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Noor Atatreh, Amal M Youssef, Mohammad A Ghattas, Mohammad Al Sorkhy, Sara Alrawashdeh, Khaled B Al-Harbi, Ibrahim M El-Ashmawy, Tariq I Almundarij, Amani A Abdelghani, Alaa S Abd-El-Aziz
In this study, the acid chlorides of pyrazolo[3,4-d]pyrimidine compounds were prepared and reacted with a number of nucleophiles. The novel compounds were experimentally tested via enzyme assay and they showed cyclooxygenase-2 inhibition activity in the middle micro molar range (4b had a COX-1 IC50 of 26 µM and a COX-2 IC50 of 34 µM, 3b had a COX-1 IC50 of 19 µM and a COX-2 IC50 of 31 µM, 3a had a COX-2 IC50 of 42 µM). These compounds were analyzed via docking and were predicted to interact with some of the COX-2 key residues...
February 5, 2019: Bioorganic Chemistry
Wessam H Abd-Elsalam, Nermeen A ElKasabgy
Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminosomes. Mucoadhesive olaminosomes were characterized for their particle size, in-vitro drug release and irritation potentiality in rabbit eyes. The reduction in intraocular pressure (IOP) through 8 hours in male New Zealand Albino rabbits was measured after administration of the selected formulations...
February 11, 2019: International Journal of Pharmaceutics
Muhammad Sufyan, Nasrudin Abd Rahim, ChiaKwang Tan, Munir Azam Muhammad, Siti Rohani Sheikh Raihan
The incessantly growing demand for electricity in today's world claims an efficient and reliable system of energy supply. Distributed energy resources such as diesel generators, wind energy and solar energy can be combined within a microgrid to provide energy to the consumers in a sustainable manner. In order to ensure more reliable and economical energy supply, battery storage system is integrated within the microgrid. In this article, operating cost of isolated microgrid is reduced by economic scheduling considering the optimal size of the battery...
2019: PloS One
Lenee Blanton, Vivien G Dugan, Anwar Isa Abd Elal, Noreen Alabi, John Barnes, Lynnette Brammer, Alicia P Budd, Erin Burns, Charisse N Cummings, Shikha Garg, Rebecca Garten, Larisa Gubareva, Krista Kniss, Natalie Kramer, Alissa O'Halloran, Carrie Reed, Melissa Rolfes, Wendy Sessions, Calli Taylor, Xiyan Xu, Alicia M Fry, David E Wentworth, Jacqueline Katz, Daniel Jernigan
CDC collects, compiles, and analyzes data on influenza activity and viruses in the United States. During September 30, 2018-February 2, 2019,* influenza activity† in the United States was low during October and November, increased in late December, and remained elevated through early February. As of February 2, 2019, this has been a low-severity influenza season (1), with a lower percentage of outpatient visits for influenza-like illness (ILI), lower rates of hospitalization, and fewer deaths attributed to pneumonia and influenza, compared with recent seasons...
February 15, 2019: MMWR. Morbidity and Mortality Weekly Report
Kumarendran Balachandran, Dana Sumilo, Michael W O'Reilly, Konstantinos A Toulis, Krishna Gokhale, Chandrika Wijeyaratne, Arri Coomarasamy, Wiebke Arlt, Abd Tahrani, Krishnarajah Nirantharakumar
OBJECTIVE: Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs. without PCOS and to examine the role of obesity in the observed findings. DESIGN: Population-based retrospective cohort study utilizing The Health Improvement Network (THIN), UK. METHODS: 76,978 women with PCOS and 143,077 age-, BMI- and location-matched women without PCOS between January 2000 and May 2017 were identified...
February 1, 2019: European Journal of Endocrinology
Doaa M Mokhtar, Manal T Hussein, Marwa M Hussein, Enas A Abd-Elhafez, Gamal Kamel
This study investigated the histomorphological features of developing rabbit respiratory acini during the postnatal period. On the 1st day of postnatal life, the epithelium of terminal bronchiole consisted of clear cells which intercalated between few ciliated and abundant non-ciliated (Clara) cells. At this age, the rabbit lung was in the alveolar stage. The terminal bronchioles branched into several alveolar ducts, which opened into atria that communicated to alveolar sacs. All primary and secondary inter-alveolar septa were thick and showed a double-capillary network (immature septa)...
February 14, 2019: Microscopy and Microanalysis
Sherif Mohamed Zaki, Mohamed Hafez Shaaban, Waleed Ahmed Abd Al Galeel, Ahmed Abdul Wahab El Husseiny
BACKGROUND: We hypothesized that the collateral circulation differs in different ethnic groups. So, the aim of our work was to study variations of the circle of Willis (COW) among Egyptian and to compare our findings with the findings of other nationalities. MATERIAL AND METHODS: One hundred patients were studied using magnetic resonance angiographic (3D-TOF-MRA). Frequency and morphologic variations in COW were studied. The diameters of the arteries of the anterior and posterior circle were verified...
