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REVIEW
Tian-Yuan Xiong, Walid Ben Ali, Yuan Feng, Kentaro Hayashida, Hasan Jilaihawi, Azeem Latib, Michael Kang-Yin Lee, Martin B Leon, Raj R Makkar, Thomas Modine, Christoph Naber, Yong Peng, Nicolo Piazza, Michael J Reardon, Simon Redwood, Ashok Seth, Lars Sondergaard, Edgar Tay, Didier Tchetche, Wei-Hsian Yin, Mao Chen, Bernard Prendergast, Darren Mylotte
Indications for transcatheter aortic valve implantation (TAVI) have expanded in many countries to include patients with aortic stenosis who are at low surgical risk, and a similar expansion to this cohort is anticipated elsewhere in the world, together with an increase in the proportion of patients with bicuspid aortic valve (BAV) morphology as the age of the patients being treated decreases. To date, patients with BAV have been excluded from major randomized trials of TAVI owing to anatomical considerations...
January 2023: Nature Reviews. Cardiology
#22
JOURNAL ARTICLE
Yuchao Guo, Dao Zhou, Mengqiu Dang, Yuxing He, Shenwei Zhang, Jun Fang, Shili Wu, Qiong Huang, Lianglong Chen, Yiqiang Yuan, Jiaqi Fan, Hasan Jilaihawi, Xianbao Liu, Jian'an Wang
Objective: To evaluate the predictors of new-onset conduction disturbances in bicuspid aortic valve patients using self-expanding valve and identify modifiable technical factors. Background: New-onset conduction disturbances (NOCDs), including complete left bundle branch block and high-grade atrioventricular block, remain the most common complication after transcatheter aortic valve replacement (TAVR). Methods: A total of 209 consecutive bicuspid patients who underwent self-expanding TAVR in 5 centers in China were enrolled from February 2016 to September 2020...
2021: Frontiers in Cardiovascular Medicine
#23
REVIEW
Makoto Nakashima, Hasan Jilaihawi
PURPOSE OF REVIEW: We review the pathology, prevalence, diagnosis, hemodynamics, risk factors, prognosis, and treatment of leaflet thrombosis (LT), and suggest future directions in this field. RECENT FINDINGS: The latest meta-analysis showed the prevalence of overall LT is 5.4% (clinical LT of 1.2% and subclinical LT of 15.1%). Either subclinical or clinical LT is not associated with risk of mortality; however, clinical LT is associated with increased risk of stroke...
November 11, 2021: Current Cardiology Reports
#24
JOURNAL ARTICLE
Makoto Nakashima, Mathew Williams, Yuxin He, Larry Latson, Muhamed Saric, Alan Vainrib, Cezar Staniloae, Kazuhiro Hisamoto, Homam Ibrahim, Michael Querijero, Joseph Tovar, Chloe Kalish, Illya Pushkar, Hasan Jilaihawi
OBJECTIVES: The aim of this study was to clarify the dynamics of the mitral annulus throughout the cardiac cycle and its relevance to transcatheter mitral valve replacement (TMVR) sizing and case selection. BACKGROUND: Limited data are available regarding the relevance of mitral annular (MA) and neo-left ventricular outflow tract (LVOT) dynamics in the overall population presenting with significant mitral valve disease. METHODS: Patients attending a combined surgical-transcatheter heart valve clinic for severe symptomatic mitral valve disease were assessed using multiphase computed tomography...
September 22, 2021: JACC. Cardiovascular Interventions
#25
REVIEW
Makoto Nakashima, Hasan Jilaihawi
Conduction disturbances (CDs) after transcatheter artic replacement remain a clinical concern and relatively common complication. A recent meta-analysis showed both new-onset persistent left bundle branch block and new permanent pacemaker implantation were related to all-cause death with risk ratio 1.32 (95% confidence interval [CI] 1.17 to 1.49; P<.001) and 1.17 (95% CI 1.11-1.25; P<.001) at 1 year, respectively. Preprocedural computed tomography imaging can highlight potential risk factors for CDs, such as membranous septum length, device landing zone calcium, and the annulus size/degree of device oversizing...
