keyword
https://read.qxmd.com/read/38526061/performance-evaluation-of-the-high-throughput-quantitative-alinity-m-bk-virus-assay
#21
JOURNAL ARTICLE
Julie W Hirschhorn, Mark M Sasaki, April Kegl, Tanjina Akter, Tanisha Dickerson, Momka Narlieva, Nhi Nhan, Tianxi Liu, Patricia Jim, Stephen Young, Erika Orner, Phyu Thwe, Danijela Lucic, D Yitzchak Goldstein
UNLABELLED: BK virus (BKV) infection or reactivation in immunocompromised individuals can lead to adverse health consequences including BKV-associated nephropathy (BKVAN) in kidney transplant patients and BKV-associated hemorrhagic cystitis (BKV-HC) in allogeneic hematopoietic stem cell transplant recipients. Monitoring BKV viral load plays an important role in post-transplant patient care. This study evaluates the performance of the Alinity m BKV Investigational Use Only (IUO) assay...
March 25, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38523965/baduanjin-is-better-balance-training-compared-to-walking-a-cross-sectional-study-based-on-center-of-gravity-trajectories
#22
JOURNAL ARTICLE
Weilan Jiang, Bingchen An, Shuangtao Liu, Chuan Xue, Chunlai Niu, Jie Qiu, Qilian Hu, Yaping Wang, Liang Chen, Liao Wang
BACKGROUND:  It has already been demonstrated by previous studies that Baduanjin training can improve the body's balance. However, its biomechanical mechanism remains unknown. Center of gravity (COG) trajectory analysis is an essential biomechanical test to explore the balance ability of the human body. Previous studies have not used the COG trajectory analysis technique to research Baduanjin training. The study utilizes COG trajectory analysis to analyze the trajectory of COG during Baduanjin training and compare it with that of walking, which is a common exercise for improving balance and aerobic ability, to determine if Baduanjin exercises affect the COG more than walking...
February 2024: Curēus
https://read.qxmd.com/read/38523298/evaluation-of-therapeutic-efficacy-of-emustil-drops-for-ocular-discomfort-and-tear-film-osmolarity-using-different-treatment-management-modes-under-dry-environmental-conditions
#23
JOURNAL ARTICLE
Ali Abusharha, E Ian Pearce, Tayyaba Afsar, Suhail Razak
BACKGROUND: We aimed to check the efficacy of Emustil (oil in water emulsion) drops on tear film index and ocular surface dynamics in dry environments through protection and relief treatment modalities. METHODS: The subjects were exposed to a dry environment using a Controlled Environment Chamber (CEC) where the relative humidity (RH) was 5% and the temperature was 21 °C and screened for ocular symptoms, tear osmolarity, ocular surface temperature (OST) and tear production using ocular Surface Disease Index questionnaire (OSDI), OcuSense TearLab Osmometer, FLIR System ThermaCAM P620 and Schirmer strips/phenol red test respectively...
March 25, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38522412/predicted-effectiveness-of-enchroma-multi-notch-filters-for-enhancing-color-perception-in-anomalous-trichromats
#24
JOURNAL ARTICLE
Lucy P Somers, Jenny M Bosten
EnChroma filters are aids designed to improve color vision for anomalous trichromats. Their use is controversial because the results of lab-based assessments of their effectiveness have so far largely failed to agree with positive anecdotal reports. However, the effectiveness of EnChroma filters will vary depending on the conditions of viewing, including whether the stimuli are broadband reflective surfaces or colors presented on RGB displays, whether illumination spectra are broadband or narrowband, the transmission spectra of particular filters, and the cone spectral sensitivity functions of the observer...
