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https://read.qxmd.com/read/30759325/refining-initial-diagnosis-of-parkinson-s-disease-after-follow-up-a-4-year-prospective-clinical-and-magnetic-resonance-imaging-study
#1
Aldo Quattrone, Maurizio Morelli, Basilio Vescio, Salvatore Nigro, Emilio Le Piane, Umberto Sabatini, Manuela Caracciolo, Virginia Vescio, Andrea Quattrone, Gaetano Barbagallo, Carlo Stanà, Giuseppe Nicoletti, Gennarina Arabia, Rita Nisticò, Fabiana Novellino, Maria Salsone
BACKGROUND: No prospective study of patients with Parkinson's disease (PD) has investigated the appearance of vertical gaze abnormalities, a feature suggestive of progressive supranuclear palsy (PSP). OBJECTIVE: To identify, within a cohort of patients with an initial diagnosis of PD, those who developed vertical gaze abnormalities during a 4-year follow-up, and to investigate the performance of new imaging biomarkers in predicting vertical gaze abnormalities. METHODS: A total of 110 patients initially classified as PD and 74 controls were enrolled...
February 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30672950/enantiomeric-nmr-discrimination-of-carboxylic-acids-using-actinomycin-d-as-a-chiral-solvating-agent
#2
Liwen Bai, Pian Chen, Jiangxia Xiang, Jiarui Sun, Xinxiang Lei
Actinomycin D (Act-D) is a biologically important polypeptide antibiotic clinically used to treat several malignant tumors. Herein, we extended its hitherto-unexplored application as an applicable chiral solvating agent (CSA) for the rapid enantiomeric determination of different chiral carboxylic acids in deuterated chloroform by 1H NMR spectroscopy. Notable enantiodiscrimination with well-splitting α-H or α-CH3 resonance signals of the enantiomers of carboxylic acids were achieved without significant interference from Act-D...
January 23, 2019: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/30649247/mir-pathway-the-integration-and-visualization-of-mirna-and-kegg-pathways
#3
Cong Pian, Guangle Zhang, Libin Gao, Xiaodan Fan, Fei Li
miRNAs represent a type of noncoding small molecule RNA. Many studies have shown that miRNAs are widely involved in the regulation of various pathways. The key to fully understanding the regulatory function of miRNAs is the determination of the pathways in which the miRNAs participate. However, the major pathway databases such as KEGG only include information regarding protein-coding genes. Here, we redesigned a pathway database (called miR+Pathway) by integrating and visualizing the 8882 human experimentally validated miRNA-target interactions (MTIs) and 150 KEGG pathways...
January 16, 2019: Briefings in Bioinformatics
https://read.qxmd.com/read/30586033/radiologic-and-histopathologic-features-in-an-intracranial-localized-castleman-disease-a-case-report-and-review-of-literature
#4
REVIEW
J Bernardo Escribano Paredes, Rodrigo Carrasco Moro, María López Gutiérrez, Héctor Pian Arias, Mónica García-Cosío, Sebastián García Madrona, Velina Nedkova Hristova, Javier Martínez Poles, Javier Buisán Catevilla Francisco
INTRODUCTION: Castleman disease (CD) is a rare pathologic process of unknown etiology, characterized by non-neoplastic lymph node enlargement. Two distinct histologic patterns are recognized; the hyaline-vascular type and the less common plasma cells type. Another intermediate type has been described. The clinical features are classified into 2 categories, localized (unicentric) and generalized (multicentric), the later associated with systemic manifestations and poor prognosis. CD affecting the central nervous system is extremely rare...
January 2019: Neurologist
https://read.qxmd.com/read/30579855/quantitative-itraq-based-proteomic-analysis-of-piperine-protected-cerebral-ischemia-reperfusion-injury-in-rat-brain
#5
Yichun Zou, Pian Gong, Wenyuan Zhao, Jianjian Zhang, Xiaolin Wu, Can Xin, Zhongwei Xiong, Zhengwei Li, Xiaohui Wu, Qi Wan, Xiang Li, Jincao Chen
Piperine is the key bioactive factor in black pepper, and has been reported to alleviate cerebral ischemic injury. However, the mechanisms underlying its neuroprotective effects following cerebral ischemia remain unclear. In this study, rats were administered vehicle (dimethyl sulfoxide) or piperine, 20 mg/kg, daily for 14 days before focal cerebral artery occlusion. After occlusion for 2 h followed by reperfusion for 24 h. Histological examinations were used to assess whether piperine has a neuroprotective effect in the rat model of cerebral ischemia/reperfusion injury...
