriac, Smaranda Diaconescu, Vasile Liviu Drug, Gheorghe Bălan, Gabriela Ștefănescu
BACKGROUND: Despite significant technical and training improvements, the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g . nonsteroidal anti-inflammatory drugs, octreotide, antioxidants, administered via various dosages, routes (oral, intrarectal or parenteral), and schedules (before or after the procedure), the results have been conflicting...
February 6, 2019: World Journal of Clinical Cases
Sina Waldherr, Alexander Fichtner, Bernd Beedgen, Thomas Bruckner, Franz Schaefer, Burkhard Tönshoff, Johannes Pöschl, Timm H Westhoff, Jens H Westhoff
BACKGROUND: Serum creatinine (SCr)- or urine output-based definitions of acute kidney injury (AKI) have important limitations in neonates. This study evaluates the diagnostic value of urinary biomarkers in very low-birth-weight (VLBW) infants receiving indomethacin for closure of a patent ductus arteriosus (PDA). METHODS: Prospective cohort study in 14 indomethacin-treated VLBW infants and 18 VLBW infants without indomethacin as controls. Urinary biomarkers were measured before, during, and after indomethacin administration...
February 11, 2019: Pediatric Research
Carmen Ferrer-Pérez, Tamara Escrivá-Martinez, Sandra Montagud-Romero, Raúl Ballestín, Marina D Reguilón, José Miñarro, Marta Rodríguez-Arias
[This corrects the article DOI: 10.1371/journal.pone.0209291.].
2019: PloS One
L B Jesus, A B Santos, E E V Jesus, R G D Santos, M S Grangeiro, A Bispo-da-Silva, M R Arruda, D S Argolo, A M Pinheiro, R S El-Bachá, S L Costa, M F D Costa
Central nervous system (CNS) is the main site for encystment of Neospora caninum in different animal species. In this tissue, glial cells (astrocytes and microglia) modulate responses to aggression in order to preserve homeostasis and neuronal function. Previous data showed that when primary cultures of glial cells are infected with N. caninum, they develop gliosis and the immune response is characterized by the release of TNF and IL-10, followed by the control of parasite proliferation. In order to elucidate this control, three enzymatic systems involved in parasite-versus-host interactions were observed on a model of neuron/glia co/cultures obtained from rat brains...
February 2019: Veterinary Parasitology
Ilmara Cecilia Pinheiro de Silva Morais, Iris Jordânia Luz Moura, Carla Kelly Barroso Sabino, Lucas Antonio Duarte Nicolau, Fabiana de Moura Souza, José Couras da Silva-Filho, Rita de Cássia Meneses Oliveira, Jand Venes Rolim Medeiros, Sidney Gonçalo de Lima, Aldeidia Pereira de Oliveira
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200-220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10-9 M-3 × 10-4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55...
February 8, 2019: Journal of Medicinal Food
Dongrong Zhu, Chen Chen, Lijuan Bai, Lingyi Kong, Jianguang Luo
Background: Pharbitis Semen, the seeds of Pharbitis nil , is widely used as a traditional purgative medicine in China, Korea, and Japan. This study investigated the laxative effects of a purified resin glycoside fraction obtained in our previous study from Pharbitis Semen in vivo and in vitro. Materials and Methods: After orally administering a purified resin glycoside fraction from Pharbitis Semen (RFP) to rats, the content of fecal water, AQP3, NF- κ B, COX-2 expression, and the prostaglandin E2 (PGE2 ) concentrations in the colon were examined...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Sara Nawfal Sharief, Nada Abdullatif Hefni, Walaa Ali Alzahrani, Iman Ibrahim Nazer, Marwa Abdullah Bayazeed, Khalid A Alhasan, Osama Y Safdar, Sherif M El-Desoky, Jameela Abdulaziz Kari
BACKGROUND: Congenital and infantile nephrotic syndrome (CNS and INS) are rare inherited defects in glomerular filtration involving a variety of gene mutations. This study aimed to analyze all genetic mutations associated with congenital and infantile nephrotic syndrome treated at our institution. We also discussed our different approach secondary to culture and resources. METHODS: A retrospective single-center study of all children diagnosed as NS before the age of 1 year over a duration of over one decade...
