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ovarian suppression

Himanshu Yadav, Bechan Lal
Despite important actions of BMP15 (a TGFβ superfamily member) in follicular development in vertebrates, studies are mostly limited to mammals. The folliculogenic processes in lower vertebrates, particularly, fishes are quite different from mammals. It was, therefore, decided to detect the presence of BMP15 in ovarian follicles and what are its role in folliculogenesis and steroidogenesis in catfish? BMP15 protein was detected in different cellular compartments of ovarian follicles of the catfish collected during different reproductive phases, using immunohistochemical and Western blotting methods, with concurrent measurement of ovarian steroids through ELISA...
February 14, 2019: Theriogenology
Osamu Yoshino, Kaori Yamada-Nomoto, Kuniyuki Kano, Yosuke Ono, Mutsumi Kobayashi, Masami Ito, Satoshi Yoneda, Akitoshi Nakashima, Tomoko Shima, Takashi Onda, Yutaka Osuga, Junken Aoki, Shigeru Saito
OBJECTS: There is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis. METHODS: The expression of sphingosine kinase (SphK) 1 in endometriosis lesions was examined by immunohistochemistry. The cystic fluid of ovarian cysts/tumors were obtained to measure S1P concentrations. Endometriotic stromal cells (ESC) derived from endometrioma were used for in vitro experiments...
February 19, 2019: Reproductive Sciences
Xuanxuan Jing, Jin Peng, Yu Dou, Jintang Sun, Chao Ma, Qingjie Wang, Lin Zhang, Xia Luo, Beihua Kong, Yun Zhang, Lijie Wang, Xun Qu
Tumor associated macrophages (TAMs) exert tumor-promoting effects. There have been reports that Estrogen receptors (ERs) are expressed on the infiltrating macrophages of endometriosis, ovarian cancer and lung cancer. However, the role of ERs in macrophages is not well characterized. In this study, we first identified that ERα expression on the macrophages of human endometrial cancer was positively correlated with cancer progression. Conditioned medium from selective ERα agonist-treated M2 macrophages induced the epithelial to mesenchymal transition (EMT) in endometrial cancer cells...
February 18, 2019: Immunology and Cell Biology
Ming Xu, Tiefeng Jin, Liyan Chen, Xianglan Zhang, Guang Zhu, Qianrong Wang, Zhenhua Lin
This study focused on mortalin expression and its relevance to the prognosis in serous ovarian carcinoma, mortalin modulated cell malignant proliferation and EMT progression via Wnt/β-Catenin signaling pathway. In this study, data obtained from Oncomine database, Cancer Cell Line Encyclopedia (CCLE) analysis and Immunohistochemical (IHC) staining was used to assess the expression of mortalin in serous ovarian carcinoma. Using Kaplan-Meier plotter database and Kaplan-Meier analyzed the prognostic value of mortalin...
February 15, 2019: Gene
Hanna E Teasley, Munseok Paul Jeong, Tae Hoon Kim
The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. MIG-6 mediates P4 signaling and acts as a tumor suppressor during endometrial tumorigenesis in both humans and mice. In previous studies, we developed the conditional knockout of Mig-6 in all uterine compartments (Pgrcre/+ Mig-6f/f ; Mig-6KO ) and endometrial epithelial cell-specific Mig-6 knockout (Sprr2fcre/+ Mig-6f/f ; Mig-6Ep-KO ) mice...
February 14, 2019: Biochemical and Biophysical Research Communications
Alexandra Higgins, Zaraq Khan, Charles C Coddington, Shahrukh K Hashmi, Mehrdad Hefazi, Hassan Alkhateeb, Mark R Litzow, William J Hogan, Elizabeth Cathcart-Rake, Carrie A Thompson, Mrinal M Patnaik
Iatrogenic menopause with consequent infertility is a major complication in reproductive aged women undergoing hematopoietic cell transplantation (HCT). Recent guidelines recommend a discussion of the possibility of infertility and the options for fertility preservation as part of informed consent before initiation of any cancer-directed therapy, including HCT. Women aged 15-49 years at the time of allogeneic HCT, between the years 2001 and 2017, were identified from the Mayo Clinic Rochester institutional HCT database...
