keyword
https://read.qxmd.com/read/38481326/cancer-cell-specific-and-pro-apoptotic-smac-peptide-doxorubicin-conjugated-prodrug-encapsulated-aposomes-for-synergistic-cancer-immunotherapy
#21
JOURNAL ARTICLE
Jinseong Kim, Man Kyu Shim, Yujeong Moon, Jeongrae Kim, Hanhee Cho, Wan Su Yun, Nayeon Shim, Joon-Kyung Seong, Yonghyun Lee, Dong-Kwon Lim, Kwangmeyung Kim
BACKGROUND: Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance to ICD-inducing chemotherapeutic drugs, and non-specific toxicity of those drugs against immune cells reduce the immunotherapy efficiency. METHODS: Herein, we propose cancer cell-specific and pro-apoptotic liposomes (Aposomes) encapsulating second mitochondria-derived activator of caspases mimetic peptide (SMAC-P)-doxorubicin (DOX) conjugated prodrug to potentiate combinational ICB therapy with ICD...
March 13, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38480047/systematic-review-on-surveillance-for-non-resected-branch-duct-intraductal-papillary-mucinous-neoplasms-of-the-pancreas
#22
JOURNAL ARTICLE
Sayada Zartasha Kazmi, Hye-Sol Jung, Youngmin Han, Won-Gun Yun, Young Jae Cho, Mirang Lee, Wooil Kwon, Carlos Fernandez-Del Castillo, Marco Del Chiaro, Giovanni Marchegiani, Brian K P Goh, Susumu Hijioka, Shounak Majumder, Yousuke Nakai, Aesun Shin, Jin-Young Jang
BACKGROUND: The management of branch-duct type intraductal papillary mucinous neoplasms (BD-IPMN) varies in existing guidelines. This study investigated the optimal surveillance protocol and safe discontinuation of surveillance considering natural history in non-resected IPMN, by systematically reviewing the published literature. METHODS: This review was guided by PRISMA. Research questions were framed in PICO format "CQ1-1: Is size criteria helpful to determine surveillance period? CQ1-2: How often should surveillance be carried out? CQ1-3: When should surveillance be discontinued? CQ1-4: Is nomogram predicting malignancy useful during surveillance?"...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38479066/molecular-detection-of-listeria-monocytogenes-from-different-dairy-and-street-food-sources-in-north-karnataka-india
#23
JOURNAL ARTICLE
Roshan Kumar Sharma, Sunil S Jalalpure, Swati Pathak, Sachit Ganapathy, Mickaël Desvaux, Subarna Roy, Satisha Hegde
BACKGROUND: Food-borne pathogen Listeria monocytogenes is abundantly present in nature and accountable for sporadic and epidemic cases of listeriosis in humans. The objective of this study was to screen common food sources for L. monocytogenes using biochemical and molecular methods to detect and characterise its toxin genes as well as for biofilm formation. METHODS: A total of 92 samples, comprising dairy and street food products, were randomly collected from various sources for this investigation...
February 29, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38469835/indian-academy-of-pediatrics-consensus-statement-on-diagnosis-and-management-of-bone-and-joint-infections-in-children
#24
JOURNAL ARTICLE
Bhaskar Shenoy, Tanu Singhal, Vijay Yewale, Jaydeep Choudhury, Pragalatha Kumar A, Mandar V Agashe, Chandrashekhar Chikkamuniyappa, Seema Janardhan, Bakul Jayant Parekh, G V Basavaraja
JUSTIFICATION: Osteoarticular infections are fairly common in children but often these are associated with underdiagnosis, delayed diagnosis and improper management. This leads to an increased incidence of complications and poor outcomes. Given the paucity of standard protocols for the management of these children in the Indian context, Indian Academy of Pediatrics (IAP) has taken the initiative to formulate guidelines for the early diagnosis and rational management of bone and joint infections (BJIs)...
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38469834/iap-ki-baat-community-ke-saath-debuting-with-a-fight-against-anemia
#25
JOURNAL ARTICLE
G V Basavaraja
No abstract text is available yet for this article.
