Yutaro Seto, Manabu Nagao, Takuya Iino, Amane Harada, Katsuhiro Murakami, Keiko Miwa, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Junko Asakura, Tomoo Fujioka, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh
BACKGROUND: Although low high-density lipoprotein cholesterol (HDL-C) levels are a common metabolic abnormality associated with insulin resistance, their role in cardiovascular risk stratification remains controversial. Recently, we developed a simple, high-throughput, cell-free assay system to evaluate the "cholesterol uptake capacity (CUC)" as a novel concept for HDL functionality. In this study, we assessed the CUC in patients with hypertriglyceridemia and diabetes mellitus. METHODS: The CUC was measured using cryopreserved serum samples from 285 patients who underwent coronary angiography or percutaneous coronary intervention between December 2014 and May 2019 at Kobe University Hospital...
April 4, 2024: Journal of Applied Laboratory Medicine