December 20, 2018: Neurochemistry International
https://read.qxmd.com/read/30572539/intracranial-hemorrhage-after-carotid-artery-stenting-in-both-anterior-and-posterior-circulation-a-case-report
#6
Pian Wang, Yan Wang, Qingbin Zhang
RATIONAL: Intracranial hemorrhage (ICH) after carotid artery stenting (CAS) is a rare but fatal complication, and it primarily occurs in the corresponding vascular distribution area. Herein, a case of ICH after CAS in both anterior and posterior circulation has been described. PATIENT CONCERNS: A 62-year-old female was referred to the hospital for left-side limb weakness and right nasal hemianopia for 1 month. DIAGNOSIS: Cerebral MRI following hospitalization revealed cerebral infarction in the right posterior cortical watershed area...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30552546/tissue-plasminogen-activator-causes-brain-microvascular-endothelial-cell-injury-after-oxygen-glucose-deprivation-by-inhibiting-sonic-hedgehog-signaling
#7
Pian Gong, Mingchang Li, Changlin Zou, Qi Tian, Zhou Xu
The thrombolytic activity of tissue plasminogen activator (tPA) has undisputed benefits. However, the documented neurotoxicity of tPA raises important issues. Currently, common treatments for stroke might not be optimum if exogenous tPA can pass through the blood-brain barrier and enter the brain, thus adding to the deleterious effects of tPA within the cerebral parenchyma. Here, we determined whether tPA could damage brain microvascular endothelial cells (BMECs) during cerebral ischemia. We showed that treatment of BMECs with tPA decreased trans-endothelial electrical resistance and cell proliferation, and blocked the cell cycle at the G0-G1 phase...
December 14, 2018: Neurochemical Research
https://read.qxmd.com/read/30535447/%C3%AE-%C3%A2-lipoic-acid-protects-against-carbon-tetrachloride%C3%A2-induced-liver-cirrhosis-through-the-suppression-of-the-tgf%C3%A2-%C3%AE-smad3-pathway-and-autophagy
#8
Guangwei Liu, Jiangkai Liu, Linping Pian, Songlin Gui, Baoping Lu
α‑lipoic acid (ALA) is a naturally occurring antioxidant with protective effects against various hepatic injuries. The aim of the present study was to investigate the mechanisms by which ALA protects the liver from carbon tetrachloride (CCl4)‑induced liver cirrhosis. The widely used liver cirrhosis rat model was established via an intraperitoneal injection of 2 mg/kg 50% CCl4, three times/week for 8 weeks. Simultaneously, 50 or 100 mg/kg ALA was orally administrated to the rats every day for 8 weeks...
December 4, 2018: Molecular Medicine Reports
https://read.qxmd.com/read/30465707/progress-on-active-analgesic-components-and-mechanisms-of-commonly-used-traditional-chinese-medicines-a-comprehensive-review
#9
Ruizhou Wang, Lu Han, Qixia Gao, Dan Chen, Yun Wang, Xia Zhang, Xin Yu, Yueming Zhang, Zhiyong Li, Changcai Bai
Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients' suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://read.qxmd.com/read/30407961/simulation-based-education-to-train-learners-to-speak-up-in-the-clinical-environment-results-of-a-randomized-trial
#10
Ceyda Oner, Nelli Fisher, Fouad Atallah, Mary Ann Son, Peter Homel, Katerina Mykhalchenko, Howard Minkoff
INTRODUCTION: Assertiveness is essential for communication and/or speaking up. We performed a randomized trial to assess the effectiveness of assertiveness/advocacy/CUS/two-challenge rule (AACT) simulation-based education for labor and delivery, as well as postpartum nurses. We aimed to determine whether this training would improve labor and delivery and postpartum nurses speaking up in the clinical setting. METHODS: We conducted a randomized controlled trial among nurses on labor and delivery and postpartum units...
