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IgA glomerulonephritis

Mineaki Kitamura, Yoko Obata, Yuki Ota, Kumiko Muta, Hiroshi Yamashita, Takashi Harada, Hiroshi Mukae, Tomoya Nishino
Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history. We hypothesized that some IgA-IRGN cases might be diagnosed as IgAN with subepithelial deposits (IgAN-SD) and aimed to clarify the significance of subepithelial deposits in patients diagnosed with IgAN. We examined 464 patients diagnosed with IgAN at Nagasaki University Hospital and affiliated hospitals between 1996 and 2013...
2019: PloS One
Alexandra Cambier, Olivia Boyer, Georges Deschenes, James Gleeson, Anne Couderc, Julien Hogan, Thomas Robert
IgA nephropathy (IgAN) is one the most common primary glomerulonephritis in children and adolescents worldwide, with 20% of children developing end-stage kidney disease (ESKD) within 20 years of diagnosis. There is a need for treatment guidelines, especially for steroids in children with primary IgAN, since the STOP-IgA trial casts doubts on the use of steroids in adults with intermediate risk. Pediatricians are prone to prescribe steroids in addition to renin-angiotensin system blockade (RASB) when proteinuria is > 0...
February 18, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Haresh Selvaskandan, Chee Kay Cheung, Masahiro Muto, Jonathan Barratt
IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in the glomerular mesangium and is the most commonly reported primary glomerulonephritis worldwide. Thirty to forty percent of patients with the disease develop progressive renal function decline, requiring renal replacement therapy within two decades of diagnosis. Despite this, accurate individual risk stratification at diagnosis and predicting treatment response remains a challenge. Furthermore, there are currently no disease specific treatments currently licensed to treat the condition due to long standing challenges in the nature and prevalence of the disease...
February 13, 2019: Clinical and Experimental Nephrology
Tadasu Kojima, Go Hirose, Shuuhei Komatsu, Taito Oshima, Kentaro Sugisaki, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada, Takashi Oda
BACKGROUND: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months. CASE PRESENTATION: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years...
January 25, 2019: BMC Nephrology
Alexander B Aria, Leon Chen, William F Glass, Amit Lahoti, Susan Y Chon
Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. The patient's biopsy-proven LCV developed one month after he began trifluridine/tipiracil treatment and resolved after discontinuation of the drug...
October 15, 2018: Dermatology Online Journal
Handan Yarkan Tuğsal, Berrin Zengin, Gökçe Kenar, Gerçek Can, Mehtat Ünlü, Fatoş Önen, Merih Birlik
The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria...
January 23, 2019: Rheumatology International
Alejandra Oralia Orozco Guillén, Ricardo Ivan Velazquez Silva, Bernardo Moguel González, Yubia Amaya Guell, Pamela Garciadiego Fossas, Iris Guadalupe Custodio Gómez, Osvaldo Miranda Araujo, Virgilia Soto Abraham, Giorgina Barbara Piccoli, Magdalena Madero
Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant...
January 18, 2019: Journal of Clinical Medicine
Keng-Thye Woo, Choong-Meng Chan, Cynthia Lim, Jason Choo, Yoke Mooi Chin, Wei Ling Teng, Alwin H L Loh, Hui-Lin Choong, Han-Kim Tan, Kok-Seng Wong, Grace S L Lee, Evan J C Lee, Stephanie Fook-Chong, Puay Hoon Tan, Marjorie Foo
This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1st decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2nd decade, the percentage of mesangial proliferative GN decreased, but membranous GN became more common, as was seen in China and Thailand. In the 3rd decade, focal segmental glomerulosclerosis (FSGS) and membranous nephropathy continued to rise, but it was only recently, in the 4th decade, that FSGS prevalence increased dramatically, although membranous nephropathy continues to increase in some Asian countries...
January 21, 2019: Clinical Nephrology
Jing-Wen Zhang, Xiang-Zhong Zhang, Yan-Ling Sun, Bing Long, Xiao-Zhen Wang, Xu-Dong Li
BACKGROUND: After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the development of HBVr combined with NS after allo-HSCT is uncommon. CASE PRESENTATION: We presented a case of a 47-year-old female with acute myelogenous leukemia who underwent HLA-identical sibling allo-HSCT and achieved leukemia free survival...
January 16, 2019: BMC Infectious Diseases
Omar Mamlouk, Umut Selamet, Shana Machado, Maen Abdelrahim, William F Glass, Amanda Tchakarov, Lillian Gaber, Amit Lahoti, Biruh Workeneh, Sheldon Chen, Jamie Lin, Noha Abdel-Wahab, Jean Tayar, Huifang Lu, Maria Suarez-Almazor, Nizar Tannir, Cassian Yee, Adi Diab, Ala Abudayyeh
RATIONALE & OBJECTIVE: The approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents. The literature on the nephrotoxicity of CPI is limited. Here, we present cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects...
January 6, 2019: Journal for Immunotherapy of Cancer
Taro Horino, Osamu Ichii, Yoshio Terada
No abstract text is available yet for this article.
January 3, 2019: American Journal of Medicine
Clarissa A Cassol, Pawan K Rao, Juarez R Braga
RATIONALE: Acute renal failure developing over a short period of time with evidence of glomerular disease by urine sediment microscopy characterizes the clinical syndrome of rapidly progressive glomerulonephritis (RPGN), of which the most common causes are ANCA-associated glomerulonephritis (GN), immune-complex mediated GN and anti-GBM disease. PATIENT CONCERNS: This was a middle-aged gentleman who presented with acute renal failure and a positive PR3-ANCA. DIAGNOSIS: Renal biopsy showed an unusual combination of PR3-ANCA GN with focal crescents, monoclonal immunoglobulin deposition disease (MIDD) and mesangial IgA deposition on renal biopsy...
