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November 2018: Indian Journal of Pathology & Microbiology
Jiangtao Yin, Xin Pan, Jue Jia, Shuangshuang Sun, Bing Wan
Mechanical ventilation support is commonly required in abdominal compartment syndrome (ACS). In the present study, pressure-regulated volume control ventilation (PRVCV) was compared to pressure control ventilation (PCV) in patients with ACS. The prospective study included 40 patients with ACS who were randomized into the PCV or PRVCV groups and subjected to the different modes of ventilation. After 6 h of ventilation, arterial blood gas, respiratory mechanics and hemodynamics parameters, as well as the intra-abdominal pressure (IAP) and Sequential Organ Failure Assessment (SOFA) scores were calculated...
March 2019: Experimental and Therapeutic Medicine
Ouissam Ayachi, Meltem Barlin, Pia Nora Broxtermann, Hamid Kashkar, Cornelia Mauch, Paola Zigrino
BACKGROUND: The X-linked inhibitor of apoptosis (XIAP) is a potent cellular inhibitor of apoptosis, based on its unique capability to bind and to inhibit caspases. However, XIAP is also involved in a number of additional cellular activities independent of its caspase inhibitory function. The aim of this study was to investigate whether modulation of XIAP expression affects apoptosis-independent functions of XIAP in melanoma cells, restores their sensitivity to apoptosis and/or affects their invasive and metastatic capacities...
February 18, 2019: Cellular Oncology (Dordrecht)
Paulina Gil-Kulik, Arkadiusz Krzyżanowski, Ewa Dudzińska, Jolanta Karwat, Piotr Chomik, Małgorzata Świstowska, Adrianna Kondracka, Anna Kwaśniewska, Maria Cioch, Mariusz Jojczuk, Adam Nogalski, Janusz Kocki
The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors of apoptosis, IAP. This protein serves a dual role. First, it regulates cell death, and second, it is an important regulator of mitosis progression, although its physiological regulatory function has not been fully understood. Many studies have shown and confirmed that survivin is practically absent in mature tissues in nature, while its overexpression has been reported in many cancerous tissues. There is little information about the significance of BIRC5 expression in normal adult human stem cells...
2019: Oxidative Medicine and Cellular Longevity
Yoshiyasu Kato, Suguru Yamada, Mitsuru Tashiro, Fuminori Sonohara, Hideki Takami, Masamichi Hayashi, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: This study aimed to evaluate novel resectability criteria for pancreatic ductal adenocarcinoma (PDAC) proposed by the International Association of Pancreatology (IAP) by comparing them with the National Comprehensive Cancer Network (NCCN) guidelines. METHODS: 369 patients who underwent upfront surgery for PDAC were retrospectively analyzed. Overall survival (OS) of each group as defined by either of the guidelines were compared and preoperative prognostic factors for OS were identified...
February 14, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Behnaz Ahangarian Abhari, Nicole McCarthy, Marie Le Berre, Michelle Kilcoyne, Lokesh Joshi, Patrizia Agostinis, Simone Fulda
Since Inhibitor of Apoptosis (IAP) proteins have been implicated in cellular adaptation to endoplasmic reticulum (ER) stress, we investigated the regulation of ER stress-induced apoptosis by small-molecule second mitochondria-derived activator of caspase (Smac) mimetics that antagonize IAP proteins. Here, we discover that Smac mimetic suppresses tunicamycin (TM)-induced apoptosis via resolution of the unfolded protein response (UPR) and ER stress. Smac mimetics such as BV6 selectively inhibit apoptosis triggered by pharmacological or genetic inhibition of protein N-glycosylation using TM or knockdown of DPAGT1, the enzyme that catalyzes the first step of protein N-glycosylation...
February 15, 2019: Cell Death & Disease
Federica Cossu, Mario Milani, Eloise Mastrangelo, Daniele Lecis
Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs were initially thought to be mainly responsible for caspase inhibition, acting as negative regulators of apoptosis, but later works have shown that IAPs also control a plethora of other different cellular pathways. As X-linked IAP (XIAP), and other IAP, levels are often deregulated in cancer cells and have been shown to correlate with patients' prognosis, several approaches have been pursued to inhibit their activity in order to restore apoptosis...
