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Parathyroid adenoma

Mesut Ozturk, Ahmet Veysel Polat, Cetin Celenk, Muzaffer Elmali, Seher Kir, Cafer Polat
PURPOSE: The aim of this study was to assess the feasibility of four-dimensional magnetic resonance imaging (4D MRI) at 3 T for the localization of parathyroid adenomas. MATERIALS AND METHODS: Preoperative 4D MRI scans, encompassing dynamic contrast-enhanced (DCE) sequences and non-contrast enhanced (non-CE) sequences, including a T2-weighted multipoint Dixon (T2-mDixon) sequence, with in-phase, out-phase, and water-only images, were evaluated retrospectively in 41 patients with surgically proven parathyroid lesions...
March 2019: European Journal of Radiology
Tatiana Daniela Sala, Simona Mureşan, Ramona Roman, Alexandra Lazăr, Răzvan Ion, Ionela Paşcanu
Introduction: A hypercalcaemic crisis, also called para thyrotoxicosis, hyper parathyroid crisis or parathyroid storm, is a complication of primary hyperparathyroidism (PHPT) and an endocrinology emergency that can have dramatic or even fatal consequences if it is not recognised and treated in time. Case presentation: Two cases presented in the emergency department with critical hypercalcaemic symptoms and severe elevation of serum calcium and parathyroid hormone levels, consistent with a hypercalcaemic crisis...
January 2019: Journal of Critical Care Medicine
Sushma Mehta, Vidita Powle, Naveen H Chandrasekhar, Vijay Pillai, Vidya Bushan, Vivek Shetty, Moni A Kuriakose, H V Sunil, K S Shivaprasad, Kranti S Khadilkar, Subramanian Kannan
No abstract text is available yet for this article.
November 2018: Indian Journal of Endocrinology and Metabolism
Philippe Robin, Ran Klein, Jeremy Gardner, Blair Ziebarth, Sadri Bazarjani, Simin Razavi, Lionel S Zuckier, Wanzhen Zeng
PURPOSE: Proposed mechanisms of parathyroid localization in 'dual-phase' technetium-99m-sestamibi imaging include increased presence of mitochondria leading to greater uptake and slower washout compared with thyroid tissues owing to reduced expression of P-glycoprotein. Using new techniques of quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT), we have measured MIBI uptake and washout to better understand factors related to conspicuity. PATIENTS AND METHODS: We retrospectively reviewed 125 consecutive patients...
February 12, 2019: Nuclear Medicine Communications
Mustafa Çalışkan, Muhammed Kızılgül, Selvihan Beysel, Bekir Uçan, Fatih Akcan, Mümtaz Takır, Mustafa Özbek, Erman Çakal
Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients. Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study...
February 11, 2019: Turkish Journal of Medical Sciences
S A Sunny, A Singh, A B Adhikary
Ectopic parathyroid are most frequently found in the anterior mediastinum, in association with the thymus or the thyroid gland. Ectopic parathyroid glands are a major cause of persistent and recurrent Hyperparathyroidism. We report a case of 65-year-old female was referred from Surgical Endocrine department to the department of Cardiac Surgery on 20 September, 2017 in Bangabandhu Sheikh Mujib Medical University with parathyroid crisis due to an ectopic mediastinal parathyroid adenoma with her serum calcium and PTH markedly increased in short time...
January 2019: Mymensingh Medical Journal: MMJ
Naomi Hatabu, Naho Katori, Takeshi Sato, Naonori Maeda, Eri Suzuki, Osamu Komiyama, Hidemitsu Tsutsui, Toshitaka Nagao, Hana Nakauchi-Takahashi, Tatsuo Matsunaga, Tomohiro Ishii, Tomonobu Hasegawa, Kazuki Yamazawa
INTRODUCTION: Primary hyperparathyroidism (PHPT) occurs as part of familial syndromes, including CDC73-related disorders caused by germline pathogenic variants of the CDC73 gene, particularly in early adulthood. Herein, we report a familial case of a whole germline CDC73 deletion discordant for PHPT. CASE DESCRIPTION: A 15-year-old boy was admitted to our hospital because of persistent nausea and vomiting. Laboratory tests showed hypercalcemia (13.6 mg/dL), hypophosphatemia (2...
February 8, 2019: Hormone Research in Pædiatrics
Benjamin John Miller, Kim Isaacs, Emran Khan, Fausto F Palazzo
No abstract text is available yet for this article.
February 7, 2019: BMJ Case Reports
Charlotte Spear, Travis Geraci, Costas Bizekis, Michael Zervos
No abstract text is available yet for this article.
February 5, 2019: Seminars in Thoracic and Cardiovascular Surgery
Kelvin Onyeka Memeh, Jeannine Esther Palacios, Rihan Khan, Marlon Alex Guerrero
INTRODUCTION: Accurate pre-operative image localization is critical in selection of minimally invasive parathyroidectomy (MIP) as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Sestamibi scan, ultrasound, computed tomography and conventional magnetic resonance imaging (MRI) has varying accuracy in localizing parathyroid adenoma. Our group had previously shown that 4D MRI is more accurate than conventional imaging in identifying single adenomas. In this study, we set out to determine if 4D-MRI is able to accurately localize the quadrant of the adenoma...