February 5, 2019: World Journal of Pediatrics: WJP
Cristin Conrad, Desi Newberry
BACKGROUND: Patent ductus arteriosus (PDA) is the persistence of a fetal shunt between the pulmonary artery and the aorta. This structure normally closes in the first 3 days after birth; however, closure is delayed in up to 80% of infants born at 25 to 28 weeks of gestation. Persistent PDA results in pulmonary overcirculation and systemic hypoperfusion. PURPOSE: The purpose of this article is to review pathophysiology and treatment options for PDA. METHODS: A literature review was conducted using PubMed, CINAHL, and Google Scholar (2013-2018)...
January 31, 2019: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Enaile Salviano de Carvalho, Cleide Adriane Signor Tirloni, Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Lucas Pires Guarnier, Aniely Oliveira Silva, Jonas da Silva Mota, Claudia Andréa Lima Cardoso, Márcio Eduardo de Barros, Arquimedes Gasparotto Junior
This work provides the first demonstration that ethanolic extract (EEEG) obtained from Echinodorus grandiflorus leaves (EEEG) and its butanolic fraction (ButFr) has important vasodilatory effects on isolated mesenteric vascular beds (MVBs). First, the EEEG was obtained and a liquid-liquid fractionation was performed. EEEG and its resulting fractions were analyzed by high-performance liquid chromatography. Then, the vasodilatory effects of EEEG and their respective fractions were evaluated. Finally, the molecular mechanisms involved in the vasodilator responses of the EEEG and ButFr were also investigated...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Xiao-Juan Zhou, Xiang-Min Kong, Ying-Chao Wang, Cheng Jiang, Zhao-Xiang Jin, Le Ai, Ling Zhang, Yi Wang
The aim of the present study is to evaluate the vasodilation effects of Tongmai Yangxin Pills (TMYX) on rat mesenteric artery as well as its mechanism of action. The relaxation effects of TMYX extracts with different concentrations were determined on isolated rat mesenteric artery in normal condition as well as pretreating by phenylephrine and KCl. Vascular relaxation effects of TMTX were also determined in mesenteric artery preincubated with L-ANME and indomethacin or in endothelium denuded mesenteric artery...
December 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Eman K A Abdelall, Phoebe F Lamie, Amira K M Ahmed, El-Shaymaa El-Nahass
Four pyrazolopyrimidine series were prepared with a substitution at position- 4 by Schiff base, triazole, oxadiazole and pyrazole moieties (7a-f, 8a,b, 9a-f, 10a,b and 13a,b), respectively. All the synthesized compounds were evaluated in vitro against COX-2 and in vivo against carrageenan-induced rat paw edema as anti-inflammatory agents. Regarding the anti-inflammatory activity (AI) compounds 7c, 7f, 8a, and 9a showed higher activity with respect to celecoxib. Compounds 9a, 7d, and 7f were closely selective to celecoxib...
January 22, 2019: Bioorganic Chemistry
Thayane Rebeca Alves-Santos, Fabiano Elias Xavier, Gloria Pinto Duarte, Rosivaldo Dos Santos Borges, Pedro Jorge Caldas Magalhães, Saad Lahlou
Mechanisms underlying the vasorelaxant effects of the synthetic nitro compound, trans-4-methoxy-β-nitrostyrene (T4MN) were studied in isolated small resistance arteries from spontaneously hypertensive rats (SHRs). T4MN caused vasorelaxation in endothelium-intact third-order branches of the mesenteric artery pre-contracted with noradrenaline (NA). This effect was unchanged by indomethacin and atropine but was significantly reduced by endothelium removal, L-NAME, LY294002, glybenclamide, TEA, apamin, TRAM 34, or by the association of apamin and TRAM 34...
February 1, 2019: European Journal of Pharmacology
Natália A Gonzaga, Wanessa M C Awata, Jose E Tanus-Santos, Júlio C Padovan, Carlos R Tirapelli
The effects on the vasculature produced by ethanol withdrawal include both vasodilatation and hypocontractility, although a detailed biochemical understanding of these processes is yet to be accomplished. Here, we sought to investigate some of the mechanisms underlying vascular hypocontractility induced by ethanol withdrawal. Male Wistar rats were treated with increasing doses of 3-9% ethanol (v/v) for 21 days and the impact of ethanol withdrawal on the vascular function was assessed 48h after immediate ethanol suspension...
