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oxygen administration

Andrea Holzer, Barbara Sitter, Oliver Kimberger, René Wenzl, Edith Fleischmann, Daniela Marhofer, Barbara Kabon
BACKGROUND: Perioperative normovolemia is a major determinant of tissue oxygen availability and postoperative outcome. Thus, adequate volume replacement therapy remains an essential part of perioperative management. Nevertheless, volume optimization in overweight and obese surgical patients with alterations in cardiovascular function, peripheral perfusion, and body composition remains challenging. We, therefore, tested the hypothesis that BMI correlates with fluid requirements during goal-directed management...
April 16, 2019: Minerva Anestesiologica
Yongfang Wang, Xin Zhang, Bin Wang, Yang Xie, Yi Wang, Xuan Jiang, Rongjia Wang, Ke Ren
OBJECTIVE: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. MATERIALS AND METHODS: Sixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points...
May 2019: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Jim Larsson, Dennis Leander, Märta Lewander Xu, Vineta Fellman, Joakim Bood, Emilie Krite Svanberg
Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), i.e. the TDLAS-GASMAS technique. Oxygen gas is detected through an absorption line near 764 nm and water vapor through an absorption line near 820 nm. A model with a lung containing interior structure is compared to a model with a hollow lung. Compared to the model with the hollow lung, both the mean absorption path length and the transmitted intensity are found to be lower for the model with the structured lung...
April 16, 2019: Journal of Biophotonics
Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Su Bin Park, Seul Ki Yoo, Hye Ju Han, Kyoung Hwan Cho, Jong Cheol Kim, Ho Jin Heo
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H₂O₂-induced PC12 cells and amyloid beta (Aβ)1-42 -induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H₂O₂-induced PC12 cells by conducting the 2',3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2',7'-dichlorofluorescein diacetate (DCF-DA) analysis...
April 15, 2019: International Journal of Molecular Sciences
C P Moore, I M Katz, M Pichelin, G Caillibotte, W H Finlay, A R Martin
BACKGROUND: High flow nasal cannula therapy is a form of respiratory support which delivers high flow rates of heated, humidified gas to the nares via specialized cannula. Two primary mechanisms of action attributed to the therapy are the provision of positive airway pressure as well as clearance of CO2 -rich exhaled gas from the upper airways. METHODS: Physiologically accurate nose-throat airway replicas were connected at the trachea to a lung simulator, where CO2 was supplied to mimic the CO2 content in exhaled gas...
April 6, 2019: Clinical Biomechanics
Vanessa Duarte Ortiz, Patrick Türck, Rayane Teixeira, Bruna Gazzi Lima-Seolin, Denise Lacerda, Schauana Freitas Fraga, Alexandre Hickmann, Tânia Regina Gatelli Fernandes, Adriane Belló-Klein, Alexandre Luz de Castro, Alex Sander da Rosa Araujo
After acute myocardial infarction (AMI), reactive oxygen species and oxidative stress have important roles in the progression to heart failure. As a therapeutic alternative, thyroid hormones (TH) revealed cardioprotective effects after AMI, including decreasing oxidative stress. Carvedilol beta-blocker, already used in the clinical treatment of AMI, also mitigate cardiac pathological remodelling. This study assessed the effects of post-AMI carvedilol and TH co-administration on oxidative stress and cardiac function as well as whether those effects were synergistic...
April 13, 2019: European Journal of Pharmacology
John Michael DiBianco, Jessica Lange, Daniel Heidenberg, Patrick Mufarrij
Background: Hydrogen peroxide (H2 O2 ) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of H2 O2 , as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke...
2019: Journal of Endourology Case Reports
Qian Kong, Xiaojing Wu, Weina Duan, Liying Zhan, Xuemin Song
Acute lung injury (ALI) is a critical syndrome that is associated with high morbidity and mortality rates. The activation of the Fas/Fas ligand (FasL) signaling pathway may be an important pathophysiological mechanism during ALI development. Penehyclidine hydrochloride (PHC) has been revealed to exhibit anti-apoptotic properties and may attenuate the observed systemic inflammatory response. The present study was performed to elucidate the molecular mechanism of PHC in the regulation of the Fas/FasL signaling pathway in rats with ALI...