March 23, 2024: Vision Research
https://read.qxmd.com/read/38521512/development-and-validation-of-an-assessment-tool-for-adult-simulated-ultrasound-guided-fascia-iliaca-block-a-prospective-monocentric-study
#25
JOURNAL ARTICLE
Frederic-Pierre Guyader, Mathieu Violeau, Jérémy Guenezan, Youcef Guechi, Cyril Breque, Pauline Betoulle-Masset, Jean-Pierre Faure, Denis Oriot, Daniel Aiham Ghazali
BACKGROUND: Fascia iliaca block (FIB) is an effective technique for analgesia. While FIB using ultrasound is preferred, there is no current standardised training technique or assessment scale. We aimed to create a valid and reliable tool to assess ultrasound-guided FIB. METHOD: This prospective observational study was conducted in the ABS-Lab simulation centre, University of Poitiers, France between 26-29 October and 14-17 December 2021. Psychometric testing included validity analysis and reliability between two independent observers...
March 23, 2024: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/38521128/measuring-the-replicability-of-our-own-research
#26
JOURNAL ARTICLE
Richard E Brown
In the study of transgenic mouse models of neurodevelopmental and neurodegenerative disorders, we use batteries of tests to measure deficits in behaviour and from the results of these tests, we make inferences about the mental states of the mice that we interpret as deficits in "learning", "memory", "anxiety", "depression", etc. This paper discusses the problems of determining whether a particular transgenic mouse is a valid mouse model of disease X, the problem of background strains, and the question of whether our behavioural tests are measuring what we say they are...
March 21, 2024: Journal of Neuroscience Methods
https://read.qxmd.com/read/38520224/impact-of-covid-19-on-patients-undergoing-scheduled-procedures-for-chronic-venous-disease
#27
JOURNAL ARTICLE
Ethan Moore, Max V Wohlauer, James Dorosh, Mahmood Kabeil, Rafael D Malgor, Leigh A O'Banion, Gabriel Lopez-Pena, Riley Gillette, Kathryn Colborn, Robert F Cuff, Leah Lucero, Amna Ali, Issam Koleilat, Paola Batarseh, Sonia Talathi, Aksim Rivera, Misty D Humphries, Kevin Ly, Nikolai Harroun, Brigitte K Smith, Anna M Darelli-Anderson, Asad Choudhry, Eric Hammond, Michael Costanza, Vipul Khetarpaul, Ashley Cosentino, Jacob Watson, Rana Afifi, Nicolas J Mouawad, Tze-Woei Tan, Mel Sharafuddin, Judith P Quevedo, Reggie Nkansah, Palcah Shibale, Sherene Shalhub, Judith C Lin
OBJECTIVE: The COVID-19 pandemic has drastically altered the medical landscape. Various strategies have been employed to preserve hospital beds, personal protective equipment, and other resources to accommodate the surges of COVID-19 positive patients, hospital overcapacities, and staffing shortages. This has had a dramatic effect on vascular surgical practice. The objective of this study is to analyze the impact of the COVID-19 pandemic on surgical delays and adverse outcomes for patients with chronic venous disease scheduled to undergo elective operations...
March 23, 2024: Vascular
https://read.qxmd.com/read/38519153/diagnosis-and-prognosis-of-abnormal-cardiac-scintigraphy-uptake-suggestive-of-cardiac-amyloidosis-using-artificial-intelligence-a-retrospective-international-multicentre-cross-tracer-development-and-validation-study
#28
JOURNAL ARTICLE
Clemens P Spielvogel, David Haberl, Katharina Mascherbauer, Jing Ning, Kilian Kluge, Tatjana Traub-Weidinger, Rhodri H Davies, Iain Pierce, Kush Patel, Thomas Nakuz, Adelina Göllner, Dominik Amereller, Maria Starace, Alice Monaci, Michael Weber, Xiang Li, Alexander R Haug, Raffaella Calabretta, Xiaowei Ma, Min Zhao, Julia Mascherbauer, Andreas Kammerlander, Christian Hengstenberg, Leon J Menezes, Roberto Sciagra, Thomas A Treibel, Marcus Hacker, Christian Nitsche
BACKGROUND: The diagnosis of cardiac amyloidosis can be established non-invasively by scintigraphy using bone-avid tracers, but visual assessment is subjective and can lead to misdiagnosis. We aimed to develop and validate an artificial intelligence (AI) system for standardised and reliable screening of cardiac amyloidosis-suggestive uptake and assess its prognostic value, using a multinational database of 99m Tc-scintigraphy data across multiple tracers and scanners. METHODS: In this retrospective, international, multicentre, cross-tracer development and validation study, 16 241 patients with 19 401 scans were included from nine centres: one hospital in Austria (consecutive recruitment Jan 4, 2010, to Aug 19, 2020), five hospital sites in London, UK (consecutive recruitment Oct 1, 2014, to Sept 29, 2022), two centres in China (selected scans from Jan 1, 2021, to Oct 31, 2022), and one centre in Italy (selected scans from Jan 1, 2011, to May 23, 2023)...