February 14, 2019: Folia Morphologica (Warsz)
Matthew A Haber, Muhammad Abd-El-Barr, William Gormley, Srinivasan Mukundan, Aaron D Sodickson, Christopher A Potter
Visits to the emergency department by patients who have recently undergone neurosurgery are a common occurrence, and these patients frequently receive emergent cross-sectional head imaging in order to evaluate for complications. Different neurosurgical approaches may have typical postoperative imaging findings that can be confused with pathology. Furthermore, particular abnormal postoperative imaging findings may signal an evolving complication. It is essential for the radiologist to understand common neurosurgical procedures and their potential complications in order to provide proper diagnostic evaluation of the postoperative neurosurgical patient...
February 13, 2019: Emergency Radiology
Alaa Zidan, Abeer M El-Naggar, Nour E A Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts. These substitutions were compared to more classical transition metal free allylations using allyl bromides.
2019: Frontiers in Chemistry
Yuan Liang Woon, Mei Fong Lim, Tg Rogayah Tg Abd Rashid, Ravindran Thayan, Suresh Kumar Chidambaram, Syed Sharizman Syed Abdul Rahim, Rose Nani Mudin, Sheamini Sivasampu
BACKGROUND: A major outbreak of the Zika virus (ZIKV) has been reported in Brazil in 2015. Since then, it spread further to other countries in the Americas and resulted in declaration of the Public Health Emergency of International Concern (PHEIC) by World Health Organization. In 2016, Singapore reported its first minor ZIKV epidemic. Malaysia shares similar ecological environment as Brazil and Singapore which may also favor ZIKV transmission. However, no ZIKV outbreak has been reported in Malaysia to date...
February 13, 2019: BMC Infectious Diseases
Abd El-Galil E Amr, Mohamed F El-Shehry, Alhussein A Ibrahim, Hanaa M Hosni, Mohamed A Al-Omar, Hazem A Ghabbour
A series of novel derivatives possessing the thiophene moiety were synthesized using ethyl 5'-amino-2,3'-bithiophene-4'-carboxylate as starting material. The new synthesized derivatives were screened as lactate dehydrogenase (LDH) inhibitors. LDH plays an important role in glucose metabolism in cancer cells and can affect tumor genesis and metastasis. 3-Substituted p-tolylthieno[2,3-d]pyrimidin-4(3H)-ones 4 were the most potent inhibitor in this study compared to Galloflavin reference drug. Molecular docking studies on Human Lactate Dehydrogenase active site was carried on the synthesized compounds and the MolDock scores are ranged between -127 to -171...
February 12, 2019: Mini Reviews in Medicinal Chemistry
Amr Shaaban Hanafy, Mohamed A Bassiony, Mohammad Abd Alkhalik Basha
BACKGROUND: Medical treatment of decompensated cirrhosis due to hepatitis C virus (HCV) remains a clinical challenge even in the era of direct-acting antiviral drugs (DAAs). We evaluated the efficacy and safety of DAAs in the management of HCV genotype 4-related decompensated cirrhosis. METHODS: The study included a treatment group (n = 160) composed of HCV patients with decompensated cirrhosis who received DAAs for 3 months and a matched control group (n = 80) who preferred not to receive DAAs, follow-up was for 24-31 months...
February 13, 2019: Hepatology International
Parisa Yousefpour, Lucie Ahn, Joel Tewksbury, Soumen Saha, Simone A Costa, Joseph J Bellucci, Xinghai Li, Ashutosh Chilkoti
Short circulation time and off-target toxicity are the main challenges faced by small-molecule chemotherapeutics. To overcome these shortcomings, an albumin-binding peptide conjugate of chemotherapeutics is developed that binds specifically to endogenous albumin and harnesses its favorable pharmacokinetics and pharmacodynamics for drug delivery to tumors. A protein-G-derived albumin-binding domain (ABD) is conjugated with doxorubicin (Dox) via a pH-sensitive linker. One to two Dox molecules are conjugated to ABD without loss of aqueous solubility...
February 13, 2019: Small
Ahmed Abdelshafy, Hassan Awwad, Amgad Abo-Gamra, Ahmed Alanwar, Ahmed M Elkotb, Mohamed Shahin, Maya Abd El-Razek, Ahmed M Abbas
OBJECTIVE: The study aimed to compare the efficacy and safety of sublingual and vaginal misoprostol for termination of pregnancy in women with first trimester missed abortion. METHODS: A single-blind, parallel group, randomised clinical trial ( NCT02686840) was conducted in a university hospital between 1 February 2016 and 31 January 2017. All women who presented with first trimester missed abortion were invited to participate in the study and were randomised to one of two groups: one group received sublingual misoprostol in three doses of 800 μg every 4 h, while a second group received vaginal misoprostol in the same dosage regimen...