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38461145/circulating-immune-signatures-in-chronic-pancreatitis-with-and-without-preceding-acute-pancreatitis-a-pilot-study
#26
JOURNAL ARTICLE
Rasmus Hagn-Meincke, Dhiraj Yadav, Dana K Andersen, Santhi Swaroop Vege, Evan L Fogel, Jose Serrano, Melena D Bellin, Mark D Topazian, Darwin L Conwell, Liang Li, Stephen K Van Den Eeden, Asbjørn M Drewes, Stephen J Pandol, Chris E Forsmark, William E Fisher, Phil A Hart, Søren S Olesen, Walter G Park
OBJECTIVE: To investigate profiles of circulating immune signatures in healthy controls and chronic pancreatitis patients (CP) with and without a preceding history of acute pancreatitis (AP). METHODS: We performed a phase 1, cross-sectional analysis of prospectively collected serum samples from the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translation StuDies (PROCEED) study. All samples were collected during a clinically quiescent phase...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38460954/investigation-of-the-seasonal-prevalence-phenotypic-and-genotypic-characteristics-of-listeria-monocytogenes-in-slaughterhouses-in-burdur
#27
JOURNAL ARTICLE
Zeki Erol, Fulya Taşçı
AIM: This study examined Listeria monocytogenes isolates from two slaughterhouses in Burdur province, southern Turkey, over four seasons for antibiotic resistance, serogroups, virulence genes, in vitro biofilm forming capacity, and genetic relatedness. METHODS AND RESULTS: Carcass (540) and environment-equipment surface (180) samples were collected from two slaughterhouses (S1, S2) for 1 year (4 samplings). Of the 89 (12.4%) positive isolates, 48 (53.9%) were from animal carcasses and 41 (46...
March 9, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38457315/comprehensive-attribute-prediction-learning-for-person-search-by-language
#28
JOURNAL ARTICLE
Kai Niu, Linjiang Huang, Yuzhou Long, Yan Huang, Liang Wang, Yanning Zhang
Person search by language refers to searching for the interested pedestrian images given natural language sentences, which requires capturing fine-grained differences to accurately distinguish different pedestrians, while still far from being well addressed by most of the current solutions. In this paper, we propose the Comprehensive Attribute Prediction Learning (CAPL) method, which explicitly carries out attribute prediction learning, for improving the modeling capabilities of fine-grained semantic attributes and obtaining more discriminative visual and textual representations...
March 8, 2024: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://read.qxmd.com/read/38455507/survivin-expression-is-associated-with-lymph-node-metastasis-and-short-survival-in-patients-with-colorectal-adenocarcinoma
#29
JOURNAL ARTICLE
Haneen Al-Maghrabi, Zuhoor Al-Mansouri, Jaudah Al-Maghrabi
BACKGROUND: Survivin, a protein belonging to the Inhibitor of apoptosis (IAP) family, is the smallest member in terms of size. It works by preventing programmed cell death and regulating the advancement of the cell cycle. Being a part of the group of inhibitors associated with apoptosis, survivin is connected to increased aggression and negative prognosis in different malignancies, including colorectal cancer (CRC). MATERIALS AND METHODS: Pathology tissue blocks of 209 primary tumors, and 44 adenomas, were used in this study, as well as an anti-Survivin antibody...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38453985/development-of-risk-prediction-nomogram-for-neonatal-sepsis-in-group-b-streptococcus-colonized-mothers-a-retrospective-study
#30
JOURNAL ARTICLE
Mengqi Wu, Yanbing Deng, Xinye Wang, Baomei He, Fangqiang Wei, Ying Zhang
Neonatal clinical sepsis is recognized as a significant health problem, This study sought to identify a predictive model of risk factors for clinical neonatal sepsis. A retrospective study was conducted from 1 October 2018 to 31 March 2023 in a large tertiary hospital in China. Neonates were divided into patients and controls based on the occurrence of neonatal sepsis. A multivariable model was used to determine risk factors and construct models.The utilization and assessment of model presentation were conducted using Norman charts and web calculators, with a focus on model differentiation, calibration, and clinical applicability (DCA)...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38451676/hydroxychavicol-sensitizes-imatinib-resistant-chronic-myelogenous-leukemia-cells-to-trail-induced-apoptosis-by-ros-mediated-iap-downregulation-erratum
#31
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38448974/exploration-of-newly-synthesized-azo-thiohydantoins-as-the-potential-alkaline-phosphatase-inhibitors-via-advanced-biochemical-characterization-and-molecular-modeling-approaches
#32
JOURNAL ARTICLE
Hafiz Muhammad Attaullah, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Rabail Ujan, Seema Zargar, Sajid Ali Channar, Reshma Sahito, Tanveer A Wani, Qamar Abbas
In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1 H-NMR, 13 C-NMR, elemental and HRMS analysis. The compounds were evaluated for alkaline phosphatase activity and it was observed that among all the synthesized compounds, derivative 7e exhibited substantial inhibitory activity (IC50  = 0.308 ± 0.065 µM), surpassing the standard inhibitor (L-Phenyl alanine, IC50  = 80...
