Pedram Gerami, Alice Chen, Natasha Sharma, Pragi Patel, Michael Hagstrom, Pranav Kancherla, Tara Geraminejad, Shantel Olivares, Asok Biswas, Marcus Bosenberg, Klaus J Busam, Arnaud de La Fouchardière, Lyn M Duncan, David E Elder, Jennifer Ko, Gilles Landman, Alexander J Lazar, Lori Lowe, Daniela Massi, Daniela Mihic-Probst, Douglas C Parker, Richard A Scolyer, Christopher R Shea, Artur Zembowicz, Sook Jung Yun, Willeke A M Blokx, Raymond L Barnhill
Drivers of Spitz neoplasms include activating point mutations in HRAS and Spitz-associated genomic fusions. It has become evident that some BRAF-mutated melanocytic neoplasms can morphologically mimic Spitz tumors (STs). These have been termed BRAF mutated and morphologically spitzoid (BAMS). In this study, 17 experts from the International Melanoma Pathology Study Group assessed 54 cases which included 40 BAMS and 14 true STs. The participants reviewed the cases blinded to the genomic data and selected among several diagnostic options, including BAMS, ST, melanoma, and other...
March 25, 2024: American Journal of Surgical Pathology