Hiroshi Ushijima, Sheikh Ariful Hoque, Yuki Akari, Ngan Thi Kim Pham, Tung Phan, Shuichi Nishimura, Masaaki Kobayashi, Kumiko Sugita, Shoko Okitsu, Satoshi Komoto, Aksara Thongprachum, Pattara Khamrin, Niwat Maneekarn, Satoshi Hayakawa
Norovirus (NoV) genogroup II, polymerase type P31, capsid genotype 4, Sydney_2012 variant (GII.P31/GII.4_Sydney_2012) has been circulating at high levels for over a decade, raising the question of whether this strain is undergoing molecular alterations without demonstrating a substantial phylogenetic difference. Here, we applied next-generation sequencing to learn more about the genetic diversity of 14 GII.P31/GII.4_Sydney_2012 strains that caused epidemics in a specific region of Japan, with 12 from Kyoto and 2 from Shizuoka, between 2012 and 2022, with an emphasis on amino acid (aa) differences in all three ORFs...
March 23, 2024: International Journal of Molecular Sciences