December 2018: Medicine (Baltimore)
Shinichi Miyazaki, Akiko Hattori, Yasumasa Kuno, Takuya Ikeda
Immunoglobulin (Ig)A nephropathy is the most common cause of primary glomerulonephritis worldwide. While IgA nephropathy has been associated with a variety of other diseases, pulmonary complications are extremely rare. A 58-year-old man presented with a 2-week history of fever and exertional dyspnoea. A chest imaging revealed bilateral consolidation predominantly in upper lungs. Laboratory findings showed elevated serum creatinine with proteinuria and haematuria. Flexible bronchoscopy revealed diffuse alveolar haemorrhage, and IgA nephropathy was confirmed on a renal biopsy...
December 22, 2018: BMJ Case Reports
Yoko Fujita, Tomo Suzuki, Wei Han, Shiika Watanabe, Koichi Yahagi, Mayumi Nakata, Takeshi Okamoto, Daisuke Ichikawa, Junki Koike, Yugo Shibagaki
Immunoglobulin (Ig) A glomerulonephritis (GN) is a heterogeneous disease affected by various factors. Genetic and other factors "hit" DNA, causing IgA malformation and ultimately glomerular injury. We describe a rare case of crescentic IgA GN with sternoclavicular (SC) arthritis in a 75-year-old woman. Despite active IgA GN with cellular crescents, the patient achieved remission of IgA GN without glucocorticoid therapy after remission of SC arthritis was achieved. Considering the patient's clinical course, this case suggested a relationship between IgA GN and SC arthritis...
September 2018: Case Reports in Nephrology and Dialysis
Shigeaki Nakazawa, Ryoichi Imamura, Masataka Kawamura, Taigo Kato, Toyofumi Abe, Tomoko Namba, Hirotsugu Iwatani, Kazuaki Yamanaka, Motohide Uemura, Hidefumi Kishikawa, Kenji Nishimura, Kazumasa Oka, Michiko Tajiri, Yoshinao Wada, Norio Nonomura
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, and disease recurrence often occurs after transplantation. On the other hands, Asymptomatic IgA deposition (IgAD) is occasionally observed in donated kidney. It is recognized that IgAD does not progress to IgAN, but the mechanism has not demonstrated yet. In IgAN, aberrant IgA1 O-glycan structure in the hinge region (HR) of serum IgA is suggested as one of the most convincing key mediators. However, little is known about IgA1 O-glycan structure in IgAD patients...
December 12, 2018: Biochemical and Biophysical Research Communications
Mohsin Raj Mantoo, Saroj Kumar Tripathy, Ravi Hari Phulware, Narendra Kumar Bagri, Pankaj Hari, Adarsh Barwad
Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. We report a 10-year-old boy with juvenile dermatomyositis and IgA nephropathy. Child responded dramatically to the conventional therapy with steroids and methotrexate for the primary disease, and did not require any additional treatment for his renal disease...
December 14, 2018: Rheumatology International
S H Jiang, A L Kennard, G D Walters
BACKGROUND: Recurrence of primary glomerulonephritis in the post-transplant period has been described in the literature but the risk remains poorly quantified and its impact on allograft outcomes and implications for subsequent transplants remain under-examined. Here we describe the rates and timing of post-transplant glomerulonephritis recurrence for IgA nephropathy, focal segmental glomerulosclerosis, mesangiocapillary GN and membranous GN based on 28 years of ANZDATA registry transplant data...
December 3, 2018: BMC Nephrology
Ying Zheng, Yong Wang, Shuwen Liu, Jie Wu, Shuwei Duan, Hanyu Zhu, Di Wu, Guangyan Cai, Xiangmei Chen
BACKGROUND/AIMS: IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA nephropathy, our aim was to critically appraise the potential BP goal in IgA nephropathy. METHODS: We performed a retrospective analysis of the BP data from 1055 patients with IgA nephropathy, extracted from the database of a nationwide, multi-center, cross-sectional study, including 61 tertiary hospitals in China...
2018: Kidney & Blood Pressure Research
Qin Zhou, Xin Yang, Meifang Wang, Huiping Wang, Jie Zhao, Yan Bi, Xiayue Wang, Jihong Yao, Ying Chen, Chuan Lin, Xishao Xie, Hong Jiang, Jianghua Chen
BACKGROUND: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years. METHODS AND RESULTS: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled...
November 2018: Renal Failure
Jonathan M Chemouny, Patrick J Gleeson, Lilia Abbad, Gabriella Lauriero, Erwan Boedec, Karine Le Roux, Céline Monot, Maxime Bredel, Julie Bex-Coudrat, Aurélie Sannier, Eric Daugas, Francois Vrtovsnik, Loreto Gesualdo, Marion Leclerc, Laureline Berthelot, Sanae Ben Mkaddem, Patricia Lepage, Renato C Monteiro
Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. We aimed to determine if an intervention targeting the gut microbiota could impact the development of disease in a humanized mouse model of IgAN, the α1KI-CD89Tg mice. Methods: Four- and 12-week old mice were divided into two groups to receive either antibiotics or vehicle control...
November 20, 2018: Nephrology, Dialysis, Transplantation
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