March 6, 2024: BMC chemistry
https://read.qxmd.com/read/38448348/association-of-autoimmune-pancreatitis-and-intraductal-papillary-mucinous-neoplasm-a-retrospective-analysis-from-a-tertiary-care-referral-center
#33
JOURNAL ARTICLE
Marco Lanzillotta, Lino Iago Belli, Giulio Belfiori, Diego Palumbo, Marco Schiavo-Lena, Gabriele Capurso, Paolo Giorgio Arcidiacono, Lorenzo Dagna, Massimo Falconi, Stefano Crippa, Emanuel Della-Torre
BACKGROUND: Autoimmune Pancreatitis (AIP) is a rare chronic inflammatory disease affecting the pancreas. Chronic pancreatic inflammation represents a risk factor for pre-neoplastic conditions such as Intraductal Papillary Mucinous Neoplasia (IPMN). Due to the rarity of AIP, the incidence, and clinical features of IPMN occurring in AIP patients remains unknown. AIMS: In the present study we aimed to explore the relationship between AIP and IPMN and to characterize the clinical features and outcomes of IPMN occurring in the context of AIP...
March 1, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38448347/guideline-adherence-in-acute-pancreatitis-still-a-long-way-to-go
#34
EDITORIAL
Soumya Jagannath Mahapatra, Søren Schou Olesen
No abstract text is available yet for this article.
March 2, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38443232/natural-history-and-growth-prediction-model-of-pancreatic-serous-cystic-neoplasms
#35
JOURNAL ARTICLE
Jenny H Chang, Breanna C Perlmutter, Chase Wehrle, Robert Naples, Kathryn Stackhouse, John McMichael, Tu Chao, Samer Naffouje, Toms Augustin, Daniel Joyce, Robert Simon, R Matthew Walsh
OBJECTIVE: Serous cystic neoplasms (SCN) are benign pancreatic cystic neoplasms that may require resection based on local complications and rate of growth. We aimed to develop a predictive model for the growth curve of SCNs to aid in the clinical decision making of determining need for surgical resection. METHODS: Utilizing a prospectively maintained pancreatic cyst database from a single institution, patients with SCNs were identified. Diagnosis confirmation included imaging, cyst aspiration, pathology, or expert opinion...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38437728/targeting-the-tnf-iap-pathway-synergizes-with-anti-cd3-immunotherapy-in-t-cell-acute-lymphoblastic-leukemia
#36
JOURNAL ARTICLE
Andrea Ávila Ávila, Kanokporn Nuantang, Mariana Lobato Oliveira, Sabine Druillennec, Benedetta Zaniboni, Etienne Lengliné, Vahid Asnafi, Jacques Ghysdael, Christine Tran Quang
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Current treatments, based on intensive chemotherapy regimens provide overall survival rates of ~85% in children and <50% in adults, calling the search of new therapeutic options. We previously reported that targeting the T cell receptor (TCR) in T-ALL with anti-CD3 (CD3) mAbs enforces a molecular program akin to thymic negative selection, a major developmental checkpoint in normal T-cell development, induces leukemic cell death and impairs leukemia progression to ultimately improve host survival...
