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Laura Miller McPherson, Julius P A Dewald
OBJECTIVE: The flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints. METHODS: Twelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Participants generated isometric shoulder abduction (SABD) and shoulder adduction (SADD) at four submaximal levels to progressively elicit the flexion and extension synergies, respectively...
January 31, 2019: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Xin Fu, Haynes Goddard, Xinhao Wang, Matthew E Hopton
Using combined sewer systems to handle excess stormwater runoff is common in older urban areas. Combined sewer overflow (CSO) events occur when hydraulic capacity is exceeded, and untreated wastewater discharges to surface waters. As urban population density increases, and more demand is placed on infrastructure, CSO events happen more often and cause serious environmental problems and public-health risks. Recently, green infrastructure (GI) has been integrated with existing gray infrastructure (GrayI) to reduce CSO events...
February 13, 2019: Journal of Environmental Management
Guansheng Zhong, Chuan Yang, Shaoqiong Liu, Yiran Zheng, Weiyang Lou, Jye Yng Teo, Chang Bao, Wei Cheng, Jeremy P K Tan, Shujun Gao, Nathaniel Park, Shrinivas Venkataraman, Yuan Huang, Min Han Tan, Xiaojia Wang, James L Hedrick, Weimin Fan, Yi Yan Yang
Although mortality continues to decline over the past two decades, cancer is still a pervasive healthcare problem worldwide due to the increase in the number of cases, multidrug resistance (MDR) and metastasis. As a consequence of multidrug resistance, cancer treatment must rely on a host of chemotherapeutic agents and chemosensitizers to achieve remission. To overcome these problems, a series of biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide (PEG-PGCx -PDLAy ) is designed as chemotherapeutic agents...
January 25, 2019: Biomaterials
Lisa Brockhaus, David Goldblum, Laura Eggenschwiler, Stefan Zimmerli, Catia Marzolini
BACKGROUND: Adjunctive systemic antibiotic therapy for treatment of bacterial endophthalmitis is controversial but common practice due to the severity of the disease. In absence of guidance documents, several antibiotic regimens are being used without applying evidence-based prescribing, thus leading to inappropriate treatment of this serious eye condition. OBJECTIVES: To summarize available data on intravitreal penetration of systemically administered antibiotics and to discuss their usefulness from a microbiological and pharmacological point of view...
February 13, 2019: Clinical Microbiology and Infection
Halimatou Diop, Kaylin Beiter, Tarik Gheit, Aissatou Sow, Aboubacry Dramé, Sandrine McKay-Chopin, Massimo Tommasino, Cheikh Saad Bouh Boye, Bakary Sylla, Coumba Touré Kane
OBJECTIVES: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines. METHODS: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG)...
February 13, 2019: Papillomavirus Research
Nikolas Löw, Jürgen Hesser, Manuel Blessing
The performance of case-based reasoning (CBR) depends on an accurate ranking of similar cases in the retrieval phase that affects all subsequent phases and profits from the potential of large databases. Unfortunately, growing databases come along with a rising amount of missing data that reduces the stability of the ranking since incomplete cases cannot be ranked as reliable as complete ones. In context of CBR hardly any work was done so far to rigorously analyze the impact of missing data and solutions to tackle this issue...
February 13, 2019: Journal of Biomedical Informatics
Marie-Luise Buchholzer, Marion Kirch, Christiane Kirchner, Werner Knoess
The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use...
February 13, 2019: Regulatory Toxicology and Pharmacology: RTP
Massimo Salvatori, Alessio Rizzo, Guido Rovera, Luca Indovina, Orazio Schillaci
Hybrid imaging procedures such as single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT) showed a rapid diffusion in recent years because of their high sensitivity, specificity, and accuracy, due to a more accurate localization and definition of scintigraphic findings. However, hybrid systems inevitably lead to an increase in patient radiation exposure because of the added CT component. Effective doses due to the radiopharmaceuticals can be estimated by multiplying the administered activities by the effective dose coefficients, while for the CT component the dose-length product can be multiplied by a conversion coefficient k...
February 15, 2019: La Radiologia Medica
Jiayi Huang, Rekha Chaudhary, Adam L Cohen, Karen Fink, Samuel Goldlust, John Boockvar, Prakash Chinnaiyan, Leping Wan, Stephen Marcus, Jian L Campian
PURPOSE: Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II study aimed to estimate the potential effectiveness of DSF/Cu to re-sensitize recurrent GBM to TMZ. METHODS: This open-label, single-arm phase II study treated recurrent TMZ-resistant GBM patients with standard monthly TMZ plus concurrent daily DSF 80 mg PO TID and Cu 1...
February 15, 2019: Journal of Neuro-oncology
Francesca Rinaldi, Susanna Giachè, Michele Spinicci, Paola Corsi, Silvia Ambu, Giacomo Gianfaldoni, Luigi Rigacci, Umberto Arena, Alessandro Bartoloni, Lorenzo Zammarchi
BACKGROUND: The Mediterranean area is endemic for the zoonotic form of visceral leishmaniasis (VL) caused by Leishmania infantum, a species which has been recently associated with unexpected epidemiological and clinical features. METHOD: We report the result of a systematic review of the literature on VL unusually presenting with spleen focal lesions, including three previously unpublished cases. RESULTS: A total of 28 cases of VL with multiple spleen focal lesions were retrieved...
February 15, 2019: Infection
Andrew S Moon, Carly A Cignetti, Jonathan A Isbell, Chong Weng, Sakthivel Rajan Rajaram Manoharan
PURPOSE: Hyperextension-distraction type injury of the thoracolumbar spine is an unstable fracture pattern that generally necessitates surgical stabilization by posterior instrumentation. Care must be taken when positioning these patients from supine to prone due to the unstable nature of their injury. The study objectives were (1) to describe a novel modification of the Jackson table turn technique, which may be safer and more effective than the conventional log-roll method and traditional Jackson table technique for positioning patients with hyperextension-distraction injuries of the thoracolumbar spine from supine to prone in the operating room and (2) to present two cases in which this technique was successfully performed...
