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M Camargo, P Intasqui, L B Belardin, M P Antoniassi, K H M Cardozo, V M Carvalho, R Fraietta, R P Bertolla
Varicocelectomy is associated to improved semen quality and sperm functional quality, but individual response is highly variable. Thus, a prospective study was performed including 25 men who collected a semen sample before and 12 months after subinguinal microsurgical varicocelectomy. Semen analysis, sperm functional analysis, and seminal plasma proteomic analysis was performed before and 12 months after varicocelectomy, and according to improvement or not of semen quality (positive and negative outcome)...
January 30, 2019: Journal of Proteomics
Medhat Kamel Amer, Ahmed Ragab Ahmed, Asmaa Ahmed Abdel Hamid, Sameh Fayek GamalEl Din
PURPOSE: We studied prospectively the role of FSH, testis volume, age, duration of infertility, hormonal therapy, varicocelectomy and testicular histopathology in determining the sperm retrieval rate (SRR) in fresh versus salvage micro-TESE. METHODS: Our study analysed retrospectively the prospectively maintained database of 330 NOA patients who underwent micro-TESE either 1st or 2nd or 3rd timers from January 2017 to August 2018 from the Andrology Clinic of a specialized IVF centre...
January 30, 2019: International Urology and Nephrology
Mustafa Suat Bolat, Fatih Kocamanoglu, Murat Gulsen, Mesut Sengul, Ramazan Asci
Impacts of a subinguinal microsurgical varicocelectomy on the sperm parameters and fertility rates were investigated in three different ages according to their age at the time of the varicocelectomy: Group 1 was ≤20 years old, Group 2 was 21-30 years old, and Group 3 was ≥31 years old. The patients were also classified both preoperatively and post-operatively according to the total motile sperm count (TMSC) into the following categories: invitro fertilisation, intrauterine insemination and naturally fertile...
January 28, 2019: Andrologia
Ciro Esposito, Francesco Turrà, Fulvia Del Conte, Serena Izzo, Francesca Gargiulo, Alessandra Farina, Giovanni Severino, Mariapina Cerulo, Maria Escolino
BACKGROUND: Laparoscopic Palomo varicocelectomy is one the most common approaches adopted to treat pediatric varicocele, but postoperative hydrocele still remains a potential problem with this procedure. This study aimed to evaluate the outcome of a new technique of lymphography using indocyanine green (ICG)-enhanced fluorescence to perform lymphatic sparing laparoscopic Palomo varicocelectomy. PATIENTS AND METHODS: The records of 25 patients who underwent laparoscopic left varicocelectomy in our unit from March 2017 to March 2018 were retrospectively evaluated...
January 24, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Fuat Kızılay, Barış Altay
In this study, we aimed to evaluate the effect of oral antioxidant treatment on semen parameters and pregnancy rates in infertile men who underwent varicocelectomy. The study was conducted between January 2016 and January 2018. Subinguinal microscopic varicocelectomy was performed in 90 patients who were referred for infertility and diagnosed with clinical varicocele. The patients were divided into two groups. The first group received antioxidant treatment for 6 months after the operation (n = 62); the second group did not receive treatment after the operation (n = 28)...
January 18, 2019: International Journal of Impotence Research
Moustafa A El Taieb, Eisa M Hegazy, Hassan M Ibrahim, Ahmed K Ibrahim
BACKGROUND AND AIM: Varicocele is one of the most common causes of male infertility. Leptin that has a role in sperm motility may have a role of varicocele. We aimed to study the effect of varicocelectomy on the serum and seminal leptin in patients with asthenozoospermia and the correlation between leptin levels, sperm parameters and varicocele grade. METHODS: Thirty-six male patients with varicocele having isolated asthenozoospermia were included in this study...
January 11, 2019: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
K Almekaty, M H Zahran, A Zoeir, S Minhas, K Salem
BACKGROUND: There is wide agreement nowadays that a clinical varicocoele should be ligated to treat male factor infertility. However, the significance of testicular artery preservation in patients with severe oligozoospermia has not been addressed before. OBJECTIVES: To assess the outcome of varicocelectomy in infertile men with severe oligozoospermia and clinical varicocoeles and to compare internal spermatic artery preservation vs. artery ligation. MATERIALS AND METHODS: This prospective randomized study included 302 infertile patients with severe oligozoospermia and clinical (grade II/III) varicocoeles...