February 12, 2019: European Journal of Contraception & Reproductive Health Care
Hanaa H Ahmed, Hadeer A Aglan, Mostafa Mabrouk, Ahmed A Abd-Rabou, Hanan H Beherei
The main target of this work was to explore the proliferative impact of selenium dioxide nanoparticles (SeO2 ) and selenium dioxide/titanium dioxide nanocomposites (Se/Ti (I), (II) and (III)) on mesenchymal stem cells (MSCs). For this purpose, SeO2 and Se/Ti (I), (II) and (III) were prepared by facile one step method and characterized by transmission electron microscopy (TEM), Zetasizer, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) along with energy-dispersive X-ray spectrometry (EDX) with reference to SeO2 nanoparticles...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Chunlan Chen, Ying He, Qiulin Chen, Dongying Zhang, Yuandi Wang, Yanling Tang, Ying Fang, Nanshan Zhong, Wenhua Jian, Jinping Zheng
Background: Forced expiratory volume in one second (FEV1 ) is widely used in grading the severity of the airflow limitation observed in chronic obstructive pulmonary disease (COPD). However, the characteristics of COPD classified by forced vital capacity (FVC) remain unknown. Hence, the characteristics of pulmonary function test (PFT) and clinical features of COPD patients classified by FVC were investigated. Methods: COPD patients were classified into three groups by FVC: (I) large consistent FVC (LC-FVC): before bronchodilator (BBD) and after bronchodilator (ABD) FVC ≥80%pred; (II) inconsistent FVC (I-FVC): BBD FVC <80%pred, while ABD FVC ≥80%pred; (III) small consistent FVC (SC-FVC): BBD and ABD FVC <80%pred...
December 2018: Journal of Thoracic Disease
Yan Qi, Xiaolin Cao, A M Abd El-Aty, Cong Ma, Hui Li, Zejun Jiang, Yongxin She, Shanshan Wang, Jing Wang, Shaoxiang Yang
A magnetic zeolitic imidazolate framework nanohybrid (Fe₃O₄/ZIF-8) was synthesized and applied as an efficient magnetic solid-phase extraction (MSPE) adsorbent for fast adsorption and separation of clothianidin, imidacloprid, acetamiprid, and thiacloprid from various water samples. Fe₃O₄ and ZIF-8 were combined via a simple modified in situ method and the obtained nanohybrid (Fe₃O₄/ZIF-8) showed both excellent adsorption capacity and convenient magnetic property. ZIF-8 was found to play a dominant role in adsorbing the analytes and π-π interaction was found to be the main adsorption mechanism of analytes by Fe₃O₄/ZIF-8...
June 1, 2019: Journal of Nanoscience and Nanotechnology
Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu, Amirrudin Muhammad, Tiffiny Chau Dee Ho, Bazilah Jusoh, Nor Azlina Zolkifli, Ravindran Thayan, Adiratna Mat Ripen, Murizal Zainol, Ami Fazlin Syed Mohamed
BACKGROUND: Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with DEN-2 dengue virus. METHODS: The AG129 mice were fed orally with FCPLJ for 3 consecutive days after 24 h of dengue virus inoculation...
February 11, 2019: BMC Complementary and Alternative Medicine
Mohamed Ahmed Elnabarawi, Randa Tag Abd El Rehem, Mahmoud Teaima, Mohammed Abary, Hala Mohammed El-Mofty, Mohamed M Khafagy, Nancy M Lotfy, Mona Salah
OBJECTIVES: This study was aimed to develop dual-purpose natamycin(NAT) loaded niosomes in ketorolac tromethamine(KT) gels topical ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation associated with Fungal keratitis(FK). SIGNIFICANCE: Nanosized carrier systems, as niosomes would provide great potential for improving NAT ocular bioavailability.NAT niosomal dispersion formulae were prepared and then incorporated in 0...
February 12, 2019: Drug Development and Industrial Pharmacy
Asmaa Ty Kishawy, Shimaa A Amer, Mohamed E Abd El-Hack, Islam M Saadeldin, Ayman A Swelum
The current study aimed to replace soybean oil in broiler diets with linseed oil, which is rich in omega-3 fatty acid supplemented with pomegranate peel extract (PPE) and measured its effect on broiler performance, carcass traits, lipid profile, as well as fatty acids composition, phenols and flavonoids content of broiler muscles and immunity of broiler chicks. A total of 300 1-day-old Cobb chicks were randomly allotted into six experimental groups, T1 fed on basal diet with soybean oil without any additives, T2 fed on basal diet with soybean oil with addition of 0...
January 4, 2019: Asian-Australasian Journal of Animal Sciences
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