April 2024: The Lancet. Digital health
https://read.qxmd.com/read/38518668/measuring-water-holding-capacity-in-poultry-meat
#29
JOURNAL ARTICLE
Shai Barbut
In the current scientific literature, one can find >100 different methods to evaluate water-holding capacity in fresh and cooked meat. The main concepts are based on removing some of the water by either gravity, application of pressure (e.g., centrifugal force), and heating while measuring water exudate to predict the water holding capacity (WHC) during storage, processing, cooking, and/or distribution. More sophisticated methods include nuclear magnetic resonance (NMR) in which the relaxation of water molecules within a meat protein/gel system is measured to predict how the water (75% in lean meat) will behave during processing...
February 22, 2024: Poultry Science
https://read.qxmd.com/read/38517632/bioaugmentation-and-vermicompost-facilitated-the-hydrocarbon-bioremediation-scaling-up-from-lab-to-field-for-petroleum-contaminated-soils
#30
JOURNAL ARTICLE
Sandra Curiel-Alegre, Aqib Hassan Ali Khan, Carlos Rad, Blanca Velasco-Arroyo, Carlos Rumbo, Rafael Rivilla, David Durán, Miguel Redondo-Nieto, Eduard Borràs, Daniele Molognoni, Soledad Martín-Castellote, Blanca Juez, Rocío Barros
The biodegradation of total petroleum hydrocarbon (TPH) in soil is very challenging due to the complex recalcitrant nature of hydrocarbon, hydrophobicity, indigenous microbial adaptation and competition, and harsh environmental conditions. This work further confirmed that limited natural attenuation of petroleum hydrocarbons (TPHs) (15% removal) necessitates efficient bioremediation strategies. Hence, a scaling-up experiment for testing and optimizing the use of biopiles for bioremediation of TPH polluted soils was conducted with three 500-kg pilots of polluted soil, and respective treatments were implemented: including control soil (CT), bioaugmentation and vermicompost treatment (BAVC), and a combined application of BAVC along with bioelectrochemical snorkels (BESBAVC), all maintained at 40% field capacity...
March 22, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38517502/clinical-decision-support-tools-useful-for-identifying-sepsis-risk
#31
JOURNAL ARTICLE
Theresa Heineman, Cary Orrick, Teresa K Phan, Linda Denke, Folefac Atem, Keri Draganic
PURPOSE: Evaluate the effectiveness of the clinical decision support tools (CDSTs), POC Advisor (POCA), and Modified Early Warning System (MEWS) in identifying sepsis risk and influencing time to treatment for inpatients, comparing their respective alert mechanisms. METHODS: This study was conducted at two academic university medical center hospitals. Data from adult inpatients in medical-surgical and telemetry units were analyzed from January 1, 2020, to December 31, 2020...