May 2019: Experimental and Therapeutic Medicine
Shufang Yang, Xiaoqiang Fei, Yu Lu, Bangkui Xu, Yongmei Ma, Hui Wan
In the present study, the function of microRNA (miR)-214 on diabetic nephropathy (DN) and diabetes of proximal tubular cells was investigated. Reverse transcription-quantitative polymerase chain reaction was used measure the expression of miR-214 in rats with DN and ELISA was performed to measure oxidative stress and ROS levels. Results indicated that miR-214 expression in the peripheral blood was significantly decreased in rats with DN. The in vitro model of DN indicated that miR-214 upregulation significantly decreased oxidative stress and reactive oxygen species (ROS) levels, but significantly increased uncoupling protein 2 (UCP2), phosphorylated (p)-Akt and p-mammalian target of rapamycin (mTOR) protein expression levels...
May 2019: Experimental and Therapeutic Medicine
Yuta Kumada, Toru Takahashi, Hiroko Shimizu, Ryu Nakamura, Emiko Omori, Kazuyoshi Inoue, Hiroshi Morimatsu
Hemorrhagic shock and resuscitation (HSR) induces a pulmonary inflammatory response and frequently causes acute lung injury. Carbon monoxide-releasing molecule-3 (CORM-3) has been reported to liberate and deliver CO under physiological conditions, which exerts organ-protective effects during systemic insults. The present study aimed to determine whether the administration of CORM-3 following HSR exerts a therapeutic effect against HSR-induced lung injury without any detrimental effects on oxygenation and hemodynamics...
May 2019: Experimental and Therapeutic Medicine
Sheila Estruel-Amades, Malén Massot-Cladera, Pau Garcia-Cerdà, Francisco J Pérez-Cano, Àngels Franch, Margarida Castell, Mariona Camps-Bossacoma
Intensive exercise can lead to oxidative stress, which can be particularly deleterious for lymphoid tissues. Hesperidin has demonstrated its antioxidant activity, but few studies focus on its influence on intensive training. The aim of this study was to assess the impact of hesperidin on the oxidant/antioxidant status of lymphoid tissues after an intensive training program. Wistar rats were trained for five weeks (five days per week), including two exhaustion tests plus three trainings per week. During this period, animals were orally administrated with 200 mg/kg of hesperidin or vehicle (three days per week)...
April 4, 2019: Nutrients
Atul Malhotra, Suzanne L Miller, Graham Jenkin, Stuart B Hooper, Beth J Allison, Foula Sozo, Valerie Zahra, Arvind Sehgal, Graeme R Polglase
BACKGROUND: Efficacy of surfactant therapy in fetal growth restricted (FGR) preterm neonates is unknown. METHODS: Twin-bearing ewes underwent surgery at 105 days gestation to induce FGR in one twin by single umbilical artery ligation. At 123-127 days, catheters and flow probes were implanted in pulmonary and carotid arteries to measure flow and pressure. Lambs were delivered, intubated and mechanically ventilated. At 10 min, surfactant (100 mg kg-1 ) was administered...
April 14, 2019: Pediatric Research
Yueqin Qiu, Xuefen Yang, Li Wang, Kaiguo Gao, Zongyong Jiang
This study aimed to explore the effect of L-arginine on lipopolysaccharide (LPS)-induced inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of toll-like receptor 4 ( TLR4 ), myeloid differentiation primary response 88 ( MyD88 ), cluster of differentiation 14 (CD14) , nuclear factor-kappaBp65 ( NF-κBp65 ), chemokine-8 ( IL-8 ), tumor necrosis factor ( TNF-α) and chemokine-6 ( IL-6 ) mRNA were significantly increased by LPS. Exposure to LPS induced oxidative stress as reactive oxygen species (ROS) and malonaldehyde (MDA) production were increased while glutathione peroxidase (GSH-Px) were decreased in LPS-treated cells compared to those in the control...
April 11, 2019: International Journal of Molecular Sciences
Giacomo Lazzarino, Ilaria Listorti, Gabriele Bilotta, Talia Capozzolo, Angela Maria Amorini, Salvatore Longo, Giuseppe Caruso, Giuseppe Lazzarino, Barbara Tavazzi, Pasquale Bilotta
Reactive oxygen species (ROS) are physiologically involved in functions like sperm maturation, capacitation and acrosome reaction, but their excess is involved in male infertility. Antioxidants in seminal plasma (SP) are an important factor balancing physiologic and harmful ROS activities. In this study, we determined and compared the full profiles of the water- and fat-soluble antioxidants in SP and serum of 15 healthy fertile subjects (ranging between the ages of 35 and 42 years). Ejaculates were obtained after 2⁻5 days of sexual abstinence...