December 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://read.qxmd.com/read/30389154/modulation-of-hypersensitivity-to-oxidative-dna-damage-in-atm-defective-cells-induced-by-potassium-bromate-by-inhibition-of-the-poly-adp-ribose-polymerase-parp
#11
P Mosesso, M Piane, G Pepe, S Cinelli, L Chessa
The ataxia telangiectasia mutated (ATM) protein is a pivotal multifunctional protein kinase predominantly involved in DNA damage response, as well as in maintaining overall functional integrity of the cells. Apart from playing its major role in regulating the cellular response to DNA damage, ATM, when mutated, can additionally determine oxidative stress, metabolic syndrome, mitochondrial dysfunction and neurodegeneration. In the present paper we aim to investigate the levels of oxidative stress potentially induced by the oxidizing rodent renal carcinogen KBrO3 in ATM-defective lymphoblastoid cell lines (LCLs) established from four classical AT patients (with different ATM mutations), one AT variant with reduced hypersensitivity to X rays, obligate AT heterozygotes and wild type intrafamilial control...
December 2018: Mutation Research
https://read.qxmd.com/read/30365078/rapamycin-induces-autophagy-to-alleviate-acute-kidney-injury-following-cerebral-ischemia-and-reperfusion-via-the-mtorc1-atg13-ulk1-signaling-pathway
#12
Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang
Acute kidney injury (AKI) is a clinically common and severe complication of ischemia‑reperfusion (I/R), associated with high morbidity and mortality rates, and prolonged hospitalization. Rapamycin is a type of macrolide, primarily used for anti‑rejection therapy following organ transplantation and the treatment of autoimmune diseases. Rapamycin has been identified to exert a protective effect against AKI induced by renal I/R as an autophagy inducer. However, whether rapamycin preconditioning may relieve AKI following cerebral I/R (CIR) remains to be fully elucidated...
December 2018: Molecular Medicine Reports
https://read.qxmd.com/read/30326837/discovering-the-dark-matters-in-expression-data-of-mirna-based-on-the-mirna-mrna-and-mirna-lncrna-networks
#13
Cong Pian, Guangle Zhang, Sanling Wu, Fei Li
BACKGROUND: Since miRNAs can play important roles in different cancer types, how to discover cancer related miRNAs is an important issue. In general, the miRNAs with differential expression is the focus of attention. However, some important cancer related miRNAs are not excavated by differential expression analysis. We take this type of miRNAs as 'dark matters' (DM-miRNA). It is our great interests to develop an algorithm to discover DM-miRNAs. RESULTS: An effective method was developed to find DM-miRNAs...
October 16, 2018: BMC Bioinformatics
https://read.qxmd.com/read/30296374/structural-and-computational-assessment-of-the-influence-of-wet-chemical-post-processing-of-the-al-substituted-cubic-li-7-la-3-zr-2-o-12
#14
Robert Kun, Frederieke Langer, Massimo Delle Piane, Saneyuki Ohno, Wolfgang G Zeier, Michael Gockeln, Lucio Colombi Ciacchi, Matthias Busse, István Fekete
Li7 La3 Zr2 O12 (LLZO) and related compounds are considered as promising candidates for future all-solid-state Li-ion battery applications. Still, the processing of those materials into thin membranes with the right stoichiometry and crystal structure is difficult and laborious. The sensitivity of the Li-ion conductive garnets against moisture and the associated Li+ /H+ cation exchange makes their processing even more difficult. Formulation of suitable polymer/ceramic hybrid solid state electrolytes could be a prosperous way to reach the future large scale production of solid state Li-ion batteries...
October 31, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30266246/cystic-meningiomas-radiological-and-pathological-correlation-with-surgical-implications
#15
Rodrigo Carrasco Moro, Herbert D Jiménez Zapata, Héctor Pian Arias, Juan S Martínez San Millán, María A Martínez Rodrigo, José M Pascual Garvi
INTRODUCTION: Meningiomas associating prominent cystic changes (CM) have challenged neurosurgeons since the beginning of this surgical discipline. We present the experience in the diagnostic and therapeutic management of this entity in our institution. MATERIAL AND METHODS: A review of our patient database was carried out, searching for those CM that were operated on in the last 15 years. Relevant clinical data were recorded and analyzed for each case, with special emphasis in the correlation of radiological and pathological findings...
September 25, 2018: Neurocirugía
https://read.qxmd.com/read/30265385/multidisciplinary-planning-teams-crucial-for-creating-effective-simulation-scenarios
#16
Maureen Hemingway, May Pian-Smith
No abstract text is available yet for this article.
