keyword
https://read.qxmd.com/read/38536615/quantification-of-unencapsulated-drug-in-target-tissues-demonstrates-pharmacological-properties-and-therapeutic-effects-of-liposomal-topotecan-ff-10850
#1
JOURNAL ARTICLE
Toshifumi Kimura, Ken Okada, Yasushi Morohashi, Yukio Kato, Mikinaga Mori, Hiroshi Kato, Takeshi Matsumoto, Susumu Shimoyama
PURPOSE: Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal drugs; however, the methodology for this has not been fully established. Herein, we aimed to investigate the enhanced therapeutic potential of a pegylated liposomal formulation of topotecan (FF-10850) by analyzing the concentrations of the unencapsulated drug in target tissues, to guide the improvement of its dosing regimen. METHODS: We developed a method for measuring unencapsulated topotecan concentrations in tumor and bone marrow interstitial fluid (BM-ISF) and applied this method to pharmacokinetic assessments...
March 27, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38536566/quality-assurance-of-3d-printed-patient-specific-anatomical-models-a-systematic-review
#2
JOURNAL ARTICLE
Martin Schulze, Lukas Juergensen, Robert Rischen, Max Toennemann, Gregor Reischle, Jan Puetzler, Georg Gosheger, Julian Hasselmann
BACKGROUND: The responsible use of 3D-printing in medicine includes a context-based quality assurance. Considerable literature has been published in this field, yet the quality of assessment varies widely. The limited discriminatory power of some assessment methods challenges the comparison of results. The total error for patient specific anatomical models comprises relevant partial errors of the production process: segmentation error (SegE), digital editing error (DEE), printing error (PrE)...
March 27, 2024: 3D Printing in Medicine
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#3
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
https://read.qxmd.com/read/38535939/a-pilot-study-on-bioaccumulation-and-tissue-distribution-of-mercury-in-barn-swallow-hirundo-rustica
#4
JOURNAL ARTICLE
Li Tian, Yujing Zhu, Ruiming Yu, Xiaobo Zheng
Although extensive research has been carried out on the occurrence of mercury (Hg) in biota, bioaccumulation and tissue distribution of Hg in songbirds have not been well characterized. In the present study, Hg was investigated in insects and barn swallows ( Hirundo rustica ) to explore the bioaccumulation characteristics of Hg. Hg in swallow feathers and tissues including muscle, liver, and bone was investigated to determine the tissue distribution of Hg. The concentrations of Hg were 1.39 ± 1.01 μg/g, 0...
March 8, 2024: Toxics
https://read.qxmd.com/read/38535773/photon-counting-computed-tomography-for-accurate-cribriform-plate-lamina-cribrosa-imaging-in-adult-patients
#5
JOURNAL ARTICLE
Anna Klempka, Eduardo Ackermann, Sven Clausen, Christoph Groden
Detailed visualization of the cribriform plate is challenging due to its intricate structure. This study investigates how computed tomography (CT) with a novel photon counting (PC) detector enhance cribriform plate visualization compared to traditionally used energy-integrated detectors in patients. A total of 40 patients were included in a retrospective analysis, with half of them undergoing PC CT (Naeotom Alpha Siemens Healthineers, Forchheim, Germany) and the other half undergoing CT scans using an energy-integrated detector (Somatom Sensation 64, Siemens, Forchheim, Germany) in which the cribriform plate was visualized with a temporal bone protocol...
March 8, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535772/musculoskeletal-pitfalls-on-molecular-imaging-studies-of-oncologic-patients-how-to-stay-out-of-trouble
#6
REVIEW
Brooke Sarna, Ty Subhawong, Efrosyni Sfakianaki, Richard Wang, Anna Christodoulou-Vega, Fabiano N Cardoso
An increasing amount of molecular imaging studies are ordered each year for an oncologic population that continues to expand and increase in age. The importance of these studies in dictating further care for oncologic patients underscores the necessity of differentiating benign from malignant findings, particularly for a population in whom incidental findings are common. The aim of this review is to provide pictorial examples of benign musculoskeletal pathologies which may be found on molecular imaging and which may be mistaken for malignant processes...
March 8, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535766/dual-energy-ct-in-oncologic-imaging
#7
REVIEW
Giovanni Foti, Giorgio Ascenti, Andrea Agostini, Chiara Longo, Fabio Lombardo, Alessandro Inno, Alessandra Modena, Stefania Gori
Dual-energy CT (DECT) is an innovative technology that is increasingly widespread in clinical practice. DECT allows for tissue characterization beyond that of conventional CT as imaging is performed using different energy spectra that can help differentiate tissues based on their specific attenuation properties at different X-ray energies. The most employed post-processing applications of DECT include virtual monoenergetic images (VMIs), iodine density maps, virtual non-contrast images (VNC), and virtual non-calcium (VNCa) for bone marrow edema (BME) detection...
