Chiara Tersigni, Nicoletta Di Simone, Donatella Lucchetti, Filomena Colella, Marianna Onori, Silvia Perossini, Annalisa Vidiri, Rita Franco, Alessandro Sgambato, Manu Vatish, Antonio Lanzone, Giovanni Scambia, Anna Franca Cavaliere
Placenta accreta spectrum (PAS) refers to excessive placental invasion into the maternal uterus and it is associated with high risk of obstetric haemorrhage and adverse maternal-neonatal outcomes. Currently, no specific circulating biomarkers of PAS have been identified. Given that in PAS disorders, the depth and the extension of placental invasion into the uterus are expected to be increased, in this study, we analysed plasma levels of syncytiotrophoblast-derived extracellular vesicles (STBEVs) in women with placenta previa (PP), at a high risk of PAS disorders, and pregnant women with normal placentation...
March 7, 2024: Reproductive Sciences