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Ruixia Hou, Leigang Wu, Jin Wang, Zhilu Yang, Qiufen Tu, Xingcai Zhang, Nan Huang
Drug-eluting stents (DES) have been widely applied for saving the life of patients with coronary artery diseases (CADs). However, conventional polymers such as polylactic acid (PLA) and poly (lactic-co-glycolic acid) (PLGA), which are widely applied for drug-eluting stents studies, have serious bulk erosion problems, like high local acidity and poor mechanical properties. Instead, we chose surface erosion polymer poly (1, 3-trimethylene carbonate) (PTMC) as a drug carrier in this study. Here, we fabricated and characterized a novel durable-polymer drug-eluting 316 L stainless steel (SS) stent, in which the inner surface was coated with a Ti⁻O film using the magnetron sputtering method to promote the growth of endothelial cells (ECs)...
February 18, 2019: Biomolecules
Feng Cheng, Yanyan Chen, Lei Zhu, Bin Zhou, Yonghong Xu, Yiran Chen, Liping Wen, Shuzheng Chen
Objective: To identify the clinicopathological features correlated to lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods: Clinical data of 785 PTMC patients who underwent surgical treatment at the Lishui Municipal Central Hospital from September 2008 to December 2017 were retrospectively analyzed. Clinical and pathological risk factors for lymph node metastasis (LNM), central lymph node metastasis (CLNM), and lateral lymph node metastasis (LLNM) were analyzed...
2019: International Journal of Endocrinology
Deng-Ke Teng, He-Qun Li, Guo-Qing Sui, Yuan-Qiang Lin, Qiang Luo, Ping Fu, Jia-Rui Du, Chun-Xiang Jin, Hui Wang
PURPOSE: To assess the safety and efficacy of microwave ablation (MWA) for primary papillary thyroid microcarcinoma (PTMC) with a large sample of 185 patients. METHODS: A total of 185 patients underwent MWA for 206 primary PTMC nodules. They received ultrasound follow-up at 1, 3, 6, and 12 months after MWA and every 6 months thereafter. Nodule volumes were calculated at each follow-up and compared with those before MWA. Additionally, the volume reduction rate (VRR) of the nodules was calculated...
February 15, 2019: Endocrine
Fan Yang, Qi Zhong, Zhigang Huang, Meng Lian, Jugao Fang
Background: Considerable modifications have been introduced in the new edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system. Based on the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database, this study aimed to compare the 7th and 8th editions of the AJCC/UICC TNM staging system for patients with papillary thyroid microcarcinoma (PTMC) and follicular variant papillary thyroid microcarcinoma (FVPTMC). Methods: A Data from 2004 to 2014 of 39,032 patients registered in the SEER database were included...
2019: Frontiers in Endocrinology
Z H Wang, Y J Zhang, G M Fu, Y B Chen
Objective: To analyze the risk factors of lymph node metastasis in central region of patients with papillary thyroid microcarcinoma (PTMC). To evaluate the reliability of different risk factors on the prognosis of cervical lymph node metastasis in PTMC patients, and to provide the clinical support for PTMC in the central area. Methods: The clinical data of 700 patients with PTMC treated with surgery from January 2015 to July 2017 were analyzed retrospectively. Risk factors for lymph node metastasis in central region were analyzed by single factor analysis, multivariate Logistic regression analysis and receiver operating characteristic curve (ROC) curve...
January 7, 2019: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Zhengchao Guo, Sandra Kofink, Honglin Chen, Jia Liang, Dirk Grijpma, André Poot
Graphene-graft-polymer has been used to improve the compatibility between graphene and a polymer matrix, and to further enhance electrical, mechanical and biological properties of polymer/graphene composites. In this study, poly(trimethylene carbonate) (PTMC) was successfully grafted onto graphene surface via "grafting from" method. Reduced graphene oxide (rGO) initiator was synthesized by azido ethanol reaction with graphene oxide (GO) at high temperature. This resulted in thermal reduction of the GO and stable hydroxyl groups on the graphene surface...
January 28, 2019: Biomedical Materials
Zhengchao Guo, Jia Liang, André Poot, Dirk Grijpma, Honglin Chen
One of the key challenges for neural tissue engineering is to exploit functional materials to guide and support nerve regeneration. Currently, reduced graphene oxide (rGO) which is well-known for its unique electrical and mechanical properties has been incorporated into biocompatible polymers to manufacture functional scaffolds for nerve tissue engineering. However, rGO has poor dispersity in polymer matrix, which limits its further application. Here, we replaced rGO with rGO-graft-PTMC. The rGO-graft-PTMC was firstly prepared by grafting trimethylene carbonate (TMC) oligomers onto rGO...