April 1, 2024: Nursing
https://read.qxmd.com/read/38516949/optimization-and-validation-of-an-ftir-based-all-in-one-system-for-viable-mdr-bacteria-detection-in-combat-related-wound-infection
#32
JOURNAL ARTICLE
Ying Chen, Andrew Leung, Yulia Wang, Nathan K Archer
INTRODUCTION: The U.S. Military members experiencing combat-related injuries have a higher chance of developing infections by multidrug-resistant (MDR) bacteria at admission to military hospitals. MDR wound infections result in higher amputation rates and greater risks for subsequent or chronic infections that require readmission or extended stay in the hospital. Currently, there is no FDA-clear, deployable early diagnostic system for suitable field use.We are reporting our efforts to improve a previously developed Rapid Label-free Pathogen Identification (RAPID) system to detect viable MDR bacteria in wound infections and perform antibiotic susceptibility testing (AST)...
March 21, 2024: Military Medicine
https://read.qxmd.com/read/38516442/deciphering-the-great-imitator-syphilis-and-neurosyphilis
#33
Alisa Zezetko, Matthew Stallings, Irene Pastis
Syphilis is an infectious disease caused by  Treponema pallidum . Often known as the "great imitator," it has periods of active disease and periods of latency. Serologic syphilis testing can be divided into treponemal and non-treponemal tests, and multiple tests are required to prove infection. Standardized algorithms exist for syphilis testing and diagnosis. Neurosyphilis, which is often the result of the progression of untreated syphilis, can be life-threatening and requires intravenous antibiotics. Despite the significant challenge of diagnosing and treating neurosyphilis, there are no standardized testing algorithms available...
February 2024: Curēus
https://read.qxmd.com/read/38515664/assessing-the-complementary-information-from-an-increased-number-of-biologically-relevant-features-in-liquid-biopsy-derived-rna-seq-data
#34
JOURNAL ARTICLE
Stavros Giannoukakos, Silvia D'Ambrosi, Danijela Koppers-Lalic, Cristina Gómez-Martín, Alberto Fernandez, Michael Hackenberg
Liquid biopsy-derived RNA sequencing (lbRNA-seq) exhibits significant promise for clinic-oriented cancer diagnostics due to its non-invasiveness and ease of repeatability. Despite substantial advancements, obstacles like technical artefacts and process standardisation impede seamless clinical integration. Alongside addressing technical aspects such as normalising fluctuating low-input material and establishing a standardised clinical workflow, the lack of result validation using independent datasets remains a critical factor contributing to the often low reproducibility of liquid biopsy-detected biomarkers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515392/exposure-to-4-4-dde-in-visceral-adipose-tissue-and-weight-loss-in-adolescents-from-the-teen-labs-cohort
#35
JOURNAL ARTICLE
Bruna Rubbo, Zhenjiang Li, Phum Tachachartvanich, Brittney O Baumert, Hongxu Wang, Shudi Pan, Sarah Rock, Justin R Ryder, Todd Jenkins, Stephanie Sisley, Xiangping Lin, Scott Bartell, Thomas H Inge, Stavra Xanthakos, Brooklynn McNeil, Anna R Robuck, Michele A La Merrill, Douglas I Walker, David V Conti, Rob McConnell, Sandrah P Eckel, Lida Chatzi
OBJECTIVE: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes. METHODS: We included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort...
