keyword
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#21
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38528529/p2x7-receptor-antagonists-modulate-experimental-autoimmune-neuritis-via-regulation-of-nlrp3-inflammasome-activation-and-th17-and-th1-cell-differentiation
#22
JOURNAL ARTICLE
Yuhan Xie, Ranran Han, Yulin Li, Weiya Li, Shichao Zhang, Yu Wu, Yuexin Zhao, Rongrong Liu, Jie Wu, Wei Jiang, Xiuju Chen
BACKGROUND: Guillain-Barré syndrome (GBS), a post-infectious, immune-mediated, acute demyelinating disease of the peripheral nerves and nerve roots, represents the most prevalent and severe acute paralyzing neuropathy. Purinergic P2X7 receptors (P2X7R) play a crucial role in central nervous system inflammation. However, little is known about their role in the immune-inflammatory response within the peripheral nervous system. METHODS: Initially, we assessed the expression of purinergic P2X7R in the peripheral blood of patients with GBS using flow cytometry and qRT-PCR...
March 25, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38526853/reprogramming-of-arachidonic-acid-metabolism-using-%C3%AE-terpineol-to-alleviate-asthma-insights-from-metabolomics
#23
JOURNAL ARTICLE
Ying Rong, Fanglin Liu, Hui Zhou, Tong Yu, Zhaolong Qin, Qianwen Cao, Luyao Liu, Xiaoge Ma, Lingbo Qu, Peirong Xu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia Xu
Asthma is a chronic inflammatory disorder in airways with typical pathologic features of airway inflammation and mucus hypersecretion. α-Terpineol is a monocyclic terpene found in many natural plants and foods. It has been reported to possess a wide range of pharmacological activities including anti-inflammatory and expectorant effects. However, the role of α-terpineol in asthma and its potential protective mechanism have not been well elucidated. This study is designed to investigate the pharmacological effect and mechanism of α-terpineol on asthmatic mice using the metabolomics platform...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38519053/targeting-refractory-recurrent-neuroblastoma-and-osteosarcoma-with-anti-cd3%C3%A3-anti-gd2-bispecific-antibody-armed-t-cells
#24
JOURNAL ARTICLE
Maxim Yankelevich, Archana Thakur, Shakeel Modak, Roland Chu, Jeffrey Taub, Alissa Martin, Dana Schalk, Amy Schienshang, Sarah Whitaker, Katie Rea, Daniel W Lee, Qin Liu, Anthony F Shields, Nai-Kong V Cheung, Lawrence G Lum
BACKGROUND: The survival benefit observed in children with neuroblastoma (NB) and minimal residual disease who received treatment with anti-GD2 monoclonal antibodies prompted our investigation into the safety and potential clinical benefits of anti-CD3×anti-GD2 bispecific antibody (GD2Bi) armed T cells (GD2BATs). Preclinical studies demonstrated the high cytotoxicity of GD2BATs against GD2+cell lines, leading to the initiation of a phase I/II study in recurrent/refractory patients...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38518665/intermittent-mild-cold-acclimation-ameliorates-intestinal-inflammation-and-immune-dysfunction-in-acute-cold-stressed-broilers-by-regulating-the-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#25
JOURNAL ARTICLE
Yanju Bi, Haidong Wei, Yiwen Chai, Hongyu Wang, Qiang Xue, Jianhong Li
To investigate the potential protective effect of prior cold stimulation on broiler intestine induced by acute cold stress (ACS). A total of 384 one-day-old broilers were divided into control (CON), ACS, cold stimulation Ⅰ (CS3+ACS), and cold stimulation Ⅱ (CS9+ACS) groups. Broilers in CON and ACS groups were reared normally, and birds in CS3+ACS and CS9+ACS groups were reared at 3℃ and 9℃ below CON group for 5 h, respectively, on alternate days from d 15 to 35. Broilers in ACS, CS3+ACS, and CS9+ACS groups were subjected to 10℃ for 24 h on d 43...
March 8, 2024: Poultry Science
https://read.qxmd.com/read/38518092/trichloroethylene-metabolite-modulates-dna-methylation-dependent-gene-expression-in-th1-polarized-cd4-t-cells-from-autoimmune-prone-mice
#26
JOURNAL ARTICLE
Samrat Roy Choudhury, Stephanie D Byrum, Sarah J Blossom
Trichloroethylene (TCE) is an industrial solvent and widespread environmental contaminant associated with CD4+ T cell activation and autoimmune disease. Prior studies showed that exposure to TCE in the drinking water of autoimmune-prone mice expanded effector/memory CD4+ T cells with an interferon-γ (IFN-γ)-secreting Th1-like phenotype. However, very little is known how TCE exposure skews CD4+ T cells towards this pro-inflammatory Th1 subset. As observed previously, TCE exposure was associated with hypermethylation of regions of the genome related to transcriptional repression in purified effector/memory CD4 T cells...