October 2021: Interventional Cardiology Clinics
#26
JOURNAL ARTICLE
Cezar Staniloae, Homam Ibrahim, Jorge Fuentes, Carlos Gonzales, Anna Kapitman, Samantha Vidal, Sonja Paschke, Kazuhiro Hisamoto, Hasan Jilaihawi, Mathew Williams
OBJECTIVES: To describe the use of orbital atherectomy to prepare iliofemoral vessels for large-bore access prior to transcatheter aortic valve replacement (TAVR). BACKGROUND: Transfemoral (TF)-TAVR has been shown to be at least equivalent to surgery. Nevertheless, many patients do not qualify for the TF approach due to severe iliofemoral occlusive disease. The use of an atherectomy device in order to facilitate TF-TAVR has only been reported in case reports. METHODS: We performed 1000 TAVR procedures from June 2017 to October 2019...
August 2021: Journal of Invasive Cardiology
#27
JOURNAL ARTICLE
Transcatheter heart valve thrombosis on the mitral stage: "The Tempest" or "Much Ado About Nothing"?
Hasan Jilaihawi
No abstract text is available yet for this article.
April 20, 2021: EuroIntervention
#28
JOURNAL ARTICLE
Justyna Rzucidlo, Vita Jaspan, Darien Paone, Hasan Jilaihawi, Yuhe Xia, Anna Kapitman, Makoto Nakashima, Yuxin He, Homam Ibrahim, Illya Pushkar, Peter J Neuburger, Muhamed Saric, Daniel Bamira, Sonja Paschke, Chloe Kalish, Cezar Staniloae, Binita Shah, Mathew Williams
BACKGROUND: Patients with renal insufficiency have poor short-term outcomes after transcatheter aortic valve replacement (TAVR). METHODS: Retrospective chart review identified 575 consecutive patients not on hemodialysis who underwent TAVR between September 2014 and January 2017. Outcomes were defined by VARC-2 criteria. Primary outcome of all-cause mortality was evaluated at a median follow-up of 811 days (interquartile range 125-1,151). RESULTS: Preprocedural glomerular filtration rate (GFR) was ≥60 ml/min in 51...
August 1, 2021: Catheterization and Cardiovascular Interventions
#29
MULTICENTER STUDY
Gregory P Fontana, Francesco Bedogni, Mark Groh, David Smith, Bassem M Chehab, H Edward Garrett, Gerald Yong, Stephen Worthley, Ganesh Manoharan, Antony Walton, James Hermiller, Gaurav Dhar, Ron Waksman, Ravi K Ramana, Paul Mahoney, Federico M Asch, Tarun Chakravarty, Hasan Jilaihawi, Raj R Makkar
OBJECTIVES: The aim of this study was to characterize the safety profile of an intra-annular self-expanding valve with a next-generation low-profile delivery system (DS). BACKGROUND: Key design modifications to the FlexNav DS include the addition of a hydrophilic-coated, integrated sheath and stability layer to facilitate gradual, controlled deployment in vessels with diameter ≥5 mm. METHODS: Patients were pooled from 2 concurrent prospective, multicenter, single-arm studies (FlexNav DS arm of PORTICO IDE [Portico Re-Sheathable Transcatheter Aortic Valve System U...
November 9, 2020: JACC. Cardiovascular Interventions
#30
EDITORIAL
Hasan Jilaihawi
No abstract text is available yet for this article.
