Leviel Fluhr, Uria Mor, Aleksandra A Kolodziejczyk, Mally Dori-Bachash, Avner Leshem, Shlomik Itav, Yotam Cohen, Jotham Suez, Niv Zmora, Claudia Moresi, Shahar Molina, Niv Ayalon, Rafael Valdés-Mas, Shanni Hornstein, Hodaya Karbi, Denise Kviatcovsky, Adi Livne, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Alexander Brandis, Tevie Mehlman, Yael Kuperman, Michael Tsoory, Noa Stettner, Alon Harmelin, Hagit Shapiro, Eran Elinav
Cigarette smoking constitutes a leading global cause of morbidity and preventable death1 , and most active smokers report a desire or recent attempt to quit2 . Smoking-cessation-induced weight gain (SCWG; 4.5 kg reported to be gained on average per 6-12 months, >10 kg year-1 in 13% of those who stopped smoking3 ) constitutes a major obstacle to smoking abstinence4 , even under stable5,6 or restricted7 caloric intake. Here we use a mouse model to demonstrate that smoking and cessation induce a dysbiotic state that is driven by an intestinal influx of cigarette-smoke-related metabolites...
December 2021: Nature