March 4, 2024: Blood
https://read.qxmd.com/read/38431446/incidence-implications-and-predictors-of-abdominal-compartment-syndrome-in-acute-pancreatitis-a-nationwide-analysis
#37
JOURNAL ARTICLE
Ali Jaan, Zouina Sarfraz, Umer Farooq, Sheza Malik, Asad Ur Rahman, Patrick Okolo
BACKGROUND: Acute pancreatitis (AP) often presents with varying severity, with a small fraction evolving into severe AP, and is associated with high mortality. Complications such as intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are intricately associated with AP. OBJECTIVE: To assess the clinical implications and predictors of ACS in AP patients. METHODS: We conducted a retrospective study using the National Inpatient Sample (NIS) database on adult AP patients, further stratified by the presence of concurrent ACS...
February 18, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38431445/intravenous-hemin-a-potential-heme-oxygenase-1-activator-does-not-protect-from-post-ercp-acute-pancreatitis-in-humans-results-of-a-randomized-multicentric-multinational-placebo-controlled-trial
#38
JOURNAL ARTICLE
Rawad A Yared, Chieh-Chang Chen, Astrid Vandorpe, Marianna Arvanitakis, Myriam Delhaye, Michael Fernandez Y Viesca, Vincent Huberty, Daniel Blero, Emmanuel Toussaint, Axel Hittelet, Didier Verset, Walter Margos, Olivier Le Moine, Hassane Njimi, Wei-Chih Liao, Jacques Devière, Arnaud Lemmers
OBJECTIVE: Hemin, a heme oxygenase 1 activator has shown efficacy in the prevention and treatment of acute pancreatitis in mouse models. We conducted a randomized controlled trial (RCT) to assess the protective effect of Hemin administration to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in patients at risk. METHODS: In this multicenter, multinational, placebo-controlled, double-blind RCT, we assigned patients at risk for PEP to receive a single intravenous dose of Hemin (4 mg/kg) or placebo immediately after ERCP...
February 15, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38428166/toxin-gene-detection-and-antibiotic-resistance-of-clostridium-perfringens-from-aquatic-sources
#39
JOURNAL ARTICLE
Mengxuan Li, Ying Wang, Bingyu Hou, Yibao Chen, Ming Hu, Xiaonan Zhao, Qing Zhang, Lulu Li, Yanbo Luo, Yuqing Liu, Yumei Cai
Clostridium perfringens is a zoonotic opportunistic pathogen that produces toxins that can cause necrotic enteritis and even "sudden death disease". This bacterium is widely distributed in the intestines of livestock and human, but there are few reports of distribution in aquatic animals (Hafeez et al., 2022). In order to explore the isolation rate of C. perfringens and the toxin genes they carry, 141 aquatic samples, including clams (Ruditapes philippinarum), oysters (Ostreidae), and mud snails (Bullacta exerata Philippi), were collected from the coastal areas of Shandong Province, China...
February 28, 2024: International Journal of Food Microbiology
https://read.qxmd.com/read/38423915/clinical-diagnosis-of-psychiatric-comorbidities-performance-of-screening-tests-and-pattern-of-psychotropic-medication-use-in-patients-with-chronic-pancreatitis
#40
JOURNAL ARTICLE
Natalie E Griffin, Robert Feldman, Andrew D Althouse, Dhiraj Yadav, Anna Evans Phillips
BACKGROUND: Psychiatric comorbidity measured by screening instruments is common in patients with chronic pancreatitis (CP) but whether this accurately reflects clinical diagnosis of psychiatric comorbidity is unknown and the prevalence of psychotropic medication prescription in CP remains largely unexplored. METHODS: Adult patients (≥18 years) with definite CP were enrolled and completed the Hospital Anxiety and Depression Scale (HADS). Demographics, clinical characteristics and medications were retrieved from case report forms and the electronic health record (EHR)...
February 18, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
keyword
keyword
109182
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.