February 15, 2019: European Spine Journal
Yifei Li, Xin Zhang, Meng Shi, Shuaishuai Guo, Lie Wang
BACKGROUND: Infertility-related stress can seriously impact the fertility quality of life (QoL) of infertile women. Resilience, as a coping resource, can effectively combat psychological stress. This study aimed to evaluate the fertility QoL of infertile women and to examine whether resilience moderates the association of infertility-related stress with fertility QoL. METHODS: This cross-sectional study was conducted in northeast of China from December 2017 to February 2018...
February 15, 2019: Health and Quality of Life Outcomes
Yanli Yue, Wenzhuo Li, Yongsheng Chai, Yan Li, Linglong Mou, Qi Wang, Xikuan Liu, Shoumin Yin
With the development of minimally invasive surgery, many open surgery has been replaced by intracavity surgery. In laparoscopic surgery, an electric fibroid morcellator must be used to remove large tissue specimens from a small abdominal incision. Of course, there are some complications in the use, in order to follow the principle of no tumor, the doctor used the laparoscopic pouch in clinical operation to reduce the risk of spreading potential tumor tissue. There are various kinds of pouches, which are classified according to their existing state before use, it can be classified into two categories:overlapping and non-overlapping...
January 30, 2019: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Lauren K Slone, Linda B Smith, Chen Yu
Object names are a major component of early vocabularies and learning object names depends on being able to visually recognize objects in the world. However, the fundamental visual challenge of the moment-to-moment variations in object appearances that learners must resolve has received little attention in word learning research. Here we provide the first evidence that image-level object variability matters and may be the link that connects infant object manipulation to vocabulary development. Using head-mounted eye tracking, the present study objectively measured individual differences in the moment-to-moment variability of visual instances of the same object, from infants' first-person views...
February 15, 2019: Developmental Science
Daniel Huys, Sina Kohl, Juan Carlos Baldermann, Lars Timmermann, Volker Sturm, Veerle Visser-Vandewalle, Jens Kuhn
BACKGROUND: For more than 15 years, deep brain stimulation (DBS) has served as a last-resort treatment for severe treatment-resistant obsessive-compulsive disorder (OCD). METHODS: From 2010 to 2016, 20 patients with OCD (10 men/10 women) were included in a single-centre trial with a naturalistic open-label design over 1 year to evaluate the effects of DBS in the anterior limb of the internal capsule and nucleus accumbens region (ALIC-NAcc) on OCD symptoms, executive functions, and personality traits...
February 15, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
Duncan Murray, Jack Luke McMurray, Suzy Eldershaw, Hayden Pearce, Nathaniel Davies, Julia J Scarisbrick, Paul Moss
Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4+ T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage...
February 26, 2019: Blood Advances
Megan Eaton, Rebecca Scully, Mary Schuller, Amy Yang, Douglas Smink, Reed G Williams, Jordan D Bohnen, Brian C George, Jonathan P Fryer, Shari L Meyerson
OBJECTIVE: The System for Improving and Measuring Procedural Learning (SIMPL) is a smart-phone application used to provide residents with an evaluation of operative autonomy and feedback. This study investigated the perceived benefits and barriers to app use. DESIGN: A database of previously performed SIMPL evaluations was analyzed to identify high, low, and never users. Potential predisposing factors to use were explored. A survey investigating key areas of value and barriers to use for the SIMPL application was sent to resident and faculty users...
February 12, 2019: Journal of Surgical Education
Joan Gené-Badia, Pierre Comice, Adriyanov Belchín, María Ángeles Erdozain, Leticia Cáliz, Susana Torres, Rocío Rodríguez
OBJECTIVE: To assess the prevalence of loneliness and social isolation in a population over 65 cared by a urban primary health team and to identify its main characteristics. DESIGN: Cross-sectional descriptive study by a telephone survey. SETTING: Basic health area of Barcelona. PARTICIPANTS: Random sample of assigned population of 65 or more years old. MAIN MEASUREMENTS: UCLA Loneliness Scale and Lubben Social Network Scale...
February 12, 2019: Atencion Primaria
L Mata-Moret, C Chiarri-Toumit, L Hernández-Bel, E Cervera-Taulet
Digital subtraction angiography (DSA) is a technique used in interventional radiology for the diagnosis of vascular cerebral conditions. Central retinal artery occlusion (CRAO) is a complication of endovascular procedures that involve atherosclerotic plaque removal with subsequent embolisation. The case is presented on a patient who noticed a sudden vision loss during a DSA. Funduscopy showed retinal pallor and a cherry red spot. The angiography showed a structure suggesting the presence of an embolus in the central retinal artery...
February 12, 2019: Archivos de la Sociedad Española de Oftalmología
Adrienne Baldwin-White, Karen Moses
One in five college women report being sexually assaulted, while men have the greatest likelihood to commit a sexual assault while attending a university. Because freshmen and sophomore college women are particularly vulnerable to victimization, it is important to provide effective sexual assault prevention education. The current study examines a multisession approach to sexual assault prevention at a southwestern university. This exploratory study assesses scores measuring knowledge of sexual assault, knowledge about healthy sexual relationships, and intent to act to prevent a sexual assault or after one has occurred, after students complete at least one of five sexual assault prevention programs (Community of Care, Consent and Respect, Step Up!, Live Well, or Frisky Business)...
February 15, 2019: Journal of Interpersonal Violence
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