October 2018: AORN Journal
https://read.qxmd.com/read/30263092/rapid-detection-of-copy-number-variations-and-point-mutations-in-brca1-2-genes-using-a-single-workflow-by-ion-semiconductor-sequencing-pipeline
#17
Aldo Germani, Fabio Libi, Stefano Maggi, Gianluca Stanzani, Augusto Lombardi, Patrizia Pellegrini, Mauro Mattei, Laura De Marchis, Claudio Amanti, Antonio Pizzuti, Maria Rosaria Torrisi, Maria Piane
Molecular analysis of BRCA1 ( MIM # 604370) and BRCA2 ( MIM #600185) genes is essential for familial breast and ovarian cancer prevention and treatment. An efficient, rapid, cost-effective accurate strategy for the detection of pathogenic variants is crucial. Mutations detection of BRCA1/2 genes includes screening for single nucleotide variants (SNVs), small insertions or deletions (indels), and Copy Number Variations (CNVs). Sanger sequencing is unable to identify CNVs and therefore Multiplex Ligation Probe amplification (MLPA) or Multiplex Amplicon Quantification (MAQ) is used to complete the BRCA1/2 genes analysis...
September 14, 2018: Oncotarget
https://read.qxmd.com/read/30218983/skin-permeable-liposome-improved-stability-and-permeability-of-bfgf-against-skin-of-mice-with-deep-second-degree-scald-to-promote-hair-follicle-neogenesis-through-inhibition-of-scar-formation
#18
He-Lin Xu, Pian-Pian Chen, Li-Fen Wang, Meng-Qi Tong, Zi-Hui Ou, Ying-Zheng Zhao, Jian Xiao, Ting-Ling Fu, Wei-Xue
Excessive deposition of extracellular matrix (ECM) usually resulted in scar formation during wound healing, which caused skin dysfunction, such as hair loss. Basic fibroblast growth factor (bFGF) was very helpful for promoting hair follicle neogenesis and regulating the remodeling of ECM during wound healing. Because of its poor stability in wound fluids and low permeability against the dense wound scar, the repairing quality of bFGF on wound was hindered largely in clinical practice. To overcome these drawbacks, herein, a novel liposome with silk fibroin hydrogel core (bFGF-SF-LIP) was firstly prepared to stabilize bFGF, followed by insertion of laurocapam, a permeation enhancer, into the liposomal membrane to construct a skin-permeable liposome (SP-bFGF-SF-LIP)...
September 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/30211866/assessing-patterns-for-compressive-fluorescence-lifetime-imaging
#19
M Ochoa, Q Pian, R Yao, N Ducros, X Intes
A novel hyperspectral single pixel system was used to compare different compressive basis patterns for intensity imaging, lifetime imaging, and FRET quantification. Six popular basis patterns were compared experimentally in a phantom containing two fluorescent dyes. The basis patterns that performed best for lifetime quantification were used to measure FRET occurrence in well-plate samples with varying acceptor-donor ratios. The ABS-WP approach using Haar patterns and the compressive sensing approach with Hadamard Ranked patterns displayed the best overall performances at a 50% compression ratio...
September 15, 2018: Optics Letters
https://read.qxmd.com/read/30195750/targeting-the-igf1r-pathway-in-breast-cancer-using-antisense-lncrna-mediated-promoter-cis-competition
#20
Lingling Pian, Xue Wen, Lihua Kang, Zhaozhi Li, Yuanyuan Nie, Zhonghua Du, Dehai Yu, Lei Zhou, Lin Jia, Naifei Chen, Dan Li, Songling Zhang, Wei Li, Andrew R Hoffman, Jingnan Sun, Jiuwei Cui, Ji-Fan Hu
Aberrant insulin-like growth factor I receptor (IGF1R) signaling pathway serves as a well-established target for cancer drug therapy. The intragenic antisense long noncoding RNA (lncRNA) IRAIN, a putative tumor suppressor, is downregulated in breast cancer cells, while IGF1R is overexpressed, leading to an abnormal IGF1R/IRAIN ratio that promotes tumor growth. To precisely target this pathway, we developed an "antisense lncRNA-mediated intragenic cis competition" (ALIC) approach to therapeutically correct the elevated IGF1R/IRAIN bias in breast cancer cells...
September 7, 2018: Molecular Therapy. Nucleic Acids
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