March 22, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38517331/icos-costimulation-in-combination-with-ctla-4-blockade-remodels-tumor-associated-macrophages-toward-an-antitumor-phenotype
#27
JOURNAL ARTICLE
Naveen Sharma, Xiaozhou Fan, Oluwatomisin T Atolagbe, Zhongqi Ge, Kelly N Dao, Padmanee Sharma, James P Allison
We have previously demonstrated synergy between ICOS costimulation (IVAX; ICOSL-transduced B16-F10 cellular vaccine) and CTLA-4 blockade in antitumor therapy. In this study, we employed CyTOF and single-cell RNA sequencing and observed significant remodeling of the lymphoid and myeloid compartments in combination therapy. Compared with anti-CTLA-4 monotherapy, the combination therapy enriched Th1 CD4 T cells, effector CD8 T cells, and M1-like antitumor proinflammatory macrophages. These macrophages were critical to the therapeutic efficacy of anti-CTLA-4 combined with IVAX or anti-PD-1...
April 1, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38517203/intranasal-delivery-of-salmonella-omvs-decorated-with-chlamydia-trachomatis-antigens-induces-specific-local-and-systemic-immune-responses
#28
JOURNAL ARTICLE
Dung T Huynh, Emanuele Nolfi, Lobna Medfai, Peter van Ulsen, Wouter S P Jong, Alice J A M Sijts, Joen Luirink
Chlamydia trachomatis is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial infections underscores the urgent need for licensed and effective vaccines to prevent transmission in populations. Bacterial outer membrane vesicles (OMVs) have emerged as promising mucosal vaccine carriers due to their inherent adjuvant properties and the ability to display heterologous antigens. In this proof-of-concept study, we evaluated the immunogenicity of Salmonella OMVs decorated with C...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38517196/heat-non-heat-treatment-alleviate-%C3%AE-conglycinin-triggered-food-allergy-reactions-by-modulating-the-th1-th2-immune-balance-in-a-balb-c-mouse-model
#29
JOURNAL ARTICLE
Tanghao Li, Guanhao Bu, Yixuan Chen, Qingqing Zhao, Yongfeng Chang
BACKGROUND: With the increasing popularity of plant protein-based diets, soy proteins are favored as the most important source of plant protein worldwide. However, potential food allergy risks limit their use in the food industry. This work aims to reveal the mechanism of β-conglycinin-induced food allergy, and to explore the regulatory mechanism of heat treatment and high hydrostatic pressure (HHP) treatment in a BALB/c mouse model. RESULTS: Our results showed that oral administration of β-conglycinin induced severe allergic symptoms in BALB/c mice, but these symptoms were effectively alleviated through heat treatment and HHP treatment...
March 22, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#30
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514014/myeloid-derived-suppressor-cells-promote-allograft-survival-by-suppressing-treg-dysfunction-in-high-risk-corneal-transplantation
#31
JOURNAL ARTICLE
Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani Ahmadabad, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H Dohlman, Sunil K Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract IL-6-mediated Treg dysfunction by expressing IL-10. Additionally, MDSC maintain FoxP3 stability and their ability to suppress IFN-γ+ Th1 cells. Administering MDSC to high-risk corneal transplant recipients demonstrates prolonged graft survival via promotion of Treg while concurrently suppressing IFN-γ+ Th1 cells...
March 19, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38513656/opposing-diet-microbiome-and-metabolite-mechanisms-regulate-inflammatory-bowel-disease-in-a-genetically-susceptible-host
#32
JOURNAL ARTICLE
Gabriel Vasconcelos Pereira, Marie Boudaud, Mathis Wolter, Celeste Alexander, Alessandro De Sciscio, Erica T Grant, Bruno Caetano Trindade, Nicholas A Pudlo, Shaleni Singh, Austin Campbell, Mengrou Shan, Li Zhang, Qinnan Yang, Stéphanie Willieme, Kwi Kim, Trisha Denike-Duval, Jaime Fuentes, André Bleich, Thomas M Schmidt, Lucy Kennedy, Costas A Lyssiotis, Grace Y Chen, Kathryn A Eaton, Mahesh S Desai, Eric C Martens
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the expansion of natural killer cells and altered immunoglobulin-A coating of some bacteria...
March 18, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38511768/serum-autophagy-related-gene-5-level-in-stroke-patients-correlation-with-cd4-t-cells-and-cognition-impairment-during-a-3-year-follow-up
#33
JOURNAL ARTICLE
Juanjuan Qu, Linxia Wu, Meng Zhang, Minchen Kan, Huimin Chen, Yanqing Shi, Shuangyu Wang, Xiaohua Wang, Fan Chen
Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4+ T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511558/extracellular-vesicles-from-virulent-p-brasiliensis-induce-tlr4-and-dectin-1-expression-in-innate-cells-and-promote-enhanced-th1-th17-response
#34
JOURNAL ARTICLE
Bruno Montanari Borges, Monique Gama de Santana, Nycolas Willian Preite, Valéria de Lima Kaminski, Gabriel Trentin, Fausto Almeida, Flávio Vieira Loures
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that transport several biomolecules and are involved in important mechanisms and functions related to the pathophysiology of fungal diseases. EVs from Paracoccidioides brasiliensis , the main causative agent of Paracoccidioidomycosis (PCM), modulate the immune response of macrophages. In this study, we assessed the EVs proteome from a virulent P. brasiliensis isolated from granulomatous lesions and compared their immunomodulatory ability with EVs isolated from the fungus before the animal passage (control EVs) when challenging macrophages and dendritic cells (DCs)...