February 14, 2019: Biology of Blood and Marrow Transplantation
Kyung Hae Jung, Patricia M LoRusso, Howard A Burris, Michael S Gordon, Yung-Jue Bang, Matthew D Hellmann, Andres Cervantes, Maria Ochoa de Olza, Aurélien Marabelle, F Stephen Hodi, Myung-Ju Ahn, Leisha A Emens, Fabrice Barlesi, Omid Hamid, Emiliano Calvo, David F McDermott, Hatem Soliman, Ina Rhee, Ray Lin, Tony Pourmohamad, Julia Suchomel, Amy Tsuhako, Kari M Morrissey, Sami Mahrus, Roland Morley, Andrea Pirzkall, S Lindsey Davis
PURPOSE: IDO1 induces immune suppression in T cells through L-tryptophan (Trp) depletion and kyneurinine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T-cells and hyperactivating Tregs. Navoximod is an investigational small molecule inhibitor of IDO1. This Phase I study evaluated safety, tolerability, PK and PD of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. EXPERIMENTAL DESIGN: The study consisted of a 3+3 dose-escalation stage (n=66) and a tumor-specific expansion stage (n=92)...
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ying Gao, Junfeng Yin, Youying Tu, Yi Charlie Chen
Theaflavin-3,3'-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that black tea consumption decreases the incidence rate of ovarian cancer. Our former research demonstrated that TF3 inhibited human ovarian cancer cells. Nevertheless, the roles of checkpoint kinase 2 (Chk2) and p27 kip1 (p27) in TF3-mediated inhibition of human ovarian cancer cells have not yet been investigated. In the current study, TF3 enhanced the phosphorylation of Chk2 to modulate the ratio of pro/anti-apoptotic Bcl-2 family proteins to initiate intrinsic apoptosis in a p53-independent manner and increased the expression of death receptors to activate extrinsic apoptosis in OVCAR-3 human ovarian carcinoma cells...
February 14, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bincy John, Christine Naczki, Chirayu Patel, Alia Ghoneum, Shadi Qasem, Ziyan Salih, Neveen Said
Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of this study is to investigate the role of SPARC in OvCa interactions with omental adipocytes and its role in OvCa colonization in the omentum. We employed multi-pronged approach using primary omental adipocytes from Sparc knockout mice, genetically engineered human omental adipocytes in 3D co-cultures with OvCa cells, as well as treatment with recombinant SPARC protein...
February 14, 2019: Oncogene
Qiqi Long, Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Despite the demonstrated efficacy of surgical treatment of endometriosis, recurrence after surgery still remains a formidable challenge. Surgery, especially when performed repeatedly, decreases ovarian reserve. Clearly, control of recurrence is an unmet medical need. So far nearly all efforts to control recurrence have been devoted to the identification of risk factors, biomarkers, and postoperative medication. One area that has been completely overlooked is the possibility of perioperative intervention. In this study, we tested the hypothesis that perioperative use of a nonspecific β-blocker and/or a nuclear factor-κB (NF-κB) inhibitor can retard the growth of residual endometriotic lesions that are left intact in the primary surgery...
February 14, 2019: Reproductive Sciences
Priyadarshini Singh Nee Priyadarshini, Bechan Lal
Authors have recently reported a gradual increase in neuropeptide Y expression in the ovarian follicles of Clarias batrachus with the progression of oogenesis, coinciding with increasing photoperiod and temperature. This indicates the involvement of photoperiod and temperature in controlling NPY expression. Therefore, a study was designed to investigate the role of photoperiod and temperature in regulation of NPY expression in ovarian follicles. The catfish were exposed to different photo-thermal regimes during the late-quiescence and late-recrudescence phases for one month, and the expression of NPY was analyzed along with other ovarian activities...
February 11, 2019: General and Comparative Endocrinology
Xiaoping Xin, Zhonghui Li, Yuyi Zhong, Qingqing Li, Jiaying Wang, Hao Zhang, Xiaolong Yuan, Jiaqi Li, Zhe Zhang
Previous studies have strongly recommended that KISS-1 metastasis suppressor ( KISS1 ) plays an essential gatekeeper of the initiation of reproductive maturation in mammals. However, KISS1 has been recently reported to highly express in ovarian granulosa cells (GCs). But the biological functionalities of KISS1 on cell apoptosis, cell cycle, and synthesis of estradiol-17β (E2) have not been explored in GCs. In this study, using porcine GCs as a cellular model, the overexpression plasmid of KISS1 was built to explore the biological effects of KISS1 on the PI3K signaling pathway, estrogen signaling pathway, cell apoptosis, cell cycle, and E2 secretion...