November 9, 2020: JACC. Cardiovascular Interventions
#31
MULTICENTER STUDY
Sung-Han Yoon, Won-Keun Kim, Abhijeet Dhoble, Stephan Milhorini Pio, Vasilis Babaliaros, Hasan Jilaihawi, Thomas Pilgrim, Ole De Backer, Sabine Bleiziffer, Flavien Vincent, Tobias Shmidt, Christian Butter, Norihiko Kamioka, Lena Eschenbach, Matthias Renker, Masahiko Asami, Mohamad Lazkani, Buntaro Fujita, Antoinette Birs, Marco Barbanti, Ashish Pershad, Uri Landes, Brad Oldemeyer, Mitusnobu Kitamura, Luke Oakley, Tomoki Ochiai, Tarun Chakravarty, Mamoo Nakamura, Philip Ruile, Florian Deuschl, Daniel Berman, Thomas Modine, Stephan Ensminger, Ran Kornowski, Rudiger Lange, James M McCabe, Mathew R Williams, Brian Whisenant, Victoria Delgado, Stephan Windecker, Eric Van Belle, Lars Sondergaard, Bernard Chevalier, Michael Mack, Jeroen J Bax, Martin B Leon, Raj R Makkar
BACKGROUND: Bicuspid aortic stenosis accounts for almost 50% of patients undergoing surgical aortic valve replacement in the younger patients. Expanding the indication of transcatheter aortic valve replacement (TAVR) toward lower-risk and younger populations will lead to increased use of TAVR for patients with bicuspid aortic valve (BAV) stenosis despite the exclusion of bicuspid anatomy in all pivotal clinical trials. OBJECTIVES: This study sought to evaluate the association of BAV morphology and outcomes of TAVR with the new-generation devices...
September 1, 2020: Journal of the American College of Cardiology
#32
MULTICENTER STUDY
Raj R Makkar, Wen Cheng, Ron Waksman, Lowell F Satler, Tarun Chakravarty, Mark Groh, William Abernethy, Mark J Russo, David Heimansohn, James Hermiller, Stephen Worthley, Bassem Chehab, Mark Cunningham, Ray Matthews, Ravi K Ramana, Gerald Yong, Carlos E Ruiz, Chunguang Chen, Federico M Asch, Mamoo Nakamura, Hasan Jilaihawi, Rahul Sharma, Sung-Han Yoon, Augusto D Pichard, Samir Kapadia, Michael J Reardon, Deepak L Bhatt, Gregory P Fontana
BACKGROUND: Randomised trial data assessing the safety and efficacy of the self-expanding intra-annular Portico transcatheter aortic valve system (Abbott Structural Heart, St Paul, MN, USA) compared with any commercially available valves are needed to compare performance among designs. METHODS: In this prospective, multicentre, non-inferiority, randomised controlled trial (the Portico Re-sheathable Transcatheter Aortic Valve System US Investigational Device Exemption trial [PORTICO IDE]), high and extreme risk patients with severe symptomatic aortic stenosis were recruited from 52 medical centres experienced in performing transcatheter aortic valve replacement in the USA and Australia...
September 5, 2020: Lancet
#33
RANDOMIZED CONTROLLED TRIAL
Raj R Makkar, Philipp Blanke, Jonathon Leipsic, Vinod Thourani, Tarun Chakravarty, David Brown, Alfredo Trento, Robert Guyton, Vasilis Babaliaros, Mathew Williams, Hasan Jilaihawi, Susheel Kodali, Isaac George, Michael Lu, James M McCabe, John Friedman, Richard Smalling, Shing Chiu Wong, Shahram Yazdani, Deepak L Bhatt, Jeroen Bax, Samir Kapadia, Howard C Herrmann, Michael Mack, Martin B Leon
BACKGROUND: Subclinical leaflet thrombosis, characterized by hypoattenuated leaflet thickening (HALT) and reduced leaflet motion observed on 4-dimensional computed tomography (CT), may represent a form of bioprosthetic valve dysfunction. OBJECTIVES: The U.S. Food and Drug Administration mandated CT studies to understand the natural history of this finding, differences between transcatheter and surgical valves, and its association with valve hemodynamics and clinical outcomes...
June 23, 2020: Journal of the American College of Cardiology
#34
COMPARATIVE STUDY
John K Forrest, Ryan K Kaple, Basel Ramlawi, Thomas G Gleason, Christopher U Meduri, Steven J Yakubov, Hasan Jilaihawi, Fang Liu, Michael J Reardon
OBJECTIVES: This study sought to compare outcomes in patients with bicuspid versus tricuspid anatomy undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: TAVR has shown excellent safety and efficacy in patients with tricuspid aortic valve stenosis, but limited data are available on the use of self-expanding valves in patients with bicuspid valves. METHODS: The Society of Thoracic Surgeons/American College of Cardiology TVT Registry was used to analyze patients who underwent TAVR with the Evolut R or Evolut PRO valves...