December 2024: Virulence
https://read.qxmd.com/read/38510254/human-milk-oligosaccharides-differentially-support-gut-barrier-integrity-and-enhance-th1-and-th17-cell-effector-responses-in-vitro
#35
JOURNAL ARTICLE
Erik Juncker Boll, Daniel Villalba Lopez, Mandy Terne, Sara Hessing, Katja Parschat, Stina Rikke Jensen
Human milk oligosaccharides (HMOs) can modulate the intestinal barrier and regulate immune cells to favor the maturation of the infant intestinal tract and immune system, but the precise functions of individual HMOs are unclear. To determine the structure-dependent effects of individual HMOs (representing different structural classes) on the intestinal epithelium as well as innate and adaptive immune cells, we assessed fucosylated (2'FL and 3FL), sialylated (3'SL and 6'SL) and neutral non-fucosylated (LNT and LNT2) HMOs for their ability to support intestinal barrier integrity, to stimulate the secretion of chemokines from intestinal epithelial cells, and to modulate cytokine release from LPS-activated dendritic cells (DCs), M1 macrophages (MØs), and co-cultures with naïve CD4+ T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38509789/role-of-par1-506-deletion-insertion-polymorphism-in-primary-sclerosing-cholangitis
#36
JOURNAL ARTICLE
Bettina Langhans, Sandra Kalthoff, Taotao Zhou, Tobias J Weismüller, Henrike Lenzen, Hans Dieter Nischalke, Christian P Strassburg, Philipp Lutz, Leona Dold
AIM: Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by inflammation of the intra- and extrahepatic bile ducts. Pathogenesis of PSC is still enigmatic but is likely to be multifactorial. Recently, we identified an interleukin-6 (IL-6)-dependent signal transducer and activator of transcription 3 (STAT3) activation in CD4+ TH1 and TH17 cells in PSC. The IL-6/STAT3 pathway was shown to be regulated by protease-activated receptor 1 (PAR1) contributing to inflammation...
March 21, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38507609/lack-of-atp2b1-in-cd4-t-cells-causes-colitis
#37
JOURNAL ARTICLE
Amarsanaa Javkhlant, Kensuke Toyama, Yasunori Abe, Joshua M Spin, Masaki Mogi
BACKGROUND: The ATP2B1 gene encodes for a calcium pump, which plays a role in removing Ca2+ from cells and maintaining intracellular Ca2+ homeostasis. Reduction of the intracellular Ca2+ concentration in CD4+ T cells is thought to reduce the severity of colitis, while elevation of Ca2+ in CD4+ T cells induces T cell hyperactivity. Our aim was to clarify the role of ATP2B1 in CD4+ T cells and in inflammatory bowel disease development. METHODS: A murine CD4+ T cell-specific knockout (KO) of ATP2B1 was created using a Cre-loxP system...
March 20, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38507580/chimeric-nod2-mincle-agonists-as-vaccine-adjuvants
#38
JOURNAL ARTICLE
Emma M Dangerfield, Shigenari Ishizuka, Kristel Kodar, Sho Yamasaki, Mattie S M Timmer, Bridget L Stocker
There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to address this is by targeting multiple immune cell pathogen recognition receptors (PRRs) using chimeric pathogen-associated molecular patterns (PAMPs). Conjugation of the PAMPs will ensure codelivery of the immunostimulatory molecules to the same cell, enhancing adjuvant activity. The macrophage inducible C-type lectin (Mincle) is a promising PRR for adjuvant development; however, no effective chimeric Mincle adjuvants have been prepared...
March 20, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38506028/-acute-and-chronic-rhinosinusitis-age-characteristics
#39
JOURNAL ARTICLE
S V Ryazantsev, I M Kirichenko, E L Savlevich, V I Popadyuk, N S Kozlova, A I Chernolev
Children's and adults' rhinosinusitis are two diseases that have both similarities and differences in anatomy, epidemiology, causes, pathogenesis, diagnosis and treatment. At the same rhinosinusitis is one of the most common in otorhinolaryngology's practice, both in children and adults. The of adults paranasal sinuses (PNS) anatomy differs from children's PNS anatomy. Although ostiomeatal complex occlusion is recognized as a major cause of poor ventilation and drainage of the adult paranasal sinuses, it does not have a strong effect on pediatric rhinosinusitis, but adenoids play a key role...
2024: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38505912/a-systems-biology-approach-unveils-a-critical-role-of-dpp4-in-upper-gastrointestinal-cancer-patient-outcomes
#40
JOURNAL ARTICLE
Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali M Yallapu, Manish K Tripathi, Meena Jaggi, Subhash C Chauhan
Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive...
2024: Journal of Environmental Pathology, Toxicology and Oncology
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