February 23, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#8
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38535643/exploring-borate-modified-calcium-phosphate-ceramics-antimicrobial-potential-and-cytocompatibility-assessment
#9
JOURNAL ARTICLE
Inna V Fadeeva, Katia Barbaro, Annalisa Altigeri, Anna A Forysenkova, Marat R Gafurov, Georgy V Mamin, Alexander V Knot'ko, Viktoriya G Yankova, Anna A Zhukova, Fabrizio Russo, Julietta V Rau
Addressing periprosthetic infections, which present significant healing challenges that often require revision surgeries, necessitates the development of novel antibacterial materials and implants. Current research focuses on creating materials that hinder bacterial adhesion, colonization, and proliferation in surrounding tissues. Boron (B)-containing compounds are known for their antibacterial properties and potential in bone metabolism for regenerative medicine. In this study, we synthesized B-containing tricalcium phosphate (0...
March 9, 2024: Nanomaterials
https://read.qxmd.com/read/38535478/effect-of-ishige-okamurae-extract-on-osteoclastogenesis-in-vitro-and-in-vivo
#10
JOURNAL ARTICLE
Su-Hyeon Cho, Hyun-Soo Kim, Juhee Ahn, Bomi Ryu, Jun-Geon Jea, Kyubin Lee, Kyunghwan Kim, Ginnae Ahn, WonWoo Lee, Kyung-Min Choi, Kil-Nam Kim
We demonstrated the effect of Ishige okamurae extract (IOE) on the receptor activator of nuclear factor-κB ligand (RANKL)-promoted osteoclastogenesis in RAW 264.7 cells and confirmed that IOE inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and osteoclast differentiation. IOE inhibited protein expression of TRAP, metallopeptidase-9 (MMP-9), the calcitonin receptor (CTR), and cathepsin K (CTK). IOE treatment suppressed the expression of activated T cell cytoplasmic 1 and activator protein-1, thus controlling the expression of osteoclast-related factors...
March 20, 2024: Marine Drugs
https://read.qxmd.com/read/38535449/the-role-of-sargahydroquinoic-acid-and-sargachromenol-in-the-anti-inflammatory-effect-of-sargassum-yezoense
#11
JOURNAL ARTICLE
Yena Park, Lei Cao, Suhyeon Baek, Seungjin Jeong, Hyun Jung Yun, Mi-Bo Kim, Sang Gil Lee
The anti-inflammatory effect of the ethanol extract of Sargassum yezoense and its fractions were investigated in this study. The ethanol extract exhibited a strong anti-inflammatory effect on lipopolysaccharide-stimulated RAW 264.7 macrophages and effectively suppressed the M1 polarization of murine bone-marrow-derived macrophages stimulated by lipopolysaccharides and IFN-γ (interferon-gamma). Through a liquid-liquid extraction process, five fractions (n-hexane, chloroform, ethyl acetate, butanol, and aqueous) were acquired...
February 26, 2024: Marine Drugs
https://read.qxmd.com/read/38535279/in-vivo-validation-of-a-nanostructured-electrospun-polycaprolactone-membrane-loaded-with-gentamicin-and-nano-hydroxyapatite-for-the-treatment-of-periodontitis
#12
JOURNAL ARTICLE
Patricia Ondine Lucaciu, Călin Cosmin Repciuc, Ioana A Matei, Nicodim I Fiț, Sanda Andrei, Raluca Marica, Bianca Nausica Petrescu, Bogdan Crișan, Ovidiu Aghiorghiesei, Ioana Codruța Mirică, Dragoș Apostu, Codruța Saroși, Florin Onișor, Evelyn Vanea, Simina Angela Lăcrimioara Iușan, Giorgiana Corina Mureșan, Ana-Maria Condor, Emilia Oprița, Luciana-Mădălina Gherman
The aim of this research was to validate the use of a gentamicin (GEN) and nano-hydroxiapatite (nHAP)-loaded polycaprolactone nanostructured membrane (NM) as an innovative, highly efficient, low-cost treatment for periodontitis. We conducted an in vivo study on Wistar rats, in which we induced periodontitis by placing silk ligatures around the first right and left upper molars. The subjects were divided into three groups; the first group received no periodontal treatment, the second group received open flap debridement, and the third group received open flap debridement, together with the positioning of the GEN and nHAP-loaded nanostructured membrane as a treatment...