2019: Computational and Structural Biotechnology Journal
Saruna Ghimire, Shiva Raj Mishra, Abhishek Sharma, Adugna Siweya, Nipun Shrestha, Bipin Adhikari
BACKGROUND: In low-income countries such as Nepal, indoor air pollution (IAP), generated by the indoor burning of biomass fuels, is the top-fourth risk factor driving overall morbidity and mortality. We present the first assessment of geographic and socio-economic determinants of the markers of IAP (specifically fuel types, cooking practices, and indoor smoking) in a nationally-representative sample of Nepalese households. METHODS: Household level data on 11,040 households, obtained from the 2016 Nepal Demographic and Health Survey, were analyzed...
February 14, 2019: BMC Public Health
Mohammad Bagher Mahmoudi, Ehsan Farashahi Yazd, Farhad Gharibdoost, Mohammad Hasan Sheikhha, Elham Karimizadeh, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND/OBJECTIVES: Recent studies suggest that, in addition to activation and hypersecretion of matrix components, fibroblasts from patients with systemic sclerosis (SSc) are resistant to apoptosis. Previous studies have shown that survivin, a member of inhibition of apoptosis (IAP) family, plays an important role in apoptosis resistance. Accordingly, we decided to study the expression of the most important members of IAP family in SSc fibroblasts, which can block apoptosis either by binding and inhibiting caspases or through caspase-independent mechanisms...
February 13, 2019: Irish Journal of Medical Science
Utkarsha Pathak, Naresh Chandra Gupta, Jagdish Chandra Suri
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality in developing nations. In this meta-analysis, we aimed to determine the association between indoor air pollution and risk of COPD. Database searches were conducted using indoor air pollution, biomass and COPD related terms to identify relevant articles. The eligible studies were case-control, retrospective cohort, cross-sectional studies and conducted in adults that assessed COPD using any diagnostic criteria. A total of 35 studies with 73,122 participants were included...
February 13, 2019: International Journal of Environmental Health Research
Srikanth Puttaiah Kadyada, Babu Ram Thapa, Narendra Dhaka, Anmol Bhatia, Jagadeesh Menon
OBJECTIVES: Endoscopic ultrasound (EUS) is a minimally invasive pancreatic imaging modality. We evaluated children with idiopathic acute pancreatitis (IAP) and acute recurrent pancreatitis (ARP) for changes of chronicity (Rosemont criteria) and biliary risk factors. Diagnostic yield of simultaneously performed transabdominal ultrasonography (TUS) was compared with EUS. METHODS: This was a prospective observational study. Patients underwent EUS and TUS after 2 months of pancreatitis attack...
February 8, 2019: Pancreas
S Balasubramanian, Abhay Shah, Harish K Pemde, Pallab Chatterjee, S Shivananda, Vijay Kumar Guduru, Santosh Soans, Digant Shastri, Remesh Kumar
JUSTIFICATION: There is a need to revise/review recommendations regarding existing vaccines in view of current developments in vaccinology. PROCESS: Advisory Committee on Vaccines and Immunization Practices (ACVIP) of Indian Academy of Pediatrics (IAP) reviewed the new evidence, had two meetings, and representatives of few vaccine manufacturers also presented their data. The recommendations were finalized unanimously. OBJECTIVES: To revise and review the IAP recommendations for 2018-19 and issue recommendations on existing and certain new vaccines...
December 15, 2018: Indian Pediatrics
Min Jang, Sooyoung Choi, In Lee, Inhyung Lee
OBJECTIVE: To describe computed tomographic (CT) features of intra-abdominal hypertension (IAH) in 3 dogs with abdominal distension. CASE SUMMARY: Three dogs with anorexia, distended abdomen, or labored breathing were presented for CT imaging. All 3 dogs were premedicated with IV butorphanol (0.2 mg/kg). A Foley urinary catheter was aseptically placed and the transvesical technique was used to obtain intra-abdominal pressure (IAP). The IAP measurements were obtained with the dogs in a standing position after a stabilization period of 5 minutes...
February 11, 2019: Journal of Veterinary Emergency and Critical Care
Aneesa Vanker, Polite M Nduru, Whitney Barnett, Felix S Dube, Peter D Sly, Robert P Gie, Mark P Nicol, Heather J Zar
Indoor air pollution (IAP) or environmental tobacco smoke (ETS) exposure may influence nasopharyngeal carriage of bacterial species and development of lower respiratory tract infection (LRTI). The aim of this study was to longitudinally investigate the impact of antenatal or postnatal IAP/ETS exposure on nasopharyngeal bacteria in mothers and infants. A South African cohort study followed mother-infant pairs from birth through the first year. Nasopharyngeal swabs were taken at birth, 6 and 12 months for bacterial culture...