March 22, 2024: Obesity
https://read.qxmd.com/read/38514697/identification-of-extracellular-vesicles-from-their-raman-spectra-via-self-supervised-learning
#36
JOURNAL ARTICLE
Mathias N Jensen, Eduarda M Guerreiro, Agustin Enciso-Martinez, Sergei G Kruglik, Cees Otto, Omri Snir, Benjamin Ricaud, Olav Gaute Hellesø
Extracellular vesicles (EVs) released from cells attract interest for their possible role in health and diseases. The detection and characterization of EVs is challenging due to the lack of specialized methodologies. Raman spectroscopy, however, has been suggested as a novel approach for biochemical analysis of EVs. To extract information from the spectra, a novel deep learning architecture is explored as a versatile variant of autoencoders. The proposed architecture considers the frequency range separately from the intensity of the spectra...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514400/advancing-entity-recognition-in-biomedicine-via-instruction-tuning-of-large-language-models
#37
JOURNAL ARTICLE
Vipina K Keloth, Yan Hu, Qianqian Xie, Xueqing Peng, Yan Wang, Andrew Zheng, Melih Selek, Kalpana Raja, Chih Hsuan Wei, Qiao Jin, Zhiyong Lu, Qingyu Chen, Hua Xu
MOTIVATION: Large Language Models (LLMs) have the potential to revolutionize the field of Natural Language Processing (NLP), excelling not only in text generation and reasoning tasks but also in their ability for zero/few-shot learning, swiftly adapting to new tasks with minimal fine-tuning. LLMs have also demonstrated great promise in biomedical and healthcare applications. However, when it comes to Named Entity Recognition (NER), particularly within the biomedical domain, LLMs fall short of the effectiveness exhibited by fine-tuned domain-specific models...
March 21, 2024: Bioinformatics
https://read.qxmd.com/read/38513942/harmful-effects-of-true-to-life-nanoplastics-derived-from-pet-water-bottles-in-human-alveolar-macrophages
#38
JOURNAL ARTICLE
Alireza Tavakolpournegari, Aliro Villacorta, Michelle Morataya-Reyes, Jéssica Arribas Arranz, Gooya Banaei, Susana Pastor, Antonia Velázquez, Ricard Marcos, Alba Hernández, Balasubramanyam Annangi
The increasing presence of secondary micro/nanoplastics (MNPLs) in the environment requires knowing if they represent a real health concern. To such end, an important point is to test representative MNPLs such as the denominated true-to-life MNPLs, resulting from the degradation of plastic goods in lab conditions. In this study, we have used polyethylene terephthalate (PET) NPLs resulting from the degradation of PET water bottles. Since inhalation is an important exposure route to environmental MNPLS, we have used mouse alveolar macrophages (MH-S) as a target cell, and the study focused only on the cells that have internalized them...
March 19, 2024: Environmental Pollution
https://read.qxmd.com/read/38511102/development-and-validation-of-an-lc-msms-method-to-quantify-creatinine-from-dried-blood-spots
#39
JOURNAL ARTICLE
Carlos Torres, Rogers A Muldrow, Anissa R Naranjo, Steven W Cotten, Christina C Pierre, Dina N Greene
INTRODUCTION: Screening for chronic kidney disease relies on accurate and precise creatinine measurements. Traditionally, creatinine is measured in serum or plasma using high-throughput chemistry analyzers. However, dried blood spots (DBS) can also be utilized to improve testing access. METHODS: Samples were obtained from a 6 mm DBS punch, which was reconstituted in water before undergoing an acetonitrile crash. The resulting supernatant was diluted using an 80:20 acetonitrile: water before injection...
April 2024: Journal of mass spectrometry and advances in the clinical lab
https://read.qxmd.com/read/38510929/development-and-application-of-an-inexpensive-open-source-dendrometer-for-detecting-xylem-water-potential-and-radial-stem-growth-at-high-spatial-and-temporal-resolution
#40
JOURNAL ARTICLE
Sean M Gleason, Jared J Stewart, Brendan Allen, Stephanie K Polutchko, Jordan McMahon, Daniel Spitzer, David M Barnard
There is currently a need for inexpensive, continuous, non-destructive water potential measurements at high temporal resolution (<1 min). We describe here the development and testing of an entirely open-source dendrometer that, when combined with periodic Scholander pressure chamber measurements, provides sub-minute resolution estimates of water potential when placed on tissues exhibiting little or no secondary growth (petioles, monocotyledon stems). The dendrometer can also be used to measure radial growth of stems and branches when placed on dicotyledon and gymnosperm species...
February 2024: AoB Plants
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