January 21, 2019: Biomedical Materials
Changxin Zhou, Jinbo Li, Yu Wang, Shoukun Xue, Yang Zhang
Differences in BRAF gene mutation frequency and thyroid-stimulating hormone receptor (TSHR) protein expression in thyroid tissues were detected to investigate their association with local tissue invasion and cervical lymph node metastasis potential of papillary thyroid microcarcinoma (PTMC). The BRAF gene mutation frequency and TSHR expression in PTMC patients were detected via qPCR and immunohistochemical method, and the association between them was discussed combined with the clinical and pathological parameters...
January 2019: Oncology Letters
Min Ji Jeon, Sung Min Chun, Ji-Young Lee, Kyeong Woon Choi, Deokhoon Kim, Tae Yong Kim, Se Jin Jang, Won Bae Kim, Young Kee Shong, Dong Eun Song, Won Gu Kim
PURPOSE: Papillary thyroid microcarcinoma (PTMC) has excellent outcomes, but extensive lymph node (LN) metastasis can be associated with fatal outcomes. We evaluated the mutational profiles of primary tumors and their metastatic LNs of PTMCs with extensive lateral cervical LN metastases. METHODS: Formalin-fixed, paraffin-embedded archival samples from 16 sets of normal thyroid tissue, the primary PTMC, and the largest metastatic LN were used for targeted sequencing...
January 15, 2019: Endocrine
Yan Shen, Miao Liu, Jie He, Shu Wu, Yong-Lin Wan, Jun Ding, Xiao-Yan Cai, Xiao-Hong Fu
BACKGROUND: The differences in treatment outcomes between ultrasound (US)-guided percutaneous microwave ablation (PMWA) and endoscopic thyroidectomy for patients with papillary thyroid microcarcinoma (PTMC) remains unknown. METHODS: An electronic search will be performed for randomized controlled trials or observational studies that reported recurrence and mortality rates in PTMC patients with US-guided PMWA or endoscopic thyroidectomy. Hazard ratios with their 95% confidence intervals will be calculated using fixed- or random-effects models according to heterogeneity...
January 2019: Medicine (Baltimore)
Ke Si Zheng, Yong Zeng, Cong Chen, Yuan Zhao Wu, Bi Chen, Wen Bing Ying, Ke Wen Zheng
Objective To explored the risk factors of lymph node metastasis in papillary thyroid microcarcinoma (PTMC) by analyzing the data from the Surveillance,Epidemiology and End Results (SEER) database.Methods The data of 31 017 patients with PTMC in the SEER database from 2002 to 2012 were retrospectively analyzed. Logistic and Cox regression analyses were used to explore the associations of the factors and the risk of lymph node metastasis in PTMC.Results Multivariate analysis revealed that male (OR=0.673,95%CI=0...
December 20, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Zhi-Kai Lei, Ming-Kui Li, Ding-Cun Luo, Zhi-Jiang Han
Purpose: This study explored ultrasound grayscale ratios (USGRs) for differentiating markedly hypoechoic and anechoic minimal thyroid nodules. Materials and Methods: Longitudinal scan images of 193 markedly hypoechoic papillary thyroid microcarcinoma (PTMC) lesions from 184 patients were retrospectively reviewed using RADinfo and compared with 123 anechoic micronodular goiters (MNGs) from 110 patients. Final diagnosis was validated by pathological examination; MNGs predominantly manifested with cyst formation...
2018: Journal of Cancer Research and Therapeutics
Sabri Ozden, Sadettin Er, Bari Saylam, Bari Dogu Yildiz, Kazim Senol, Mesut Tez
OBJECTIVE: Prophylactic central lymph node dissection(CLND) is a controversial issue in papillary thyroid microcarcinoma( PTMC) patients without lymphatic metastasis. Artificial neural network(ANN) has been proposed as an alternative statistical technique for predicting complex biologic phenomena. Our aim is to develop an ANN model in predicting central lymph node metastases(CLNM) in patients with PTMC, in comparison to traditional logistic regression(LR) analysis. STUDY DESIGN: Eighty patients who underwent total thyroidectomy plus CLND for PTMC were included in the study...
2018: Annali Italiani di Chirurgia
Bin Xu, Ning-Ming Zhou, Wei-Tian Cao, Shu-Yan Gu
AIM: To compare the effect and postoperative trauma of ultrasound-guided percutaneous microwave ablation and surgical resection in the treatment of papillary thyroid microcarcinoma (PTMC). METHODS: Eighty-seven patients with PTMC treated at Fudan University affiliated Shanghai Fifth People's Hospital were enrolled as subjects. The patients were divided into a microwave ablation group (41 cases) and a surgical group (46 cases). The operative time, intraoperative blood loss, length of hospital stay, serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), thyroid-related hormonal changes, and complications 7 d and 30 d after surgery were observed...