February 2019: ERJ Open Research
Diana Trnski, Maja Gregorić, Sonja Levanat, Petar Ozretić, Nikolina Rinčić, Tajana Majić Vidaković, Držislav Kalafatić, Ivana Maurac, Slavko Orešković, Maja Sabol, Vesna Musani
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in late stages when treatment options are limited. Hedgehog-GLI (HH-GLI) signaling is a major developmental pathway involved in organogenesis and stem cell maintenance, and is activated in OC. One of its targets is survivin ( BIRC5 ), an inhibitor of apoptosis protein (IAP) that plays a role in multiple processes, including proliferation and cell survival. We wanted to investigate the role of different GLI proteins in the regulation of survivin isoform expression (WT, 2α, 2B, 3B, and Δex3) in the SKOV-3 OC cell line...
February 6, 2019: Cells
Xiaoyan Hu, Yang Meng, Lian Xu, Lei Qiu, Mingtian Wei, Dan Su, Xu Qi, Ziqiang Wang, Shengyong Yang, Cong Liu, Junhong Han
CRL4, a well-defined E3 ligase, has been reported to be upregulated and is proposed to be a potential drug target in ovarian cancers. However, the biological functions of CRL4 and the underlying mechanism regulating cancer chemoresistance are still largely elusive. Here, we show that CRL4 is considerably increased in cisplatin-resistant ovarian cancer cells, and CRL4 knockdown with shRNAs is able to reverse cisplatin-resistance of ovarian cancer cells. Moreover, CRL4 knockdown markedly inhibits the expression of BIRC3, one of the inhibitors of apoptosis proteins (IAPs)...
February 4, 2019: Cell Death & Disease
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Sumit Chanda, Susan J Little, Norbert Wiedemann, Gregoire Vuagniaux, Philippe A Gallay
Antiretroviral therapy (ART) suppresses HIV replication, but does not cure the infection because replication-competent virus persists within latently infected CD4+ T cells throughout years of therapy. These reservoirs contain integrated HIV-1 genomes and can resupply active virus. Thus, the development of strategies to eliminate the reservoir of latently infected cells is a research priority of global significance. In this study, we tested efficacy of a new inhibitor of apoptosis protein antagonist (IAPa) called Debio 1143 at reversing HIV latency and investigated its mechanisms of action...
2019: PloS One
Hongye Wang, Jiwei Yu
OBJECTIVE: To investigate the secondary pathological changes in lung of abdominal compartment syndrome (ACS). METHODS: Twenty-five healthy adult clean New Zealand rabbits were randomly divided into control group (n = 5) and experimental group (n = 20) according to the random number table method. The experimental group was subdivided into two subgroups according to the observation time: 24 hours and 48 hours, with 10 rabbits in each subgroup. A high pressure liquid animal model of abdominal cavity was reproduced by water bag superposition pressurization...
January 2019: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Enya F Fullston, Michael J Doyle, Mary F Higgins, Susan J Knowles
BACKGROUND: Early-onset group B Streptococcus (EOGBS/GBS) infection remains a significant cause of neonatal morbidity and mortality. AIMS: Aiming to improve antimicrobial stewardship and reduce unnecessary maternal and infant exposure to intrapartum antibiotic prophylaxis (IAP), this study assessed the clinical use of a commercially available GBS polymerase chain reaction (PCR) assay for term women with pre-labour rupture of membranes. METHODS: This was a retrospective study in a tertiary level maternity unit of term women with pre-labour rupture of membranes (ROM), without any clinical suspicion of infection performed between November and December 2017...
January 31, 2019: Irish Journal of Medical Science
Peng Chen, Tao-Tao Kang, Xi-Yan Bao, Zhan-Qi Dong, Yan Zhu, Wen-Fu Xiao, Min-Hui Pan, Cheng Lu
As an important insect immune response, apoptosis plays a critical role in the interaction between baculoviruses and insect hosts. Previous reports have identified inhibitor of apoptosis (IAP) proteins in both insects and baculoviruses, but the relationship between these proteins is still not clearly understood. Here, we found that insect IAP proteins were clustered with baculovirus IAP3, suggesting that the baculovirus iap3 gene might be derived from the Lepidoptera or Diptera. We demonstrated that Bombyx mori inhibitor of apoptosis (Bmiap) gene had an inhibitory effect on apoptosis in silkworm cells...
January 30, 2019: Insect Science
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