February 12, 2019: Animals: An Open Access Journal From MDPI
Huizhu Gan, Lin Lin, Nanjun Hu, Yang Yang, Yu Gao, Yu Pei, Kang Chen, Butong Sun
BACKGROUND: Aspirin, an anti-inflammatory drug, has been widely investigated in the treatment of many cancer types, including colorectal, ovarian, breast, and prostate cancers. MicroRNAs (miRNAs) are the most well studied noncoding RNAs in cancers. In the current study, we were interested in defining the function of aspirin in lung cancer treatment and the related noncoding RNAs involved in this process. METHODS: The function of aspirin in lung cancer growth was evaluated by cell viability and colony formation assays...
February 12, 2019: Thoracic Cancer
Bowen Sun, Nathaniel R Jensen, Dongjun Chung, Meixiang Yang, Amanda C LaRue, Hiu Wing Cheung, Qi Wang
The scaffold/adaptor growth factor receptor bound 2 (GRB2)-associated binding protein 2 (GAB2) is frequently amplified and/or overexpressed in primary high-grade serous ovarian cancers (HGSOCs). Here we investigate a novel treatment strategy by targeting SHP2 and PI3K signaling in HGSOCs with GAB2 amplification/overexpression (GAB2High ). The expression of GAB2 was analyzed in primary HGSOCs and ovarian cancer cell lines. In vitro and in vivo assays were performed to demonstrate the effect of SHP2 and PI3K-mediated GAB2High HGSOC progression...
2019: American Journal of Cancer Research
Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang, Kangsheng Tu
BACKGROUND: Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in human cancers including lung cancer, ovarian cancer and intestinal cancer. However, the expression, function and the underlying mechanisms of SHMT1 in HCC remain uncovered. METHODS: qRT-PCR, immunohistochemistry and immunoblotting were performed to detect the expression of SHMT1 in HCC tissues and cell lines...
February 12, 2019: Journal of Experimental & Clinical Cancer Research: CR
Daniela Pelclová
The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome...
2019: Casopís Lékar̆ů C̆eských
Kuei-Pin Huang, Charlotte C Ronveaux, Guillaume de Lartigue, Nori Geary, Lori Asarian, Helen E Raybould
Deletion of the leptin receptor from vagal afferent neurons (VAN) using a conditional deletion (Nav1.8/LepRfl/fl ) results in an obese phenotype with increased food intake and lack of exogenous cholecystokinin (CCK)-induced satiation in male mice. Female mice are partially protected from weight gain and increased food intake in response to ingestion of high-fat (HF) diets. However, whether lack of leptin signaling in VAN leads to an obese phenotype or disruption of hypothalamic-pituitary-gonadal axis function in female mice is unclear...
February 12, 2019: American Journal of Physiology. Endocrinology and Metabolism
Emily Rickert, Marina O Fernandez, Irene Choi, Michael Gorman, Jerrold M Olefsky, Nicholas J G Webster
Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy balance and glucose metabolism. In this study, we generated mice expressing an enzymatically inactive form ( N -MUT) or wild-type (WT) SIRT1 ( N -OX) in mature neurons. N -OX male and female mice had impaired glucose tolerance, and N -MUT female, but not male, mice had improved glucose tolerance compared with that of WT littermates...
February 1, 2019: Journal of the Endocrine Society
Kathy Pan, Linda Diana Bosserman, Rowan T Chlebowski
No abstract text is available yet for this article.
February 11, 2019: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Chunjing Bian, Chao Zhang, Tao Luo, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong, Xiaochun Yu
ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) using NAD+ as ADP-ribose donor. PARPs play an indispensable role in DNA damage repair and small molecule PARP inhibitors have emerged as potent anticancer drugs. However, to date, PARP inhibitor treatment has been restricted to patients with BRCA1/2 mutation-associated breast and ovarian cancer. One of the major challenges to extend the therapeutic potential of PARP inhibitors to other cancer types is the absence of predictive biomarkers...
February 11, 2019: Nature Communications
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