February 26, 2024: Membranes
https://read.qxmd.com/read/38535259/bone-marrow-derived-mesenchymal-stem-cell-laden-nanocomposite-scaffolds-enhance-bone-regeneration-in-rabbit-critical-size-segmental-bone-defect-model
#13
JOURNAL ARTICLE
Elangovan Kalaiselvan, Swapan Kumar Maiti, Shivaraju Shivaramu, Shajahan Amitha Banu, Khan Sharun, Divya Mohan, Sangeetha Palakkara, Sadhan Bag, Monalisa Sahoo, Suresh Ramalingam, Jürgen Hescheler
Bone regeneration poses a significant challenge in the field of tissue engineering, prompting ongoing research to explore innovative strategies for effective bone healing. The integration of stem cells and nanomaterial scaffolds has emerged as a promising approach, offering the potential to enhance regenerative outcomes. This study focuses on the application of a stem cell-laden nanomaterial scaffold designed for bone regeneration in rabbits. The in vivo study was conducted on thirty-six healthy skeletally mature New Zealand white rabbits that were randomly allocated into six groups...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535253/three-dimensional-printing-methods-for-bioceramic-based-scaffold-fabrication-for-craniomaxillofacial-bone-tissue-engineering
#14
REVIEW
Zeeshan Sheikh, Vasudev Vivekanand Nayak, Umer Daood, Anupreet Kaur, Hanan Moussa, Abbas Canteenwala, Pierre-Luc Michaud, Ísis de Fátima Balderrama, Edisa de Oliveira Sousa, Nick Tovar, Andrea Torroni, Michael Glogauer, Huzefa Talib, Paulo G Coelho, Lukasz Witek
Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and an increased risk of implant failure...
March 1, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535092/performance-of-a-novel-eight-color-flow-cytometry-panel-for-measurable-residual-disease-assessment-of-chronic-lymphocytic-leukemia
#15
JOURNAL ARTICLE
Xiao Chen, Xia Chen, Sishu Zhao, Yu Shi, Ninghan Zhang, Zhen Guo, Chun Qiao, Huimin Jin, Liying Zhu, Huayuan Zhu, Jianyong Li, Yujie Wu
BACKGROUND: Measurable residual disease (MRD) is an important prognostic indicator of chronic lymphocytic leukemia (CLL). Different flow cytometric panels have been developed for the MRD assessment of CLL in Western countries; however, the application of these panels in China remains largely unexplored. METHODS: Owing to the requirements for high accuracy, reproducibility, and comparability of MRD assessment in China, we investigated the performance of a flow cytometric approach (CD45-ROR1 panel) to assess MRD in patients with CLL...
March 27, 2024: Cytometry. Part B, Clinical Cytometry
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#16
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534851/knee-measurement-system-with-osteoarthritis-levels-using-artificial-cartilage-and-skeletons
#17
JOURNAL ARTICLE
Minchae Kang, Suyeon Seo, Hyewon Lee, Min-Woo Han
Knee osteoarthritis (OA), also known as degenerative arthritis, is a disease characterized by irreversible changes in the cartilage and bones comprising the joints, resulting in pain, impaired function, and deformity. Furthermore, independent of natural aging, the rate of change in joint cartilage has increased in recent years, which is mainly attributed to environmental factors. The rising incidence of knee-related disorders emphasizes the importance of analyzing the morphology and kinematics of knee structure...
March 8, 2024: Biomimetics
https://read.qxmd.com/read/38534839/use-of-biomaterials-in-3d-printing-as-a-solution-to-microbial-infections-in-arthroplasty-and-osseous-reconstruction
#18
REVIEW
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata, Serban Dragosloveanu, Iosif-Aliodor Timofticiuc, Spyrangelos Georgatos-Garcia, Andreea-Elena Scheau, Konstantinos Periferakis, Ana Caruntu, Ioana Anca Badarau, Cristian Scheau, Constantin Caruntu
The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#19
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534368/unique-spatial-transcriptomic-profiling-of-the-murine-femoral-fracture-callus-a-preliminary-report
#20
JOURNAL ARTICLE
Will Jiang, Dennis L Caruana, Jungho Back, Francis Y Lee
Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Previous sequencing techniques such as single-cell RNA and in situ hybridization are limited by missing spatial context and low throughput, respectively. We present a preliminary approach using the Visium CytAssist spatial transcriptomics platform to provide the first spatially intact characterization of genetic expression changes within an orthopedic model of impaired fracture healing...
March 16, 2024: Cells
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