January 7, 2019: Andrology
S I Gamidov, V M Popkov, T V Shatylko, A Yu Popova, A Yu Korolev, R I Ovchinnikov, N G Gasanov
Varicocele-related infertility is traditionally considered an indication for surgery. At the same time in some specific clinical settings, especially with subclinical varicocele, conservative therapy using hormonal or antioxidant drugs is also possible. The potential role of drug therapy in this patient category remains controversial. The article discusses the options and treatment regimens for men with varicocele-related infertility. Given the difficulties in interpreting the results of studies and the heterogeneity of the data, it is not yet possible to recommend abandoning varicocelectomy in favor of drug therapy...
December 2018: Urologii︠a︡
R H Tian, H X Chen, L Y Zhao, C Yang, P Li, Z Wan, Y H Huang, E L Zhi, N C Liu, C C Yao, X B Wang, Y J Xue, Y H Gong, Y Hong, Z Li
Objective: To discuss the efficacy and safety of subinguinal microsurgical varicocelectomy in the treatment of non-obstructive azoospermia (NOA) with varicocele. Methods: The clinical data of 141 patients with NOA and varicocele who underwent subinguinal microsurgical varicocelectomy from March 2015 to June 2017 in Shanghai General Hospital was collected.One hundred and ten patients suffered from varicocele on the left side, 1 on the right side, and the rest (30 cases) were bilateral varicocele. Grade Ⅰ varicocele were found on 7 sides (the right and left side was count respectively), grade Ⅱ on 121 sides, and grade Ⅲ on 43 sides...
December 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jack Elder
No abstract text is available yet for this article.
November 21, 2018: European Urology
Khaleeq Ur Rehman, Hafsa Zaneb, Abdul Basit Qureshi, Ahsan Numan, Muhammad Shahbaz Yousaf, Imtiaz Rabbani, Habib Rehman
BACKGROUND: Varicocele is known to be associated with infertility and sperm disorders. The exact cause of this ailment is not fully understood. There are limited numbers of studies where venous blood gases (VBGs) of varicocele veins were determined with conflicting results. Therefore, we have investigated the pattern of VBGs in both internal spermatic and external spermatic varicocele veins and correlation with semen quality parameters in infertile individuals who underwent left microsurgical varicocelectomy...
November 13, 2018: BMC Urology
Erhan Ates, Murat Ucar, Mehmet Zeynel Keskin, Ahmet Gokce
Various studies have been reported to predict the success of varicocelectomy. Neutrophil-lymphocyte ratio (NLR) is a frequently used indicator of systemic inflammation. We aimed to evaluate the effect of inflammation on the success of varicocelectomy using the NLR. The data of 86 patients who underwent varicocelectomy for infertility were evaluated retrospectively. Pre-operative demographic characteristics of patients, laboratory results such as haemogram, and semen analysis and clinical data were recorded...
November 5, 2018: Andrologia
Cailey Guercio, Dattatraya Patil, Akanksha Mehta
We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA. We queried the 2009-2015 MarketScan Database using relevant ICD9, ICD10, and CPT codes to identify all 18-45 year olds with varicoceles. Differences in age, area of residence, clinical characteristics, and medical management between men who did and did not undergo varicocelectomy (open, laparoscopic, or microsurgical) during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables, respectively...
October 26, 2018: Asian Journal of Andrology
Abdelshakour A Al-Mohammady, Ahmed F El-Sherbiny, Amira B Mehaney, Yasser A Ghobara
PURPOSE: This study sought to evaluate the impact of varicocele repair on intracytoplasmic sperm injection outcomes. PATIENTS AND METHODS: A prospective comparative study was conducted at the Assisted Reproduction Unit, International Islamic Center for Population Studies and Researches, Al-Azhar University. This study included 100 non-azoospermic infertile men with a history of varicocele who were scheduled for intracytoplasmic sperm injection, half of them had already undergone prior subinguinal varicocelectomy at least 12 months prior to ICSI without clinically evident recurrence (treated group 1), and the other half has any grade of an unrepaired clinical varicocele (untreated group 2) at sperm injection...