January 18, 2019: Endocrine Practice
Y S Kushchayeva, S H Tella, S V Kushchayev, D Van Nostrand, K Kulkarni
Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism. We investigated the degree and causes of localization failure among different types of hyperparathyroidism. Pre-operative parathyroid hormone levels and size of the gland were major determinants of Tc99m-sestamibi positivity; 123 I scan may be helpful in localization failures. INTRODUCTION: Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism...
January 31, 2019: Osteoporosis International
Jianguo Chen, Zhiqiang Ma, Jianchun Yu
RATIONALE: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Until now, there are no specific guidelines on the management of cystic ectopic intrathyroidal parathyroid adenoma (ETPA)...
February 2019: Medicine (Baltimore)
Sohini Khan, Charles C Choe, Ahmed Shabaik, Michael Bouvet
RATIONALE: Spontaneous anterior cervical or mediastinal hemorrhage is a rare presentation of parathyroid adenoma. PATIENT CONCERNS: A 69-year-old woman presented with neck hematoma and dysphagia and was found to have a soft tissue mass adjacent to her thyroid gland as seen on MRI and neck ultrasound. DIAGNOSIS: Laboratory testing demonstrated elevated calcium and parathyroid hormone supporting diagnosis of parathyroid adenoma. INTERVENTIONS: She underwent right inferior parathyroidectomy and en bloc right hemithyroidectomy due to significant fibrosis...
February 2019: Medicine (Baltimore)
Tarek Ezzat Abdel-Aziz, Fergus Gleeson, Greg Sadler, Radu Mihai
BACKGROUD: This study compares the outcome of parathyroidectomy for primary hyperparathyroidism (PHPT) in patients whose adenomas' weights were at the extremes of the distribution curve. As the size of parathyroid adenomas influences the success rate of localization studies for PHPT, it is possible that a difference in cure rate could be observed between subgroups of patients. MATERIALS AND METHODS: Data were retrieved from a prospective database maintained in a large university hospital...
January 25, 2019: Journal of Surgical Research
Paola Parra Ramírez, Antonio Santiago Hernando, Beatriz Barquiel Alcalá, Patricia Martín Rojas-Marcos, Arturo Lisbona Catalán, Cristina Álvarez Escolá
OBJECTIVES: We aimed to compare the effectiveness of contrast-enhanced ultrasound (CEUS), technetium Tc 99m methoxyisobutylisonitrile (99m Tc-MIBI) single-photon emission computed tomographic (SPECT) scintigraphy, and high-resolution ultrasound (US) in the detection of a pathologic parathyroid gland in patients with primary hyperparathyroidism (pHPT). METHODS: Twenty-nine consecutive patients with pHPT were prospectively enrolled and underwent preoperative imaging with 99m Tc-MIBI SPECT scintigraphy, high-resolution US, and CEUS and subsequent parathyroidectomy...
January 29, 2019: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Mihaela Stanciu, Loredana Camelia Boicean, Florina Ligia Popa
RATIONALE: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. PATIENT CONCERNS: We presented the case of a male Caucasian patient, aged 67 years, who was investigated for hypercalcemia...
January 2019: Medicine (Baltimore)
Ameet Singh, Michelle A Giuffrida, Christopher B Thomson, Jared Baum, Betty Kramek, Julius M Liptak, Philip Hyndman, Brendon Ringwood, Daniel Smeak, Kathleen Ham, John Berg, Kelley Thieman-Mankin, Shauna L Blois, Sarah E Boston
OBJECTIVE: To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT). STUDY DESIGN: Multi-institutional, retrospective case series. ANIMALS: Thirty-two client-owned cats. METHODS: Medical records of cats treated with surgical removal of 1 or more parathyroid gland(s) with confirmed histopathologic evaluation were reviewed...
January 21, 2019: Veterinary Surgery: VS
Jian Shen, Qiong Wu, Yan Wang
BACKGROUND: The coexistence of primary hyperparathyroidism(PHPT) and papillary thyroid cancer(PTC) is a known entity; it is a rare and complicated setting for diagnostic imaging. METHODS: After reviewing clinical data of 112 patients who had been treated for PHPT in our facility between January 2015 and December 2017, we identified 7 non-medullary thyroid carcinoma (NMTC) (6.25%). All of them had taken an ultrasound scan and undergone operation. In addition, we have also reviewed relevant reports from other facilities addressing PHPT and NMTC (Mainly PTC)...
January 18, 2019: BMC Medical Imaging
Laura Masi
The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. The most common disorders include primary hyperparathyroidism (PHPT), malignancy, granulomatous diseases, and medications. PHPT is a disease characterized by excessive secretion of PTH...
2019: Frontiers of Hormone Research
Natalia G Mokrysheva, Anna K Eremkina, Svetlana S Mirnaya, Lyudmila Y Rozhinskaya, Nikolay S Kuznetsov, Rosa M Yesayan, Natalia E Kan, Ekaterina N Dudinskaya
BACKGROUND Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate. CASE REPORT During her second pregnancy, a 28-year-old woman presented with symptoms of general weakness, bone and joint pain, multiple fractures with bone deformity, muscle weakness, and gait disturbance...
January 14, 2019: American Journal of Case Reports
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