January 30, 2019: European Journal of Pharmacology
Yun Mi Lee, Eunjung Son, Seung-Hyung Kim, Ohn Soon Kim, Dong-Seon Kim
CONTEXT: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model. OBJECTIVE: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. MATERIALS AND METHODS: The dried whole plants of M. pentaphylla were extracted with 70% ethanol under reflux...
December 2019: Pharmaceutical Biology
Daniela Schulz, Florian Schlieckau, Sara Fill Malfertheiner, Edith Reuschel, Birgit Seelbach-Göbel, Wolfgang Ernst
Despite considerable progress in the field of perinatal care, infectious diseases, especially when caused by gram negative bacteria, remain a major reason for neonatal morbidity and mortality. Notably infants born prematurely and those with very low birth weight are at risk due to their immature and deficient immune system and their prolonged hospitalization which promotes nosocomial infections. In case of impending preterm birth, betamethasone is given to induce lung maturation and tocolytic agents like indomethacin or fenoterol are administered to suppress premature labor...
January 28, 2019: Cytokine
Oliver Werzer, Stephan Tumphart, Roman Keimel, Paul Christian, Anna Maria Coclite
Control over drug delivery may be interestingly achieved by using temperature responsive encapsulants, which change their thickness and mesh size with temperature. The prototype N-isopropylacrylamide hydrogel cross-linked with di(ethylene glycol) divinyl ether p(NIPAAm-co-DEGDVE) swells at low temperature and collapses above the lower critical solution temperature (LCST), ∼29 °C in a buffer. It might be expected that drug release from such encapsulation is always favored below the LCST, due to the larger free volume present in the swollen polymer film...
January 30, 2019: Soft Matter
Maryam Kashanian, Shaghayegh Shirvani, Narges Sheikhansari, Forough Javanmanesh
INTRODUCTION: Preterm delivery is an important issue in obstetrics, which is the most common cause of neonatal mortality and morbidity. Therefore, finding a way to prevent it is always under serious concern. OBJECTIVE: The study aimed to compare the efficacy of two tocolytic agents, nifedipine and indomethacin, for inhibiting preterm uterine contractions as monotherapy and combination therapy. MATERIALS AND METHODS: A double-blind randomized clinical trial was performed on pregnant women with gestational age of 26-34 weeks of pregnancy who referred to hospital for preterm labor...
January 29, 2019: Journal of Maternal-fetal & Neonatal Medicine
Suraj S Patil, Dipak D Kumbhar, Jagdish V Manwar, Rajesh G Jadhao, Ravindra L Bakal, Sharad Wakode
This work is devoted to design a novel nanostructured hybrid vesicle (NHV) made of lecithin and an acrylate/C10-C30 alkyl acrylate for the nasal delivery of a model active indomethacin (IND), and further to probe its microstructure, intermolecular interactions, drug release behavior, ex vivo permeation, and stability. NHVs were prepared by cavitation technology employing RSM-based central composite design (CCD). Amount of lecithin (X1 ), power of ultrasound (X2 ), and sonication time (X3 ) were selected as three independent variables while the studied response included Z-Avg (nm), polydispersity index (PDI), and zeta potential (mV)...
January 29, 2019: AAPS PharmSciTech
Haixiang Yu, Chunpeng Zhang, Kai Zhang, Yangyang Zhou, Chunsheng Li
Hindrance to successful therapy of colon cancer is generally characterized with reduced potency of a single drug at the active site of cancer, poor drug release, and most importantly, potential toxic side effects of the drug resulting in cytotoxicity. Therefore, we investigated combinatorial drug micelles which are a potent combination of twin anticancer drugs (indomethacin and piroxicam, IND+PIR mc) for successful therapeutics of colon cancer. The novel combinatorial micelles showed improved drug encapsulation efficiency, an in vitro burst release of the dual drugs, increased cytocompatibility and increased efficacy in tumor reduction (weight and volume) than in single drug micelles (IND mc or PIR mc)...
January 29, 2019: Journal of Cellular Physiology
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