December 6, 2018: World Journal of Clinical Cases
Yanqing Zhang, Jiaqi Pan, Desheng Xu, Zhengkai Yang, Jingxue Sun, Lulu Sun, Yanmeizhi Wu, Hong Qiao
Circulating microRNAs (miRNAs) are promising diagnostic markers in various types of cancers, including papillary thyroid carcinoma (PTC). However, there is sparse information reported with regards to miRNA expression in papillary thyroid microcarcinoma (PTMC) or concerning the role of a combination of miRNAs and ultrasound (US) in the diagnosis of PTMC before surgery. Therefore, we designed a study that aimed to evaluate miRNA expression levels and their potential associations with US findings and determine whether miRNAs could be used as diagnostic and prognostic biomarkers of PTMC...
December 2018: Oncology Reports
Joon-Hyop Lee, Yong Soon Chun, Yoo Seung Chung
BACKGROUND: Papillary thyroid microcarcinomas (PTMCs) often demonstrate lateral lymph node (LN) metastasis. The purpose of this study was to assess whether the size of primary tumor should be considered in deciding lateral neck dissection extent. METHODS: We conducted a retrospective comparison of patients with PTMC and papillary thyroid carcinoma (PTC) larger than 1 cm who received lateral LN dissection from 2009 to 2015. RESULTS: PTMC group had more frequent metachronous metastasis, multifocality, less involvement of lower third thyroid, lower metastatic central LN counts and ratio, and lower metastatic total LN ratio...
December 10, 2018: Head & Neck
Adela Corina Nechifor-Boilă, Emőke Andrea Szász, Françoise Descotes, Nicole Berger, Ancuţa Elena Zahan, Andrada Loghin, Delia Maria Ceteraş, Angela Borda
BACKGROUND: The B-Raf proto-oncogene serine∕threonine kinase (BRAF) V600E (BRAF(V600E)) mutation represents a very specific marker for papillary thyroid carcinoma (PTC), including microcarcinomas (PTMCs). However, assessment of the BRAF(V600E) mutational status is expensive and not available in all pathology laboratories. AIM: We aimed to evaluate if we can identify those morphological features that could predict the presence of the BRAF(V600E) mutation in a series of PTMCs...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Shoupeng Cao, Loai K E A Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S Williams, Jan C M van Hest
Herein we describe biodegradable nanovectors comprised of block copolymers of poly(ethylene glycol) and poly(trimethylene carbonate) (PEG-PTMC) that change their morphology and surface charge when exposed to tumor environment conditions. Well-defined, drug-loaded nanovectors were prepared via direct hydration using liquid oligo(ethylene glycol) as a dispersant. Systematic introduction of basic imidazole-functional TMC derivatives, through modular polymerization, resulted in polymers that self-assembled in multilamellar nanoparticles (at neutral pH) and that were loaded with hydrophobic drugs...
November 20, 2018: ACS Macro Letters
Tinghai Xiang, Wenyan Yan, Longan Zhou
We performed a retrospective chart review of 245 patients with papillary thyroid microcarcinoma (PTMC) to define factors linked to central lymph node metastasis and thus prognosis. Univariate and multivariate analyses showed that being male ( p < 0.001), age <45 years at diagnosis ( p = 0.045), maximum tumor size > 5 mm ( p = 0.030), multifocal tumor ( p = 0.040) and tumor envelope invasion ( p < 0.001) were all independent risk factors for central compartment lymph node metastasis. Unifocal lesions at the thyroid gland's upper pole, middle and lower pole, had lymph node metastasis rates of 22...
October 30, 2018: Oncotarget
Roberto Vita, Antonio Ieni, Giovanni Tuccari, Salvatore Benvenga
Although the incidence of some malignancy has decreased over the recent years, this is not the case of papillary thyroid microcarcinoma (PTMC), whose incidence has increased worldwide. Most PTMC are found incidentally after histological examination of specimens from surgery for benign thyroid disease. Hashimoto's thyroiditis, whose incidence has also increased, coexists in about one in three PTMC patients. Three different mechanisms have been proposed to clarify the association between chronic lymphocytic thyroiditis and PTMC, namely tumor development/growth by: (i) TSH stimulation, (ii) expression of certain proto-oncogenes, (iii) chemokines and other molecules produced by the lymphocytic infiltrate...
November 20, 2018: Reviews in Endocrine & Metabolic Disorders
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