August 10, 2020: JACC. Cardiovascular Interventions
#35
EDITORIAL
Hasan Jilaihawi
No abstract text is available yet for this article.
May 11, 2020: JACC. Cardiovascular Interventions
#36
EDITORIAL
Hasan Jilaihawi
No abstract text is available yet for this article.
January 27, 2020: JACC. Cardiovascular Interventions
#37
EDITORIAL
Jonathon Leipsic, Bjarne L Nørgaard, Omar Khalique, João L Cavalcante, Dee Dee Wang, Hasan Jilaihawi, Victoria Delgado, Jeroen J Bax, Phlipp Blanke
No abstract text is available yet for this article.
December 2019: JACC. Cardiovascular Imaging
#38
RANDOMIZED CONTROLLED TRIAL
Ole De Backer, George D Dangas, Hasan Jilaihawi, Jonathon A Leipsic, Christian J Terkelsen, Raj Makkar, Annapoorna S Kini, Karsten T Veien, Mohamed Abdel-Wahab, Won-Keun Kim, Prakash Balan, Nicolas Van Mieghem, Ole N Mathiassen, Raban V Jeger, Martin Arnold, Roxana Mehran, Ana H C Guimarães, Bjarne L Nørgaard, Klaus F Kofoed, Philipp Blanke, Stephan Windecker, Lars Søndergaard
BACKGROUND: Subclinical leaflet thickening and reduced leaflet motion of bioprosthetic aortic valves have been documented by four-dimensional computed tomography (CT). Whether anticoagulation can reduce these phenomena after transcatheter aortic-valve replacement (TAVR) is not known. METHODS: In a substudy of a large randomized trial, we randomly assigned patients who had undergone successful TAVR and who did not have an indication for long-term anticoagulation to a rivaroxaban-based antithrombotic strategy (rivaroxaban [10 mg] plus aspirin [75 to 100 mg] once daily) or an antiplatelet-based strategy (clopidogrel [75 mg] plus aspirin [75 to 100 mg] once daily)...
January 9, 2020: New England Journal of Medicine
#39
JOURNAL ARTICLE
Hasan Jilaihawi, Zhengang Zhao, Run Du, Cezar Staniloae, Muhamed Saric, Peter J Neuburger, Michael Querijero, Alan Vainrib, Kazuhiro Hisamoto, Homam Ibrahim, Tara Collins, Emily Clark, Illya Pushkar, Daniel Bamira, Ricardo Benenstein, Afnan Tariq, Mathew Williams
OBJECTIVES: This study sought to minimize the risk of permanent pacemaker implantation (PPMI) with contemporary repositionable self-expanding transcatheter aortic valve replacement (TAVR). BACKGROUND: Self-expanding TAVR traditionally carries a high risk of PPMI. Limited data exist on the use of the repositionable devices to minimize this risk. METHODS: At NYU Langone Health, 248 consecutive patients with severe aortic stenosis underwent TAVR under conscious sedation with repositionable self-expanding TAVR with a standard approach to device implantation...
September 23, 2019: JACC. Cardiovascular Interventions
#40
JOURNAL ARTICLE
Homam Ibrahim, Eleonora Vapheas, Binita Shah, Ahmad AlKhalil, Michael Querijero, Hasan Jilaihawi, Peter Neuburger, Cezar Staniloae, Mathew R Williams
BACKGROUND: Thrombocytopenia after transcatheter aortic valve replacement (TAVR) is associated with adverse clinical outcomes. Whether preprocedural P2Y12 inhibition prevents postprocedural thrombocytopenia is uncertain. METHODS: This retrospective analysis identified consecutive patients (n = 266) undergoing TAVR between November 2016 and July 2017. Preprocedure clopidogrel load ≥300 mg or maintenance P2Y12 inhibitor therapy defined preprocedural P2Y12 inhibition...
November 15, 2019: Catheterization and Cardiovascular Interventions
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