April 11, 2019: Antioxidants (Basel, Switzerland)
Jitai Zhang, Hui An, Kaidi Ni, Bin Chen, Hui Li, Yanqin Li, Guilian Sheng, Chuanzan Zhou, Mengzhen Xie, Saijing Chen, Tong Zhou, Gaoxiong Yang, Xiufang Chen, Gaojun Wu, Shengwei Jin, Ming Li
Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes. A strong positive correlation between sugar consumption and diabetic incidence is revealed, but the underlying mechanisms remain obscure. Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to β-cells gaining metabolic memory in reactive oxygen species (ROS) stress. This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and β-cell dedifferentiation and functional failure...
April 11, 2019: Cell Death & Disease
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Arjan Te Pas, Richard Plavka, Charles C Roehr, Ola D Saugstad, Umberto Simeoni, Christian P Speer, Maximo Vento, Gerhard H A Visser, Henry L Halliday
As management of respiratory distress syndrome (RDS) advances, clinicians must continually revise their current practice. We report the fourth update of "European Guidelines for the Management of RDS" by a European panel of experienced neonatologists and an expert perinatal obstetrician based on available literature up to the end of 2018. Optimising outcome for babies with RDS includes prediction of risk of preterm delivery, need for appropriate maternal transfer to a perinatal centre and timely use of antenatal steroids...
April 11, 2019: Neonatology
Zhengang Wang, Yimei Yuan, Zhaoguang Zhang, Kuiying Ding
Stroke is a leading cause of death and disability, but treatment options remain limited. Recent studies have suggested that cerebral ischemia-induced neurogenesis plays a vital role in post-stroke repair. Overactivation of AMP-activated protein kinase (AMPK), a master sensor of energy balance, has been reported to exacerbate neuron apoptosis, but the role of chronic AMPK stimulus in post-stroke recovery remains unclear. MicroRNAs have emerged as regulators of neurogenesis and have been reported to be involved in neurological function...
February 25, 2019: FEBS Open Bio
Shohei Ouchi, Hideharu Ogiyama, Shusaku Tsutsui, Ayaka Nasu, Kayo Seto, Masashi Horiki, Tamana Sanomura, Kazuho Imanaka, Yoko Murayama, Hiroyasu Iishi
A 44-year-old man was administered Niflec® containing macrogol 4000 as a bowel cleanser for colonoscopic examination. Immediately after ingestion, he experienced oral cavity discomfort and nasal congestion, followed by acute urticaria and presyncope. His systolic blood pressure and peripheral capillary oxygen saturation dropped to 66mmHg and 89%, respectively. Fluid infusion, as well as steroid and epinephrine administration, improved his symptoms. Skin prick tests were then performed using Niflec® , macrogol 4000, and Actosin® ointment (containing macrogol 4000), all of which were positive...
2019: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Tyler W LeBaron, Ismail Laher, Branislav Kura, Jan Slezak
H2 has been clinically demonstrated to provide anti-oxidant and anti-inflammatory effects, which makes it an attractive agent in exercise medicine. Although exercise provides a multiplicity of benefits including decreased risk of disease, it can also have detrimental effects. For example, chronic high-intensity exercise in elite athletes, or sporadic bouts of exercise (i.e. noxious exercise) in untrained individuals, result in similar pathological factors such as inflammation, oxidation and cellular damage that arise from and result in disease...
April 10, 2019: Canadian Journal of Physiology and Pharmacology
Tze-Fun Lee, Min Lu, Matteo P Pasquin, Georg M Schmölzer, Po-Yin Cheung
Background: Asphyxiated neonates often have myocardial dysfunction and renal insufficiency. Previously we demonstrated that doxycycline improved cardio-renal function through matrix metalloproteinase (MMP)-2 inhibition in an acute swine model of neonatal hypoxia-reoxygenation. The prolonged cardio-renal protective effects of doxycycline in neonates still remained unknown. We therefore hypothesized that the protective effects of doxycycline persisted in surviving subjects. Methods: Newborn piglets were instrumented and subjected to 1 h of hypoxia followed by reoxygenation with 21-25% oxygen and observed for 4 days...
2019: Frontiers in Pediatrics
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