October 29, 2018: Andrologia
Seung Ryong Baek, Hyun Jun Park, Nam Cheol Park
We investigated the clinical characteristics of patients with varicocele according to the presence or absence of scrotal pain. We retrospectively reviewed the records of patients who underwent varicocelectomy. The age, body mass index, grade, laterality of varicocele, testicular volume difference, time to hospital visit, serum testosterone level and semen parameters were evaluated. A total of 954 patients were included. The painful group had lower mean age, lower BMI, higher grade of varicocele, smaller testicular volume difference and shorter time to hospital visit than the painless group...
October 25, 2018: Andrologia
L Belardin, M Camargo, P Intasqui, M Antoniassi, R Fraietta, R Bertolla
BACKGROUND: Cysteine-rich secretory protein (CRISP-3), a protein involved in inflammatory response, is highly increased in seminal plasma of adolescents with varicocoele and altered semen analysis, but not in adolescents with varicocoele and normal semen. It is not known, however, whether this increased seminal concentration occurs as an acute marker during the initial stages of varicocoele or whether this persists as an altered protein pathway. OBJECTIVE: The purpose of this study, thus, was to test the hypothesis that this inflammatory state persists through adulthood and the correction of varicocoele could correct this state, by identifying the levels of CRISP-3 in seminal plasma...
October 24, 2018: Andrology
Helen Levey Bernie, Marc Goldstein
As men age, serum testosterone levels decrease. This reduction in testosterone levels may cause symptoms leading to hypogonadism. In addition, the presence of a varicocele can impair Leydig cell function, resulting in decreased testosterone production in men. Varicocelectomy and testosterone replacement therapy are both viable treatment options for hypogonadism in elderly male patients. The correct modality of treatment will vary for each patient, but education is essential in order to help men understand their options...
April 2018: European Urology Focus
Hesamoddin Sajadi, Jalil Hosseini, Faramarz Farrahi, Farid Dadkhah, Mahdi Sepidarkish, Marjan Sabbaghian, Poopak Eftekhari-Yazdi, Mohammad Ali Sadighi Gilani
Background: Assessing the net-results of microsurgical varicocelectomy in infertile men with non-obstructive azoospermic (NOA) and clinical varicocele in five years at Royan Institute. Materials and Methods: This is a descriptive retrospective cohort study. A backward-looking review of patients treated for NOA and varicocele from march 2011 to march 2016 was performed. In addition, MDTESE results of 57 patients with NOA and clinical varicocele, with 537 NOA patients without varicocele were compared...
January 2019: International Journal of Fertility & Sterility
M Zavattaro, C Ceruti, G Motta, S Allasia, L Marinelli, C Di Bisceglie, M P Tagliabue, M Sibona, L Rolle, F Lanfranco
PURPOSE: Varicocele is defined as a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow through the internal spermatic vein. The prevalence of clinically relevant varicocele ranges from 5 to 20% in the male population and is often associated with infertility and reduction of sperm quality. In this review, the pathophysiology and clinical aspects of varicocele are reviewed along with therapeutic options and treatment effects on sperm parameters and fertility both in adult and in pediatric/adolescent subjects...
December 2018: Journal of Endocrinological Investigation
Kostas Chondros, Evangelos Kountourakis, Marina Kalogridaki, Konstantinos Grekos
Varicocele represents a common problem in young men with infertility or chronic scrotal pain and it is located on the left side in the vast majority of the cases. Right isolated varicocele is a quite rare entity, especially in middle-aged men and as the single pathology responsible for chronic pain. Further investigation might be needed to exclude other retroperitoneal or scrotal hidden lesions. Several surgical options are available for symptomatic patients with clinical varicocele including the laparoscopic approach of high ligation of the spermatic veins...
2018: AME case reports
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